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Volumn 25, Issue 3, 2013, Pages 201-208

Recent progress using systems biology approaches to better understand molecular mechanisms of immunity

Author keywords

Computational modeling; Global analysis; Heterogeneity; High throughput; Signaling networks; Single cell analysis; Transcriptional networks

Indexed keywords

CHEMOKINE RECEPTOR; CYTOKINE RECEPTOR; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR;

EID: 84887616973     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2012.11.002     Document Type: Review
Times cited : (19)

References (80)
  • 3
    • 77954600981 scopus 로고    scopus 로고
    • Allosteric regulation of protease activity by small molecules
    • Shen A. Allosteric regulation of protease activity by small molecules. Molecular bioSystems 2010, 6(8):1431-1443.
    • (2010) Molecular bioSystems , vol.6 , Issue.8 , pp. 1431-1443
    • Shen, A.1
  • 4
    • 0028838971 scopus 로고
    • Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling
    • Hunter T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 1995, 80(2):225-236.
    • (1995) Cell , vol.80 , Issue.2 , pp. 225-236
    • Hunter, T.1
  • 5
    • 0034797512 scopus 로고    scopus 로고
    • The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture
    • Cohen P. The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture. European Journal of Biochemistry/FEBS 2001, 268(19):5001-5010.
    • (2001) European Journal of Biochemistry/FEBS , vol.268 , Issue.19 , pp. 5001-5010
    • Cohen, P.1
  • 7
    • 80052769923 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer
    • M111 011015
    • Michalski A., Damoc E., Hauschild J.P., Lange O., Wieghaus A., Makarov A., et al. Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer. Molecular & Cellular Proteomics: MCP 2011, 10(9). M111 011015.
    • (2011) Molecular & Cellular Proteomics: MCP , vol.10 , Issue.9
    • Michalski, A.1    Damoc, E.2    Hauschild, J.P.3    Lange, O.4    Wieghaus, A.5    Makarov, A.6
  • 8
    • 78649849874 scopus 로고    scopus 로고
    • Feasibility of large-scale phosphoproteomics with higher energy collisional dissociation fragmentation
    • Nagaraj N., D'Souza R.C., Cox J., Olsen J.V., Mann M. Feasibility of large-scale phosphoproteomics with higher energy collisional dissociation fragmentation. Journal of Proteome Research 2010, 9(12):6786-6794.
    • (2010) Journal of Proteome Research , vol.9 , Issue.12 , pp. 6786-6794
    • Nagaraj, N.1    D'Souza, R.C.2    Cox, J.3    Olsen, J.V.4    Mann, M.5
  • 10
    • 57449099865 scopus 로고    scopus 로고
    • MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
    • Cox J., Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nature Biotechnology 2008, 26(12):1367-1372.
    • (2008) Nature Biotechnology , vol.26 , Issue.12 , pp. 1367-1372
    • Cox, J.1    Mann, M.2
  • 11
    • 80053387432 scopus 로고    scopus 로고
    • IProphet: multi-level integrative analysis of shotgun proteomic data improves peptide and protein identification rates and error estimates
    • M111 007690
    • Shteynberg D., Deutsch E.W., Lam H., Eng J.K., Sun Z., Tasman N., et al. iProphet: multi-level integrative analysis of shotgun proteomic data improves peptide and protein identification rates and error estimates. Molecular & Cellular Proteomics: MCP 2011, 10(12). M111 007690.
    • (2011) Molecular & Cellular Proteomics: MCP , vol.10 , Issue.12
    • Shteynberg, D.1    Deutsch, E.W.2    Lam, H.3    Eng, J.K.4    Sun, Z.5    Tasman, N.6
  • 12
    • 79953202189 scopus 로고    scopus 로고
    • T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component
    • Brockmeyer C., Paster W., Pepper D., Tan C.P., Trudgian D.C., McGowan S., et al. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. The Journal of Biological Chemistry 2011, 286(9):7535-7547.
