Role of intestinal cytochrome P450 enzymes in diclofenac-induced toxicity in the small intestine

Journal of Pharmacology and Experimental Therapeutics

Volumn 343, Issue 2, 2012, Pages 362-370

  Zhu, Yi ^a   Zhang, Qing Yu ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 REDUCTASE; DICLOFENAC; DRUG METABOLITE; GLUTATHIONE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; FOOD DRUG INTERACTION; GRAPEFRUIT JUICE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE ULCER; MALE; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; WILD TYPE;

AGED; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOTRANSFORMATION; CITRUS PARADISI; CYTOCHROME P-450 ENZYME SYSTEM; DICLOFENAC; FEMALE; FOOD-DRUG INTERACTIONS; GLUTATHIONE; HUMANS; INTESTINAL DISEASES; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; MICE; MICE, KNOCKOUT; MICROSOMES; MIDDLE AGED; ULCER;

EID: 84867583625     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.198077     Document Type: Article

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