Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen

Toxicology Letters

Volumn 224, Issue 2, 2014, Pages 272-281

  Dragovic, Sanja ^a   Venkataraman, Harini ^a   Begheijn, Selina ^a   Vermeulen, Nico P E ^a   Commandeur, Jan N M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Adverse drug reactions; Bioinactivation; Cytochrome P450; Glutathione S transferase P1 1; Polymorphism; Reactive metabolites

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 4 CHLORO 7 NITROBENZOFURAZAN; 5 METHYLCHRYSENE DIPOLXIDE; ACROLEIN; AMINO ACID; ATRAZINE; BENZO[A]PYRENE DIOLEPOXIDE; BENZO[C]CHRYSENE DIOLEPOXIDE 1; BENZO[C]CHRYSENE DIOLEPOXIDE 2; CHLORAMBUCIL; CHRYSENE DIOLEPOXIDE; CLOZAPINE; CLOZAPINE NITRENIUM ION; CROTONALDEHYDE; CYTOCHROME P450; CYTOCHROME P450 BM3; DICLOFENAC; DICLOFENAC 1,4 QUINONEIMINE; DICLOFENAC 2,5 QUINONEIMINE; DRUG METABOLITE; ETACRYNIC ACID; GLUTATHIONE TRANSFERASE; N ACETYL P BENZOQUINONEIMINE; PARACETAMOL; THIOTEPA; UNCLASSIFIED DRUG; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1; GSTP1 PROTEIN, HUMAN;

ALLELE; ARTICLE; BACTERIAL MUTATION; BINDING AFFINITY; COMPARATIVE STUDY; DETOXIFICATION; DRUG ACTIVATION; DRUG CONJUGATION; DRUG STRUCTURE; ENZYME POLYMORPHISM; GENE MUTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN LIVER MICROSOME; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; LIVER TOXICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SITE DIRECTED MUTAGENESIS; WILD TYPE; ADVERSE DRUG REACTIONS; BIOINACTIVATION; DRUG DETOXIFICATION; GENETICS; GENOTYPE; GLUTATHIONE-S-TRANSFERASE P1-1; HUMAN; METABOLISM; POLYMORPHISM; REACTIVE METABOLITES; SINGLE NUCLEOTIDE POLYMORPHISM; DRUG INACTIVATION;

ADVERSE DRUG REACTIONS; BIOINACTIVATION; CYTOCHROME P450; GLUTATHIONE-S-TRANSFERASE P1-1; POLYMORPHISM; REACTIVE METABOLITES;

ACETAMINOPHEN; CLOZAPINE; DICLOFENAC; GENOTYPE; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; METABOLIC DETOXICATION, DRUG; POLYMORPHISM, SINGLE NUCLEOTIDE; INACTIVATION, METABOLIC;

EID: 84888397847     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.10.023     Document Type: Article

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