Peptide inhibitors of MK2 show promise for inhibition of abdominal adhesions

Journal of Surgical Research

Volumn 169, Issue 1, 2011, Pages

  Ward, Brian C ^a   Kavalukas, Sandra ^b   Brugnano, Jamie ^a   Barbul, Adrian ^b   Panitch, Alyssa ^a  

^a PURDUE UNIVERSITY   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

abdominal adhesion; IL 1 ; IL 6; MAPKAP Kinase 2; MK2; TNF

Indexed keywords

HYDROXYPROLINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MMI 0100; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ABDOMINAL ADHESION; ABDOMINAL WALL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLON; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG SPECIFICITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDIDYMIS FAT; HUMAN; HUMAN CELL; IC 50; INTESTINE ANASTOMOSIS; MESOTHELIUM CELL; NONHUMAN; OMENTUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOMETRY; RAT; SMALL INTESTINE; STIMULUS RESPONSE; TISSUE ADHESION; UPREGULATION; WEIGHT REDUCTION; WOUND HEALING;

ABDOMEN; ANIMALS; CELL-PENETRATING PEPTIDES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; HYDROXYPROLINE; INHIBITORY CONCENTRATION 50; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, ANIMAL; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RATS; TIME FACTORS; TISSUE ADHESIONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79958239562     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.01.043     Document Type: Article

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