Validation of a human cell based high-throughput genotoxicity assay 'Anthem's Genotoxicity screen' using ECVAM recommended lists of genotoxic and non-genotoxic chemicals

Toxicology in Vitro

Volumn 28, Issue 1, 2014, Pages 46-53

  Rajakrishna, Lakshmi ^a   Krishnan Unni, Salini ^a   Subbiah, Madhuri ^a   Sadagopan, Sathish ^a   Nair, Ayyappan R ^a   Chandrappa, Ravindra ^a   Sambasivam, Ganesh ^a   Sukumaran, Sunil Kumar ^a  

^a Anthem Biosciences Pvt Ltd   (India)

Author keywords

ECVAM; GADD153; High throughput; Human cell based; In vitro genotoxicity screen; P21; P53; Reporter based screen

Indexed keywords

GENOTOXIN; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CELL ENGINEERING; COLON CARCINOMA; CONTROLLED STUDY; GENOTOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; SENSITIVITY AND SPECIFICITY; VALIDATION STUDY;

ECVAM; GADD153; HIGH-THROUGHPUT; HUMAN CELL BASED; IN VITRO GENOTOXICITY SCREEN; P21; P53; REPORTER BASED SCREEN;

COLONIC NEOPLASMS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; GENES, REPORTER; HCT116 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MUTAGENICITY TESTS; MUTAGENS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 84888302463     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2013.06.027     Document Type: Article

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