    • (2011) The Journal of Biological Chemistry , vol.286 , Issue.9 , pp. 7535-7547
    • Brockmeyer, C.1    Paster, W.2    Pepper, D.3    Tan, C.P.4    Trudgian, D.C.5    McGowan, S.6
  • 15
  • 16
    • 77956742502 scopus 로고    scopus 로고
    • Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics
    • Matsumura T., Oyama M., Kozuka-Hata H., Ishikawa K., Inoue T., Muta T., et al. Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics. Biochemical and Biophysical Research Communications 2010, 400(2):265-270.
    • (2010) Biochemical and Biophysical Research Communications , vol.400 , Issue.2 , pp. 265-270
    • Matsumura, T.1    Oyama, M.2    Kozuka-Hata, H.3    Ishikawa, K.4    Inoue, T.5    Muta, T.6
  • 18
    • 62049084688 scopus 로고    scopus 로고
    • Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival
    • Bidere N., Ngo V.N., Lee J., Collins C., Zheng L., Wan F., et al. Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature 2009, 458(7234):92-96.
    • (2009) Nature , vol.458 , Issue.7234 , pp. 92-96
    • Bidere, N.1    Ngo, V.N.2    Lee, J.3    Collins, C.4    Zheng, L.5    Wan, F.6
  • 19
    • 34948841986 scopus 로고    scopus 로고
    • Workflow based framework for life science informatics
    • Tiwari A., Sekhar A.K. Workflow based framework for life science informatics. Computational Biology and Chemistry 2007, 31(5-6):305-319.
    • (2007) Computational Biology and Chemistry , vol.31 , Issue.5-6 , pp. 305-319
    • Tiwari, A.1    Sekhar, A.K.2
  • 20
    • 70350462371 scopus 로고    scopus 로고
    • Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions
    • Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., et al. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Science Signaling 2009, 2(84):ra46.
    • (2009) Science Signaling , vol.2 , Issue.84
    • Mayya, V.1    Lundgren, D.H.2    Hwang, S.I.3    Rezaul, K.4    Wu, L.5    Eng, J.K.6
  • 21
    • 79952699891 scopus 로고    scopus 로고
    • Coreceptors and HIV-1 pathogenesis
    • Gorry P.R., Ancuta P. Coreceptors and HIV-1 pathogenesis. Current HIV/AIDS Reports 2011, 8(1):45-53.
    • (2011) Current HIV/AIDS Reports , vol.8 , Issue.1 , pp. 45-53
    • Gorry, P.R.1    Ancuta, P.2
  • 22
    • 74549178998 scopus 로고    scopus 로고
    • Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    • Wu Y., Yoder A. Chemokine coreceptor signaling in HIV-1 infection and pathogenesis. PLoS Pathogens 2009, 5(12):e1000520.
    • (2009) PLoS Pathogens , vol.5 , Issue.12
    • Wu, Y.1    Yoder, A.2
  • 24
    • 80755126865 scopus 로고    scopus 로고
    • Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
    • Li S., Wang L., Berman M., Kong Y.Y., Dorf M.E. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity 2011, 35(3):426-440.
    • (2011) Immunity , vol.35 , Issue.3 , pp. 426-440
    • Li, S.1    Wang, L.2    Berman, M.3    Kong, Y.Y.4    Dorf, M.E.5
  • 26
    • 74849118341 scopus 로고    scopus 로고
    • Lipid rafts as a membrane-organizing principle
    • Lingwood D., Simons K. Lipid rafts as a membrane-organizing principle. Science 2010, 327(5961):46-50.
    • (2010) Science , vol.327 , Issue.5961 , pp. 46-50
    • Lingwood, D.1    Simons, K.2
  • 27
    • 80053130680 scopus 로고    scopus 로고
    • New insights into the T cell synapse from single molecule techniques
    • Dustin M.L., Depoil D. New insights into the T cell synapse from single molecule techniques. Nature Reviews. Immunology 2011, 11(10):672-684.
