메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages 228-238

Mini-review: Bmx kinase inhibitors for cancer therapy

Author keywords

Bmx; Breast cancer; Btk; Etk; Glioblastoma; Kinase inhibitor; Lung cancer; Prostate cancer; Tec

Indexed keywords

1,3 CYCLOPENTADIONE DERIVATIVE; 2 CYANO N (2,5 DIBROMOPHENYL) 3 HYDROXYCROTONAMIDE; ACACIA NILOTICA EXTRACT; AVL 292; BMX KINASE INHIBITOR; BORTEZOMIB; CANERTINIB; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; IBRUTINIB; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; PROTEIN KINASE INHIBITOR; PYRROLO [2, 3 D] PYRIMIDINE DERIVATIVE; SHORT HAIRPIN RNA; TOZASERTIB; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT; XANTHOHUMOL;

EID: 84888020497     PISSN: 15748928     EISSN: None     Source Type: Journal    
DOI: 10.2174/15748928113089990043     Document Type: Review
Times cited : (21)

References (66)
  • 1
    • 0001584969 scopus 로고    scopus 로고
    • The Tec family of cytoplasmic tyrosine kinases: Mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species
    • Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, Vihinen M. The Tec family of cytoplasmic tyrosine kinases: Mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species. Bioessays 2001; 23(5): 436-46.
    • (2001) Bioessays , vol.23 , Issue.5 , pp. 436-446
    • Smith, C.I.1    Islam, T.C.2    Mattsson, P.T.3    Mohamed, A.J.4    Nore, B.F.5    Vihinen, M.6
  • 2
    • 84860435487 scopus 로고    scopus 로고
    • Tec family kinases in inflammation and disease
    • Horwood NJ, Urbaniak AM, Danks L. Tec family kinases in inflammation and disease. Int Rev Immunol 2012; 31(2): 87-103.
    • (2012) Int Rev Immunol , vol.31 , Issue.2 , pp. 87-103
    • Horwood, N.J.1    Urbaniak, A.M.2    Danks, L.3
  • 3
    • 0034693754 scopus 로고    scopus 로고
    • Signaling network of the Btk family kinases
    • Qiu Y, Kung HJ. Signaling network of the Btk family kinases. Oncogene 2000; 19(49): 5651-61.
    • (2000) Oncogene , vol.19 , Issue.49 , pp. 5651-5661
    • Qiu, Y.1    Kung, H.J.2
  • 4
    • 0036676540 scopus 로고    scopus 로고
    • Beyond calcium: New signaling pathways for Tec family kinases
    • Takesono A, Finkelstein LD, Schwartzberg PL. Beyond calcium: New signaling pathways for Tec family kinases. J Cell Sci 2002; 115(Pt 15): 3039-48.
    • (2002) J Cell Sci , vol.115 , Issue.Pt 15 , pp. 3039-3048
    • Takesono, A.1    Finkelstein, L.D.2    Schwartzberg, P.L.3
  • 5
    • 0033621489 scopus 로고    scopus 로고
    • Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells
    • Wen X, Lin HH, Shih HM, Kung HJ, Ann DK. Kinase activation of the non-receptor tyrosine kinase Etk/BMX alone is sufficient to transactivate STAT-mediated gene expression in salivary and lung epithelial cells. J Biol Chem 1999; 274(53): 38204-10.
    • (1999) J Biol Chem , vol.274 , Issue.53 , pp. 38204-38210
    • Wen, X.1    Lin, H.H.2    Shih, H.M.3    Kung, H.J.4    Ann, D.K.5
  • 6
    • 79953757100 scopus 로고    scopus 로고
    • Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
    • Guryanova OA, Wu Q, Cheng L, Lathia JD, Huang Z, Yang J, et al. Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell 2011; 19(4): 498-511.
    • (2011) Cancer Cell , vol.19 , Issue.4 , pp. 498-511
    • Guryanova, O.A.1    Wu, Q.2    Cheng, L.3    Lathia, J.D.4    Huang, Z.5    Yang, J.6
  • 7
    • 0029791422 scopus 로고    scopus 로고
    • BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias
    • Kaukonen J, Lahtinen I, Laine S, Alitalo K, Palotie A. BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias. Br J Haematol 1996; 94(3): 455-60.
