Relationship between mutation of serine residue at 315th position in M. tuberculosis catalase-peroxidase enzyme and Isoniazid susceptibility: An in silico analysis

Journal of Molecular Modeling

Volumn 17, Issue 4, 2011, Pages 869-877

  Purohit, Rituraj ^a   Rajendran, Vidya ^a   Sethumadhavan, Rao ^a  

^a VIT UNIVERSITY   (India)

Author keywords

Binding affinity; Catalase peroxidase; Docking; Isoniazid; Molecular dynamic simulation; Resistance mutation; Solvent accessibility

Indexed keywords

ISONIAZID; SERINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL MUTATION; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPUTER MODEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTITUBERCULAR AGENTS; BINDING SITES; CATALASE; DRUG RESISTANCE, BACTERIAL; ENZYME INHIBITORS; HYDROGEN BONDING; ISONIAZID; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PEROXIDASE; PROTEIN BINDING; PROTEIN CONFORMATION; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79958089433     PISSN: 16102940     EISSN: 09485023     Source Type: Journal    
DOI: 10.1007/s00894-010-0785-6     Document Type: Article

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