Effect of different ingredients in traditional Korean medicine for human uterine leiomyoma on normal myometrial and leiomyomal smooth muscle cell proliferation

Archives of Pharmacal Research

Volumn 32, Issue 11, 2009, Pages 1555-1563

  Bajracharya, Prati ^a   Lee, Eun Ju ^a   Lee, Dong Mok ^a   Shim, Sang Hee ^a   Kim, Keuk Jun ^b   Lee, Sung Ho ^b   Bae, Jei Jun ^b   Chun, Sang Sik ^c   Lee, Tae Kyun ^d   Kwon, Seok Hoon ^e   Choi, Inho ^a  

^a Yeungnam University   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

^d Dr Lee's Traditional Korean Medicine Clinic   (South Korea)

^e NONE   (South Korea)

Author keywords

Cell proliferation; Fibroids; Traditional korean medicine; Transforming growth factor beta receptor 2 (TGFBR2); Uterine leiomyoma

Indexed keywords

ACETIC ACID ETHYL ESTER; ANGELICA GIGAS EXTRACT; CHLOROFORM; CINNAMOMUM CASSIA EXTRACT; CORYDALIS TERNATA EXTRACT; CURCUMA ZEDOARIA EXTRACT; EUONYMUS ALATUS EXTRACT; HEXANE; INULA HELENIUM EXTRACT; LEONURUS SIBIRICUS EXTRACT; PAEONIA LACTIFLORA EXTRACT; PHLOMIS UMBROSA EXTRACT; PLANT EXTRACT; SCUTELLARIA BARBATA EXTRACT; SPARGANIUM STOLONIFERUM EXTRACT; SPATHOLOBUS SUBERECTUS EXTRACT; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TROGOPTERUS XANTHIPES EXTRACT; UNCLASSIFIED DRUG; WATER;

ADULT; ANGELICA; ANGELICA GIGAS; ARTICLE; BARK; CELL PROLIFERATION; CELL STRUCTURE; CINNAMOMUM CASSIA; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CORYDALIS; CORYDALIS TERNATA; CURCUMA LONGA; CURCUMA ZEDOARIA; DRUG EFFECT; DRUG ISOLATION; ELECAMPANE; EUONYMUS; EUONYMUS ALATUS; FECES; FEMALE; HERB; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INULA; KOREA; LEONURUS SIBIRICUS; MEDICINAL PLANT; MITOSIS INHIBITION; MYOMETRIUM; PAEONIA; PAEONIA LACTIFLORA; PHLOMIS; PHLOMIS UMBROSA; PLANT STEM; PLANT TUBER; RHIZOME; SCUTELLARIA; SCUTELLARIA BARBATA; SMOOTH MUSCLE FIBER; SPARGANIUM STOLONIFERUM; SPATHOLOBUS SUBERECTUS; TRADITIONAL MEDICINE; TROGOPTERUS XANTHIPES; TUMOR CELL LINE; UTERUS MYOMA;

ADULT; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LEIOMYOMA; MEDICINE, KOREAN TRADITIONAL; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; MYOMETRIUM; PLANT EXTRACTS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 72049089558     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-2107-z     Document Type: Article

References (32)

