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Volumn 259, Issue 1, 2008, Pages 39-49

Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer

Author keywords

Akt; Apigenin; Gemcitabine; NF B; Pancreatic cancer

Indexed keywords

APIGENIN; GEMCITABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B;

EID: 36849075271     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.09.015     Document Type: Article
Times cited : (104)

References (38)
  • 2
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
    • Burris III H.A., Moore M.J., Andersen J., Green M.R., Rothenberg M.L., Modiano M.R., et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. 15 (1997) 2403-2413
    • (1997) J. Clin. Oncol. , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3    Green, M.R.4    Rothenberg, M.L.5    Modiano, M.R.6
  • 3
    • 0037103069 scopus 로고    scopus 로고
    • New applications of gemcitabine and future directions in the management of pancreatic cancer
    • Abbruzzese J.L. New applications of gemcitabine and future directions in the management of pancreatic cancer. Cancer 95 (2002) 941-945
    • (2002) Cancer , vol.95 , pp. 941-945
    • Abbruzzese, J.L.1
  • 5
    • 0036964816 scopus 로고    scopus 로고
    • Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization
    • Bharti A.C., and Aggarwal B.B. Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization. Ann. N. Y. Acad. Sci. 973 (2002) 392-395
    • (2002) Ann. N. Y. Acad. Sci. , vol.973 , pp. 392-395
    • Bharti, A.C.1    Aggarwal, B.B.2
  • 6
    • 2942690157 scopus 로고    scopus 로고
    • Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line
    • Li Y., Ellis K.L., Ali S., El-Rayes B.F., Nedeljkovic-Kurepa A., Kucuk O., et al. Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell line. Pancreas 28 (2004) e90-e95
    • (2004) Pancreas , vol.28
    • Li, Y.1    Ellis, K.L.2    Ali, S.3    El-Rayes, B.F.4    Nedeljkovic-Kurepa, A.5    Kucuk, O.6
  • 7
    • 25444493107 scopus 로고    scopus 로고
    • Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer
    • Banerjee S., Zhang Y., Ali S., Bhuiyan M., Wang Z., Chiao P.J., et al. Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer. Cancer Res. 65 (2005) 9064-9072
    • (2005) Cancer Res. , vol.65 , pp. 9064-9072
    • Banerjee, S.1    Zhang, Y.2    Ali, S.3    Bhuiyan, M.4    Wang, Z.5    Chiao, P.J.6
  • 8
    • 0026564258 scopus 로고
    • Genotoxicities of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems
    • Kuo M.L., Lee K.C., and Lin J.K. Genotoxicities of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems. Mutat. Res. 270 (1992) 87-95
    • (1992) Mutat. Res. , vol.270 , pp. 87-95
    • Kuo, M.L.1    Lee, K.C.2    Lin, J.K.3
  • 10
    • 0029080674 scopus 로고
    • Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes
    • Kuo M.L., and Yang N.C. Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes. Biochem. Biophys. Res. Commun. 212 (1995) 767-775
    • (1995) Biochem. Biophys. Res. Commun. , vol.212 , pp. 767-775
    • Kuo, M.L.1    Yang, N.C.2
  • 11
    • 0035812747 scopus 로고    scopus 로고
    • Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells
    • Gupta S., Afaq F., and Mukhtar H. Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. Biochem. Biophys. Res. Commun. 287 (2001) 914-920
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 914-920
    • Gupta, S.1    Afaq, F.2    Mukhtar, H.3
  • 13
    • 0033933197 scopus 로고    scopus 로고
    • Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines
    • Wang W., Heideman L., Chung C.S., Pelling J.C., Koehler K.J., and Birt D.F. Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines. Mol. Carcinog. 28 (2000) 102-110
    • (2000) Mol. Carcinog. , vol.28 , pp. 102-110
    • Wang, W.1    Heideman, L.2    Chung, C.S.3    Pelling, J.C.4    Koehler, K.J.5    Birt, D.F.6
  • 14
    • 0035059767 scopus 로고    scopus 로고
    • Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells
    • Yin F., Giuliano A.E., Law R.E., and Van Herle A.J. Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-CDK regulators and ERK MAP kinase activation in breast carcinoma cells. Anticancer Res. 21 (2001) 413-420
    • (2001) Anticancer Res. , vol.21 , pp. 413-420
    • Yin, F.1    Giuliano, A.E.2    Law, R.E.3    Van Herle, A.J.4
