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Volumn 224, Issue 1, 2014, Pages 157-164

Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells

Author keywords

Apigenin; IKK ; NF B; Pancreatic cancer

Indexed keywords

APIGENIN; BETA ACTIN; CASPASE 3; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA;

EID: 84888058645     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.10.007     Document Type: Article
Times cited : (72)

References (42)
  • 3
    • 0030271387 scopus 로고    scopus 로고
    • NF-κB: ten years after
    • Baeuerle P.A., Baltimore D. NF-κB: ten years after. Cell 1996, 87:13-20.
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 5
    • 41649104112 scopus 로고    scopus 로고
    • Activated NF-κB in colorectal cancer: predictive or prognostic factor
    • Brandi G., Pantaleo M.A., Biasco G., Paterini P. Activated NF-κB in colorectal cancer: predictive or prognostic factor. J. Clin. Oncol. 2008, 26:1388-1389.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1388-1389
    • Brandi, G.1    Pantaleo, M.A.2    Biasco, G.3    Paterini, P.4
  • 9
    • 58849100438 scopus 로고    scopus 로고
    • Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-κB-dependent pathway
    • Chen P.H., Yang C.R. Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-κB-dependent pathway. J. Immunol. 2008, 181:8441-8449.
    • (2008) J. Immunol. , vol.181 , pp. 8441-8449
    • Chen, P.H.1    Yang, C.R.2
  • 10
    • 84873053877 scopus 로고    scopus 로고
    • Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria
    • Das S., Das J., Samadder A., Boujedaini N., Khuda-Bukhsh A.R. Apigenin-induced apoptosis in A375 and A549 cells through selective action and dysfunction of mitochondria. Exp. Biol. Med. (Maywood) 2012, 237:1433-1448.
    • (2012) Exp. Biol. Med. (Maywood) , vol.237 , pp. 1433-1448
    • Das, S.1    Das, J.2    Samadder, A.3    Boujedaini, N.4    Khuda-Bukhsh, A.R.5
  • 14
    • 8844263797 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in cancer therapy
    • Fulda S., Debatin K.M. Targeting apoptosis pathways in cancer therapy. Curr. Cancer Drug Targets 2004, 4:569-576.
    • (2004) Curr. Cancer Drug Targets , vol.4 , pp. 569-576
    • Fulda, S.1    Debatin, K.M.2
  • 15
    • 34547160717 scopus 로고    scopus 로고
    • Biology and management of pancreatic cancer
    • Ghaneh P., Costello E., Neoptolemos J.P. Biology and management of pancreatic cancer. Gut 2007, 56:1134-1152.
    • (2007) Gut , vol.56 , pp. 1134-1152
    • Ghaneh, P.1    Costello, E.2    Neoptolemos, J.P.3
  • 16
    • 0029007855 scopus 로고
    • The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
    • Hsu H., Xiong J., Goeddel D.V. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 1995, 81:495-504.
    • (1995) Cell , vol.81 , pp. 495-504
    • Hsu, H.1    Xiong, J.2    Goeddel, D.V.3
  • 17
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: the control of NF-κB activity
    • Karin M., Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 2000, 18:621-663.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 18
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: a treasure trove for drug development
    • Karin M., Yamamoto Y., Wang Q.M. The IKK NF-κB system: a treasure trove for drug development. Nat. Rev. Drug Discov. 2004, 3:17-26.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 19
    • 36849075271 scopus 로고    scopus 로고
    • Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer
    • Lee S.H., Ryu J.K., Lee K.Y., Woo S.M., Park J.K., Yoo J.W., Kim Y.T., Yoon Y.B. Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer. Cancer Lett. 2008, 259:39-49.
    • (2008) Cancer Lett. , vol.259 , pp. 39-49
    • Lee, S.H.1    Ryu, J.K.2    Lee, K.Y.3    Woo, S.M.4    Park, J.K.5    Yoo, J.W.6    Kim, Y.T.7    Yoon, Y.B.8
