A high-throughput single-cell analysis of human CD8 + T cell functions reveals discordance for cytokine secretion and cytolysis

Journal of Clinical Investigation

Volumn 121, Issue 11, 2011, Pages 4322-4331

  Varadarajan, Navin ^a,f   Julg, Boris ^b   Yamanaka, Yvonne J ^a   Chen, Huabiao ^b,c   Ogunniyi, Adebola O ^a   McAndrew, Elizabeth ^b   Porter, Lindsay C ^b   Piechocka Trocha, Alicja ^b,c   Hill, Brenna J ^d   Douek, Daniel C ^d   Pereyra, Florencia ^b   Walker, Bruce D ^b,c   Love, J Christopher ^a,b,e  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^f UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON;

ANTIGEN EXPRESSION; ARTICLE; CD8+ T LYMPHOCYTE; CELL ACTIVITY; CELL FUNCTION; CELL ISOLATION; CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXICITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; LYMPHOCYTE FUNCTION; LYSIS; PRIORITY JOURNAL; SINGLE CELL ANALYSIS;

ADAPTIVE IMMUNITY; ANTIGEN-PRESENTING CELLS; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; HIGH-THROUGHPUT SCREENING ASSAYS; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV LONG-TERM SURVIVORS; HUMANS; INTERFERON-GAMMA; SINGLE-CELL ANALYSIS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 80555148949     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI58653     Document Type: Article

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