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Volumn 67, Issue 3, 2013, Pages 837-851

Evidence of Colorectal Cancer-Associated Mutation in MCAK: A Computational Report

Author keywords

Colorectal cancer; Genotype phenotype association; MCAK protein; Molecular dynamics simulation; SNP analysis

Indexed keywords

ADENOSINE TRIPHOSPHATE; KIF2C PROTEIN, HUMAN; KINESIN; LIGAND;

EID: 84888365817     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-013-9572-1     Document Type: Article
Times cited : (49)

References (53)
  • 1
    • 79960004101 scopus 로고    scopus 로고
    • The bidirectional depolymerizer MCAK generates force by disassembling both microtubule ends
    • Oguchi, Y., Uchimura, S., Ohki, T., Mikhailenko, S. V., & Ishiwata, S. (2011). The bidirectional depolymerizer MCAK generates force by disassembling both microtubule ends. Nature Cell Biology, 13, 846-852.
    • (2011) Nature Cell Biology , vol.13 , pp. 846-852
    • Oguchi, Y.1    Uchimura, S.2    Ohki, T.3    Mikhailenko, S.V.4    Ishiwata, S.5
  • 3
    • 0030298137 scopus 로고    scopus 로고
    • A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
    • Merdes, A., Ramyar, K., Vechio, J. D., & Cleveland, D. W. (1996). A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell, 87, 447-458.
    • (1996) Cell , vol.87 , pp. 447-458
    • Merdes, A.1    Ramyar, K.2    Vechio, J.D.3    Cleveland, D.W.4
  • 4
    • 0030665077 scopus 로고    scopus 로고
    • CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
    • Wood, K. W., Sakowicz, R., Goldstein, L. S. B., & Cleveland, D. W. (1997). CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell, 91, 357-366.
    • (1997) Cell , vol.91 , pp. 357-366
    • Wood, K.W.1    Sakowicz, R.2    Goldstein, L.S.B.3    Cleveland, D.W.4
  • 5
    • 0028887847 scopus 로고
    • Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis
    • Wordeman, L., & Mitchison, T. J. (1995). Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. Journal of Cell Biology, 128, 95-104.
    • (1995) Journal of Cell Biology , vol.128 , pp. 95-104
    • Wordeman, L.1    Mitchison, T.J.2
  • 6
    • 84863008444 scopus 로고    scopus 로고
    • Mitotic centromere-associated kinesin (MCAK): A potential cancer drug target
    • Sanhaji, M., Friel, C. T., Wordeman, L., Louwen, F., & Yuan, J. (2011). Mitotic centromere-associated kinesin (MCAK): A potential cancer drug target. Oncotarget, 2, 935-947.
    • (2011) Oncotarget , vol.2 , pp. 935-947
    • Sanhaji, M.1    Friel, C.T.2    Wordeman, L.3    Louwen, F.4    Yuan, J.5
  • 7
    • 0030031999 scopus 로고    scopus 로고
    • XKCM1: A xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly
    • Walczak, C. E., Mitchison, T. J., & Desai, A. (1996). XKCM1: A xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell, 84, 37-47.
    • (1996) Cell , vol.84 , pp. 37-47
    • Walczak, C.E.1    Mitchison, T.J.2    Desai, A.3
  • 8
    • 0031873388 scopus 로고    scopus 로고
    • Mitotic centromere-associated kinesin is important for anaphase chromosome segregation
    • Maney, T., Hunter, A. W., Wagenbach, M., & Wordeman, L. (1998). Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. Journal of Cell Biology, 142, 787-801.
    • (1998) Journal of Cell Biology , vol.142 , pp. 787-801
    • Maney, T.1    Hunter, A.W.2    Wagenbach, M.3    Wordeman, L.4
  • 9
    • 19644379975 scopus 로고    scopus 로고
    • Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy
    • Tomonaga, T., Matsushita, K., Ishibashi, M., Nezu, M., Shimada, H., Ochiai, T., et al. (2005). Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy. Cancer Research, 65, 4683-4689.