  • 20
    • 51049098742 scopus 로고    scopus 로고
    • Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms
    • Long X., Fan M., Bigsby R.M., Nephew K.P. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms. Mol. Cancer Ther. 2008, 7:2096-2108.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2096-2108
    • Long, X.1    Fan, M.2    Bigsby, R.M.3    Nephew, K.P.4
  • 22
    • 70349881605 scopus 로고    scopus 로고
    • Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-κB
    • Murtaza I., Adhami V.M., Hafeez B.B., Saleem M., Mukhtar H. Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-κB. Int. J. Cancer 2009, 125:2465-2473.
    • (2009) Int. J. Cancer , vol.125 , pp. 2465-2473
    • Murtaza, I.1    Adhami, V.M.2    Hafeez, B.B.3    Saleem, M.4    Mukhtar, H.5
  • 23
    • 38449107785 scopus 로고    scopus 로고
    • Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation
    • Nicholas C., Batra S., Vargo M.A., Voss O.H., Gavrilin M.A., Wewers M.D., Guttridge D.C., Grotewold E., Doseff A.I. Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation. J. Immunol. 2007, 179:7121-7127.
    • (2007) J. Immunol. , vol.179 , pp. 7121-7127
    • Nicholas, C.1    Batra, S.2    Vargo, M.A.3    Voss, O.H.4    Gavrilin, M.A.5    Wewers, M.D.6    Guttridge, D.C.7    Grotewold, E.8    Doseff, A.I.9
  • 24
    • 77954344875 scopus 로고    scopus 로고
    • NF-κB activation enhances cell death by antimitotic drugs in human prostate cancer cells
    • Parrondo R., de las Pozas A., Reiner T., Rai P., Perez-Stable C. NF-κB activation enhances cell death by antimitotic drugs in human prostate cancer cells. Mol. Cancer 2010, 9:182.
    • (2010) Mol. Cancer , vol.9 , pp. 182
    • Parrondo, R.1    de las Pozas, A.2    Reiner, T.3    Rai, P.4    Perez-Stable, C.5
  • 25
    • 0038206722 scopus 로고    scopus 로고
    • Inhibition of constitutive NF-κB activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis
    • Pham L.V., Tamayo A.T., Yoshimura L.C., Lo P., Ford R.J. Inhibition of constitutive NF-κB activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J. Immunol. 2003, 171:88-95.
    • (2003) J. Immunol. , vol.171 , pp. 88-95
    • Pham, L.V.1    Tamayo, A.T.2    Yoshimura, L.C.3    Lo, P.4    Ford, R.J.5
  • 26
    • 0036717195 scopus 로고    scopus 로고
    • Nf-κB, chemokine gene transcription and tumour growth
    • Richmond A. Nf-κB, chemokine gene transcription and tumour growth. Nat. Rev. Immunol. 2002, 2:664-674.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 664-674
    • Richmond, A.1
  • 27
    • 33644847672 scopus 로고    scopus 로고
    • Functional diversity of flavonoids in the inhibition of the proinflammatory NF-κB, IRF, and Akt signaling pathways in murine intestinal epithelial cells
    • Ruiz P.A., Haller D. Functional diversity of flavonoids in the inhibition of the proinflammatory NF-κB, IRF, and Akt signaling pathways in murine intestinal epithelial cells. J. Nutr. 2006, 136:664-671.
    • (2006) J. Nutr. , vol.136 , pp. 664-671
    • Ruiz, P.A.1    Haller, D.2
  • 28
    • 2442424073 scopus 로고    scopus 로고
    • Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor NF-κB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-κB-responsive genes
    • Shukla S., Gupta S. Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor NF-κB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-κB-responsive genes. Clin. Cancer Res. 2004, 10:3169-3178.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3169-3178
    • Shukla, S.1    Gupta, S.2
  • 29
    • 33646583485 scopus 로고    scopus 로고
    • Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft
    • Shukla S., Gupta S. Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft. Mol. Cancer Ther. 2006, 5:843-852.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 843-852
