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Volumn 8, Issue 3, 2013, Pages 405-414

Monitoring Binding of HIV-1 Capsid Assembly Inhibitors Using 19F Ligand-and 15N Protein-Based NMR and X-ray Crystallography: Early Hit Validation of a Benzodiazepine Series

(13) Goudreau, Nathalie a Coulombe, René a Faucher, Anne Marie a,b Grand Maître, Chantal a Lacoste, Jean Eric a Lemke, Christopher T a Malenfant, Eric a Bousquet, Yves a Fader, Lee a Simoneau, Bruno a Mercier, Jean François a Titolo, Steve a,c Mason, Stephen W a,d

a BOEHRINGER INGELHEIM CANADA LTD (Canada)

b UNIVERSITÉ DE MONTRÉAL (Canada)

c AL G Technologies Inc (Canada)

d BRISTOL MYERS SQUIBB (United States)

Author keywords

Binding studies; Fluorine; HIV 1 capsids; NMR spectroscopy; X ray crystallography

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZODIAZEPINE DERIVATIVE; VIRUS CAPSID ANTIGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; CIS TRANS ISOMERISM; DRUG BINDING; DRUG BINDING SITE; DRUG CONFORMATION; DRUG PROTEIN BINDING; FLUORINE NUCLEAR MAGNETIC RESONANCE; LIGAND BINDING; MONITORING; NITROGEN NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; VALIDATION STUDY; VIRUS CAPSID; X RAY CRYSTALLOGRAPHY;

BENZODIAZEPINES; BINDING SITES; CAPSID PROTEINS; CRYSTALLOGRAPHY, X-RAY; FLUORINE; HIV-1; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; NITROGEN ISOTOPES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84874340334 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201200580 Document Type: Article

Times cited : (14)

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