Overexpression of transforming growth factor β1 in malignant prostate cells is partly caused by a runaway of TGF-β1 Auto-induction mediated through a defective recruitment of protein phosphatase 2A by TGF-β type i receptor

Urology

Volumn 76, Issue 6, 2010, Pages 1519.e8-1519.e13

  Yu, Nengwang ^a,b   Kozlowski, James M ^a   Park, Irwin I ^a   Chen, Lin ^a   Zhang, Qiang ^a   Xu, Danfeng ^b   Doll, Jennifer A ^c   Crawford, Susan E ^c   Brendler, Charles B ^c   Lee, Chung ^a,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PHOSPHOPROTEIN PHOSPHATASE 2A; RETROVIRUS VECTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UO 126;

ARTICLE; CANCER CELL; CELL STRAIN; CELL STRAIN DU 145; CELL STRAIN PC 3; CONTROLLED STUDY; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

EID: 78649903609     PISSN: 00904295     EISSN: 15279995     Source Type: Journal    
DOI: 10.1016/j.urology.2010.03.061     Document Type: Article

References (30)

1. C. Lee, S.M. Sintich, and E.P. Mathews Transforming growth factor-beta in benign and malignant prostate Prostate 39 1999 285 290
2. J. Massague TGFbeta in cancer Cell 134 2008 215 230
3. C. Pardoux, and R. Derynck JNK regulates expression and autocrine signaling of TGF-beta1 Mol Cell 15 2004 170 171
4. J. Kelley, S. Shull, and J.J. Walsh Auto-induction of transforming growth factor-beta in human lung fibroblasts Am J Respir Cell Mol Biol 8 1993 417 424
5. S.J. Kim, P. Angel, and R. Lafyatis Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex Mol Cell Biol 10 1990 1492 1497
6. J. Li, B.J. Tripathi, and K.V. Chalam Transforming growth factor-beta 1 and -beta 2 positively regulate TGF-beta 1 mRNA expression in trabecular cells Invest Ophthalmol Vis Sci 37 1996 2778 2782
7. R.Y. Lin, K.M. Sullivan, and P.A. Argenta Exogenous transforming growth factor-beta amplifies its own expression and induces scar formation in a model of human fetal skin repair Ann Surg 222 1995 146 154
8. E. Van Obberghen-Schilling, N.S. Roche, and K.C. Flanders Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells J Biol Chem 263 1988 7741 7746
9. J. Annes, M. Vassallo, and J.S. Munger A genetic screen to identify latent transforming growth factor beta activators Anal Biochem 327 2004 45 54
10. M. Zhang, D. Fraser, and A. Phillips ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells Am J Pathol 169 2006 1282 1293
11. H. Aoki, H. Ohnishi, and K. Hama Autocrine loop between TGF-beta1 and IL-1beta through SmadIII- and ERK-dependent pathways in rat pancreatic stellate cells Am J Physiol Cell Physiol 290 2006 C1100 C1108
12. G. Chen, and N. Khalil TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases Respir Res 7 2006 2
13. B. Guo, K. Inoki, and M. Isono MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells Kidney Int 68 2005 972 984
14. M.K. Lee, C. Pardoux, and M.C. Hall TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA EMBO J 26 2007 3957 3967
15. T. Nickl-Jockschat, F. Arslan, and A. Doerfelt An imbalance between Smad and MAPK pathways is responsible for TGF-beta tumor promoting effects in high-grade gliomas Int J Oncol 30 2007 499 507
16. M. Dixon, L. Agius, and S.J. Yeaman Inhibition of rat hepatocyte proliferation by transforming growth factor beta and glucagon is associated with inhibition of ERK2 and p70 S6 kinase J Hepatol 29 1999 1418 1424
17. K. Giehl, B. Seidel, and P. Gierschik TGFbeta1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation Oncogene 19 2000 4531 4541
18. X. Luo, Q. Zhang, and V. Liu Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK J Immunol 180 2008 2757 2761
19. S. Ramesh, X.J. Qi, and G.M. Wildey TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2 EMBO Rep 9 2008 990 997
20. A. Sebestyen, M. Hajdu, and L. Kis SmadIV-independent, PP2A-dependent apoptotic effect of exogenous transforming growth factor beta 1 in lymphoma cells Exp Cell Res 313 2007 3167 3174
21. A.H. Shah, W.B. Tabayoyong, and S.Y. Kimm Reconstitution of lethally irradiated adult mice with dominant negative TGF-beta type II receptor-transduced bone marrow leads to myeloid expansion and inflammatory disease J Immunol 169 2002 3485 3491
22. Q. Zhang, B.T. Helfand, and T.L. Jang Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy Clin Cancer Res 15 2009 3557 3567
23. P. Dent, T. Jelinek, and D.K. Morrison Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases Science 268 1995 1902 1906
24. M.R. Junttila, S.P. Li, and J. Westermarck Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival FASEB J 22 2008 954 965
25. C. MacKintosh, K.A. Beattie, and S. Klumpp Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants FEBS Lett 264 1990 187 192
26. I. Griswold-Prenner, C. Kamibayashi, and E.M. Maruoka Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A Mol Cell Biol 1998 6595 6604
27. R. Derynck, and Y.E. Zhang Smad-dependent and Smad-independent pathways in TGF-beta family signalling Nature 425 2003 577 584
28. A. Hata TGFbeta signaling and cancer Exp Cell Res 264 2001 111 116
29. J.M. Wolff, T. Fandel, and H. Borchers Transforming growth factor-beta1 serum concentration in patients with prostatic cancer and benign prostatic hyperplasia Br J Urol 81 1998 403 405
30. S.A. Robertson Seminal plasma and male factor signalling in the female reproductive tract Cell Tissue Res 322 2005 43 52