Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 4, 2013, Pages 1132-1135

  Zentner, Isaac ^a   Sierra, Luz Jeannette ^a   MacIunas, Lina ^a   Vinnik, Andrei ^b   Fedichev, Peter ^b   Mankowski, Marie K ^c   Ptak, Roger G ^c   Martín García, Julio ^a   Cocklin, Simon ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b QuantumLead   (Russian Federation)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

Antiviral; HIV 1 matrix protein; Surface plasmon resonance; Virtual screening

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MATRIX PROTEIN; N 2 (PHENOXYACETYL) N [4 (1PIPERIDINYLCARBONYL)BENZYL]GLYCINAMIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND BINDING; MOLECULAR DOCKING; SEQUENCE ALIGNMENT; SURFACE PLASMON RESONANCE; VIRUS REPLICATION;

ANTI-HIV AGENTS; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; SURFACE PLASMON RESONANCE;

EID: 84872931922     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.041     Document Type: Article

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