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Volumn 2012, Issue , 2012, Pages

Inhibition of aldose reductase activates hepatic peroxisome proliferator-activated receptor-α and ameliorates hepatosteatosis in diabetic db/db mice

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; SHORT HAIRPIN RNA; TRIACYLGLYCEROL; ZOPOLRESTAT; BENZOTHIAZOLE DERIVATIVE; ENZYME INHIBITOR; PHTHALAZINE DERIVATIVE; SMALL INTERFERING RNA;

EID: 84855180612     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2012/789730     Document Type: Article
Times cited : (31)

References (47)
  • 2
    • 0023039051 scopus 로고
    • The polyol pathway. A historical review
    • Clements R. S., The polyol pathway. A historical review Drugs 1986 32 2 3 5
    • (1986) Drugs , vol.32 , Issue.2 , pp. 3-5
    • Clements, R.S.1
  • 3
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • DOI 10.1038/414813a
    • Brownlee M., Biochemistry and molecular cell biology of diabetic complications Nature 2001 414 6865 813 820 (Pubitemid 34000785)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 4
    • 0032693720 scopus 로고    scopus 로고
    • Aldose reductase inhibitors: Therapeutic implications for diabetic complications
    • Oates P. J., Mylari B. L., Aldose reductase inhibitors: therapeutic implications for diabetic complications Expert Opinion on Investigational Drugs 1999 8 12 2095 2119
    • (1999) Expert Opinion on Investigational Drugs , vol.8 , Issue.12 , pp. 2095-2119
    • Oates, P.J.1    Mylari, B.L.2
  • 6
    • 0020663065 scopus 로고
    • Tissue distribution of mammalian aldose reductase and related enzymes
    • DOI 10.1016/0006-2944(83)90051-0
    • Markus H. B., Raducha M., Harris H., Tissue distribution of mammalian aldose reductase and related enzymes Biochemical Medicine 1983 29 1 31 45 (Pubitemid 13160612)
    • (1983) Biochemical Medicine , vol.29 , Issue.1 , pp. 31-45
    • Markus, H.B.1    Raducha, M.2    Harris, H.3
  • 8
    • 0242422957 scopus 로고
    • Enzyme relationships in a sorbitol pathway that bypasses glycolysis and pentose phosphates in glucose metabolism
    • 4 I
    • Jeffery J., Jornvall H., Enzyme relationships in a sorbitol pathway that bypasses glycolysis and pentose phosphates in glucose metabolism Proceedings of the National Academy of Sciences of the United States of America 1983 80 4 I 901 905 (Pubitemid 13118062)
    • (1983) Proceedings of the National Academy of Sciences of the United States of America , vol.80 , pp. 901-905
    • Jeffery, J.1    Jornvall, H.2
  • 11
    • 0029127117 scopus 로고
    • Elevation of aldose reductase gene expression in rat primary hepatoma and hepatoma cell lines: Implication in detoxification of cytotoxic aldehydes
    • Takahashi M., Fujii J., Miyoshi E., Hoshi A., Taniguchi N., Elevation of aldose reductase gene expression in rat primary hepatoma and hepatoma cell lines: implication in detoxification of cytotoxic aldehydes International Journal of Cancer 1995 62 6 749 754
    • (1995) International Journal of Cancer , vol.62 , Issue.6 , pp. 749-754
    • Takahashi, M.1    Fujii, J.2    Miyoshi, E.3    Hoshi, A.4    Taniguchi, N.5
  • 12
    • 0035097039 scopus 로고    scopus 로고
    • Overexpression of aldose reductase in liver cancers may contribute to drug resistance
    • DOI 10.1097/00001813-200102000-00005
    • Lee K. W. Y., Ko B. C. B., Jiang Z., Cao D., Chung S. S. M., Overexpression of aldose reductase in liver cancers may contribute to drug resistance Anti-Cancer Drugs 2001 12 2 129 132 (Pubitemid 32207361)
    • (2001) Anti-Cancer Drugs , vol.12 , Issue.2 , pp. 129-132
    • Lee, K.W.Y.1    Ko, B.C.B.2    Jiang, Z.3    Cao, D.4    Chung, S.S.M.5
  • 13
  • 14
    • 66149088144 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in type 2 diabetes mellitus
