Inchin-ko-to prevents medium-term liver fibrosis in postoperative biliary atresia patients

Pediatric Surgery International

Volumn 23, Issue 4, 2007, Pages 343-347

  Tamura, Tsuyoshi ^a   Kobayashi, Hiroyuki ^a   Yamataka, Atsuyuki ^a   Lane, Geoffrey J ^a   Koga, Hiroyuki ^a   Miyano, Takeshi ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

Biliary atresia; Hyaluronic acid; Inchin ko to; Liver fibrosis; Type IV collagen

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILIRUBIN; BIOLOGICAL MARKER; COLLAGEN TYPE 4; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HYALURONIC ACID; INCHINKO TO;

ABSENCE OF SIDE EFFECTS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID BLOOD LEVEL; BILE DUCT ATRESIA; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG TOLERABILITY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; LIVER FIBROSIS; LIVER FUNCTION; MALE; POSTOPERATIVE CARE; PRESCHOOL CHILD; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

APOPTOSIS; BILIARY ATRESIA; BILIARY TRACT SURGICAL PROCEDURES; BIOLOGICAL MARKERS; CHILD, PRESCHOOL; CHOLAGOGUES AND CHOLERETICS; COLLAGEN TYPE IV; DISEASE PROGRESSION; DRUGS, CHINESE HERBAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYALURONIC ACID; LIVER CIRRHOSIS; MALE; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 33947531304     PISSN: 01790358     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00383-007-1887-9     Document Type: Article

References (13)

1. Altman RP, Lilly JR, Greenfeld J, et al (1997) A multivariable risk factor analysis of the portoenterostomy (Kasai) procedure for biliary atresia: twenty-five years of experience from two centers. Ann Surg 226:348-355
2. Kobayashi H, Horikoshi K, Yamataka A, et al (2001) Are stable postoperative biliary atresia patients really stable? Pediatr Surg Int 17:104-107
3. Nittono H, Tokita A, Hayashi M, et al (1988) Ursodeoxycholic acid in biliary atresia. Lancet 1(8584):528
4. Kiso Y, Ogasawara Y, Hirota K, et al (1984) Antihepatotoxic principles of Artemisia capillaris buds. Planta Med 1:81-85
5. Takeda S, Endo T, Aburada M (1981) Pharmacological studies on iridoid compounds. III: the choleretic mechanism of iridoid compounds. J Pharmaobiodyn 4:612-623
6. Okuno I, Uchida K, Nakamura M, et al (1988) Studies on choleretic constituents in Artemisia capillaris THUNB. Chem Parmacol Bull 36:769-775
7. Komiyama T, Tsukui M, Oshiro H (1976) Studies of 'Inchinkoto'. I. Capillarisin, a new choleretic substances. Yakugaku Zassi 96:841-854
8. Yamamoto M, Ogawa K, Morita M, et al (1996) The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor beta 1. Hepatology 23:552-559
9. Kosai K, Matsumoto K, Nagata S, et al (1988) Abrogation of fas-induced fulminant hepatic failure in mice by hepatocye growth factor. Biochem Biophys Res Commun 244: 683-690
10. Yamamoto M, Miura N, Ohtake N, et al (2000) Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice. Gastroenterology 118:380-389
11. Kobayashi H, Horikoshi K, Yamataka A, et al (2001) Beneficial effect of a traditional herbal medicine (inchin-ko-to) in postoperative biliary atresia patients. Pediatr Surg Int 17:386-389
12. Inao M, Mochida S, Matsui A, et al (2004) Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis. J Hepatol 41:584-591
13. Muraji T, Nio M, Ohhama Y et al (2004) Postoperative corticosteroid therapy for bile drainage in biliary atresia - a nationwide survey. J Pediatr Surg 39:1803-1805