    • (1996) Br J Haematol , vol.94 , Issue.3 , pp. 455-460
    • Kaukonen, J.1    Lahtinen, I.2    Laine, S.3    Alitalo, K.4    Palotie, A.5
  • 8
    • 0033190523 scopus 로고    scopus 로고
    • Tec family of protein-tyrosine kinases: An overview of their structure and function
    • Mano H. Tec family of protein-tyrosine kinases: An overview of their structure and function. Cytokine Growth Factor Rev 1999; 10(3-4): 267-80.
    • (1999) Cytokine Growth Factor Rev , vol.10 , Issue.3-4 , pp. 267-280
    • Mano, H.1
  • 9
    • 0038557038 scopus 로고    scopus 로고
    • Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK
    • Mueller C, August A. Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK. J Immunol 2003; 170(10): 5056-63.
    • (2003) J Immunol , vol.170 , Issue.10 , pp. 5056-5063
    • Mueller, C.1    August, A.2
  • 11
    • 0033213484 scopus 로고    scopus 로고
    • Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells
    • Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, et al. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Immunity 1999; 11(4): 399-409.
    • (1999) Immunity , vol.11 , Issue.4 , pp. 399-409
    • Fowell, D.J.1    Shinkai, K.2    Liao, X.C.3    Beebe, A.M.4    Coffman, R.L.5    Littman, D.R.6
  • 12
    • 4644237821 scopus 로고    scopus 로고
    • Selective Itk inhibitors block T-cell activation and murine lung inflammation
    • Lin TA, McIntyre KW, Das J, Liu C, O'Day KD, Penhallow B, et al. Selective Itk inhibitors block T-cell activation and murine lung inflammation. Biochemistry 2004; 43(34): 11056-62.
    • (2004) Biochemistry , vol.43 , Issue.34 , pp. 11056-11062
    • Lin, T.A.1    McIntyre, K.W.2    Das, J.3    Liu, C.4    O'Day, K.D.5    Penhallow, B.6
  • 13
    • 77949878560 scopus 로고    scopus 로고
    • Itk inhibitors: A patent review
    • Lo HY. Itk inhibitors: A patent review. Expert Opin Ther Pat 2010; 20(4): 459-69.
    • (2010) Expert Opin Ther Pat , vol.20 , Issue.4 , pp. 459-469
    • Lo, H.Y.1
  • 15
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large Bcell lymphoma
    • Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, et al. Chronic active B-cell-receptor signalling in diffuse large Bcell lymphoma. Nature 2010; 463(7277): 88-92.
    • (2010) Nature , vol.463 , Issue.7277 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3    Tolar, P.4    Young, R.M.5    Romesser, P.B.6
  • 16
    • 77955625479 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
    • Honigberg LA, Smith AM, Sirisawad M, Verner E, Loury D, Chang B, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci USA 2010; 107(29): 13075-80.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.29 , pp. 13075-13080
    • Honigberg, L.A.1    Smith, A.M.2    Sirisawad, M.3    Verner, E.4    Loury, D.5    Chang, B.6
  • 17
    • 0035800799 scopus 로고    scopus 로고
    • Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells
    • Bagheri-Yarmand R, Mandal M, Taludker AH, Wang RA, Vadlamudi RK, Kung HJ, et al. Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. J Biol Chem 2001; 276(31): 29403-9.
    • (2001) J Biol Chem , vol.276 , Issue.31 , pp. 29403-29409
    • Bagheri-Yarmand, R.1    Mandal, M.2    Taludker, A.H.3    Wang, R.A.4    Vadlamudi, R.K.5    Kung, H.J.6
  • 18
    • 1842534326 scopus 로고    scopus 로고
    • The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells
    • Chen KY, Huang LM, Kung HJ, Ann DK, Shih HM. The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells. Oncogene 2004; 23(10): 1854-62.
    • (2004) Oncogene , vol.23 , Issue.10 , pp. 1854-1862
    • Chen, K.Y.1    Huang, L.M.2    Kung, H.J.3    Ann, D.K.4    Shih, H.M.5
  • 19
    • 77955296482 scopus 로고    scopus 로고
    • Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: Signaling partners, hierarchy and physiological significance
    • Cohen I, Maoz M, Turm H, Grisaru-Granovsky S, Maly B, Uziely B, et al. Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: Signaling partners, hierarchy and physiological significance. PLoS One 2010; 5(6): e11135.
