Icariin augments bone formation and reverses the phenotypes of osteoprotegerin-deficient mice through the activation of WNT/ β -Catenin-BMP Signaling

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Li, Xiao Feng ^a   Xu, Hao ^a   Zhao, Yong Jian ^a   Tang, De Zhi ^a   Xu, Guo Hua ^b   Holz, Jonathan ^c   Wang, Jing ^a   Cheng, Shao Dan ^a   Shi, Qi ^a   Wang, Yong Jun ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c ST JOHN FISHER COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; DICKKOPF 1 PROTEIN; ICARIIN; LYMPHOID ENHANCER FACTOR 1; OSTEOCALCIN; OSTEOPROTEGERIN; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR RUNX2; WNT1 PROTEIN; WNT3A PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE STRENGTH; CALVARIA; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GENE TARGETING; IN VITRO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TREATMENT DURATION; UPREGULATION;

EID: 84888635065     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/652317     Document Type: Article

References (35)

1. Pluijm S. M. F., Koes B., de Laet C., van Schoor N. M., Kuchuk N. O., Rivadeneira F., Mackenbach J. P., Lips P., Pols H. A., Steyerberg E. W., A simple risk score for the assessment of absolute fracture risk in general practice based on two longitudinal studies. Journal of Bone and Mineral Research 2009 24 5 768 774 2-s2.0-65949118473 10.1359/jbmr.081244
2. Rubin C. D., Emerging concepts in osteoporosis and bone strength. Current Medical Research and Opinion 2005 21 7 1049 1056 2-s2.0-22744432780 10.1185/030079905X50525 (Pubitemid 41032694)
3. Nakagawa S., Arai Y., Mazda O., Kishida T., Takahashi K. A., Sakao K., Saito M., Honjo K., Imanishi J., Kubo T., N-acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritis. Journal of Orthopaedic Research 2010 28 2 156 163 2-s2.0-73849152727 10.1002/jor.20976
4. Khosla S., Burr D., Cauley J., Dempster D. W., Ebeling P. R., Felsenberg D., Gagel R. F., Gilsanz V., Guise T., Koka S., McCauley L. K., McGowan J., McKee M. D., Mohla S., Pendrys D. G., Raisz L. G., Ruggiero S. L., Shafer D. M., Shum L., Silverman S. L., van Poznak C. H., Watts N., Woo S., Shane E., Bisphosphonate-associated osteonecrosis of the jaw: report of a Task Force of the American Society for Bone and Mineral Research. Journal of Bone and Mineral Research 2007 22 10 1479 1491 2-s2.0-34848841461 10.1359/jbmr.0707onj (Pubitemid 351229318)
5. Bilezikian J. P., Combination anabolic and antiresorptive therapy for osteoporosis: opening the anabolic window. Current Osteoporosis Reports 2008 6 1 24 30 2-s2.0-44849121708 10.1007/s11914-008-0005-9
6. Black D. M., Greenspan S. L., Ensrud K. E., Palermo L., McGowan J. A., Lang T. F., Garnero P., Bouxsein M. L., Bilezikian J. P., Rosen C. J., The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. The New England Journal of Medicine 2003 349 13 1207 1215 2-s2.0-0141684971 10.1056/NEJMoa031975 (Pubitemid 37152030)
7. Zhang G., Qin L., Shi Y., Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. Journal of Bone and Mineral Research 2007 22 7 1072 1079 2-s2.0-34548577294 10.1359/jbmr.070405 (Pubitemid 351343696)
8. Qin L., Zhang G., Hung W., Shi Y., Leung K., Yeung H., Leung P., Phytoestrogen-rich herb formula "xLGB" prevents OVX-induced deterioration of musculoskeletal tissues at the hip in old rats. Journal of Bone and Mineral Metabolism 2005 23 supplement 1 55 61 2-s2.0-21444456060 10.1007/BF03026324
