Poly(glycoamidoamine) vehicles promote pDNA uptake through multiple routes and efficient gene expression via caveolae-mediated endocytosis

Molecular Pharmaceutics

Volumn 7, Issue 3, 2010, Pages 738-750

  McLendon, Patrick M ^a,b   Fichter, Katye M ^c,d   Reineke, Theresa M ^a,c  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d Oregon Health and Science University Department of Biomedical Engineering   (United States)

Author keywords

Caveolae; Clathrin; Flow cytometry; Membrane disruption; Nonviral DNA delivery; Transfection

Indexed keywords

CELL ENZYME; CLATHRIN; PLASMID DNA; POLYAMIDOAMINE; POLYGLYCOAMIDOAMINE; POLYMER; UNCLASSIFIED DRUG;

ANTIBODY LABELING; ARTICLE; CAVEOLA; CELL ENERGY; COATED VESICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; ENDOCYTOSIS; ENDOSOME; GENE EXPRESSION; GENE TARGETING; HELA CELL; HUMAN; HUMAN CELL; INTERNALIZATION; PINOCYTOSIS; PRIORITY JOURNAL; TRANSGENE;

AMINES; CAVEOLAE; DNA; ENDOCYTOSIS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; LIPOSOMES; MICROSCOPY, CONFOCAL; MODELS, THEORETICAL; POLYMERS; TRANSFECTION;

EID: 77953259088     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900282e     Document Type: Article

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