Aldose reductase regulates miR-200a-3p/141-3p to coordinate Keap1-Nrf2, Tgfβ1/2, and Zeb1/2 signaling in renal mesangial cells and the renal cortex of diabetic mice

Free Radical Biology and Medicine

Volumn 67, Issue , 2014, Pages 91-102

  Wei, Jie ^a   Zhang, Ye ^a   Luo, Yu ^a,b   Wang, Zhen ^a   Bi, Shulin ^a   Song, Dan ^a   Dai, Yuan ^a   Wang, Tao ^a   Qiu, Longxin ^c   Wen, Longping ^d   Yuan, Li ^a   Yang, James Y ^a  

^a XIAMEN UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c LONGYAN UNIVERSITY   (China)

^d UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Aldose reductase; Antioxidant defense; Epithelial mesenchymal transition; Fibrogenesis; Free radicals; miR 200a 3p 141 3p

Indexed keywords

ALBUMIN; ALDEHYDE REDUCTASE; FIBRONECTIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MICRORNA 141; MICRORNA 200A; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; CYTOSKELETON PROTEIN; HOMEODOMAIN PROTEIN; KEAP1 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; MICRORNA; MIRN141 MICRORNA, MOUSE; MIRN200 MICRORNA, MOUSE; NFE2L2 PROTEIN, MOUSE; REPRESSOR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; ZEB1 PROTEIN, MOUSE; ZEB2 PROTEIN, HUMAN; GLUTATHIONE; MESSENGER RNA; MICRORNA 200B; MICRORNA 200C; MICRORNA 429; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ZEB2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; ENZYME DEFICIENCY; FIBROGENESIS; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; KIDNEY CORTEX; MALE; MESANGIUM CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; UPREGULATION; URINARY EXCRETION; ANIMAL; C57BL MOUSE; CELL LINE; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; PATHOLOGY; TRANSGENIC MOUSE; DIABETES MELLITUS; GENETIC MANIPULATION; GENOTYPE; IN VIVO STUDY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALIA; MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALDEHYDE REDUCTASE; ANIMALS; CELL LINE; CYTOSKELETAL PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; KIDNEY CORTEX; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MESANGIAL CELLS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRORNAS; NF-E2-RELATED FACTOR 2; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84888092409     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.10.811     Document Type: Article

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