메뉴 건너뛰기




Volumn 13, Issue 6, 2013, Pages 864-868

Flavonoids as drugs at the small intestinal level

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE; AMYLASE; ASTRAGALIN; BREAST CANCER RESISTANCE PROTEIN; CHRYSIN; CYTOSTATIC AGENT; FISETIN; FLAVANOL DERIVATIVE; FLAVANONE DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; FLAVONOID GLYCOSIDE; FLAVONOL DERIVATIVE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 2; ISOFLAVONE DERIVATIVE; LUTEOLIN; MULBERRY EXTRACT; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MYRICETIN; NARINGENIN; PELARGONIDIN; PHLORIZIN; QUERCETIN; RUTOSIDE; SODIUM GLUCOSE COTRANSPORTER 1; TOPOTECAN; UNINDEXED DRUG;

EID: 84888202598     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2013.08.015     Document Type: Review
Times cited : (23)

References (45)
  • 1
    • 0033859612 scopus 로고    scopus 로고
    • Flavonoids as antioxidants
    • P.G. Pietta Flavonoids as antioxidants J Nat Prod 63 2000 1035 1042
    • (2000) J Nat Prod , vol.63 , pp. 1035-1042
    • Pietta, P.G.1
  • 2
    • 84877996799 scopus 로고    scopus 로고
    • Recent trends in the pharmacological activity of isoprenyl phenolics
    • M. Marín, and S. Máñez Recent trends in the pharmacological activity of isoprenyl phenolics Curr Med Chem 20 2013 272 279
    • (2013) Curr Med Chem , vol.20 , pp. 272-279
    • Marín, M.1    Máñez, S.2
  • 3
    • 84867562091 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease: Changing the focus from glycemic control to improving long-term survival
    • C.C. Wang, and J.E. Reusch Diabetes and cardiovascular disease: changing the focus from glycemic control to improving long-term survival Am J Cardiol 110 2012 58B 68B
    • (2012) Am J Cardiol , vol.110
    • Wang, C.C.1    Reusch, J.E.2
  • 4
    • 84867344530 scopus 로고    scopus 로고
    • Obesity and cancer risk: Evidence, mechanisms, and recommendations
    • I. Vucenik, and J.P. Stains Obesity and cancer risk: evidence, mechanisms, and recommendations Ann N Y Acad Sci 1271 2012 37 43
    • (2012) Ann N y Acad Sci , vol.1271 , pp. 37-43
    • Vucenik, I.1    Stains, J.P.2
  • 5
    • 84871781148 scopus 로고    scopus 로고
    • Worldwide relative burden of cancer death in 2008 extrapolated from the WHO mortality database
    • A. Matsuda, and R. Machii Worldwide relative burden of cancer death in 2008 extrapolated from the WHO mortality database Jpn J Clin Oncol 43 2013 102
    • (2013) Jpn J Clin Oncol , vol.43 , pp. 102
    • Matsuda, A.1    Machii, R.2
  • 8
    • 84874081668 scopus 로고    scopus 로고
    • The effects of flavonoids on the ABC transporters: Consequences for the pharmacokinetics of substrate drugs
    • Y. Li, and J.W. Paxton The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs Expert Opin Drug Metab Toxicol 9 2013 267 285
    • (2013) Expert Opin Drug Metab Toxicol , vol.9 , pp. 267-285
    • Li, Y.1    Paxton, J.W.2
  • 9
    • 84855932106 scopus 로고    scopus 로고
    • Flavonoids and their glycosides, including anthocyanins
    • N.C. Veitch, and R.J. Grayer Flavonoids and their glycosides, including anthocyanins Nat Prod Rep 28 2011 1626 1695
    • (2011) Nat Prod Rep , vol.28 , pp. 1626-1695
    • Veitch, N.C.1    Grayer, R.J.2
  • 10
    • 84863482399 scopus 로고    scopus 로고
    • Alpha-glucosidase inhibitors 2012 - Cardiovascular considerations and trial evaluation
    • E. Standl, and O. Schnell Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation Diab Vasc Dis Res 9 2012 163 169
    • (2012) Diab Vasc Dis Res , vol.9 , pp. 163-169
    • Standl, E.1    Schnell, O.2
  • 11
    • 79960440902 scopus 로고    scopus 로고
    • Mulberry leaf extract reduces postprandial hyperglycemia with few side effects by inhibiting α-glucosidase in normal rats
    • G.N. Kim, Y.I. Kwon, and H.D. Jang Mulberry leaf extract reduces postprandial hyperglycemia with few side effects by inhibiting α-glucosidase in normal rats J Med Food 14 2011 712 717