    • (2011) Nature Reviews. Immunology , vol.11 , Issue.10 , pp. 672-684
    • Dustin, M.L.1    Depoil, D.2
  • 28
    • 74049157769 scopus 로고    scopus 로고
    • TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
    • Lillemeier B.F., Mortelmaier M.A., Forstner M.B., Huppa J.B., Groves J.T., Davis M.M. TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nature Immunology 2010, 11(1):90-96.
    • (2010) Nature Immunology , vol.11 , Issue.1 , pp. 90-96
    • Lillemeier, B.F.1    Mortelmaier, M.A.2    Forstner, M.B.3    Huppa, J.B.4    Groves, J.T.5    Davis, M.M.6
  • 30
    • 84872841992 scopus 로고    scopus 로고
    • RuleBender: integrated modeling, simulation and visualization for rule-based intracellular biochemistry
    • Smith A.M., Xu W., Sun Y., Faeder J.R., Marai G.E. RuleBender: integrated modeling, simulation and visualization for rule-based intracellular biochemistry. BMC Bioinformatics 2012, 13(Suppl. 8):S3.
    • (2012) BMC Bioinformatics , vol.13 , Issue.SUPPL. 8
    • Smith, A.M.1    Xu, W.2    Sun, Y.3    Faeder, J.R.4    Marai, G.E.5
  • 31
    • 84862777639 scopus 로고    scopus 로고
    • Computational modeling of cellular signaling processes embedded into dynamic spatial contexts
    • Angermann B.R., Klauschen F., Garcia A.D., Prustel T., Zhang F., Germain R.N. Computational modeling of cellular signaling processes embedded into dynamic spatial contexts. Nature Methods 2012, 9(3):283-289.
    • (2012) Nature Methods , vol.9 , Issue.3 , pp. 283-289
    • Angermann, B.R.1    Klauschen, F.2    Garcia, A.D.3    Prustel, T.4    Zhang, F.5    Germain, R.N.6
  • 32
    • 79551555393 scopus 로고    scopus 로고
    • Efficient modeling: simulation and coarse-graining of biological complexity with NFsim
    • Sneddon M.W., Faeder J.R., Emonet T. Efficient modeling: simulation and coarse-graining of biological complexity with NFsim. Nature Methods 2011, 8(2):177-183.
    • (2011) Nature Methods , vol.8 , Issue.2 , pp. 177-183
    • Sneddon, M.W.1    Faeder, J.R.2    Emonet, T.3
  • 34
    • 77949971595 scopus 로고    scopus 로고
    • Selective transcription in response to an inflammatory stimulus
    • Smale S.T. Selective transcription in response to an inflammatory stimulus. Cell 2010, 140(6):833-844.
    • (2010) Cell , vol.140 , Issue.6 , pp. 833-844
    • Smale, S.T.1
  • 35
    • 82255175259 scopus 로고    scopus 로고
    • Strategies to discover regulatory circuits of the mammalian immune system
    • Amit I., Regev A., Hacohen N. Strategies to discover regulatory circuits of the mammalian immune system. Nature Reviews. Immunology 2011, 11(12):873-880.
    • (2011) Nature Reviews. Immunology , vol.11 , Issue.12 , pp. 873-880
    • Amit, I.1    Regev, A.2    Hacohen, N.3
  • 36
    • 33646547951 scopus 로고    scopus 로고
    • Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
    • Gilchrist M., Thorsson V., Li B., Rust A.G., Korb M., Roach J.C., et al. Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature 2006, 441(7090):173-178.
    • (2006) Nature , vol.441 , Issue.7090 , pp. 173-178
    • Gilchrist, M.1    Thorsson, V.2    Li, B.3    Rust, A.G.4    Korb, M.5    Roach, J.C.6
  • 37
    • 62849092708 scopus 로고    scopus 로고
    • Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals
    • Litvak V., Ramsey S.A., Rust A.G., Zak D.E., Kennedy K.A., Lampano A.E., et al. Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals. Nature Immunology 2009, 10(4):437-443.