    • Cusi K., Nonalcoholic fatty liver disease in type 2 diabetes mellitus Current Opinion in Endocrinology, Diabetes and Obesity 2009 16 2 141 149
    • (2009) Current Opinion in Endocrinology, Diabetes and Obesity , vol.16 , Issue.2 , pp. 141-149
    • Cusi, K.1
  • 15
    • 79959795387 scopus 로고    scopus 로고
    • NASH: A global health problem
    • Sanyal A. J., NASH: a global health problem Hepatology Research 2011 41 7 670 674
    • (2011) Hepatology Research , vol.41 , Issue.7 , pp. 670-674
    • Sanyal, A.J.1
  • 16
    • 66149100956 scopus 로고    scopus 로고
    • Metabonomics studies of intact hepatic and renal cortical tissues from diabetic db/db mice using high-resolution magic-angle spinning 1H NMR spectroscopy
    • Xu J., Zhang J., Cai S., Dong J., Yang J. Y., Chen Z., Metabonomics studies of intact hepatic and renal cortical tissues from diabetic db/db mice using high-resolution magic-angle spinning 1H NMR spectroscopy Analytical and Bioanalytical Chemistry 2009 393 6-7 1657 1668
    • (2009) Analytical and Bioanalytical Chemistry , vol.393 , Issue.67 , pp. 1657-1668
    • Xu, J.1    Zhang, J.2    Cai, S.3    Dong, J.4    Yang, J.Y.5    Chen, Z.6
  • 18
    • 0031920049 scopus 로고    scopus 로고
    • Aldose reductase in glucose toxicity: A potential target for the prevention of diabetic complications
    • Yabe-Nishimura C., Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications Pharmacological Reviews 1998 50 1 21 33 (Pubitemid 28158840)
    • (1998) Pharmacological Reviews , vol.50 , Issue.1 , pp. 21-33
    • Yabe-Nishimura, C.1
  • 19
    • 0036479751 scopus 로고    scopus 로고
    • Increased fructose concentrations in blood and urine in patients with diabetes
    • DOI 10.2337/diacare.25.2.353
    • Kawasaki T., Akanuma H., Yamanouchi T., Increased fructose concentrations in blood and urine in patients with diabetes Diabetes Care 2002 25 2 353 357 (Pubitemid 41079635)
    • (2002) Diabetes Care , vol.25 , Issue.2 , pp. 353-357
    • Kawasaki, T.1    Akanuma, H.2    Yamanouchi, T.3
  • 20
    • 0035130522 scopus 로고    scopus 로고
    • Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass-spectrometry in type 2 diabetes to assess polyol pathway activity
    • DOI 10.1016/S0168-8227(00)00221-7, PII S0168822700002217
    • Yoshii H., Uchino H., Ohmura C., Watanabe K., Tanaka Y., Kawamori R., Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass-spectrometry in type 2 diabetes to assess polyol pathway activity Diabetes Research and Clinical Practice 2001 51 2 115 123 (Pubitemid 32140863)
    • (2001) Diabetes Research and Clinical Practice , vol.51 , Issue.2 , pp. 115-123
    • Yoshii, H.1    Uchino, H.2    Ohmura, C.3    Watanabe, K.4    Tanaka, Y.5    Kawamori, R.6
  • 22
    • 0037128460 scopus 로고    scopus 로고
    • Aldose reductase: An aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia
    • DOI 10.1016/S1566-0702(01)00385-X, PII S156607020100385X
    • Kawamura M., Eisenhofer G., Kopin I. J., Kador P. F., Lee Y. S., Fujisawa S., Sato S., Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia Autonomic Neuroscience: Basic and Clinical 2002 96 2 131 139 (Pubitemid 34175165)
    • (2002) Autonomic Neuroscience: Basic and Clinical , vol.96 , Issue.2 , pp. 131-139
    • Kawamura, M.1    Eisenhofer, G.2    Kopin, I.J.3    Kador, P.F.4    Lee, Y.S.5    Fujisawa, S.6    Sato, S.7
  • 25
    • 0032530765 scopus 로고    scopus 로고
    • A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor α-deficient mice
    • Djouadi F., Weinheimer C. J., Saffitz J. E., Pitchford C., Bastin J., Gonzalez F. J., Kelly D. P., A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor -deficient mice Journal of Clinical Investigation 1998 102 6 1083 1091 (Pubitemid 28436268)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.6 , pp. 1083-1091
    • Djouadi, F.1    Weinheimer, C.J.2    Saffitz, J.E.3    Pitchford, C.4    Bastin, J.5    Gonzalez, F.J.6    Kelly, D.P.7