    • (2005) Cancer Research , vol.65 , pp. 4683-4689
    • Tomonaga, T.1    Matsushita, K.2    Ishibashi, M.3    Nezu, M.4    Shimada, H.5    Ochiai, T.6    Yoda, K.7    Nomura, F.8
  • 10
    • 4143066950 scopus 로고    scopus 로고
    • Mitotic spindle assembly and chromosome segregation: Refocusing on microtubule dynamics
    • Kline-Smith, S. L., & Walczak, C. E. (2004). Mitotic spindle assembly and chromosome segregation: Refocusing on microtubule dynamics. Molecular Cell, 15, 317-327.
    • (2004) Molecular Cell , vol.15 , pp. 317-327
    • Kline-Smith, S.L.1    Walczak, C.E.2
  • 11
    • 34547882734 scopus 로고    scopus 로고
    • Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer
    • Nakamura, Y., Tanaka, F., Haraguchi, N., Mimori, K., Matsumoto, T., Inoue, H., et al. (2007). Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer. British Journal of Cancer, 97, 543-549.
    • (2007) British Journal of Cancer , vol.97 , pp. 543-549
    • Nakamura, Y.1    Tanaka, F.2    Haraguchi, N.3    Mimori, K.4    Matsumoto, T.5    Inoue, H.6    Yanaga, K.7    Mori, M.8
  • 12
    • 0027172019 scopus 로고
    • Prothymosin-alpha mRNA expression correlates with that of c-myc in human colon cancer
    • Mori, M., Barnard, G. F., Staniunas, R. J., Jessup, J. M., Steele, G. D., & Chen, L. B., Jr. (1993). Prothymosin-alpha mRNA expression correlates with that of c-myc in human colon cancer. Oncogene, 8, 2821-2826.
    • (1993) Oncogene , vol.8 , pp. 2821-2826
    • Mori, M.1    Barnard, G.F.2    Staniunas, R.J.3    Jessup, J.M.4    Steele, G.D.5    Chen Jr., L.B.6
  • 13
    • 44349151502 scopus 로고    scopus 로고
    • Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer
    • Ishikawa, K., Kamohara, Y., Tanaka, F., Haraguchi, N., Mimori, K., Inoue, H., et al. (2008). Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer. British Journal of Cancer, 98, 1824-1829.
    • (2008) British Journal of Cancer , vol.98 , pp. 1824-1829
    • Ishikawa, K.1    Kamohara, Y.2    Tanaka, F.3    Haraguchi, N.4    Mimori, K.5    Inoue, H.6    Mori, M.7
  • 15
    • 68149165614 scopus 로고    scopus 로고
    • Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
    • Kumar, P., Henikoff, S., & Ng, P. C. (2009). Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nature Protocols, 4, 1073-1081.
    • (2009) Nature Protocols , vol.4 , pp. 1073-1081
    • Kumar, P.1    Henikoff, S.2    Ng, P.C.3
  • 17
    • 33751013750 scopus 로고    scopus 로고
    • Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information
    • Capriotti, E., Calabrese, R., & Casadio, R. (2006). Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information. Bioinformatics, 22, 2729-2734.
    • (2006) Bioinformatics , vol.22 , pp. 2729-2734
    • Capriotti, E.1    Calabrese, R.2    Casadio, R.3
  • 19
    • 80053297561 scopus 로고    scopus 로고
    • A new disease-specific machine learning approach for the prediction of cancer-causing missense variants
    • Capriotti, E., & Altman, R. B. (2011). A new disease-specific machine learning approach for the prediction of cancer-causing missense variants. Genomics, 98, 310-317.
    • (2011) Genomics , vol.98 , pp. 310-317
    • Capriotti, E.1    Altman, R.B.2
  • 20
    • 0035173378 scopus 로고    scopus 로고
    • dbSNP: The NCBI database of genetic variation
    • Sherry, S. T., et al. (2001). dbSNP: The NCBI database of genetic variation. Nucleic Acids Research, 29, 308-311.