    • (2009) Nature Immunology , vol.10 , Issue.4 , pp. 437-443
    • Litvak, V.1    Ramsey, S.A.2    Rust, A.G.3    Zak, D.E.4    Kennedy, K.A.5    Lampano, A.E.6
  • 38
    • 79957566441 scopus 로고    scopus 로고
    • An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling
    • Sciammas R., Li Y., Warmflash A., Song Y., Dinner A.R., Singh H. An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Molecular Systems Biology 2011, 7:495.
    • (2011) Molecular Systems Biology , vol.7 , pp. 495
    • Sciammas, R.1    Li, Y.2    Warmflash, A.3    Song, Y.4    Dinner, A.R.5    Singh, H.6
  • 39
    • 33747133955 scopus 로고    scopus 로고
    • Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation
    • Sciammas R., Shaffer A.L., Schatz J.H., Zhao H., Staudt L.M., Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 2006, 25(2):225-236.
    • (2006) Immunity , vol.25 , Issue.2 , pp. 225-236
    • Sciammas, R.1    Shaffer, A.L.2    Schatz, J.H.3    Zhao, H.4    Staudt, L.M.5    Singh, H.6
  • 41
    • 70349882120 scopus 로고    scopus 로고
    • Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses
    • Amit I., Garber M., Chevrier N., Leite A.P., Donner Y., Eisenhaure T., et al. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science 2009, 326(5950):257-263.
    • (2009) Science , vol.326 , Issue.5950 , pp. 257-263
    • Amit, I.1    Garber, M.2    Chevrier, N.3    Leite, A.P.4    Donner, Y.5    Eisenhaure, T.6
  • 42
    • 27144509163 scopus 로고    scopus 로고
    • A network-based analysis of systemic inflammation in humans
    • Calvano S.E., Xiao W., Richards D.R., Felciano R.M., Baker H.V., Cho R.J., et al. A network-based analysis of systemic inflammation in humans. Nature 2005, 437(7061):1032-1037.
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1032-1037
    • Calvano, S.E.1    Xiao, W.2    Richards, D.R.3    Felciano, R.M.4    Baker, H.V.5    Cho, R.J.6
  • 45
    • 41849123062 scopus 로고    scopus 로고
    • Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics
    • Ramsey S.A., Klemm S.L., Zak D.E., Kennedy K.A., Thorsson V., Li B., et al. Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics. PLoS Computational Biology 2008, 4(3):e1000021.
    • (2008) PLoS Computational Biology , vol.4 , Issue.3
    • Ramsey, S.A.1    Klemm, S.L.2    Zak, D.E.3    Kennedy, K.A.4    Thorsson, V.5    Li, B.6
  • 46
    • 77949977555 scopus 로고    scopus 로고
    • Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages
    • Ghisletti S., Barozzi I., Mietton F., Polletti S., De Santa F., Venturini E., et al. Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity 2010, 32(3):317-328.
    • (2010) Immunity , vol.32 , Issue.3 , pp. 317-328
    • Ghisletti, S.1    Barozzi, I.2    Mietton, F.3    Polletti, S.4    De Santa, F.5    Venturini, E.6
  • 47
  • 48
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
    • Heinz S., Benner C., Spann N., Bertolino E., Lin Y.C., Laslo P., et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Molecular Cell 2010, 38(4):576-589.
    • (2010) Molecular Cell , vol.38 , Issue.4 , pp. 576-589
    • Heinz, S.1    Benner, C.2    Spann, N.3    Bertolino, E.4    Lin, Y.C.5    Laslo, P.6
  • 49
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116(2):281-297.