  • 27
    • 0038643427 scopus 로고    scopus 로고
    • Central role of PPARα-dependent hepatic lipid turnover in dietary steatohepatitis in mice
    • DOI 10.1053/jhep.2003.50307
    • Ip E., Farrell G. C., Robertson G., Hall P., Kirsch R., Leclercq I., Central role of PPAR -dependent hepatic lipid turnover in dietary steatohepatitis in mice Hepatology 2003 38 1 123 132 (Pubitemid 36775803)
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 123-132
    • Ip, E.1    Farrell, G.C.2    Robertson, G.3    Hall, P.4    Kirsch, R.5    Leclercq, I.6
  • 29
    • 80051795701 scopus 로고    scopus 로고
    • Pharmacological activation of peroxisome proliferator-activated receptor delta Improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice
    • Wu H. T., Chen C. T., Cheng K. C., Li Y. X., Yeh C. H., Cheng J. T., Pharmacological activation of peroxisome proliferator-activated receptor delta Improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice Hormone and Metabolic Research 2011 43 631 635
    • (2011) Hormone and Metabolic Research , vol.43 , pp. 631-635
    • Wu, H.T.1    Chen, C.T.2    Cheng, K.C.3    Li, Y.X.4    Yeh, C.H.5    Cheng, J.T.6
  • 31
    • 0029759110 scopus 로고    scopus 로고
    • Transcriptional control of triglyceride metabolism: Fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR
    • Auwerx J., Schoonjans K., Fruchart J. C., Staels B., Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR Atherosclerosis 1996 124 S29 S37
    • (1996) Atherosclerosis , vol.124
    • Auwerx, J.1    Schoonjans, K.2    Fruchart, J.C.3    Staels, B.4
  • 34
    • 79551487017 scopus 로고    scopus 로고
    • Fructose induced lipogenesis: From sugar to fat to insulin resistance
    • Samuel V. T., Fructose induced lipogenesis: from sugar to fat to insulin resistance Trends in Endocrinology and Metabolism 2011 22 2 60 65
    • (2011) Trends in Endocrinology and Metabolism , vol.22 , Issue.2 , pp. 60-65
    • Samuel, V.T.1
  • 35
    • 78349283092 scopus 로고    scopus 로고
    • Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome
    • Dekker M. J., Su Q., Baker C., Rutledge A. C., Adeli K., Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome American Journal of Physiology 2010 299 5 E685 E694
    • (2010) American Journal of Physiology , vol.299 , Issue.5
    • Dekker, M.J.1    Su, Q.2    Baker, C.3    Rutledge, A.C.4    Adeli, K.5
  • 36
    • 79958807284 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and fructose: Bad for us, better for mice
    • Anania F. A., Non-alcoholic fatty liver disease and fructose: bad for us, better for mice Journal of Hepatology 2011 55 1 218 220
    • (2011) Journal of Hepatology , vol.55 , Issue.1 , pp. 218-220
    • Anania, F.A.1
  • 37
    • 78751541079 scopus 로고    scopus 로고
    • Fructose at the center of necroinflammation and fibrosis in nonalcoholic steatohepatitis
    • Alisi A., Manco M., Pezzullo M., Nobili V., Fructose at the center of necroinflammation and fibrosis in nonalcoholic steatohepatitis Hepatology 2011 53 1 372 373
    • (2011) Hepatology , vol.53 , Issue.1 , pp. 372-373
    • Alisi, A.1    Manco, M.2    Pezzullo, M.3    Nobili, V.4
  • 39
  • 40
    • 3142698736 scopus 로고    scopus 로고
    • Single nucleotide polymorphism (-468 Gly to Ala) at the promoter region of sterol regulatory element-binding protein-1c associates with genetic defect of fructose-induced hepatic lipogenesis
    • DOI 10.1074/jbc.M309449200
    • Nagata R., Nishio Y., Sekine O., Nagai Y., Maeno Y., Ugi S., Maegawa H., Kashiwagi A., Single nucleotide polymorphism (-468 Gly to Ala) at the promoter region of sterol regulatory element-binding protein-1c associates with genetic defect of fructose-induced hepatic lipogenesis Journal of Biological Chemistry 2004 279 28 29031 29042 (Pubitemid 38915773)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.28 , pp. 29031-29042
