Interleukin (IL) 1β induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IκB kinase α pathway targeting activator protein-1

Journal of Biological Chemistry

Volumn 283, Issue 38, 2008, Pages 25900-25912

  Cahill, Catherine M ^a,b   Rogers, Jack T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MA GenHosp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; CHEMICAL REACTIONS; PHOSPHORYLATION; TRANSCRIPTION;

ACTIVATOR PROTEINS; AKT PHOSPHORYLATIONS; GENE TRANSCRIPTIONS; INHIBITORY EFFECTS; INTERLEUKIN1; LY294002; OVEREXPRESSION; PARALLEL PATHWAYS; PARTIAL INHIBITIONS; PHARMACOLOGICAL INHIBITIONS; PHOSPHATIDYLINOSITOL; PHOSPHORYLATION SITES; PROMOTER ACTIVATIONS; PROTEIN PRODUCTIONS; WORTMANNIN;

ELECTRIC LOAD MANAGEMENT;

2 MORPHOLINO 8 PHENYLCHROMONE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; THREONINE; TRANSCRIPTION FACTOR AP 1; WORTMANNIN; ENZYME INHIBITOR; I KAPPA B; INTERLEUKIN 1; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; GENE MUTATION; HEAT SHOCK; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; BIOLOGICAL MODEL; GENETICS; METABOLISM; MUTATION; PHOSPHORYLATION; PROMOTER REGION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CACO-2 CELLS; ENZYME INHIBITORS; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-1; INTERLEUKIN-1BETA; INTERLEUKIN-6; MODELS, BIOLOGICAL; MUTATION; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 54449088686     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707692200     Document Type: Article

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