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 51
    • 79952186298 scopus 로고    scopus 로고
    • MicroRNAs: the fine-tuners of Toll-like receptor signalling
    • O'Neill L.A., Sheedy F.J., McCoy C.E. MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nature Reviews. Immunology 2011, 11(3):163-175.
    • (2011) Nature Reviews. Immunology , vol.11 , Issue.3 , pp. 163-175
    • O'Neill, L.A.1    Sheedy, F.J.2    McCoy, C.E.3
  • 52
    • 80053054678 scopus 로고    scopus 로고
    • Systems biology reveals microRNA-mediated gene regulation
    • Watanabe Y., Kanai A. Systems biology reveals microRNA-mediated gene regulation. Frontiers in Genetics 2011, 2:29.
    • (2011) Frontiers in Genetics , vol.2 , pp. 29
    • Watanabe, Y.1    Kanai, A.2
  • 53
    • 80052659396 scopus 로고    scopus 로고
    • MicroRNA regulation of molecular networks mapped by global microRNA: mRNA, and protein expression in activated T lymphocytes
    • Grigoryev Y.A., Kurian S.M., Hart T., Nakorchevsky A.A., Chen C., Campbell D., et al. MicroRNA regulation of molecular networks mapped by global microRNA: mRNA, and protein expression in activated T lymphocytes. Journal of Immunology 2011, 187(5):2233-2243.
    • (2011) Journal of Immunology , vol.187 , Issue.5 , pp. 2233-2243
    • Grigoryev, Y.A.1    Kurian, S.M.2    Hart, T.3    Nakorchevsky, A.A.4    Chen, C.5    Campbell, D.6
  • 54
    • 79955381895 scopus 로고    scopus 로고
    • Mammalian genes are transcribed with widely different bursting kinetics
    • Suter D.M., Molina N., Gatfield D., Schneider K., Schibler U., Naef F. Mammalian genes are transcribed with widely different bursting kinetics. Science 2011, 332(6028):472-474.
    • (2011) Science , vol.332 , Issue.6028 , pp. 472-474
    • Suter, D.M.1    Molina, N.2    Gatfield, D.3    Schneider, K.4    Schibler, U.5    Naef, F.6
  • 56
    • 79952638264 scopus 로고    scopus 로고
    • Cellular decision making and biological noise: from microbes to mammals
    • Balazsi G., van Oudenaarden A., Collins J.J. Cellular decision making and biological noise: from microbes to mammals. Cell 2011, 144(6):910-925.
    • (2011) Cell , vol.144 , Issue.6 , pp. 910-925
    • Balazsi, G.1    van Oudenaarden, A.2    Collins, J.J.3
  • 57
    • 53549123008 scopus 로고    scopus 로고
    • Nature, nurture, or chance: stochastic gene expression and its consequences
    • Raj A., van Oudenaarden A. Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 2008, 135(2):216-226.
    • (2008) Cell , vol.135 , Issue.2 , pp. 216-226
    • Raj, A.1    van Oudenaarden, A.2
  • 60
    • 25444468618 scopus 로고    scopus 로고
    • Noise in gene expression: origins, consequences, and control
    • Raser J.M., O'Shea E.K. Noise in gene expression: origins, consequences, and control. Science 2005, 309(5743):2010-2013.
    • (2005) Science , vol.309 , Issue.5743 , pp. 2010-2013
    • Raser, J.M.1    O'Shea, E.K.2
  • 61
    • 79953266898 scopus 로고    scopus 로고
    • Single-cell genomics
    • Kalisky T., Quake S.R. Single-cell genomics. Nature Methods 2011, 8(4):311-314.
    • (2011) Nature Methods , vol.8 , Issue.4 , pp. 311-314
    • Kalisky, T.1    Quake, S.R.2
  • 63
    • 79958122357 scopus 로고    scopus 로고
    • A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells
    • Ma C., Fan R., Ahmad H., Shi Q., Comin-Anduix B., Chodon T., et al. A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells. Nature Medicine 2011, 17(6):738-743.