    • (2010) PLoS One , vol.5 , Issue.6
    • Cohen, I.1    Maoz, M.2    Turm, H.3    Grisaru-Granovsky, S.4    Maly, B.5    Uziely, B.6
  • 20
    • 33748071774 scopus 로고    scopus 로고
    • Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse
    • Dai B, Kim O, Xie Y, Guo Z, Xu K, Wang B, et al. Tyrosine kinase Etk/BMX is up-regulated in human prostate cancer and its overexpression induces prostate intraepithelial neoplasia in mouse. Cancer Res 2006; 66(16): 8058-64.
    • (2006) Cancer Res , vol.66 , Issue.16 , pp. 8058-8064
    • Dai, B.1    Kim, O.2    Xie, Y.3    Guo, Z.4    Xu, K.5    Wang, B.6
  • 21
    • 77954370361 scopus 로고    scopus 로고
    • Compensatory upregulation of tyrosine kinase Etk/BMX in response to androgen deprivation promotes castration-resistant growth of prostate cancer cells
    • Dai B, Chen H, Guo S, Yang X, Linn DE, Sun F, et al. Compensatory upregulation of tyrosine kinase Etk/BMX in response to androgen deprivation promotes castration-resistant growth of prostate cancer cells. Cancer Res 2010; 70(13): 5587-96.
    • (2010) Cancer Res , vol.70 , Issue.13 , pp. 5587-5596
    • Dai, B.1    Chen, H.2    Guo, S.3    Yang, X.4    Linn, D.E.5    Sun, F.6
  • 22
    • 80052009547 scopus 로고    scopus 로고
    • Essential role of Stat3 in PI3K-induced oncogenic transformation
    • Hart JR, Liao L, Yates JR, Vogt PK. Essential role of Stat3 in PI3K-induced oncogenic transformation. Proc Natl Acad Sci USA 2011; 108(32): 13247-52.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.32 , pp. 13247-13252
    • Hart, J.R.1    Liao, L.2    Yates, J.R.3    Vogt, P.K.4
  • 23
    • 84866019998 scopus 로고    scopus 로고
    • PI3K and STAT3: A new alliance
    • Vogt PK, Hart JR. PI3K and STAT3: A new alliance. Cancer Discov 2011; 1(6): 481-6.
    • (2011) Cancer Discov , vol.1 , Issue.6 , pp. 481-486
    • Vogt, P.K.1    Hart, J.R.2
  • 24
    • 0034954684 scopus 로고    scopus 로고
    • Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium
    • Rajantie I, Ekman N, Iljin K, Arighi E, Gunji Y, Kaukonen J, et al. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Mol Cell Biol 2001; 21(14): 4647-55.
    • (2001) Mol Cell Biol , vol.21 , Issue.14 , pp. 4647-4655
    • Rajantie, I.1    Ekman, N.2    Iljin, K.3    Arighi, E.4    Gunji, Y.5    Kaukonen, J.6
  • 35
    • 84856461639 scopus 로고    scopus 로고
    • Trial watch: BTK inhibitor shows positive results in B cell malignancies
    • Harrison C. Trial watch: BTK inhibitor shows positive results in B cell malignancies. Nat Rev Drug Discov 2012; 11(2): 96.
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.2 , pp. 96
    • Harrison, C.1
  • 37
    • 84867889132 scopus 로고    scopus 로고
    • Phase Ib trial of AVL-292, a covalent inhibitor of Bruton's tyrosine kinase (Btk), in chronic lymphocytic leukemia (CLL) and B-non-Hodgkin lymphoma (B-NHL)
    • Brown JR, Sharman JP, Harb WA, Kelly KR, Schreeder MT, Sweetenham JW, et al. Phase Ib trial of AVL-292, a covalent inhibitor of Bruton's tyrosine kinase (Btk), in chronic lymphocytic leukemia (CLL) and B-non-Hodgkin lymphoma (B-NHL). ASCO Meeting Abstr 2012; 30(15 suppl): 8032.