    • (2001) Nucleic Acids Research , vol.29 , pp. 308-311
    • Sherry, S.T.1
  • 22
    • 77956634216 scopus 로고    scopus 로고
    • Structural basis for the resilience of Darunavir (TMC114) resistance major flap mutations of HIV-1 protease
    • Purohit, R., & Sethumadhavan, R. (2009). Structural basis for the resilience of Darunavir (TMC114) resistance major flap mutations of HIV-1 protease. Interdisciplinary Science, 1, 320-328.
    • (2009) Interdisciplinary Science , vol.1 , pp. 320-328
    • Purohit, R.1    Sethumadhavan, R.2
  • 23
    • 79958089433 scopus 로고    scopus 로고
    • Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and isoniazid susceptibility: An in silico analysis
    • Purohit, R., Rajendran, V., & Sethumadhavan, R. (2011). Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and isoniazid susceptibility: An in silico analysis. Journal of Molecular Modeling, 17, 869-877.
    • (2011) Journal of Molecular Modeling , vol.17 , pp. 869-877
    • Purohit, R.1    Rajendran, V.2    Sethumadhavan, R.3
  • 24
    • 79959449643 scopus 로고    scopus 로고
    • Studies on adaptability of binding residues and flap region of TMC-114 resistance HIV-1 protease mutants
    • Purohit, R., Rajendran, V., & Sethumadhavan, R. (2011). Studies on adaptability of binding residues and flap region of TMC-114 resistance HIV-1 protease mutants. Journal of Biomolecular Structure & Dynamics, 29, 137-152.
    • (2011) Journal of Biomolecular Structure & Dynamics , vol.29 , pp. 137-152
    • Purohit, R.1    Rajendran, V.2    Sethumadhavan, R.3
  • 25
    • 84864771186 scopus 로고    scopus 로고
    • In silico investigation of molecular mechanism of laminopathy cause by a point mutation (R482 W) in lamin A/C protein
    • Rajendran, V., Purohit, R., & Sethumadhavan, R. (2012). In silico investigation of molecular mechanism of laminopathy cause by a point mutation (R482 W) in lamin A/C protein. Amino Acids, 43, 603-615.
    • (2012) Amino Acids , vol.43 , pp. 603-615
    • Rajendran, V.1    Purohit, R.2    Sethumadhavan, R.3
  • 29
    • 84872270918 scopus 로고    scopus 로고
    • Computational screening and molecular dynamics simulation of disease associated nsSNPs in CENP-E
    • 28-37
    • Kumar, A., & Purohit, R. (2012). Computational screening and molecular dynamics simulation of disease associated nsSNPs in CENP-E. Mutation Research, 738-739, 28-37. http://dx. doi. org/10. 1016/j. mrfmmm. 2012. 08. 005.
    • (2012) Mutation Research , pp. 738-739
    • Kumar, A.1    Purohit, R.2
  • 30
    • 84861790146 scopus 로고    scopus 로고
    • Computational investigation of pathogenic nsSNPs in CEP63 protein
    • Kumar, A., & Purohit, R. (2012). Computational investigation of pathogenic nsSNPs in CEP63 protein. Gene, 503, 75-82.
    • (2012) Gene , vol.503 , pp. 75-82
    • Kumar, A.1    Purohit, R.2
  • 31
    • 84861090227 scopus 로고    scopus 로고
    • SNPeffect 4. 0: On-line prediction of molecular and structural effects of protein-coding variants
    • De, Baets, & G., et al. (2012). SNPeffect 4. 0: On-line prediction of molecular and structural effects of protein-coding variants. Nucleic Acids Research, 40(database issue), D935-9.
    • (2012) Nucleic Acids Research , vol.40 , Issue.Database issue
    • De, B.1
  • 33
    • 23144441494 scopus 로고    scopus 로고
    • SRide: A server for identifying stabilizing residues in proteins
    • Magyar, C., Gromiha, M. M., Pujadas, G., Tusnady, G. E., & Simon, I. (2005). SRide: A server for identifying stabilizing residues in proteins. Nucleic Acids Research, 33(web server issue), W303-5.
