Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21

American Journal of Respiratory Cell and Molecular Biology

Volumn 22, Issue 6, 2000, Pages 747-754

  Nakanishi, Yoichi ^a   Pei, Xin Hai ^a   Takayama, Koichi ^a   Bai, Feng ^a   Izumi, Miiru ^a   Kimotsuki, Kanehito ^a   Inoue, Koji ^a   Minami, Takahiro ^a   Wataya, Hiroshi ^a   Hara, Nobuyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034089593     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.22.6.3877     Document Type: Article

References (38)

1. 1. Wingo, P. A., T. Tong, and S. Bolden. 1995. Cancer statistics. Cancer J. Clin. 45:8-30.
2. 2. Bai, F., Y. Nakanishi, K. Takayama, X. H. Pei, H. Tokiwa, and N. Hara. 1998. Ki-ras mutation and cell proliferation of lung lesions induced by 1-nitropyrene in A/J mice. Mol. Carcinog. 22:258-264.
3. 3. Harvey, R. G. 1991. Polycyclic Aromatic Hydrocarbons: Chemistry and Carcinogenicity. Cambridge University Press, Cambridge, UK.
4. 4. Dipple, A. 1994. Reaction of polycyclic aromatic hydrocarbons with DNA, In DNA Adducts: Identification and Biological Significance. K. Hemminki, A. Dipple, D. Segeback, F. F. Kadlubar, D. Shuker, and H. Bartsch, editors. IARC Scientific Publications, Lyon. 107-129.
5. 5. Durant, J. L., W. F. Busby, Jr., A. L. Lafleur, B. W. Penman, and C. L. Crespi. 1996. Human cell mutagenicity of oxygenated, nitrated and unsubstituted polycyclic aromatic hydrocarbons associated with urban aerosols. Mutat. Res. 371:123-157.
6. 6. Denissenko, M. F., A. Pao, M. Tang, and G. P. Pfeifer. 1996. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 274:430-432.
7. 7. Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
8. 8. Lane, D. P. 1992. Cancer. p53, guardian of the genome. Nature 358:15-16.
9. 9. Livingstone, L. R., A. White, J. Sprouse, E. Livanos, T. Jacks, and T. D. Tlsty. 1992. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70:923-935.
10. 10. Yin, Y., M. A. Tainsky, F. Z. Bischoff, L. C. Strong, and G. M. Wahl. 1992. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-948.
11. 11. Sancar, A. 1995. DNA repair in humans. Annu. Rev. Genet. 29:69-105.
12. 12. Kastan, M. B., O. Onyekwere, D. Sidransky, B. Vogelstein, and R. W. Craig. 1991. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51:6304-6311.
13. 13. Kastan, M. B., O. Zhan, W. S. el-Deiry, F. Carrier, T. Jacks, W. V. Walsh, B. S. Plunkett, B. Vogelstein, and A. J. Fornace, Jr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71:587-597.
14. 14. Kuerbitz, S. J., B. S. Plunkett, W. V. Walsh, and M. B. Kastan. 1992. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89:7491-7495.
15. 15. Nelson, W. G., and M. B. Kastan. 1994. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14:1815-1823.
16. 16. Fritsche, M., C. Haessler, and G. Brandner. 1993. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 8:307-318.
17. 17. Maltzman, W., and L. Czyzyk. 1984. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4:1689-1694.
18. 18. Meek, D. W. 1994. Post-translational modification of p53. Semin. Cancer Biol. 5:203-210.
19. 19. Venkatachalam, S., M. Denissenko, and A. A. Wani. 1997. Modulation of ( + / -)-anti-BPDE mediated p53 accumulation by inhibitors of protein kinase C and poly(ADP-ribose) polymerase. Oncogene 14:801-809.
20. 20. Vaziri, C., and D. V. Faller. 1997. A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts. J. Biol. Chem. 272:2762-2769.