    • (2012) ASCO Meeting Abstr , vol.30 , Issue.15 SUPPL. , pp. 8032
    • Brown, J.R.1    Sharman, J.P.2    Harb, W.A.3    Kelly, K.R.4    Schreeder, M.T.5    Sweetenham, J.W.6
  • 38
    • 2342639645 scopus 로고    scopus 로고
    • VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
    • Harrington EA, Bebbington D, Moore J, Rasmussen RK, Ajose-Adeogun AO, Nakayama T, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 2004; 10(3): 262-7.
    • (2004) Nat Med , vol.10 , Issue.3 , pp. 262-267
    • Harrington, E.A.1    Bebbington, D.2    Moore, J.3    Rasmussen, R.K.4    Ajose-Adeogun, A.O.5    Nakayama, T.6
  • 39
    • 33845743957 scopus 로고    scopus 로고
    • Aurora kinases: New targets for cancer therapy
    • Carvajal RD, Tse A, Schwartz GK. Aurora kinases: New targets for cancer therapy. Clin Cancer Res 2006; 12(23): 6869-75.
    • (2006) Clin Cancer Res , vol.12 , Issue.23 , pp. 6869-6875
    • Carvajal, R.D.1    Tse, A.2    Schwartz, G.K.3
  • 42
    • 33745298429 scopus 로고    scopus 로고
    • Rational design of inhibitors that bind to inactive kinase conformations
    • Liu Y, Gray NS. Rational design of inhibitors that bind to inactive kinase conformations. Nat Chem Biol 2006; 2(7): 358-64.
    • (2006) Nat Chem Biol , vol.2 , Issue.7 , pp. 358-364
    • Liu, Y.1    Gray, N.S.2
  • 43
    • 0030739229 scopus 로고    scopus 로고
    • Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase
    • Hayess K, Benndorf R. Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase. Biochem Pharmacol 1997; 53(9): 1239-47.
    • (1997) Biochem Pharmacol , vol.53 , Issue.9 , pp. 1239-1247
    • Hayess, K.1    Benndorf, R.2
  • 44
    • 79958239562 scopus 로고    scopus 로고
    • Peptide inhibitors of MK2 show promise for inhibition of abdominal adhesions
    • Ward BC, Kavalukas S, Brugnano J, Barbul A, Panitch A. Peptide inhibitors of MK2 show promise for inhibition of abdominal adhesions. J Surg Res 2011; 169(1): e27-36.
    • (2011) J Surg Res , vol.169 , Issue.1
    • Ward, B.C.1    Kavalukas, S.2    Brugnano, J.3    Barbul, A.4    Panitch, A.5
  • 46
    • 13144266690 scopus 로고    scopus 로고
    • Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor
    • Fry DW, Bridges AJ, Denny WA, Doherty A, Greis KD, Hicks JL, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci USA 1998; 95(20): 12022-7.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.20 , pp. 12022-12027
    • Fry, D.W.1    Bridges, A.J.2    Denny, W.A.3    Doherty, A.4    Greis, K.D.5    Hicks, J.L.6
  • 47
    • 0035168761 scopus 로고    scopus 로고
    • CI-1033, a pan-erbB tyrosine kinase inhibitor
    • Slichenmyer WJ, Elliott WL, Fry DW. CI-1033, a pan-erbB tyrosine kinase inhibitor. Semin Oncol 2001; 28(5 Suppl 16): 80-5.
    • (2001) Semin Oncol , vol.28 , Issue.5 SUPPL. 16 , pp. 80-85
    • Slichenmyer, W.J.1    Elliott, W.L.2    Fry, D.W.3
  • 50
    • 0037069931 scopus 로고    scopus 로고
    • Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation
    • Chau CH, Chen KY, Deng HT, Kim KJ, Hosoya K, Terasaki T, et al. Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation. Oncogene 2002; 21(57): 8817-29.
    • (2002) Oncogene , vol.21 , Issue.57 , pp. 8817-8829
    • Chau, C.H.1    Chen, K.Y.2    Deng, H.T.3    Kim, K.J.4    Hosoya, K.5    Terasaki, T.6
  • 51
    • 0347065353 scopus 로고    scopus 로고
    • Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factorinduced angiogenic pathway
    • Zhang R, Xu Y, Ekman N, Wu Z, Wu J, Alitalo K, et al. Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factorinduced angiogenic pathway. J Biol Chem 2003; 278(51): 51267-76.