1. S. H. Baek D. C. Kim 2006 The effect of Leonurus sibiricus on the proliferation inhibition of human uterine leiomyoma cell and expression of gene related cell apoptosis Korean medical database 19 1 12
2. G. C. Blobe W. P. Schiemann H. F. Losish 2000 Role of transforming growth factor β in human disease N. Engl. J. Med. 342 1350 1358 10.1056/NEJM200005043421807 1:CAS:528:DC%2BD3cXjtlyksrY%3D 10793168 (Pubitemid 30408720)
3. N. Chegini X. Luo L. Ding D. Ripley 2003 The expression of Smads and transforming growth factor beta receptors in leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy Mol. Cell. Endocrinol. 209 9 16 10.1016/j.mce.2003.08.007 1:CAS:528:DC%2BD3sXos1Knt78%3D 14604812 (Pubitemid 37353078)
4. D. C. Dorn M. Alexenizer J. G. Hengstler A. Dorn 2006 Tumor cell specific toxicity of Inula helenium extracts Phytother. Res. 20 970 980 10.1002/ptr.1991 16912983 (Pubitemid 44763783)
5. Q. Dou Y. Zhao R. W. Tarnuzzer H. Rong R. S. Williams G. S. Schultz N. Chegini 1996 Suppression of transforming growth factor-beta (TGF beta) and TGF beta receptor messenger ribonucleic acid and protein expression in leiomyomata in women receiving gonadotropin-releasing hormone agonist therapy J. Clin. Endocrinol. Metab. 81 3222 3230 10.1210/jc.81.9.3222 1:CAS:528: DyaK28Xls1Orsbk%3D 8784073 (Pubitemid 26296192)
6. K. C. Flanders 2004 Smad3 as a mediator of the fibrotic response Int. J. Exp. Pathol. 85 47 64 10.1111/j.0959-9673.2004.00377.x 1:CAS:528: DC%2BD2cXlt1Wqsrg%3D 15154911 (Pubitemid 38703594)
7. A. J. Friedman 1989 Clinical experience in the treatment of fibroids with leuprolide and other GnRH agonists Obstet. Gynecol. Surv. 44 311 313 1:STN:280:DyaL1M3mt12kuw%3D%3D 2498793
8. M. A. Islam F. Ahmed A. K. Das S. C. Bachar 2005 Analgesic and anti-inflammatory activity of Leonurus sibiricus Fitoterapia 76 359 362 10.1016/j.fitote.2005.03.014 15890463 (Pubitemid 40745214)
9. H. Ka H. J. Park H. J. Jung J. W. Choi K. S. Cho J. Ha K. T. Lee 2003 Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells Cancer Lett. 196 143 152 10.1016/S0304-3835(03)00238-6 1:CAS:528:DC%2BD3sXlt1egs7s%3D 12860272 (Pubitemid 36830893)
10. C. H. Kim D. I. Kim C. N. Kwon S. K. Kang U. H. Jin S. J. Suh T. K. Lee I. S. Lee 2006 Euonymus alatus (Thunb.) Sieb induces apoptosis via mitochondrial pathway as prooxidant in human uterine leiomyomal smooth muscle cells Int. J. Gynecol. Cancer 16 843 848 10.1111/j.1525-1438.2006.00524.x 1:CAS:528: DC%2BD28XkvFGntL8%3D 16681771
11. D. C. Kim S. Ramachandran S. H. Baek S. H. Kwon K. Y. Kwon S. D. Cha I. Bae C. H. Cho 2008 Induction of growth inhibition and apoptosis in human uterine leiomyoma cells by isoliquiritigenin Reprod. Sci. 15 552 558 10.1177/1933719107312681 1:CAS:528:DC%2BD1cXovFCjt78%3D 18487228 (Pubitemid 351875956)
12. K. W. Kim U. H. Jin D. I. Kim T. K. Lee M. S. Kim M. J. Oh M. S. Kim D. Y. Kwon Y. C. Lee C.H. Kim 2008 Antiproliferative effect of Scutellaria barbata D. Don. on cultured human uterine leiomyoma cells by downregulation of the expression of Bcl-2 protein Phytother. Res. 22 583 590 10.1002/ptr.1996 18444248 (Pubitemid 351716544)
13. B. M. Kwon S. H. Lee S. U. Choi S. H. Park C. O. Lee Y. K. Cho N. D. Sung S. H. Bok 1998 Synthesis and in vitro cytotoxicity of cinnamaldehydes to human solid tumor cells Arch. Pharm. Res. 21 147 152 10.1007/BF02976760 1:CAS:528:DyaK1cXivVegu70%3D 9875422
14. B. S. Lee R. A. Nowak 2001 Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF beta J. Clin. Endocrinol. Metab. 86 913 920 10.1210/jc.86.2.913 1:CAS:528:DC%2BD3MXht1Knurg%3D 11158066 (Pubitemid 32207515)
15. C. W. Lee S. H. Lee J. W. Lee J. O. Ban S. Y. Lee H. S. Yoo J. K. Jung D. C. Moon K. W. Oh J. T. Hong 2007 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation J. Pharmacol. Sci. 104 19 28 10.1254/jphs.FP0061204 1:CAS:528:DC%2BD2sXmt1Wrtr8%3D 17510524 (Pubitemid 46790312)
