A traditional formula, Chunggan extract, attenuates thioacetamide-induced hepatofibrosis via GSH system in rats

Human and Experimental Toxicology

Volumn 30, Issue 9, 2011, Pages 1322-1332

  Kwak, Kyeong Gue ^a   Wang, Jing Hua ^a   Shin, Jang Woo ^a   Lee, Dong Soo ^b   Son, Chang Gue ^a  

^a Daejeon University   (South Korea)

^b Daejeon St Mary's Hospital   (South Korea)

Author keywords

glutathione system; hepatic satellite cells; liver fibrosis; oxidative stress; thioacetamide

Indexed keywords

CATALASE; CHUNGGAN EXTRACT; CONNECTIVE TISSUE GROWTH FACTOR; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROXYPROLINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SUPEROXIDE DISMUTASE; THIOACETAMIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HISTOPATHOLOGIC SKIN REACTION; LIVER; LIVER FIBROSIS; LIVER INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL;

ANIMALS; BIOLOGICAL MARKERS; DRUGS, CHINESE HERBAL; GLUTATHIONE; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER FUNCTION TESTS; MALE; MEDICINE, KOREAN TRADITIONAL; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; THIOACETAMIDE;

RATTUS;

EID: 80052539024     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110389502     Document Type: Article

References (36)

1. World health statistics 2008. Switzerland: WHO press ; 2008 :
2. Albanis E, Friedman SL. Antifibrotic agents for liver disease. Am J Transplant. 2006 ; 6: 12-19 (Pubitemid 43382195)
3. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005 ; 115: 209-218 (Pubitemid 40385459)
4. Kumar V, Abbas AK, Fausto N Robbins and Cotran pathologic basis of disease. Philadelphia, PA: Elsevier Saunders ; 2004 :
5. Hammel P, Couvelard A, O'Toole D, et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med. 2001 ; 344: 418-423 (Pubitemid 32128674)
6. Gines P, Cardenas A. The management of ascites and hyponatremia in cirrhosis. Semin Liver Dis. 2008 ; 2008: 28-43
7. Levy C, Seeff LD, Lindor KD. Use of herbal supplements for chronic liver disease. Clin Gastroenterol Hepatol. 2004 ; 2: 947-956 (Pubitemid 39539743)
8. Rino Y, Tarao K, Morinaga S, et al. Reduction therapy of alanine aminotransferase levels prevent HCC development in patients with HCV-associated cirrhosis. Anticancer Res. 2006 ; 26: 2221-2226 (Pubitemid 43980176)
9. Yen MH, Weng TC, Liu SY, Chai CY, Lin CC. The hepatoprotective effect of Bupleurum kaoi, an endemic plant to Taiwan, against dimethylnitrosamine-induced hepatic fibrosis in rats. Biol Pharm Bull. 2005 ; 2005: 28-442
10. Cho JH, Lee YY, Seo SH, et al. A clinical report about 57 patients with chronic liver disease. Korean J Orient Med. 2001 ; 21: 112-121
11. Hu XP, Shin JW, Wang JH, et al. Antioxidative and hepatoprotective effect of CGX, an herbal medicine, against toxic acute injury in mice. J Ethnopharmacol. 2008 ; 120: 51-55
12. Shin JW, Son JY, Oh SM, et al. An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats. World J Gastroenterol. 2006 ; 12: 6142-6148
13. Wang JH, Shin JW, Son JY, Cho JH, Son CG. Antifibrotic effects of CGX, a traditional herbal formula, and its mechanisms in rats. J Ethnopharmacol. 2010 ; 127: 534-542
14. George J, Rao KR, Stern R, Chandrakasan G. Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen. Toxicology. 2001 ; 156: 129-138 (Pubitemid 32119485)
15. Muller A, Machnik F, Zimmermann T, Schubert H. Thioacetamide-induced cirrhosis-like liver lesions in rats-usefulness and reliability of this animal model. Exp Pathol. 1988 ; 34: 229-236
16. Guide for the care and use of laboratory animals. Washington, DC: National Academy Press ; 1996 :
17. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978 ; 86: 271-278 (Pubitemid 9050395)
18. Beers RF Jr, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 1952 ; 195: 133-140
19. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959 ; 82: 70-77
20. Esson DW, Neelakantan A, Iyer SA, et al. Expression of connective tissue growth factor after glaucoma filtration surgery in a rabbit model. Invest Ophthalmol Vis Sci. 2004 ; 45: 485-491 (Pubitemid 38140505)
21. Bataller R, Brenner DA. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis. 2001 ; 21: 437-451 (Pubitemid 32923771)
22. Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008 ; 134: 1655-1669 (Pubitemid 351615417)
23. Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJ. Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver. Gastroenterology. 1996 ; 110: 821-831 (Pubitemid 26071850)
24. Rippe RA, Brenner DA. From quiescence to activation: gene regulation in hepatic stellate cells. Gastroenterology. 2004 ; 127: 1260-1262 (Pubitemid 39345894)
25. Drotman RB, Lawhorn GT. Serum enzymes as indicators of chemically induced liver damage. Drug Chem Toxicol. 1978 ; 1: 163-171 (Pubitemid 8379694)
26. Nieto N, Friedman SL, Cederbaum AI. Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem. 2002 ; 277: 9853-9864 (Pubitemid 34968090)
27. Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol. 2001 ; 35: 297-306 (Pubitemid 32803489)
28. Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest. 2007 ; 117: 539-548 (Pubitemid 46348508)
29. Wang J, Guo J, Liu S. [Inhibitory effect of glycyrrhizin on NF-kappa B binding activity in CCl4 plus ethanol induced liver cirrhosis in rats]. Zhonghua Gan Zang Bing Za Zhi. 1999 ; 7: 42-43
30. Wang BE. Treatment of chronic liver diseases with traditional Chinese medicine. J Gastroenterol Hepatol. 2000 ; 15: E67 - E70
31. Tsai JH, Liu JY, Wu TT, et al. Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats. J Viral Hepat. 2008 ; 15: 508-514 (Pubitemid 351798986)
32. Ono M, Miyamura M, Kyotani S, Saibara T, Ohnishi S, Nishioka Y. Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats. J Pharm Pharmacol. 1999 ; 51: 1079-1084 (Pubitemid 29462398)
33. Huseini HF, Alavian SM, Heshmat R, Heydari MR, Abolmaali K. The efficacy of Liv-52 on liver cirrhotic patients: a randomized, double-blind, placebo-controlled first approach. Phytomedicine. 2005 ; 12: 619-624 (Pubitemid 41169807)
34. Choi WJ, Shin JW, Son JY, et al. Toxicological study of the hepatotherapeutic herbal formula, Chunggan extract, in beagle dogs. World J Gastroenterol. 2006 ; 12: 7497-7502
35. Shin JW, Kim HG, Park HJ, Sung NW, Son CG. Safety of the traditional Korean herbal medicine CGX: a 6-month repeated-dose study in rats. J Ethnopharmacol. 2010 ; 128: 221-229
36. Shin JW, Park HJ, Kwon M, Son CG. Scientific evaluation of the chronic toxicity of the herbal medicine CGX in beagle dogs. Food Chem Toxicol. 2010 ; 48: 743-749