  • 15
    • 0032763752 scopus 로고    scopus 로고
    • Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO)
    • Yin F., Giuliano A.E., and Van Herle A.J. Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO). Anticancer Res. 19 (1999) 4297-4303
    • (1999) Anticancer Res. , vol.19 , pp. 4297-4303
    • Yin, F.1    Giuliano, A.E.2    Van Herle, A.J.3
  • 16
    • 33644847672 scopus 로고    scopus 로고
    • Functional diversity of flavonoids in the inhibition of the proinflammatory NF-kappaB, IRF, and Akt signaling pathways in murine intestinal epithelial cells
    • Ruiz P.A., and Haller D. Functional diversity of flavonoids in the inhibition of the proinflammatory NF-kappaB, IRF, and Akt signaling pathways in murine intestinal epithelial cells. J. Nutr. 136 (2006) 664-671
    • (2006) J. Nutr. , vol.136 , pp. 664-671
    • Ruiz, P.A.1    Haller, D.2
  • 17
    • 2442424073 scopus 로고    scopus 로고
    • Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes
    • Shukla S., and Gupta S. Suppression of constitutive and tumor necrosis factor alpha-induced nuclear factor (NF)-kappaB activation and induction of apoptosis by apigenin in human prostate carcinoma PC-3 cells: correlation with down-regulation of NF-kappaB-responsive genes. Clin. Cancer Res. 10 (2004) 3169-3178
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3169-3178
    • Shukla, S.1    Gupta, S.2
  • 18
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • Bruns C.J., Solorzano C.C., Harbison M.T., Ozawa S., Tsan R., Fan D., et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60 (2000) 2926-2935
    • (2000) Cancer Res. , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3    Ozawa, S.4    Tsan, R.5    Fan, D.6
  • 19
    • 0042736473 scopus 로고    scopus 로고
    • Chemotherapeutic advances in pancreatic cancer
    • Berlin J.D., and Rothenberg M.L. Chemotherapeutic advances in pancreatic cancer. Curr. Oncol. Rep. 5 (2003) 219-226
    • (2003) Curr. Oncol. Rep. , vol.5 , pp. 219-226
    • Berlin, J.D.1    Rothenberg, M.L.2
  • 20
    • 2942696037 scopus 로고    scopus 로고
    • New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers
    • Diaz-Rubio E. New chemotherapeutic advances in pancreatic, colorectal, and gastric cancers. Oncologist 9 (2004) 282-294
    • (2004) Oncologist , vol.9 , pp. 282-294
    • Diaz-Rubio, E.1
  • 22
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: tumour resistance to apoptosis
    • Igney F.H., and Krammer P.H. Death and anti-death: tumour resistance to apoptosis. Nat. Rev. Cancer 2 (2002) 277-288
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 24
    • 0036919717 scopus 로고    scopus 로고
    • Induction of apoptosis in cancer: new therapeutic opportunities
    • Ding H.F., and Fisher D.E. Induction of apoptosis in cancer: new therapeutic opportunities. Ann. Med. 34 (2002) 451-469
    • (2002) Ann. Med. , vol.34 , pp. 451-469
    • Ding, H.F.1    Fisher, D.E.2
  • 25
    • 0037279198 scopus 로고    scopus 로고
    • p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis
    • Clarke R.B. p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis. Breast Cancer Res. 5 (2003) 162-163
    • (2003) Breast Cancer Res. , vol.5 , pp. 162-163
    • Clarke, R.B.1
  • 26
    • 0037352170 scopus 로고    scopus 로고
    • Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
    • Chang F., Lee J.T., Navolanic P.M., Steelman L.S., Shelton J.G., Blalock W.L., et al. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17 (2003) 590-603
    • (2003) Leukemia , vol.17 , pp. 590-603
    • Chang, F.1    Lee, J.T.2    Navolanic, P.M.3    Steelman, L.S.4    Shelton, J.G.5    Blalock, W.L.6
  • 27
    • 0041338049 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
    • Bondar V.M., Sweeney-Gotsch B., Andreeff M., Mills G.B., and McConkey D.J. Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol. Cancer Ther. 1 (2002) 989-997
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 989-997
    • Bondar, V.M.1    Sweeney-Gotsch, B.2    Andreeff, M.3    Mills, G.B.4    McConkey, D.J.5
  • 28
    • 0035992417 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway
    • Li Y., and Sarkar F.H. Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin. Cancer Res. 8 (2002) 2369-2377