    • Shukla, S.1    Gupta, S.2
  • 30
    • 34547114744 scopus 로고    scopus 로고
    • Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice
    • Shukla S., MacLennan G.T., Flask C.A., Fu P., Mishra A., Resnick M.I., Gupta S. Blockade of beta-catenin signaling by plant flavonoid apigenin suppresses prostate carcinogenesis in TRAMP mice. Cancer Res. 2007, 67:6925-6935.
    • (2007) Cancer Res. , vol.67 , pp. 6925-6935
    • Shukla, S.1    MacLennan, G.T.2    Flask, C.A.3    Fu, P.4    Mishra, A.5    Resnick, M.I.6    Gupta, S.7
  • 31
    • 28744436917 scopus 로고    scopus 로고
    • Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice
    • Shukla S., Mishra A., Fu P., MacLennan G.T., Resnick M.I., Gupta S. Up-regulation of insulin-like growth factor binding protein-3 by apigenin leads to growth inhibition and apoptosis of 22Rv1 xenograft in athymic nude mice. FASEB J. 2005, 19:2042-2044.
    • (2005) FASEB J. , vol.19 , pp. 2042-2044
    • Shukla, S.1    Mishra, A.2    Fu, P.3    MacLennan, G.T.4    Resnick, M.I.5    Gupta, S.6
  • 32
    • 0032562085 scopus 로고    scopus 로고
    • Cytokine induced expression of porcine inhibitor of apoptosis protein (iap) family member is regulated by NF-κB
    • Stehlik C., de Martin R., Binder B.R., Lipp J. Cytokine induced expression of porcine inhibitor of apoptosis protein (iap) family member is regulated by NF-κB. Biochem. Biophys. Res. Commun. 1998, 243:827-832.
    • (1998) Biochem. Biophys. Res. Commun. , vol.243 , pp. 827-832
    • Stehlik, C.1    de Martin, R.2    Binder, B.R.3    Lipp, J.4
  • 33
    • 41049097824 scopus 로고    scopus 로고
    • NF-κB: a new player in angiostatic therapy
    • Tabruyn S.P., Griffioen A.W. NF-κB: a new player in angiostatic therapy. Angiogenesis 2008, 11:101-106.
    • (2008) Angiogenesis , vol.11 , pp. 101-106
    • Tabruyn, S.P.1    Griffioen, A.W.2
  • 35
    • 67049134412 scopus 로고    scopus 로고
    • Inflammatory NF-κB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production
    • Tsai J., Zhang R., Qiu W., Su Q., Naples M., Adeli K. Inflammatory NF-κB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 296:G1287-G1298.
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.296
    • Tsai, J.1    Zhang, R.2    Qiu, W.3    Su, Q.4    Naples, M.5    Adeli, K.6
  • 37
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB
    • Wang C.Y., Mayo M.W., Baldwin A.S. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 1996, 274:784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 39
    • 0030611595 scopus 로고    scopus 로고
    • IκB kinase-beta: NF-κB activation and complex formation with IκB kinase-alpha and NIK
    • Woronicz J.D., Gao X., Cao Z., Rothe M., Goeddel D.V. IκB kinase-beta: NF-κB activation and complex formation with IκB kinase-alpha and NIK. Science 1997, 278:866-869.
    • (1997) Science , vol.278 , pp. 866-869
    • Woronicz, J.D.1    Gao, X.2    Cao, Z.3    Rothe, M.4    Goeddel, D.V.5
  • 40
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-beta
    • Yin M.J., Yamamoto Y., Gaynor R.B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-beta. Nature 1998, 396:77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 41
    • 18044376489 scopus 로고    scopus 로고
    • Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-κB pathway in pancreatic carcinoma cells
    • Yip-Schneider M.T., Nakshatri H., Sweeney C.J., Marshall M.S., Wiebke E.A., Schmidt C.M. Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-κB pathway in pancreatic carcinoma cells. Mol. Cancer Ther. 2005, 4:587-594.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 587-594
    • Yip-Schneider, M.T.1    Nakshatri, H.2    Sweeney, C.J.3    Marshall, M.S.4    Wiebke, E.A.5    Schmidt, C.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.