Hypoxia level and matrix metalloproteinases-2 and -9 activity in lewis lung carcinoma: Correlation with metastasis

Experimental Oncology

Volumn 27, Issue 3, 2005, Pages 202-205

  Osinsky, S P ^a   Ganusevich, I I ^a   Bubnovskaya, L N ^a   Valkovskaya, N V ^a   Kovelskaya, A V ^a   Sergienko, T K ^a   Zimina, S V ^a  

^a R E KAVETSKY INSTITUTE OF EXPERIMENTAL PATHOLOGY   (Ukraine)

Author keywords

31P NMR spectroscopy; Hypoxia; Lewis lung carcinoma; Matrix metalloproteinases; Metastasis

Indexed keywords

GELATINASE A; GELATINASE B; PERCHLORIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; FEMALE; HYPOXIA; IN VIVO STUDY; LEWIS CARCINOMA; METASTASIS; MOUSE; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; TUMOR GROWTH;

ANIMALS; CARCINOMA, LEWIS LUNG; CELL HYPOXIA; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; NEOPLASM METASTASIS;

EID: 27744567839     PISSN: 18129269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Höckel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001; 93: 266-76.
2. Brown JM, Ciaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res 1998; 58: 1408-16.
3. Pugh ChW, Ratcliff PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Med 2003; 9: 677-84.
4. Dachs GU, Tozer GM. Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation. Eur J Cancer 2000; 36: 1649-60.
5. Buchler P, Reber HA, Lavey RS, Tomlinson J, Buchler MW, Friess H, Hines OJ. Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model. J Surg Res 2004; 120: 295-303.
6. Chambers AF, Matrisian LM. Changing views of role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 1997; 89: 1260-70.
7. Engers R, Gabbert HE. Mechanisms of tumor metastasis: cell biological aspects and clinical implications. J Res Clin Oncol 2000; 126: 682-92.
8. Vihinen P, Kahari V-M. Matrix metalloproteinases in cancer: prognostic markers and therapeutic tagets. Int J Cancer 2002; 99: 157-66.
9. Chen PS, Zhai WR, Zhou XM, Zhang JS, Zhang YE, Ling YQ, Gu YH. Effects of hypoxia, hyperoxia on the regulation of expression and activity of matrix metalloproteinase-2 in hepatic stellate cells. World J Gastroenterol 2001; 7: 647-51.
10. Cha HS, Ahn KS, Jeon CH, Kim J, Song YW, Koh EM. Influence of hypoxia on the expression of matrix metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 in rheumatoid synovial fibroblasts. Clin Exp Rheumatol 2003; 21: 593-8.
11. Canning MT, Postovit LM, Clarke SH, Graham CH. Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells. Exp Cell Res 2001; 267: 88-94.
12. Himelstein BP, Koch CJ. Studies of type IV collagenase regulation by hypoxia. Cancer Lett 1998; 124: 127-33.
13. Guo W, Ran Y, Wang G, Liu J, Yu L, Sun L, Yang Z. Expression and hypoxic regulation of vascular endothelial growth factor and matrix metalloproteinase-9 in esophageal carcinoma. Zhonghua Zhong Liu Za Zhi 2002; 24: 44-7.
14. Bubnovskaya LN, Michailenko V, Kondnchin I, Osinsky S, Kovelskaya A, Levitin I, Sigan A. Detection of tumor response to Co(III) and Fe(III) complexes by 31P-nuclear magnetic resonance spectroscopy. Exp Oncol 2002; 24: 128-34.
15. Maxwell RJ. Application of nuclear magnetic resonance for investigation of the tumor microenvironment. In: Blood perfusion and microenvironment of human tumors. Molls M, Vaupel P, eds. Berlin, Heidelberg, New York: Springer-Verlag 1998; 145-60.
16. Scott KA, Holdsworth H, Balkwill FR, DIas S. Exploiting changes in the tumor microenvironment with sequential cytokine and matrix metalloproteinase inhibitor treatment in a murine breast cancer model. Br J Cancer 2000; 83: 1538-43.
17. Moore S, Stein WH. A modified ninhydrin reagent for the photometric determination of amino acids and related compounds. J Biol Chem 1954; 211: 907-13.
18. Okunieff P, Urano M, Kallinowski F, Vaupel P, Neuringer J. Tumors growing in irradiated tissue: oxygenation, metabolic state, and pH. Int J Radiat Oncol Biol Phys 1991; 21: 667-73.
19. 31P NMR spectroscopy measurements, tumor size, hypoxic fraction and cell survival after radiotherapy. Int J Radiat Oncol Biol Phys 1990; 181: 1341-50.
20. 2 tension measurements in a murine fibrosarcoma. Radiat Res 1989; 120: 477-93.
21. Rofstad EK, Halsar EF. Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8. Br J Cancer 2002; 86: 301-8.
22. Airley R, Loncaster J, Davidson S, Bromley M, Roberts S, Patterson A, Hunter R, Stratford I, West C. Glucose transporter Glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin Cancer Res 2001; 7: 928-34.
23. Loncaster JA, Harris AL, Davidson S, Logue JP, Hunter RD, Wycoff CC, Pastorek J, Ratcliffe PJ, Stratford I, West C. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 2001; 61: 6394-9.
24. De Jaeger K, Kavanagh M-C, Hill RP. Relationship of hypoxia to metastatic ability in rodent tumours. Br J Cancer 2001; 84: 1280-5.
25. Brizel DM, Scully PS, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, Dewhirst MW. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 1996; 56: 941-3.
26. Nordsmark M, Aisner J, Keller J, Nielsen OS, Jensen OM, Horsman MR, Overgaard J. Hypoxia in human soft tissue sarcoma: adverse impact on survival and no association with p 53 mutations. Br J Cancer 2001; 84: 1070-5.
27. Höckel M, Schlenger K, Arai B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996; 56: 4509-15.
28. Zhang L, Hill RP. Hypoxia enhances metastatic efficiency by up-regulation Mdm2 in KHT cells and increasing resistance to apoptosis. Cancer Res 2004; 64: 4180-9.
29. Cuvier C, Jang A, Hill RP. Exposure to hypoxia, glucose starvation and acidosis: effect on invasive capacity of murine tumor cells and correlation with cathepsin (L + B) secretion. Clin Exp Metastasis 1997; 15: 19-25.