16. S. M. Lee M. L. Li Y. C. Tse S. C. Leung M. M. Lee S. K. Tsui K. P. Fung C. Y. Lee M. M. Waye 2002 Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway Life Sci. 71 2267 2277 10.1016/S0024-3205(02)01962-8 1:CAS:528:DC%2BD38Xms1ymu7g%3D 12215374 (Pubitemid 35246215)
17. S. Lee Y. S. Lee S. H. Jung K. H. Shin B. K. Kim S. S. Kang 2003 Anti-tumor activities of decursinol angelate and decursin from Angelica gigas Arch. Pharm. Res. 26 727 730 10.1007/BF02976682 1:CAS:528:DC%2BD3sXotFKksbk%3D 14560921 (Pubitemid 43073788)
18. T. K. Lee J. Y. Lee D. I. Kim Y. C. Lee C. H. Kim 2005 Differential regulation of protein kinase C activity by modulating factors and Euonymus alatus (Thunb.) Sieb in human myometrial and uterine leiomyomal smooth muscle cells Int. J. Gynecol. Cancer. 15 349 358 10.1111/j.1525-1438.2005.15228.x 15823124 (Pubitemid 40396977)
19. A. Lethaby B. Vollenhoven 2002 Fibroids (uterine myomatosis, leiomyomas) Clin. Evid. 7 1666 1678 12230780
20. L. Mehl-Madrona 2002 Complementary medicine treatment of uterine fibroids: a pilot study Altern. Ther. Health Med. 8 34 46 11890384
21. E. Y. Moon M. R. Lee A. G. Wang J. H. Lee H. C. Kim H. M. Kim J. M. Kim B. M. Kwon D. Y. Yu 2006 Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes Eur. J. Pharmacol. 530 270 275 10.1016/j.ejphar.2005.11.053 1:CAS:528:DC%2BD28XjvVCmsw%3D%3D 16405947 (Pubitemid 43078488)
22. M. D. D. Moura J. D. S. Silva R. A. G. Oliveira M. F. F. M. Diniz J. M. Barbosa-filho 2002 Natural products reported as potential inhibitors of uterine cervical neoplasia Acta Farm. Bonaerense 21 67 74
23. H. Nagasawa T. Onoyama M. Suzuki A. Hibino T. Segawa H. Inatomi 1990 Effects of motherwort (Leonurus sibiricus L) on preneoplastic and neoplastic mammary gland growth in multiparous GR/A mice Anticancer Res. 10 1019 1023 1:STN:280:DyaK3czktlalsg%3D%3D 2382973
24. C. R. Pamplona M. M. de Souza S. Machado Mda V. Cechinel Filho D. Navarro R. A. Yunes F. Delle Monache R. Niero 2006 Seasonal variation and analgesic properties of different parts from Curcuma zedoaria Roscoe (Zingiberaceae) grown in Brazil Z. Naturforsch. C. 61 6 10 1:CAS:528:DC%2BD28XjsFCguro%3D 16610209
25. W. H. Parker 2007 Etiology, symptomatology, and diagnosis of uterine myomas Fertil. Steril. 87 725 736 10.1016/j.fertnstert.2007.01.093 17430732 (Pubitemid 46553757)
26. S. Sakamoto H. Yoshino Y. Shirahata K. Shimodairo R. Okamoto 1992 Pharmacotherapeutic effects of Kueichih-fu-ling-wan (Keishi-bukuryo-go) on human uterine myomas Am. J. Chin. Med. 20 313 317 10.1142/S0192415X92000333 1:STN:280:DyaK3s7htFaquw%3D%3D 1471615
27. S. Sankaran 2008 Medical management of fibroids Best Pract. Res. Clin. Obstet. Gynaecol. 22 655 676 10.1016/j.bpobgyn.2008.03.001 18468953 (Pubitemid 351804125)
28. M. Satoh Y. Satoh K. Isobe Y. Fujimoto 2003 Studies on the constituents of Leonurus sibiricus L Chem. Pharm. Bull. (Tokyo) 51 341 342 10.1248/cpb.51.341 1:CAS:528:DC%2BD3sXjtl2jtro%3D
29. H. W. Schnaper T. Hayashida S. C. Hubchak A. C. Poncelet 2003 TGF-β signal transduction and mesangial cell fibrogenesis Am. J. Physiol. 284 F243 F252 1:CAS:528:DC%2BD3sXhtlOqtLo%3D
30. I. I. Tepkeeva E. V. Moiseeva A. V. Chaadaeva E. V. Zhavoronkova Y. V. Kessler S. G. Semushina V. P. Demushkin 2008 Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb(8.17)1Iem mice Bull. Exp. Biol. Med. 145 464 466 10.1007/s10517-008-0119-1 1:STN:280:DC%2BD1M%2FgvF2jsA%3D%3D 19110595
31. C. L. Walker E. A. Stewart 2005 Uterine fibroids: the elephant in the room Science 308 1589 1592 10.1126/science.1112063 1:CAS:528: DC%2BD2MXltFemsb0%3D 15947177 (Pubitemid 40807499)
32. T. Yoshioka E. Fujii M. Endo K. Wada Y. Tokunaga N. Shiba H. Hohsho H. Shibuya T. Muraki 1998 Anti-inflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene Inflamm. Res. 47 476 481 10.1007/s000110050361 1:CAS:528:DyaK1MXitlGmtw%3D%3D 9892041 (Pubitemid 29015636)