    • (2011) J Med Food , vol.14 , pp. 712-717
    • Kim, G.N.1    Kwon, Y.I.2    Jang, H.D.3
  • 12
    • 33744951125 scopus 로고    scopus 로고
    • Inhibition of alpha-glucosidase and alpha-amylase by flavonoids
    • K. Tadera, Y. Minami, K. Takamatsu, and T. Matsuoka Inhibition of alpha-glucosidase and alpha-amylase by flavonoids J Nutr Sci Vitaminol 52 2006 149 153
    • (2006) J Nutr Sci Vitaminol , vol.52 , pp. 149-153
    • Tadera, K.1    Minami, Y.2    Takamatsu, K.3    Matsuoka, T.4
  • 13
    • 0034330742 scopus 로고    scopus 로고
    • Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid
    • J.S. Kim, C.S. Kwon, and K.H. Son Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid Biosci Biotechnol Biochem 64 2000 2458 2461
    • (2000) Biosci Biotechnol Biochem , vol.64 , pp. 2458-2461
    • Kim, J.S.1    Kwon, C.S.2    Son, K.H.3
  • 14
    • 84872122319 scopus 로고    scopus 로고
    • Possible effects of dietary polyphenols on sugar absorption and digestion
    • G. Williamson Possible effects of dietary polyphenols on sugar absorption and digestion Mol Nutr Food Res 57 2013 48 57
    • (2013) Mol Nutr Food Res , vol.57 , pp. 48-57
    • Williamson, G.1
  • 15
  • 18
    • 34547135694 scopus 로고    scopus 로고
    • +/glucose transporter when expressed in Xenopus laevis oocytes, but effectively inhibit electrogenic glucose uptake
    • DOI 10.1124/jpet.107.124040
    • +/glucose transporter when expressed in Xenopus laevis oocytes, but effectively inhibit electrogenic glucose uptake J Pharmacol Exp Ther 322 2007 829 835 (Pubitemid 47105799)
    • (2007) Journal of Pharmacology and Experimental Therapeutics , vol.322 , Issue.2 , pp. 829-835
    • Kottra, G.1    Daniel, H.2
  • 20
    • 80053407853 scopus 로고    scopus 로고
    • GLUT2 accumulation in enterocyte apical and intracellular membranes: A study in morbidly obese human subjects and ob/ob and high fat-fed mice
    • A. Ait-Omar, M. Monteiro-Sepulveda, C. Poitou, M. Le Gall, A. Cotillard, J. Gilet, K. Garbin, A. Houllier, and D. Château GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice Diabetes 60 2011 2598 2607
    • (2011) Diabetes , vol.60 , pp. 2598-2607
    • Ait-Omar, A.1    Monteiro-Sepulveda, M.2    Poitou, C.3    Le Gall, M.4    Cotillard, A.5    Gilet, J.6    Garbin, K.7    Houllier, A.8    Château, D.9
  • 21
    • 33846803914 scopus 로고    scopus 로고
    • Inhibition of the intestinal glucose transporter GLUT2 by flavonoids
    • DOI 10.1096/fj.06-6620com
    • O. Kwon, P. Eck, S. Chen, C.P. Corpe, J.H. Lee, M. Kruhlak, and M. Levine Inhibition of the intestinal glucose transporter GLUT2 by flavonoids FASEB J 21 2007 366 377 (Pubitemid 46213484)
    • (2007) FASEB Journal , vol.21 , Issue.2 , pp. 366-377
    • Kwon, O.1    Eck, P.2    Chen, S.3    Corpe, C.P.4    Lee, J.-H.5    Kruhlak, M.6    Levine, M.7
  • 22
    • 80054920652 scopus 로고    scopus 로고
    • Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes
    • N. Suksomboon, N. Poolsup, S. Boonkaew, and C.C. Suthisisang Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes J Ethnopharmacol 137 2011 1328 1333
    • (2011) J Ethnopharmacol , vol.137 , pp. 1328-1333
    • Suksomboon, N.1    Poolsup, N.2    Boonkaew, S.3    Suthisisang, C.C.4
  • 23
    • 84859197004 scopus 로고    scopus 로고
    • Tiliroside, a glycosidic flavonoid, inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract
    • T. Goto, M. Horita, H. Nagai, A. Nagatomo, N. Nishida, Y. Matsuura, and S. Nagaoka Tiliroside, a glycosidic flavonoid, inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract Mol Nutr Food Res 56 2012 435 445
    • (2012) Mol Nutr Food Res , vol.56 , pp. 435-445
    • Goto, T.1    Horita, M.2    Nagai, H.3    Nagatomo, A.4    Nishida, N.5    Matsuura, Y.6    Nagaoka, S.7
  • 25
    • 4744373549 scopus 로고    scopus 로고