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2369-2377
    • Li, Y.1    Sarkar, F.H.2
  • 29
    • 3042642131 scopus 로고    scopus 로고
    • Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells
    • Rahman K.M., Li Y., and Sarkar F.H. Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. Nutr. Cancer 48 (2004) 84-94
    • (2004) Nutr. Cancer , vol.48 , pp. 84-94
    • Rahman, K.M.1    Li, Y.2    Sarkar, F.H.3
  • 30
    • 0035990924 scopus 로고    scopus 로고
    • Inhibition of protein kinase B/Akt. implications for cancer therapy
    • Hill M.M., and Hemmings B.A. Inhibition of protein kinase B/Akt. implications for cancer therapy. Pharmacol. Ther. 93 (2002) 243-251
    • (2002) Pharmacol. Ther. , vol.93 , pp. 243-251
    • Hill, M.M.1    Hemmings, B.A.2
  • 31
    • 14644432362 scopus 로고    scopus 로고
    • Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways
    • Fang J., Xia C., Cao Z., Zheng J.Z., Reed E., and Jiang B.H. Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways. FASEB J. 19 (2005) 342-353
    • (2005) FASEB J. , vol.19 , pp. 342-353
    • Fang, J.1    Xia, C.2    Cao, Z.3    Zheng, J.Z.4    Reed, E.5    Jiang, B.H.6
  • 32
    • 1042289764 scopus 로고    scopus 로고
    • Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway
    • Way T.D., Kao M.C., and Lin J.K. Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway. J. Biol. Chem. 279 (2004) 4479-4489
    • (2004) J. Biol. Chem. , vol.279 , pp. 4479-4489
    • Way, T.D.1    Kao, M.C.2    Lin, J.K.3
  • 33
    • 1242319394 scopus 로고    scopus 로고
    • Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis
    • Schniewind B., Christgen M., Kurdow R., Haye S., Kremer B., Kalthoff H., et al. Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis. Int. J. Cancer 109 (2004) 182-188
    • (2004) Int. J. Cancer , vol.109 , pp. 182-188
    • Schniewind, B.1    Christgen, M.2    Kurdow, R.3    Haye, S.4    Kremer, B.5    Kalthoff, H.6
  • 34
    • 0031595523 scopus 로고    scopus 로고
    • Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis
    • Liu J.R., Fletcher B., Page C., Hu C., Nunez G., and Baker V. Bcl-xL is expressed in ovarian carcinoma and modulates chemotherapy-induced apoptosis. Gynecol. Oncol. 70 (1998) 398-403
    • (1998) Gynecol. Oncol. , vol.70 , pp. 398-403
    • Liu, J.R.1    Fletcher, B.2    Page, C.3    Hu, C.4    Nunez, G.5    Baker, V.6
  • 35
    • 0031032294 scopus 로고    scopus 로고
    • Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents
    • Decaudin D., Geley S., Hirsch T., Castedo M., Marchetti P., Macho A., et al. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res. 57 (1997) 62-67
    • (1997) Cancer Res. , vol.57 , pp. 62-67
    • Decaudin, D.1    Geley, S.2    Hirsch, T.3    Castedo, M.4    Marchetti, P.5    Macho, A.6
  • 36
    • 0029846602 scopus 로고    scopus 로고
    • Association of bcl-2, bax, bcl-xL and interleukin-1 beta-converting enzyme expression with initial response to chemotherapy in acute myeloid leukemia
    • Stoetzer O.J., Nussler V., Darsow M., Gullis E., Pelka-Fleischer R., Scheel U., et al. Association of bcl-2, bax, bcl-xL and interleukin-1 beta-converting enzyme expression with initial response to chemotherapy in acute myeloid leukemia. Leukemia 10 Suppl. 3 (1996) S18-S22
    • (1996) Leukemia , vol.10 , Issue.SUPPL. 3
    • Stoetzer, O.J.1    Nussler, V.2    Darsow, M.3    Gullis, E.4    Pelka-Fleischer, R.5    Scheel, U.6
  • 37
    • 0032921777 scopus 로고    scopus 로고
    • Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content
    • Bold R.J., Chandra J., and McConkey D.J. Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann. Surg. Oncol. 6 (1999) 279-285
    • (1999) Ann. Surg. Oncol. , vol.6 , pp. 279-285
    • Bold, R.J.1    Chandra, J.2    McConkey, D.J.3
  • 38
    • 0036092840 scopus 로고    scopus 로고
    • Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents
    • Xu Z.W., Friess H., Buchler M.W., and Solioz M. Overexpression of Bax sensitizes human pancreatic cancer cells to apoptosis induced by chemotherapeutic agents. Cancer Chemother. Pharmacol. 49 (2002) 504-510
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , pp. 504-510
    • Xu, Z.W.1    Friess, H.2    Buchler, M.W.3    Solioz, M.4


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