    • (2011) Nature Medicine , vol.17 , Issue.6 , pp. 738-743
    • Ma, C.1    Fan, R.2    Ahmad, H.3    Shi, Q.4    Comin-Anduix, B.5    Chodon, T.6
  • 64
    • 80555148949 scopus 로고    scopus 로고
    • A high-throughput single-cell analysis of human CD8(+) T cell functions reveals discordance for cytokine secretion and cytolysis
    • Varadarajan N., Julg B., Yamanaka Y.J., Chen H., Ogunniyi A.O., McAndrew E., et al. A high-throughput single-cell analysis of human CD8(+) T cell functions reveals discordance for cytokine secretion and cytolysis. The Journal of Clinical Investigation 2011, 121(11):4322-4331.
    • (2011) The Journal of Clinical Investigation , vol.121 , Issue.11 , pp. 4322-4331
    • Varadarajan, N.1    Julg, B.2    Yamanaka, Y.J.3    Chen, H.4    Ogunniyi, A.O.5    McAndrew, E.6
  • 66
    • 33644833555 scopus 로고    scopus 로고
    • Mapping normal and cancer cell signalling networks: towards single-cell proteomics
    • Irish J.M., Kotecha N., Nolan G.P. Mapping normal and cancer cell signalling networks: towards single-cell proteomics. Nature Reviews. Cancer 2006, 6(2):146-155.
    • (2006) Nature Reviews. Cancer , vol.6 , Issue.2 , pp. 146-155
    • Irish, J.M.1    Kotecha, N.2    Nolan, G.P.3
  • 68
    • 84856278095 scopus 로고    scopus 로고
    • Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes
    • Newell E.W., Sigal N., Bendall S.C., Nolan G.P., Davis M.M. Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity 2012, 36(1):142-152.
    • (2012) Immunity , vol.36 , Issue.1 , pp. 142-152
    • Newell, E.W.1    Sigal, N.2    Bendall, S.C.3    Nolan, G.P.4    Davis, M.M.5
  • 69
    • 77954541844 scopus 로고    scopus 로고
    • Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing
    • Tay S., Hughey J.J., Lee T.K., Lipniacki T., Quake S.R., Covert M.W. Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing. Nature 2010, 466(7303):267-271.
    • (2010) Nature , vol.466 , Issue.7303 , pp. 267-271
    • Tay, S.1    Hughey, J.J.2    Lee, T.K.3    Lipniacki, T.4    Quake, S.R.5    Covert, M.W.6
  • 70
    • 80054829921 scopus 로고    scopus 로고
    • Sources of cell-to-cell variability in canonical nuclear factor-kappaB (NF-kappaB) signaling pathway inferred from single cell dynamic images
    • Kalita M.K., Sargsyan K., Tian B., Paulucci-Holthauzen A., Najm H.N., Debusschere B.J., et al. Sources of cell-to-cell variability in canonical nuclear factor-kappaB (NF-kappaB) signaling pathway inferred from single cell dynamic images. The Journal of Biological Chemistry 2011, 286(43):37741-37757.
    • (2011) The Journal of Biological Chemistry , vol.286 , Issue.43 , pp. 37741-37757
    • Kalita, M.K.1    Sargsyan, K.2    Tian, B.3    Paulucci-Holthauzen, A.4    Najm, H.N.5    Debusschere, B.J.6
  • 71
    • 84856072934 scopus 로고    scopus 로고
    • Activation-induced B cell fates are selected by intracellular stochastic competition
    • Duffy K.R., Wellard C.J., Markham J.F., Zhou J.H., Holmberg R., Hawkins E.D., et al. Activation-induced B cell fates are selected by intracellular stochastic competition. Science 2012, 335(6066):338-341.