    • The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice
    • U.J. Jung, M.K. Lee, K.S. Jeong, and M.S. Choi The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice J Nutr 134 2004 2499 2503 (Pubitemid 39315245)
    • (2004) Journal of Nutrition , vol.134 , Issue.10 , pp. 2499-2503
    • Jung, U.J.1    Lee, M.-K.2    Jeong, K.-S.3    Choi, M.-S.4
  • 27
    • 51649112597 scopus 로고    scopus 로고
    • Microbial metabolism of soy isoflavones by human intestinal bacterial strains
    • R. Tsuchihashi, S. Sakamoto, M. Kodera, T. Nohara, and J. Kinjo Microbial metabolism of soy isoflavones by human intestinal bacterial strains J Nat Med 62 2008 456 460
    • (2008) J Nat Med , vol.62 , pp. 456-460
    • Tsuchihashi, R.1    Sakamoto, S.2    Kodera, M.3    Nohara, T.4    Kinjo, J.5
  • 28
    • 84865726906 scopus 로고    scopus 로고
    • Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption
    • T.L. Farrell, M. Gomez-Juaristi, L. Poquet, K. Redeuil, K. Nagy, M. Renouf, and G. Williamson Absorption of dimethoxycinnamic acid derivatives in vitro and pharmacokinetic profile in human plasma following coffee consumption Mol Nutr Food Res 56 2012 1413 1423
    • (2012) Mol Nutr Food Res , vol.56 , pp. 1413-1423
    • Farrell, T.L.1    Gomez-Juaristi, M.2    Poquet, L.3    Redeuil, K.4    Nagy, K.5    Renouf, M.6    Williamson, G.7
  • 29
    • 77953213772 scopus 로고    scopus 로고
    • Assessment of intestinal absorption of total flavones of Hippophae rhamnoides L. in rat using in situ absorption models
    • Y. Xie, X. Zeng, G. Li, Z. Cai, N. Ding, and G. Ji Assessment of intestinal absorption of total flavones of Hippophae rhamnoides L. in rat using in situ absorption models Drug Dev Ind Pharm 36 2010 787 794
    • (2010) Drug Dev Ind Pharm , vol.36 , pp. 787-794
    • Xie, Y.1    Zeng, X.2    Li, G.3    Cai, Z.4    Ding, N.5    Ji, G.6
  • 30
    • 0036023329 scopus 로고    scopus 로고
    • 14C-TCDD in growing pigs
    • DOI 10.1016/S0045-6535(02)00145-5, PII S0045653502001455
    • C. Laurent, C. Feidt, N. Grova, D. Mpassi, E. Lichtfouse, F. Laurent, and G. Rychen Portal absorption of 14C after ingestion of spiked milk with 14C-phenanthrene, 14C-benzo[a]pyrene or 14C-TCDD in growing pigs Chemosphere 48 2002 843 848 (Pubitemid 34857480)
    • (2002) Chemosphere , vol.48 , Issue.8 , pp. 843-848
    • Laurent, C.1    Feidt, C.2    Grova, N.3    Mpassi, D.4    Lichtfouse, E.5    Laurent, F.6    Rychen, G.7
  • 31
    • 84878102548 scopus 로고    scopus 로고
    • Mechanisms and insights into drug resistance in cancer
    • H. Zahreddine, and K.L. Borden Mechanisms and insights into drug resistance in cancer Front Pharmacol 4 2013 28
    • (2013) Front Pharmacol , vol.4 , pp. 28
    • Zahreddine, H.1    Borden, K.L.2
  • 32
    • 84861916495 scopus 로고    scopus 로고
    • The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics
    • Y. Li, J. Lu, and J.W. Paxton The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics Curr Drug Metab 13 2012 624 639
    • (2012) Curr Drug Metab , vol.13 , pp. 624-639
    • Li, Y.1    Lu, J.2    Paxton, J.W.3
  • 33
    • 84881643375 scopus 로고    scopus 로고
    • Disposition of pharmacologically active dietary isoflavones in biological systems
    • Wahajuddin, I. Taneja, S. Arora, K.S. Raju, and N. Siddiqui Disposition of pharmacologically active dietary isoflavones in biological systems Curr Drug Metab 14 2013 369 380
    • (2013) Curr Drug Metab , vol.14 , pp. 369-380
    • Wahajuddin1    Taneja, I.2    Arora, S.3    Raju, K.S.4    Siddiqui, N.5
  • 34
    • 0346728729 scopus 로고    scopus 로고
    • The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
    • DOI 10.1016/j.ejps.2003.07.003
    • L.M. Chan, S. Lowes, and B.H. Hirst The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability Eur J Pharm Sci 21 2004 25 51 (Pubitemid 38050202)