21. 21. Wakamatsu, K., Y. Nakanishi, K. Takayama, H. Miyazaki, K. Hayashi, and N. Hara. 1999. Frequent expression of p53 protein without mutation in the atypical epithelium of human bronchus. Am. J. Respir. Cell Mol. Biol. 21:209-215.
22. 22. Khan, Q. A., K. H. Vousden, and A. Dipple. 1997. Cellular response to DNA damage from a potent carcinogen involves stabilization of p53 without induction of p21(waf1/cip1). Carcinogenesis 18:2313-2318.
23. 23. Khan, Q. A., R. Agarwal, A. Seidel, H. Frank, K. H. Vousden, and A. Dipple. 1998. DNA adduct levels associated with p53 induction and delay of MCF-7 cells in S phase after exposure to benzo[g]chrysene dihydrodiol epoxide enantiomers. Mol. Carcinog. 23:115-120.
24. 24. Gartel, A. L., and A. L. Tyner. 1999. Transcriptional regulation of the p21(WAF1/CIP1)gene. Exp. Cell Res. 246:280-289.
25. 25. Maki, C. G., and P. M. Howley. 1997. Ubiquilination of p53 and p21 is differentially affected by ionizing and UV radiation. Mol. Cell. Biol. 17:355-363.
26. 26. Pagano, M. 1997. Cell cycle regulation by the ubiquitin pathway. FASEB J. 11:1067-1075.
27. 27. El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
28. 28. Nakano, K., T. Mizuno, Y. Sowa, T. Orita, T. Yoshino, Y. Okuyama, T. Fujita, N. Ohtani-Fujita, Y. Matsukawa, T. Tokino, H. Yamagishi, T. Oka, H. Nomura, and T. Sakai. 1997. Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J. Biol. Chem. 272: 22199-22206.
29. 29. Halazonetis, T. D., L. J. Davis, and A. N. Kandil. 1993. Wild-type p53 adopts a "mutant"-like conformation when bound to DNA. EMRO J. 12:1021-1028.
30. 30. Michieli, P., M. Chedid, D. Lin, J. H. Pierce, W. E. Mercer, and D. Givol. 1994. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res. 54:3391-3395.
31. 31. Ramet, M., K. Castren, K. Jarvinen, K. Pekkala, H. T. Turpeenniemi-Hujanen, Y. Soini, P. Paakko, and K. Vahakangas. 1995. p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. Carcinogenesis 16:2117-2124.
32. 32. Luch, A., K. Kudla, A. Seidel, J. Doehmer, H. Greim and W. M. Baird. 1999. The level of DNA modification by (+)-syn-(11S, 12R, 13S, 14R)-and (-)-anti-(11S, 12R, 13S, 14R)-dihydrodiol epoxides of debenzo[a, /]pyrene determined the effect on the proteins p53 and p21 WAF1 in the human mammary carcinoma cell line MCF-7. Carcinogenesis 20:859-865.
33. 33. Grana, X., and E. P. Reddy. 1995. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11:211-219.
34. 34. Di Leonardo, A., S. P. Linke, K. Clarkin, and G. M. Wahl. 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8:2540-2551.
35. 35. El-Deiry, W. S., J. W. Harper, P. M. O'Connor, V. E. Velculescu, C. E. Canman, J. Jackman, J. A. Pietenpol, M. Burrell, D. E. Hill, Y. Wang, K. G. Wiman, W. E. Mercer, M. B. Kastan, K. W. Kohn, S. J. Elledge, K. W. Kinzler, and B. Vogelstein. 1994. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1169-1174.
36. 36. Maki, C. G., J. M. Huibregtse, and P. M. Howley. 1996. In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res. 56:2649-2654.
37. 37. Fukuchi, K., S. Tomoyasu, T. Nakamaki, N. Tsuruoka, and K. Gomi. 1998. DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells. Biochim. Biophys. Acta 1404:405-411.
38. 38. Cayrol, C., and B. Ducommun. 1998. Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21. Oncogene 17:2437-2444.