9. Qian G., Zhang X., Lu L., Wu X., Li S., Meng J., Regulation of Cbfa1 expression by total flavonoids of Herba epimedii. Endocrine Journal 2006 53 1 87 94 2-s2.0-33644993478 10.1507/endocrj.53.87
10. Mok S. K., Chen W. F., Lai W. P., Leung P. C., Wang X. L., Yao X. S., Wong M. S., Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells. British Journal of Pharmacology 2010 159 4 939 949 2-s2.0-77249175670 10.1111/j.1476-5381.2009.00593.x
11. Nian H., Ma M.-H., Nian S.-S., Xu L.-L., Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 2009 16 4 320 326 2-s2.0-62549091847 10.1016/j.phymed.2008.12.006
12. Teitelbaum S. L., Bone resorption by osteoclasts. Science 2000 289 5484 1504 1508 2-s2.0-0034284970 10.1126/science.289.5484.1504
13. Aykin-Burns N., Franklin E. A., Ercal N., Effects of N-acetylcysteine on lead-exposed PC-12 cells. Archives of Environmental Contamination and Toxicology 2005 49 1 119 123 2-s2.0-23444456615 10.1007/s00244-004-0025-0 (Pubitemid 41126142)
14. Boyle W. J., Simonet W. S., Lacey D. L., Osteoclast differentiation and activation. Nature 2003 423 6937 337 342 2-s2.0-0037673945 10.1038/nature01658 (Pubitemid 40852708)
15. Bucay N., Sarosi I., Dunstan C. R., Morony S., Tarpley J., Capparelli C., Scully S., Tan H. L., Xu W., Lacey D. L., Boyle W. J., Simonet W. S., Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes and Development 1998 12 9 1260 1268 2-s2.0-0032079445 (Pubitemid 28213402)
16. Mizuno A., Amizuka N., Irie K., Murakami A., Fujise N., Kanno T., Sato Y., Nakagawa N., Yasuda H., Mochizuki S., Gomibuchi T., Yano K., Shima N., Washida N., Tsuda E., Morinaga T., Higashio K., Ozawa H., Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochemical and Biophysical Research Communications 1998 247 3 610 615 2-s2.0-0032577903 10.1006/bbrc.1998.8697 (Pubitemid 28418439)
17. Nakamura M., Udagawa N., Matsuura S., Mogi M., Nakamura H., Horiuchi H., Saito N., Hiraoka B. Y., Kobayashi Y., Takaoka K., Ozawa H., Miyazawa H., Takahashi N., Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption. Endocrinology 2003 144 12 5441 5449 2-s2.0-0344825808 10.1210/en.2003-0717 (Pubitemid 37476073)
18. Koide M., Kobayashi Y., Ninomiya T., Osteoprotegerin-deficient male mice as a model for severe alveolar bone loss: comparison with RANKL-overexpressing transgenic male mice. Endocrinology 2013 154 773 782
19. Songlin P., Ge Z., Yixin H., Xinluan W., Pingchung L., Kwoksui L., Ling Q., Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. Bone 2009 45 3 534 544 2-s2.0-67949098855 10.1016/j.bone.2009.05.022
20. Yin X., Chen Z., Liu Z., Ma Q., Dang G., Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2. Chinese Medical Journal 2007 120 3 204 210 2-s2.0-33847080418
21. Zhao J., Ohba S., Shinkai M., Chung U., Nagamune T., Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochemical and Biophysical Research Communications 2008 369 2 444 448 2-s2.0-40849100000 10.1016/j.bbrc.2008.02.054
22. Zheng D., Peng S., Yang S. H., Shao Z. W., Yang C., Feng Y., Wu W., Zhen W. X., The beneficial effect of Icariin on bone is diminished in osteoprotegerin-deficient mice. Bone 2012 51 85 92
23. Zhao M., Ko S., Liu J., Chen D., Zhang J., Wang B., Harris S. E., Oyajobi B. O., Mundy G. R., Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Molecular and Cellular Biology 2009 29 5 1291 1305 2-s2.0-61749093281 10.1128/MCB.01566-08