    • (2003) J Biol Chem , vol.278 , Issue.51 , pp. 51267-51276
    • Zhang, R.1    Xu, Y.2    Ekman, N.3    Wu, Z.4    Wu, J.5    Alitalo, K.6
  • 52
    • 0036838086 scopus 로고    scopus 로고
    • Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: Role in endothelial cell migration and angiogenesis
    • Pan S, An P, Zhang R, He X, Yin G, Min W. Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: Role in endothelial cell migration and angiogenesis. Mol Cell Biol 2002; 22(21): 7512-23.
    • (2002) Mol Cell Biol , vol.22 , Issue.21 , pp. 7512-7523
    • Pan, S.1    An, P.2    Zhang, R.3    He, X.4    Yin, G.5    Min, W.6
  • 53
    • 84863955477 scopus 로고    scopus 로고
    • Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth
    • Holopainen T, Alpuche VL, Zheng W, Heljasvaara R, Jones D, He Y, et al. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res 2012; 72(14): 3512-21.
    • (2012) Cancer Res , vol.72 , Issue.14 , pp. 3512-3521
    • Holopainen, T.1    Alpuche, V.L.2    Zheng, W.3    Heljasvaara, R.4    Jones, D.5    He, Y.6
  • 54
    • 42349086371 scopus 로고    scopus 로고
    • Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium
    • Tu T, Thotala D, Geng L, Hallahan DE, Willey CD. Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium. Cancer Res 2008; 68(8): 2861-9.
    • (2008) Cancer Res , vol.68 , Issue.8 , pp. 2861-2869
    • Tu, T.1    Thotala, D.2    Geng, L.3    Hallahan, D.E.4    Willey, C.D.5
  • 56
    • 77957341495 scopus 로고    scopus 로고
    • Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells
    • Mathews LA, Hurt EM, Zhang X, Farrar WL. Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells. Mol Cancer 2010; 9: 267.
    • (2010) Mol Cancer , vol.9 , pp. 267
    • Mathews, L.A.1    Hurt, E.M.2    Zhang, X.3    Farrar, W.L.4
  • 57
    • 9644295729 scopus 로고    scopus 로고
    • Bidirectional regulation between tyrosine kinase Etk/Bmx and tumor suppressor p53 in response to DNA damage
    • Jiang T, Guo Z, Dai B, Kang M, Ann DK, Kung HJ, et al. Bidirectional regulation between tyrosine kinase Etk/Bmx and tumor suppressor p53 in response to DNA damage. J Biol Chem 2004; 279(48): 50181-9.
    • (2004) J Biol Chem , vol.279 , Issue.48 , pp. 50181-50189
    • Jiang, T.1    Guo, Z.2    Dai, B.3    Kang, M.4    Ann, D.K.5    Kung, H.J.6
  • 58
    • 47149085266 scopus 로고    scopus 로고
    • Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF-kappaB
    • Yu L, Mohamed AJ, Simonson OE, Vargas L, Blomberg KE, Björkstrand B, et al. Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF-kappaB. Blood 2008; 111(9): 4617-26.
    • (2008) Blood , vol.111 , Issue.9 , pp. 4617-4626
    • Yu, L.1    Mohamed, A.J.2    Simonson, O.E.3    Vargas, L.4    Blomberg, K.E.5    Björkstrand, B.6
  • 59
    • 70350212976 scopus 로고    scopus 로고
    • STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells
    • Sherry MM, Reeves A, Wu JK, Cochran BH. STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells. Stem Cells 2009; 27(10): 2383-92.