    • (2004) European Journal of Pharmaceutical Sciences , vol.21 , Issue.1 , pp. 25-51
    • Chan, L.M.S.1    Lowes, S.2    Hirst, B.H.3
  • 35
    • 49649120671 scopus 로고    scopus 로고
    • Intestinal efflux transporters and drug absorption
    • T. Murakami, and M. Takano Intestinal efflux transporters and drug absorption Expert Opin Drug Metab Toxicol 4 2008 923 939
    • (2008) Expert Opin Drug Metab Toxicol , vol.4 , pp. 923-939
    • Murakami, T.1    Takano, M.2
  • 36
    • 67650084777 scopus 로고    scopus 로고
    • Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs
    • P. Matsson, J.M. Pedersen, U. Norinder, C.A. Bergström, and P. Artursson Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs Pharm Res 26 2009 1816 1831
    • (2009) Pharm Res , vol.26 , pp. 1816-1831
    • Matsson, P.1    Pedersen, J.M.2    Norinder, U.3    Bergström, C.A.4    Artursson, P.5
  • 37
    • 84859708410 scopus 로고    scopus 로고
    • Investigational ABC transporter inhibitors
    • M. Falasca, and K.J. Linton Investigational ABC transporter inhibitors Expert Opin Investig Drugs 21 2012 657 666
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 657-666
    • Falasca, M.1    Linton, K.J.2
  • 38
    • 33748298894 scopus 로고    scopus 로고
    • Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: Evidence for multifactorial multidrug resistance
    • DOI 10.1016/j.ejps.2006.06.001, PII S0928098706001655
    • Y. Su, S.H. Lee, and P.J. Sinko Inhibition of efflux transporter ABCG2/BCRP does not restore mitoxantrone sensitivity in irinotecan-selected human leukemia CPT-K5 cells: evidence for multifactorial multidrug resistance Eur J Pharm Sci 29 2006 102 110 (Pubitemid 44332882)
    • (2006) European Journal of Pharmaceutical Sciences , vol.29 , Issue.2 , pp. 102-110
    • Su, Y.1    Lee, S.-H.2    Sinko, P.J.3
  • 39
    • 39749084704 scopus 로고    scopus 로고
    • Development of inhibitors of ATP-binding cassette drug transporters - present status and challenges
    • DOI 10.1517/17425255.4.2.205
    • S. Shukla, C.P. Wu, and S.V. Ambudkar Development of inhibitors of ATP-binding cassette drug transporters: present status and challenges Expert Opin Drug Metab Toxicol 4 2008 205 223 (Pubitemid 351308418)
    • (2008) Expert Opinion on Drug Metabolism and Toxicology , vol.4 , Issue.2 , pp. 205-223
    • Shukla, S.1    Wu, C.-P.2    Ambudkar, S.V.3
  • 40
    • 74049143120 scopus 로고    scopus 로고
    • Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response
    • A.I. Alvarez, R. Real, M. Pérez, G. Mendoza, J.G. Prieto, and G. Merino Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response J Pharm Sci 99 2009 598 617
    • (2009) J Pharm Sci , vol.99 , pp. 598-617
    • Alvarez, A.I.1    Real, R.2    Pérez, M.3    Mendoza, G.4    Prieto, J.G.5    Merino, G.6
  • 41
    • 34548580164 scopus 로고    scopus 로고
    • Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: Transporter specificity and structure-activity relationship
    • DOI 10.1007/s00280-007-0426-7
    • K. Katayama, K. Masuyama, S. Yoshioka, H. Hasegawa, J. Mitsuhashi, and Y. Sugimoto Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship Cancer Chemother Pharmacol 60 2007 789 797 (Pubitemid 47389385)
    • (2007) Cancer Chemotherapy and Pharmacology , vol.60 , Issue.6 , pp. 789-797
    • Katayama, K.1    Masuyama, K.2    Yoshioka, S.3    Hasegawa, H.4    Mitsuhashi, J.5    Sugimoto, Y.6
  • 43
    • 33749444911 scopus 로고    scopus 로고
    • The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms
    • DOI 10.2174/138920006778520570
    • R. Cermak, and S. Wolffram The potential of flavonoids to influence drug metabolism and pharmacokinetics by local gastrointestinal mechanisms Curr Drug Metab 7 2006 729 744 (Pubitemid 44509679)
    • (2006) Current Drug Metabolism , vol.7 , Issue.7 , pp. 729-744
    • Cermak, R.1    Wolffram, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.