    • (2012) Science , vol.335 , Issue.6066 , pp. 338-341
    • Duffy, K.R.1    Wellard, C.J.2    Markham, J.F.3    Zhou, J.H.4    Holmberg, R.5    Hawkins, E.D.6
  • 72
    • 84883491202 scopus 로고    scopus 로고
    • Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response
    • Rand U., Rinas M., Schwerk J., Nohren G., Linnes M., Kroger A., et al. Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response. Molecular Systems Biology 2012, 8:584.
    • (2012) Molecular Systems Biology , vol.8 , pp. 584
    • Rand, U.1    Rinas, M.2    Schwerk, J.3    Nohren, G.4    Linnes, M.5    Kroger, A.6
  • 73
    • 70349466529 scopus 로고    scopus 로고
    • Population context determines cell-to-cell variability in endocytosis and virus infection
    • Snijder B., Sacher R., Ramo P., Damm E.M., Liberali P., Pelkmans L. Population context determines cell-to-cell variability in endocytosis and virus infection. Nature 2009, 461(7263):520-523.
    • (2009) Nature , vol.461 , Issue.7263 , pp. 520-523
    • Snijder, B.1    Sacher, R.2    Ramo, P.3    Damm, E.M.4    Liberali, P.5    Pelkmans, L.6
  • 74
    • 84861133687 scopus 로고    scopus 로고
    • Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis
    • Gaudet S., Spencer S.L., Chen W.W., Sorger P.K. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Computational Biology 2012, 8(4):e1002482.
    • (2012) PLoS Computational Biology , vol.8 , Issue.4
    • Gaudet, S.1    Spencer, S.L.2    Chen, W.W.3    Sorger, P.K.4
  • 75
    • 84883829346 scopus 로고    scopus 로고
    • Modeling a snap-action: variable-delay switch controlling extrinsic cell death
    • Albeck J.G., Burke J.M., Spencer S.L., Lauffenburger D.A., Sorger P.K. Modeling a snap-action: variable-delay switch controlling extrinsic cell death. PLoS Biology 2008, 6(12):2831-2852.
    • (2008) PLoS Biology , vol.6 , Issue.12 , pp. 2831-2852
    • Albeck, J.G.1    Burke, J.M.2    Spencer, S.L.3    Lauffenburger, D.A.4    Sorger, P.K.5
  • 76
    • 27844541328 scopus 로고    scopus 로고
    • Modeling T cell antigen discrimination based on feedback control of digital ERK responses
    • Altan-Bonnet G., Germain R.N. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biology 2005, 3(11):e356.
    • (2005) PLoS Biology , vol.3 , Issue.11
    • Altan-Bonnet, G.1    Germain, R.N.2
  • 77
    • 50149090966 scopus 로고    scopus 로고
    • Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    • Feinerman O., Veiga J., Dorfman J.R., Germain R.N., Altan-Bonnet G. Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 2008, 321(5892):1081-1084.
    • (2008) Science , vol.321 , Issue.5892 , pp. 1081-1084
    • Feinerman, O.1    Veiga, J.2    Dorfman, J.R.3    Germain, R.N.4    Altan-Bonnet, G.5
  • 78
    • 41349119880 scopus 로고    scopus 로고
    • Stochastic switching as a survival strategy in fluctuating environments
    • Acar M., Mettetal J.T., van Oudenaarden A. Stochastic switching as a survival strategy in fluctuating environments. Nature Genetics 2008, 40(4):471-475.
    • (2008) Nature Genetics , vol.40 , Issue.4 , pp. 471-475
    • Acar, M.1    Mettetal, J.T.2    van Oudenaarden, A.3
  • 79
    • 77956520011 scopus 로고    scopus 로고
    • Functional roles for noise in genetic circuits
    • Eldar A., Elowitz M.B. Functional roles for noise in genetic circuits. Nature 2010, 467(7312):167-173.
    • (2010) Nature , vol.467 , Issue.7312 , pp. 167-173
    • Eldar, A.1    Elowitz, M.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.