    • (2009) Stem Cells , vol.27 , Issue.10 , pp. 2383-2392
    • Sherry, M.M.1    Reeves, A.2    Wu, J.K.3    Cochran, B.H.4
  • 60
    • 80052722954 scopus 로고    scopus 로고
    • Ligand-independent activation of the arylhydrocarbon receptor by ETK (Bmx) tyrosine kinase helps MCF10AT1 breast cancer cells to survive in an apoptosis-inducing environment
    • Fujisawa Y, Li W, Wu D, Wong P, Vogel C, Dong B, et al. Ligand-independent activation of the arylhydrocarbon receptor by ETK (Bmx) tyrosine kinase helps MCF10AT1 breast cancer cells to survive in an apoptosis-inducing environment. Biol Chem 2011; 392(10): 897-908.
    • (2011) Biol Chem , vol.392 , Issue.10 , pp. 897-908
    • Fujisawa, Y.1    Li, W.2    Wu, D.3    Wong, P.4    Vogel, C.5    Dong, B.6
  • 61
    • 33845415264 scopus 로고    scopus 로고
    • Anti-breast cancer activity of LFM-A13, a potent inhibitor of Pololike kinase (PLK)
    • Uckun FM, Dibirdik I, Qazi S, Vassilev A, Ma H, Mao C, et al. Anti-breast cancer activity of LFM-A13, a potent inhibitor of Pololike kinase (PLK). Bioorg Med Chem 2007; 15(2): 800-14.
    • (2007) Bioorg Med Chem , vol.15 , Issue.2 , pp. 800-814
    • Uckun, F.M.1    Dibirdik, I.2    Qazi, S.3    Vassilev, A.4    Ma, H.5    Mao, C.6
  • 62
    • 77952564029 scopus 로고    scopus 로고
    • Non-receptor tyrosine kinase Etk is involved in the apoptosis of small cell lung cancer cells
    • Guo L, Chen P, Zhou Y, Sun Y. Non-receptor tyrosine kinase Etk is involved in the apoptosis of small cell lung cancer cells. Exp Mol Pathol 2010; 88(3): 401-6.
    • (2010) Exp Mol Pathol , vol.88 , Issue.3 , pp. 401-406
    • Guo, L.1    Chen, P.2    Zhou, Y.3    Sun, Y.4
  • 63
    • 79953313816 scopus 로고    scopus 로고
    • Tyrosine kinase Etk/Bmx protects nasopharyngeal carcinoma cells from apoptosis induced by radiation
    • Zhang Z, Zhu W, Zhang J, Guo L. Tyrosine kinase Etk/Bmx protects nasopharyngeal carcinoma cells from apoptosis induced by radiation. Cancer Biol Ther 2011, 11(7): 690-8.
    • (2011) Cancer Biol Ther , vol.11 , Issue.7 , pp. 690-698
    • Zhang, Z.1    Zhu, W.2    Zhang, J.3    Guo, L.4
  • 64
    • 79952358749 scopus 로고    scopus 로고
    • Tyrosine kinase ETK/Bmx is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy
    • Guo S, Sun F, Guo Z, Li W, Alfano A, Chen H, et al. Tyrosine kinase ETK/Bmx is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy. PLoS One 2011; 6(3): e17778.
    • (2011) PLoS One , vol.6 , Issue.3
    • Guo, S.1    Sun, F.2    Guo, Z.3    Li, W.4    Alfano, A.5    Chen, H.6
  • 65
    • 41549110303 scopus 로고    scopus 로고
    • Expression of Etk/Bmx tyrosine kinase in intrahepatic cholangiocarcinoma
    • Guo L, Guo Y, Xiao S. Expression of Etk/Bmx tyrosine kinase in intrahepatic cholangiocarcinoma. J Surg Oncol 2008; 97(5): 428-32.
    • (2008) J Surg Oncol , vol.97 , Issue.5 , pp. 428-432
    • Guo, L.1    Guo, Y.2    Xiao, S.3
  • 66
    • 39049115413 scopus 로고    scopus 로고
    • Expression of tyrosine kinase Etk/Bmx and its relationship with AP-1-and NF-kappaB-associated proteins in hepatocellular carcinoma
    • Guo L, Guo Y, Xiao S. Expression of tyrosine kinase Etk/Bmx and its relationship with AP-1-and NF-kappaB-associated proteins in hepatocellular carcinoma. Oncology 2007; 72(5-6): 410-6.
    • (2007) Oncology , vol.72 , Issue.5-6 , pp. 410-416
    • Guo, L.1    Guo, Y.2    Xiao, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.