Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1

Chemical Research in Toxicology

Volumn 25, Issue 11, 2012, Pages 2532-2541

  Boerma, Jan Simon ^a   Dragovic, Sanja ^a   Vermeulen, Nico P E ^a   Commandeur, Jan N M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOQUINONE DERIVATIVE; CYTOCHROME P450; DICLOFENAC; DRUG METABOLITE; GLUTATHIONE TRANSFERASE P1; IMINE;

ARTICLE; ATOM; BIOLOGICAL ACTIVITY; CONJUGATION; CYTOTOXICITY; DECARBOXYLATION; ENZYME MODIFICATION; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OXIDATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN PURIFICATION; PROTEIN TARGETING; SUBSTITUTION REACTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; GLUTATHIONE S-TRANSFERASE PI; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84869408727     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx300334w     Document Type: Article

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