    • (2005) Nucleic Acids Research , vol.33 , Issue.Web server issue
    • Magyar, C.1    Gromiha, M.M.2    Pujadas, G.3    Tusnady, G.E.4    Simon, I.5
  • 34
    • 33747818007 scopus 로고    scopus 로고
    • CASTp: Computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues
    • Dundas, J., Ouyang, Z., Tseng, J., Binkowski, A., Turpaz, Y., et al. (2006). CASTp: Computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues. Nucleic Acids Research, 34, W116-W118.
    • (2006) Nucleic Acids Research , vol.34
    • Dundas, J.1    Ouyang, Z.2    Tseng, J.3    Binkowski, A.4    Turpaz, Y.5
  • 39
    • 0029170114 scopus 로고
    • Molecular dynamics simulations on solvated biomolecular systems: The particle mesh Ewald method leads to stable trajectories of DNA, RNA, and proteins
    • Cheatham, T. E., Miller, J. L., Fox, T., Darden, T. A., & Kollman, A. (1995). Molecular dynamics simulations on solvated biomolecular systems: The particle mesh Ewald method leads to stable trajectories of DNA, RNA, and proteins. Journal of the American Chemical Society, 14, 4193-4194.
    • (1995) Journal of the American Chemical Society , vol.14 , pp. 4193-4194
    • Cheatham, T.E.1    Miller, J.L.2    Fox, T.3    Darden, T.A.4    Kollman, A.5
  • 41
    • 33847314487 scopus 로고    scopus 로고
    • Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis
    • Carvalho, M. A., et al. (2007). Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis. Cancer Research, 67, 1494-1501.
    • (2007) Cancer Research , vol.67 , pp. 1494-1501
    • Carvalho, M.A.1
  • 42
    • 58249090764 scopus 로고    scopus 로고
    • Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1
    • Carvalho, M., et al. (2009). Analysis of a set of missense, frameshift, and in-frame deletion variants of BRCA1. Mutation Research, 660, 1-11.
    • (2009) Mutation Research , vol.660 , pp. 1-11
    • Carvalho, M.1
  • 43
    • 79958845071 scopus 로고    scopus 로고
    • Identification and in silico analysis of novel von Hippel-Lindau (VHL) gene variants from a large population
    • Leonardi, E., et al. (2011). Identification and in silico analysis of novel von Hippel-Lindau (VHL) gene variants from a large population. Annals of Human Genetics, 75, 483-496.
    • (2011) Annals of Human Genetics , vol.75 , pp. 483-496
    • Leonardi, E.1
  • 44
    • 24044541648 scopus 로고    scopus 로고
    • Genetic association, post-translational modification, and protein-protein interactions in type 2 diabetes mellitus
    • Sharma, A., et al. (2005). Genetic association, post-translational modification, and protein-protein interactions in type 2 diabetes mellitus. Molecular and Cellular Proteomics, 4, 1029-1037.
    • (2005) Molecular and Cellular Proteomics , vol.4 , pp. 1029-1037
    • Sharma, A.1
  • 45
    • 12944281622 scopus 로고    scopus 로고
    • Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins
    • Savas, S., et al. (2005). Candidate nsSNPs that can affect the functions and interactions of cell cycle proteins. Proteins, 58, 697-705.
    • (2005) Proteins , vol.58 , pp. 697-705
    • Savas, S.1
  • 46
    • 33749254585 scopus 로고    scopus 로고
    • Applications of computational algorithm tools to identify functional SNPs in cytokine genes
    • Shen, J., et al. (2006). Applications of computational algorithm tools to identify functional SNPs in cytokine genes. Cytokine, 35, 62-66.