    • Nagata, R.1    Nishio, Y.2    Sekine, O.3    Nagai, Y.4    Maeno, Y.5    Ugi, S.6    Maegawa, H.7    Kashiwagi, A.8
  • 41
    • 4344674170 scopus 로고    scopus 로고
    • Erratum: Single nucleotide polymorphism (-468 Gly to Ala) at the promoter region of sterol regulatory element-binding protein-1c associates with genetic defect of fructose-induced hepatic lipogenesis (Journal of Biological Chemistry (2004) 279 (29031-29042))
    • Nagata R., Nishio Y., Sekine O., Nagai Y., Maeno Y., Ugi S., Maegawa H., Kashiwagi A., Erratum: Single nucleotide polymorphism (-468 Gly to Ala) at the promoter region of sterol regulatory element-binding protein-1c associates with genetic defect of fructose-induced hepatic lipogenesis (Journal of Biological Chemistry (2004) 279 (29031-29042)) Journal of Biological Chemistry 2004 279 35 37210 (Pubitemid 39129073)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.35 , pp. 37210
    • Nagata, R.1    Nishio, Y.2    Sekine, O.3    Nagai, Y.4    Maeno, Y.5    Ugi, S.6    Maegawa, H.7    Kashiwagi, A.8
  • 42
    • 0031456894 scopus 로고    scopus 로고
    • Chronic exogenous insulin and chronic carbohydrate supplementation increase de novo VLDL triglyceride fatty acid production in rats
    • Park J., Lemieux S., Lewis G. F., Kuksis A., Steiner G., Chronic exogenous insulin and chronic carbohydrate supplementation increase de novo VLDL triglyceride fatty acid production in rats Journal of Lipid Research 1997 38 12 2529 2536 (Pubitemid 28028137)
    • (1997) Journal of Lipid Research , vol.38 , Issue.12 , pp. 2529-2536
    • Park, J.1    Lemieux, S.2    Lewis, G.F.3    Kuksis, A.4    Steiner, G.5
  • 44
    • 18244375243 scopus 로고    scopus 로고
    • Fructose-induced fatty liver disease: Hepatic effects of blood pressure and plasma triglyceride reduction
    • DOI 10.1161/01.HYP.0000164570.20420.67
    • Ackerman Z., Oron-Herman M., Grozovski M., Rosenthal T., Pappo O., Link G., Sela B. A., Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction Hypertension 2005 45 5 1012 1018 (Pubitemid 40628952)
    • (2005) Hypertension , vol.45 , Issue.5 , pp. 1012-1018
    • Ackerman, Z.1    Oron-Herman, M.2    Grozovski, M.3    Rosenthal, T.4    Pappo, O.5    Link, G.6    Sela, B.-A.7
  • 45
    • 79957609993 scopus 로고    scopus 로고
    • Fructose-induced steatosis in mice: Role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells
    • Kanuri G., Spruss A., Wagnerberger S., Bischoff S. C., Bergheim I., Fructose-induced steatosis in mice: role of plasminogen activator inhibitor-1, microsomal triglyceride transfer protein and NKT cells Laboratory Investigation 2011 91 6 885 895
    • (2011) Laboratory Investigation , vol.91 , Issue.6 , pp. 885-895
    • Kanuri, G.1    Spruss, A.2    Wagnerberger, S.3    Bischoff, S.C.4    Bergheim, I.5
  • 46
    • 84855184243 scopus 로고    scopus 로고
    • High fructose feeding induces copper deficiency in sprague-dawley rats: A novel mechanism for obesity related fatty liver
    • Song M., Schuschke D. A., Zhou Z., High fructose feeding induces copper deficiency in sprague-dawley rats: a novel mechanism for obesity related fatty liver. Journal of Hepatology. In press
    • Journal of Hepatology. In Press
    • Song, M.1    Schuschke, D.A.2    Zhou, Z.3
  • 47
    • 77952692915 scopus 로고    scopus 로고
    • Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
    • Abdelmalek M. F., Suzuki A., Guy C., Unalp-Arida A., Colvin R., Johnson R. J., Diehl A. M., Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease Hepatology 2010 51 6 1961 1971
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 1961-1971
    • Abdelmalek, M.F.1    Suzuki, A.2    Guy, C.3    Unalp-Arida, A.4    Colvin, R.5    Johnson, R.J.6    Diehl, A.M.7


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