Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines as a new class of antimalarial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 11, 2008, Pages 3306-3309

  Gupta, Leena ^a   Srivastava, Kumkum ^a   Singh, Shubhra ^a   Puri, S K ^a   Chauhan, Prem M S ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Chloroquine; Malaria; Plasmodium falciparum; Tetrahydro carboline

Indexed keywords

ANTIMALARIAL AGENT; CARBOLINE DERIVATIVE; CHLOROQUINE;

ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMODIUM FALCIPARUM; SUBSTITUTION REACTION;

ANIMALS; ANTIMALARIALS; CARBOLINES; CHLOROQUINE; COMBINATORIAL CHEMISTRY TECHNIQUES; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 44249085638     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.030     Document Type: Article

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25. 3, 200 MHz): δ (ppm) 8.52 (br s, 1H), 8.30 (d, 1H, J = 6.9 Hz), 8.05 (s, 1H), 7.75 (d, 1H, J = 2.7Hz), 7.38 (br s, 1H), 7.10 (d, 1H, J = 8.0Hz), 7.15 to 7.11 ( m, 4H), 6.99 (d, 2H, J = 7.6 Hz), 6.72 (d, 2H, J = 7.8 Hz), 6.45 (d, 1H, J = 3.5 Hz), 5.39 (s, 1H), 4.13 (t, 2H, J = 6.8 Hz), 3.72 (s, 3H), 3.65 (dd, 1H, J = 4.0, 4.3 Hz), 3.10 to 2.99 (m, 2H), 2.12 (t, 2H, J = 5.2 Hz), 1.72 to 1.65 (m, 2H).