In Vitro evaluation of cytochrome P450 and glucuronidation activities in hepatocytes isolated from liver-humanized mice

Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 6, 2010, Pages 539-550

  Yamasaki, Chihiro ^a,b   Kataoka, Miho ^b   Kato, Yumiko ^a   Kakuni, Masakazu ^a   Usuda, Sadakazu ^c   Ohzone, Yoshihiro ^d   Matsuda, Sunao ^d   Adachi, Yasuhisa ^d   Ninomiya, Shin Ichi ^d   Itamoto, Toshiyuki ^e   Asahara, Toshimasa ^e   Yoshizato, Katsutoshi ^a,b   Tateno, Chise ^a,b  

^a PhoenixBio USA Corporation   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c ImmunoFrontier Inc   (Japan)

^d SEKISUI CHEMICAL CO LTD   (Japan)

^e HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Chimeric mice; Cytochrome p450; Human hepatocytes; Ketoprofen; UDP glucuronosyltransferase

Indexed keywords

CYTOCHROME P450; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; UROKINASE;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL VIABILITY; CHIMERA; CONTROLLED STUDY; CRYOPRESERVATION; ENZYME ACTIVITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE MUTATION; GENETIC POLYMORPHISM; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; IN VITRO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PURIFICATION; REPRODUCIBILITY; SCID MOUSE; TANDEM MASS SPECTROMETRY;

EID: 78951482519     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-RG-047     Document Type: Article

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