24. Zhao M., Harris S. E., Horn D., Geng Z., Nishimura R., Mundy G. R., Chen D., Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. Journal of Cell Biology 2002 157 6 1049 1060 2-s2.0-0037054548 10.1083/jcb.200109012 (Pubitemid 34839779)
25. Parfitt A. M., Drezner M. K., Glorieux F. H., Kanis J. A., Malluche H., Meunier P. J., Ott S. M., Recker R. R., Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. Journal of Bone and Mineral Research 1987 2 6 595 610 2-s2.0-0023488581
26. Yan Y., Tang D., Chen M., Huang J., Xie R., Jonason J. H., Tan X., Hou W., Reynolds D., Hsu W., Harris S. E., Puzas J. E., Awad H., O'Keefe R. J., Boyce B. F., Chen D., Axin2 controls bone remodeling through the β -catenin-BMP signaling pathway in adult mice. Journal of Cell Science 2009 122 19 3566 3578 2-s2.0-70350379620 10.1242/jcs.051904
27. Zhu M., Tang D., Wu Q., Hao S., Chen M., Xie C., Rosier R. N., O'Keefe R. J., Zuscik M., Chen D., Activation of β -catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult β -catenin conditional activation mice. Journal of Bone and Mineral Research 2009 24 1 12 21 2-s2.0-58149097603 10.1359/jbmr.080901
28. Anderson D. M., Maraskovsky E., Billingsley W. L., Dougall W. C., Tometsko M. E., Roux E. R., Teepe M. C., DuBose R. F., Cosman D., Galibert L., A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 1997 390 6656 175 179 2-s2.0-0030714605 10.1038/36593 (Pubitemid 27507987)
29. Wong B. R., Rho J., Arron J., Robinson E., Orlinick J., Chao M., Kalachikov S., Cayani E., Bartlett F. S. III, Frankel W. N., Lee S. Y., Choi Y., TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. The Journal of Biological Chemistry 1997 272 40 25190 25194 2-s2.0-14444272043 10.1074/jbc.272.40.25190 (Pubitemid 27415705)
30. Simonet W. S., Lacey D. L., Dunstan C. R., Kelley M., Chang M.-S., Lüthy R., Nguyen H. Q., Wooden S., Bennett L., Boone T., Shimamoto G., DeRose M., Elliott R., Colombero A., Tan H.-L., Trall G., Sullivan J., Davy E., Bucay N., Renshaw-Gegg L., Hughes T. M., Hill D., Pattison W., Campbell P., Sander S., Van G., Tarpley J., Derby P., Lee R., Boyle W. J., Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997 89 2 309 319 2-s2.0-0031005576 (Pubitemid 27199902)
31. Yamaguchi A., Komori T., Suda T., Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocrine Reviews 2000 21 4 393 411 2-s2.0-0034455051 10.1210/er.21.4.393 (Pubitemid 32275586)
32. Cao X., Chen D., The BMP signaling and in vivo bone formation. Gene 2005 357 1 1 8 2-s2.0-24644482494 10.1016/j.gene.2005.06.017 (Pubitemid 41267309)
33. Lee M., Kim Y., Kim H., Park H., Kang A., Kyung H., Sung J., Wozney J. M., Kim H., Ryoo H., BMP-2-induced Runx2 expression is mediated by Dlx5, and TGF-beta 1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression. The Journal of Biological Chemistry 2003 278 36 34387 34394 2-s2.0-0042891942 10.1074/jbc.M211386200 (Pubitemid 37553284)
34. Nakashima K., Zhou X., Kunkel G., Zhang Z., Deng J. M., Behringer R. R., de Crombrugghe B., The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation. Cell 2002 108 1 17 29 2-s2.0-0037059614 10.1016/S0092-8674(01)00622-5 (Pubitemid 34137009)
35. Zhang R., Oyajobi B. O., Harris S. E., Wnt/ β -catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone 2013 52 145 156