Functional conservation of HIV-1 Gag: Implications for rational drug design

Retrovirology

Volumn 10, Issue 1, 2013, Pages

  Li, Guangdi ^a   Verheyen, Jens ^b   Rhee, Soo Yon ^a,c   Voet, Arnout ^d   Vandamme, Anne Mieke ^a,e   Theys, Kristof ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d RIKEN   (Japan)

^e INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

Author keywords

Amino acid conservation; Capsid; Drug binding site; Gag inhibitor; HIV subtype; Matrix; Natural polymorphism; Nucleocapsid

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZIMIDAZOLE; BENZODIAZEPINE; BEVIRIMAT; CAPSID PROTEIN; GAG INHIBITOR; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MATRIX INHIBITOR; PF 3450074; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING SITE; DRUG DESIGN; DRUG TARGETING; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC VARIABILITY; HUMAN IMMUNODEFICIENCY VIRUS 1; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN POLYMORPHISM;

HUMAN IMMUNODEFICIENCY VIRUS 1; MIRIDAE;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; DRUG DESIGN; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GENETIC VARIATION; HIV INFECTIONS; HIV-1; HUMANS; MUTATION, MISSENSE; VIRUS REPLICATION;

EID: 84887394848     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-126     Document Type: Article

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