    • (2006) Cytokine , vol.35 , pp. 62-66
    • Shen, J.1
  • 47
    • 17244367767 scopus 로고    scopus 로고
    • Bioinformatics approaches and resources for single nucleotide polymorphism functional analysis
    • Mooney, S. (2005). Bioinformatics approaches and resources for single nucleotide polymorphism functional analysis. Briefings in Bioinformatics, 6, 44-56.
    • (2005) Briefings in Bioinformatics , vol.6 , pp. 44-56
    • Mooney, S.1
  • 48
    • 84887212608 scopus 로고    scopus 로고
    • Investigation of binding phenomenon of NSP3 and p130Cas mutants and their effect on cell signalling
    • doi: 10. 1007/s12013-013-9551-6
    • Balu, K., Rajendran, V., Sethumadhavan, R., & Purohit, R. (2013). Investigation of binding phenomenon of NSP3 and p130Cas mutants and their effect on cell signalling. Cell Biochemistry and Biophysics. doi: 10. 1007/s12013-013-9551-6.
    • (2013) Cell Biochemistry and Biophysics
    • Balu, K.1    Rajendran, V.2    Sethumadhavan, R.3    Purohit, R.4
  • 49
    • 84867629652 scopus 로고    scopus 로고
    • Computational centrosomics: An approach to understand the dynamic behaviour of centrosome
    • Kumar, A., & Purohit, R. (2012). Computational centrosomics: An approach to understand the dynamic behaviour of centrosome. Gene, 511(1), 125-126.
    • (2012) Gene , vol.511 , Issue.1 , pp. 125-126
    • Kumar, A.1    Purohit, R.2
  • 50
    • 84867464864 scopus 로고    scopus 로고
    • In silico prediction of a disease-associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ)
    • Kumar, A., Rajendran, V., Sethumadhavan, R., & Purohit, R. (2012). In silico prediction of a disease-associated STIL mutant and its affect on the recruitment of centromere protein J (CENPJ). FEBS Open Bio, 2, 285-293.
    • (2012) FEBS Open Bio , vol.2 , pp. 285-293
    • Kumar, A.1    Rajendran, V.2    Sethumadhavan, R.3    Purohit, R.4
  • 51
    • 84880943928 scopus 로고    scopus 로고
    • Computational investigation of cancer-associated molecular mechanism in aurora A (S155R) mutation
    • doi:10.1007/s12013-013-9524-9
    • Kumar, A., Rajendran, V., Sethumadhavan, R., & Purohit, R. (2013). Computational investigation of cancer-associated molecular mechanism in aurora A (S155R) mutation. Cell Biochemistry and Biophysics,. doi: 10. 1007/s12013-013-9524-9.
    • (2013) Cell Biochemistry and Biophysics
    • Kumar, A.1    Rajendran, V.2    Sethumadhavan, R.3    Purohit, R.4
  • 52
    • 84892966839 scopus 로고    scopus 로고
    • Relationship between a point mutation S97C in CK1δ protein and its affect on ATP binding affinity
    • doi: 10. 1080/07391102. 2013. 770373
    • Kumar, A., Rajendran, V., Sethumadhavan, R., & Purohit, R. (2013). Relationship between a point mutation S97C in CK1δ protein and its affect on ATP binding affinity. Journal of Biomolecular Structure & Dynamics. doi: 10. 1080/07391102. 2013. 770373.
    • (2013) Journal of Biomolecular Structure & Dynamics
    • Kumar, A.1    Rajendran, V.2    Sethumadhavan, R.3    Purohit, R.4
  • 53
    • 84889685004 scopus 로고    scopus 로고
    • Drug resistance mechanism of PncA in Mycobacterium tuberculosis
    • doi: 10. 1080/07391102. 2012. 759885
    • Rajendran, V., & Sethumadhavan, R. (2013). Drug resistance mechanism of PncA in Mycobacterium tuberculosis. Journal of Biomolecular Structure & Dynamics. doi: 10. 1080/07391102. 2012. 759885.
    • (2013) Journal of Biomolecular Structure & Dynamics
    • Rajendran, V.1    Sethumadhavan, R.2


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