Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK)

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 800-814

  Uckun, Fatih M ^a,b,c   Dibirdik, Ilker ^a,b,c   Qazi, Sanjive ^a,b,c   Vassilev, Alexei ^a,b,c   Ma, Hong ^a,b,c   Mao, Chen ^a,b,c   Benyumov, Alexey ^a,b,c   Emami, Katayoon H ^a,b,c  

^a Paradigm Pharmaceuticals   (United States)

^b Parker Hughes Cancer Center   (United States)

^c CGEN Discovery Inc   (United States)

Author keywords

Cancer; Mitosis; Polo like kinase; Transgenic mouse

Indexed keywords

ABELSON KINASE; ALPHA CYANO BETA HYDROXY BETA METHYL N (2,5 DIBROMOPHENYL)PROPENAMIDE; ANTINEOPLASTIC AGENT; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 3; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GEMCITABINE; I KAPPA B KINASE; JANUS KINASE 2; LFM A13; MITOGEN ACTIVATED PROTEIN KINASE 1; PACLITAXEL; PEPTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLO LIKE KINASE; POLO LIKE KINASE 3; PROTEIN KINASE FYN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; BLOOD CELL COUNT; BLOOD TOXICITY; BONE MARROW EXAMINATION; BREAST CANCER; CANCER CELL; CELL DIVISION; CELL FUSION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOLYSIS; EMBRYO; EMBRYO DEVELOPMENT; ENZYME INHIBITION; EPITHELIUM CELL; GLIOBLASTOMA; HUMAN; HUMAN CELL; IC 50; MITOSIS INHIBITION; MITOSIS SPINDLE; MOLECULAR MODEL; MOUSE; NONHUMAN; PHOSPHORYLATION; PROMETAPHASE; RAT; TRANSGENIC MOUSE; TUMOR GROWTH; XENOPUS; ZEBRA FISH;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DNA, RECOMBINANT; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; FLUORESCENCE; HUMANS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MICROINJECTIONS; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; NITRILES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RATS; ZEBRAFISH;

DANIO RERIO; MUS MUSCULUS;

EID: 33845415264     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.050     Document Type: Article

References (45)

