Implication of transcriptional repression in compound C-induced apoptosis in cancer cells

Cell Death and Disease

Volumn 4, Issue 10, 2013, Pages

  Dai, R Y ^a,b,c   Zhao, X F ^b,d   Li, J J ^b   Chen, R ^a   Luo, Z L ^b   Yu, L X ^b   Chen, S K ^a   Zhang, C Y ^a   Duan, C Y ^a   Liu, Y P ^a   Feng, C H ^c   Xia, X M ^c   Li, H ^a   Fu, J ^b   Wang, H Y ^b,e  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIVERSITY   (China)

^d NANJING UNIVERSITY   (China)

^e SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cancer; Compound C; Transcriptional inhibition

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; ANTINEOPLASTIC AGENT; COMPOUND C; DACTINOMYCIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 2ALPHA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53; PROTEIN SERINE THREONINE KINASE INHIBITOR; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION TERMINATION;

ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELL LINE, TUMOR; DOWN-REGULATION; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION, NEOPLASTIC; MICE; MICE, NUDE; NEOPLASMS; PHOSPHORYLATION; PYRAZOLES; PYRIMIDINES; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84887486036     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.419     Document Type: Article

References (60)

1. Brown JM, Attardi LD. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005; 5: 231-237
2. Sauter B, Albert ML, Francisco L, Larsson M, Somersan S, Bhardwaj N. Consequences of cell death: Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells. J Exp Med 2000; 191: 423-434
3. Amaravadi RK, Thompson CB. The roles of therapy-induced autophagy and necrosis in cancer treatment. Clin Cancer Res 2007; 13: 7271-7279
4. Edinger AL, Thompson CB. Death by design: Apoptosis, necrosis and autophagy. Curr Opin Cell Biol 2004; 16: 663-669
5. Kono K, Mimura K, Kiessling R. Immunogenic tumor cell death induced by chemoradiotherapy: Molecular mechanisms and a clinical translation. Cell Death Dis 2013; 4: E688
6. Berger I, Blanco AG, Boelens R, Cavarelli J, Coll M, Folkers GE et al. Structural insights into transcription complexes. J Struct Biol 2011; 175: 135-146
7. Kornberg RD. The molecular basis of eucaryotic transcription. Cell Death Differ 2007; 14: 1989-1997
8. Boeger H, Bushnell DA, Davis R, Griesenbeck J, Lorch Y, Strattan JS et al. Structural basis of eukaryotic gene transcription. FEBS Lett 2005; 579: 899-903
9. Chen R, Keating MJ, Gandhi V, Plunkett W. Transcription inhibition by flavopiridol: Mechanism of chronic lymphocytic leukemia cell death. Blood 2005; 106: 2513-2519
10. Radhakrishnan SK, Gartel AL. A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity. Cancer Res 2006; 66: 3264-3270
11. Gartel AL. Transcriptional inhibitors, p53 and apoptoss. Biochim Biophys Acta 2008; 1786: 83-86
12. Derheimer FA, Chang CW, Ljungman M. Transcription inhibition: A potential strategy for cancer therapeutics. Eur J Cancer 2005; 41: 2569-2576
13. Blagosklonny MV. Flavopiridol, an inhibitor of transcription: Implications, problems and solutions. Cell Cycle 2004; 3: 1537-1542
14. Radhakrishnan SK, Halasi M, Bhat UG, Kurmasheva RT, Houghton PJ, Gartel AL. Proapoptotic compound ARC targets Akt and N-myc in neuroblastoma cells. Oncogene 2008; 27: 694-699
15. Rosato RR, Almenara JA, Kolla SS, Maggio SC, Coe S, Gimenez MS et al. Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions. Mol Cancer Ther 2007; 6: 692-702
16. Koumenis C, Giaccia A. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Mol Cell Biol 1997; 17: 7306-7316
17. Chao SH, Fujinaga K, Marion JE, Taube R, Sausville EA, Senderowicz AM et al. Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. J Biol Chem 2000; 275: 28345-28348
18. Shapiro GI. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 2006; 24: 1770-1783
19. Benson C, White J, De Bono J, O'Donnell A, Raynaud F, Cruickshank C et al. A phase I trial of the selective oral cyclin-dependent kinase inhibitor seliciclib (CYC202; R-Roscovitine), administered twice daily for 7 days every 21 days. Br J Cancer 2007; 96: 29-37
20. Lin TS, Ruppert AS, Johnson AJ, Fischer B, Heerema NA, Andritsos LA et al. Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease. J Clin Oncol 2009; 27: 6012-6018
21. Dispenzieri A, Gertz MA, Lacy MQ, Geyer SM, Fitch TR, Fenton RG et al. Flavopiridol in patients with relapsed or refractory multiple myeloma: A phase 2 trial with clinical and pharmacodynamic end-points. Haematologica 2006; 91: 390-393
22. MacCallum DE, Melville J, Frame S, Watt K, Anderson S, Gianella-Borradori A et al. Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res 2005; 65: 5399-5407
23. Byrd JC, Lin TS, Dalton JT, Wu D, Phelps MA, Fischer B et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 2007; 109: 399-404
24. Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011; 13: 1016-1023
25. Luo Z, Zang M, Guo W. AMPK as a metabolic tumor suppressor: Control of metabolism and cell growth. Future Oncol 2010; 6: 457-470
26. Kawano K, Ikeda Y, Handa M, Kamata T, Anbo H, Araki Y et al. Enhancing effect by heparin on shear-induced platelet aggregation. Semin Thromb Hemost 1990; 16(Suppl): 60-65
27. Laderoute KR, Amin K, Calaoagan JM, Knapp M, Le T, Orduna J et al. 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol Cell Biol 2006; 26: 5336-5347