1. Donaldson M.M., Tavares A.A., Hagan I.M., Nigg E.A., and Glover D.M. J. Cell Sci. 114 (2001) 2357-2358
2. Glover D.M., Hagan I.M., and Tavares A.A. Genes Dev. 12 (1998) 3777-3787
3. Nigg E.A. Curr. Opin. Cell Biol. 10 (1998) 776-783
4. Roshak A.K., Capper E.A., Imburgia C., Fornwald J., Scott G., and Marshall L.A. Cell. Signal. 12 (2000) 405-411
5. Abrieu A., Brassac T., Galas S., Fisher D., Labbe J.C., and Doree M. J. Cell Sci. 111 (1998) 1751-1757
6. Descombes P., and Nigg E.A. EMBO J. 17 (1998) 1328-1335
7. Kumagai A., and Dunphy W.G. Science 273 (1996) 1377-1380
8. Song S., Grenfell T.Z., Garfield S., Erikson R.L., and Lee K.S. Mol. Cell. Biol. 20 (2000) 286-298
9. Lee K.S., and Erikson R.L. Mol. Cell. Biol. 17 (1997) 3408-3417
10. Knecht R., Elez R., Oechler M., Solbach C., von Ilberg C., and Strebhardt K. Cancer Res. 59 (1999) 2794-2797
11. Strebhardt K., Kneisel L., Linhart C., Bernd A., and Kaufmann R. JAMA 283 (2000) 479-480
12. Takai N., Miyazaki T., Fujisawa K., Nasu K., Hamanaka R., and Miyakawa I. Cancer Lett. 164 (2001) 41-49
13. Tokumitsu Y., Mori M., Tanaka S., Akazawa K., Nakano S., and Niho Y. Int. J. Oncol. 15 (1999) 687-692
14. Wolf G., Elez R., Doermer A., Holtrich U., Ackermann H., Stutte H.J., Altmannsberger H.M., Rubsamen-Waigmann H., and Strebhardt K. Oncogene 14 (1997) 543-549
15. Kanaji S., Saito H., Tsujitani S., Matsumoto S., Tatebe S., Kondo A., Ozaki M., Ito H., and Ikeguchi M. Oncology 70 (2006) 126-133
16. Reagan-Shaw S., and Ahmad N. IUBMB Life 57 (2005) 677-682
17. Spankuch-Schmitt B., Wolf G., Solbach C., Loibl S., Knecht R., Stegmuller M., von Minckwitz G., Kaufmann M., and Strebhardt K. Oncogene 21 (2002) 3162-3171
18. Weichert W., Kristiansen G., Winzer K.J., Schmidt M., Gekeler V., Noske A., Muller B.M., Niesporek S., Dietel M., and Denkert C. Virchows Arch. 446 (2005) 442-450
19. Spankuch B., Heim S., Kurunci-Csacsko E., Lindenau C., Yuan J., Kaufmann M., and Strebhardt K. Cancer Res. 66 (2006) 5836-5846
20. Cogswell J.P., Brown C.E., Bisi J.E., and Neill S.D. Cell Growth Differ. 11 (2000) 615-623
21. Liu X., and Erikson R.L. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 5789-5794
22. Ahmad N. FASEB J. 18 (2004) 5-7
23. Lane H.A., and Nigg E.A. J. Cell Biol. 135 (1996) 1701-1713
24. Spankuch-Schmitt B., Bereiter-Hahn J., Kaufmann M., and Strebhardt K. J. Natl. Cancer Inst. 94 (2002) 1863-1877
25. Spankuch B., Matthess Y., Knecht R., Zimmer B., Kaufmann M., and Strebhardt K. J. Natl. Cancer Inst. 96 (2004) 862-872
26. Uckun F.M., Vassilev A.O., Dibirdik I., Liu X.P., Erbeck D., Tibbles H.E., Qazi S., and Venkatachalam T.K. Arzneimittelforschung 54 (2004) 715-731
27. Navara C.S., Benyumov A., Vassilev A., Narla R.K., Ghosh P., and Uckun F.M. Anticancer Drugs 12 (2001) 369-376
28. Uckun F.M., Zheng Y., Cetkovic-Cvrlje M., Vassilev A., Lisowski E., Waurzyniak B., Chen H., Carpenter R., and Chen C.L. Clin. Cancer Res. 8 (2002) 1224-1233
29. Tibbles H.E., Samuel P., Erbeck D., Mahajan S., and Uckun F.M. Arzneimittelforschung 54 (2004) 330-339
30. Vassilev A., Ozer Z., Navara C., Mahajan S., and Uckun F.M. J. Biol. Chem. 274 (1999) 1646-1656
31. Kim Y.J., Sekiya F., Poulin B., Bae Y.S., and Rhee S.G. Mol. Cell. Biol. 24 (2004) 9986-9999
32. Heinonen J.E., Smith C.I., and Nore B.F. FEBS Lett. 527 (2002) 274-278
33. Glassford J., Soeiro I., Skarell S.M., Banerji L., Holman M., Klaus G.G., Kadowaki T., Koyasu S., and Lam E.W. Oncogene 22 (2003) 2248-2259
34. Feldhahn N., Rio P., Soh B.N., Liedtke S., Sprangers M., Klein F., Wernet P., Jumaa H., Hofmann W.K., Hanenberg H., Rowley J.D., and Muschen M. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 13266-13271
35. Fernandes M.J., Lachance G., Pare G., Rollet-Labelle E., and Naccache P.H. J. Leukocyte Biol. 78 (2005) 524-532
36. McInnes C., Mezna M., and Fischer P.M. Curr. Top. Med. Chem. 5 (2005) 181-197
37. Strebhardt K., and Ullrich A. Nat. Rev. Cancer 6 (2006) 321-330
38. Kelm O., Wind M., Lehmann W.D., and Nigg E.A. J. Biol. Chem. 277 (2002) 25247-25256
39. Mahajan S., Ghosh S., Sudbeck E.A., Zheng Y., Downs S., Hupke M., and Uckun F.M. J. Biol. Chem. 274 (1999) 9587-9599
40. Kumagai A., Guo Z., Emami K.H., Wang S.X., and Dunphy W.G. J. Cell Biol. 142 (1998) 1559-1569
41. Appleman J.R., and Lienhard G.E. J. Biol. Chem. 260 (1985) 4575-4578
42. Epps D.E., Raub T.J., Caiolfa V., Chiari A., and Zamai M. J. Pharm. Pharmacol. 51 (1999) 41-48
43. Dixon M. Biochem. J. 55 (1953) 170-171
44. Tipton K.F. In: Engel P.C. (Ed). Enzymology: LabFax (1996), Academic Press, San Diego, CA 115-121
45. Cheng Y., and Prusoff W.H. Biochem. Pharmacol. 2 (1973) 3099-3108