28. Hardie DG, Ross FA, Hawley SA. AMPK: A nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012; 13: 251-262
29. Munoz-Pinedo C, El Mjiyad N, Ricci JE. Cancer metabolism: Current perspectives and future directions. Cell Death Dis 2012; 3: E248
30. Choi YK, Park KG. Metabolic roles of AMPK and metformin in cancer cells. Mol Cells 2013; e-pub ahead of print 19 June 2013; doi:10.1007/s10059-013-0169-8
31. Pimentel GD, Ropelle ER, Rocha GZ, Carvalheira JB. The role of neuronal AMPK as a mediator of nutritional regulation of food intake and energy homeostasis. Metabolism 2013; 62: 171-178
32. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108: 1167-1174
33. Jin Q, Feng L, Behrens C, Bekele BN, Wistuba II, Hong WK et al. Implication of AMPactivated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin. Cancer Res 2007; 67: 11630-11639
34. Park HU, Suy S, Danner M, Dailey V, Zhang Y, Li H et al. AMP-activated protein kinase promotes human prostate cancer cell growth and survival. Mol Cancer Ther 2009; 8: 733-741
35. Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB et al. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ 2007; 14: 1948-1957
36. Zhou W, Han WF, Landree LE, Thupari JN, Pinn ML, Bililign T et al. Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells. Cancer Res 2007; 67: 2964-2971
37. Langelueddecke C, Jakab M, Ketterl N, Lehner L, Hufnagl C, Schmidt S et al. Effect of the AMP-kinase modulators AICAR, metformin and compound C on insulin secretion of INS-1E rat insulinoma cells under standard cell culture conditions. Cell Physiol Biochem 2012; 29: 75-86
38. Hsu YC, Meng X, Ou L, Ip MM. Activation of the AMP-activated protein kinase-p38 MAP kinase pathway mediates apoptosis induced by conjugated linoleic acid in p53-mutant mouse mammary tumor cells. Cell Signal 2010; 22: 590-599
39. Baumann P, Mandl-Weber S, Emmerich B, Straka C, Schmidmaier R. Inhibition of adenosine monophosphate-activated protein kinase induces apoptosis in multiple myeloma cells. Anticancer Drugs 2007; 18: 405-410
40. Jin J, Mullen TD, Hou Q, Bielawski J, Bielawska A, Zhang X et al. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res 2009; 50: 2389-2397
41. Vucicevic L, Misirkic M, Janjetovic K, Harhaji-Trajkovic L, Prica M, Stevanovic D et al. AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem Pharmacol 2009; 77: 1684-1693
42. Huang SW, Wu CY, Wang YT, Kao JK, Lin CC, Chang CC et al. p53 modulates the AMPK inhibitor compound C induced apoptosis in human skin cancer cells. Toxicol Appl Pharmacol 2013; 267: 113-124
43. Yang WL, Perillo W, Liou D, Marambaud P, Wang P. AMPK inhibitor compound C suppresses cell proliferation by induction of apoptosis and autophagy in human colorectal cancer cells. J Surg Oncol 2012; 106: 680-688
44. Lai E, Teodoro T, Volchuk A. Endoplasmic reticulum stress: Signaling the unfolded protein response. Physiology 2007; 22: 193-201
45. Hsiao JR, Chang KC, Chen CW, Wu SY, Su IJ, Hsu MC et al. Endoplasmic reticulum stress triggers XBP-1-mediated up-regulation of an EBV oncoprotein in nasopharyngeal carcinoma. Cancer Res 2009; 69: 4461-4467
46. Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007; 8: 519-529
47. Arima Y, Nitta M, Kuninaka S, Zhang D, Fujiwara T, Taya Y et al. Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. J Biol Chem 2005; 280: 19166-19176
48. Demidenko ZN, Blagosklonny MV. Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor. Cancer Res 2004; 64: 3653-3660
49. Lu W, Chen L, Peng Y, Chen J. Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 2001; 20: 3206-3216
50. Yu J, Zhang L. The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 2005; 331: 851-858
51. Sun XM, Bratton SB, Butterworth M, MacFarlane M, Cohen GM. Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem 2002; 277: 11345-11351
52. Adams JM, Cory S. The Bcl-2 protein family: Arbiters of cell survival. Science 1998; 281: 1322-1326
53. Murphy KM, Ranganathan V, Farnsworth ML, Kavallaris M, Lock RB. Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells. Cell Death Differ 2000; 7: 102-111
54. Sassone J, Maraschi A, Sassone F, Silani V, Ciammola A. Defining the role of the Bcl-2 family proteins in Huntington's disease. Cell Death Dis 2013; 4: E772
55. Wek RC, Jiang HY, Anthony TG. Coping with stress: EIF2 kinases and translational control. Biochem Soc Trans 2006; 34(Pt 1): 7-11
56. Vucicevic L, Misirkic M, Janjetovic K, Vilimanovich U, Sudar E, Isenovic E et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 2011; 7: 40-50
57. Saito S, Furuno A, Sakurai J, Park HR, Shin-ya K, Tomida A. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One 2012; 7: E45845
58. te Poele RH, Okorokov AL, Joel SP. RNA synthesis block by 5, 6-dichloro-1-beta-Dribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene 1999; 18: 5765-5772
59. Dai R, Li J, Fu J, Chen Y, Yu L, Zhao X et al. Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem 2012; 287: 14586-14597
60. Dai R, Li J, Fu J, Chen Y, Wang R, Zhao X et al. The tyrosine kinase c-Met contributes to the pro-tumorigenic function of the p38 kinase in human bile duct cholangiocarcinoma cells. J Biol Chem 2012; 287: 39812-39823