-
1
-
-
0001363865
-
Integration
-
Cold Spring Harbor Laboratory Press Coffin J, Hughes S, Varmus H
-
Brown P Integration Retroviruses Cold Spring Harbor Laboratory Press Coffin J, Hughes S, Varmus H 1997 161-205 http://www.ncbi.nlm.nih.gov/ books/bv.fcgi?rid=rv.chapter.1526
-
(1997)
Retroviruses
, pp. 161-205
-
-
Brown, P.1
-
2
-
-
0035968306
-
HIV integrase, a brief overview from chemistry to therapeutics
-
11346660
-
Craigie R HIV integrase, a brief overview from chemistry to therapeutics J Biol Chem 2001, 276:23213-23216 11346660
-
(2001)
J Biol Chem
, vol.276
, pp. 23213-23216
-
-
Craigie, R.1
-
3
-
-
2942553781
-
Structure and function of HIV-1 integrase
-
15134551
-
Chiu TK Davies DR Structure and function of HIV-1 integrase Curr Top Med Chem 2004, 4:965-977 15134551
-
(2004)
Curr Top Med Chem
, vol.4
, pp. 965-977
-
-
Chiu, T.K.1
Davies, D.R.2
-
5
-
-
0034682511
-
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
-
26930 10890912
-
Chen JC Krucinski J Miercke LJ Finer-Moore JS Tang AH Leavitt AD Stroud RM Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding Proc Natl Acad Sci USA 2000, 97:8233-8238 26930 10890912
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 8233-8238
-
-
Chen, J.C.1
Krucinski, J.2
Miercke, L.J.3
Finer-Moore, J.S.4
Tang, A.H.5
Leavitt, A.D.6
Stroud, R.M.7
-
6
-
-
0037126629
-
Structure of a two-domain fragment of HIV-1 integrase: Implications for domain organization in the intact protein
-
125787 11743009
-
Wang JY Ling H Yang W Craigie R Structure of a two-domain fragment of HIV-1 integrase: Implications for domain organization in the intact protein Embo J 2001, 20:7333-7343 125787 11743009
-
(2001)
Embo J
, vol.20
, pp. 7333-7343
-
-
Wang, J.Y.1
Ling, H.2
Yang, W.3
Craigie, R.4
-
7
-
-
13044295993
-
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
-
23896 10557269
-
Goldgur Y Craigie R Cohen GH Fujiwara T Yoshinaga T Fujishita T Sugimoto H Endo T Murai H Davies DR Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design Proc Natl Acad Sci USA 1999, 96:13040-13043 23896 10557269
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 13040-13043
-
-
Goldgur, Y.1
Craigie, R.2
Cohen, G.H.3
Fujiwara, T.4
Yoshinaga, T.5
Fujishita, T.6
Sugimoto, H.7
Endo, T.8
Murai, H.9
Davies, D.R.10
-
8
-
-
37249085616
-
HIV-1 integrase inhibitors: Update and perspectives
-
18086413
-
Semenova EA Marchand C Pommier Y HIV-1 integrase inhibitors: Update and perspectives Adv Pharmacol 2008, 56:199-228 18086413
-
(2008)
Adv Pharmacol
, vol.56
, pp. 199-228
-
-
Semenova, E.A.1
Marchand, C.2
Pommier, Y.3
-
9
-
-
34447263572
-
Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
-
17668566
-
Lataillade M Chiarella J Kozal MJ Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance Antivir Ther 2007, 12:563-570 17668566
-
(2007)
Antivir Ther
, vol.12
, pp. 563-570
-
-
Lataillade, M.1
Chiarella, J.2
Kozal, M.J.3
-
10
-
-
0030446464
-
Methods for comparing a DNA sequence with a protein sequence
-
9021268
-
Huang X Zhang J Methods for comparing a DNA sequence with a protein sequence Comput Appl Biosci 1996, 12:497-506 9021268
-
(1996)
Comput Appl Biosci
, vol.12
, pp. 497-506
-
-
Huang, X.1
Zhang, J.2
-
11
-
-
33751249244
-
HIV-1 subtype and circulating recombinant form (CRF) reference sequences, 2005
-
Los Alamos National Laboratories
-
Leitner T Korber B Daniels M Calef C Foley B HIV-1 subtype and circulating recombinant form (CRF) reference sequences, 2005 HIV Sequence Compendium Los Alamos National Laboratories 2005 http://www.hiv.lanl.gov/content/sequence/HIV/COMPENDIUM/ 2005compendium.html
-
(2005)
HIV Sequence Compendium
-
-
Leitner, T.1
Korber, B.2
Daniels, M.3
Calef, C.4
Foley, B.5
-
12
-
-
0026342532
-
Information-theoretical entropy as a measure of sequence variability
-
1758884
-
Shenkin PS Erman B Mastrandrea LD Information-theoretical entropy as a measure of sequence variability Proteins 1991, 11:297-313 1758884
-
(1991)
Proteins
, vol.11
, pp. 297-313
-
-
Shenkin, P.S.1
Erman, B.2
Mastrandrea, L.D.3
-
13
-
-
34249660534
-
HIV-1 Subtype B Protease and Reverse Transcriptase Amino Acid Covariation
-
1866358 17500586
-
Rhee SY Liu TF Holmes SP Shafer RW HIV-1 Subtype B Protease and Reverse Transcriptase Amino Acid Covariation PLoS Comput Biol 2007, 3:e87 1866358 17500586
-
(2007)
PLoS Comput Biol
, vol.3
-
-
Rhee, S.Y.1
Liu, T.F.2
Holmes, S.P.3
Shafer, R.W.4
-
14
-
-
0001677717
-
Controlling the false discovery rate: A practical and powerful approach to multiple testing
-
Benjamini Y Hochberg Y Controlling the false discovery rate: A practical and powerful approach to multiple testing J R Stat Soc Ser B 1995, 57:289-300
-
(1995)
J R Stat Soc Ser B
, vol.57
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
15
-
-
0034597625
-
Active site binding modes of HIV-1 integrase inhibitors
-
11063607
-
Sotriffer CA Ni H McCammon JA Active site binding modes of HIV-1 integrase inhibitors J Med Chem 2000, 43:4109-4117 11063607
-
(2000)
J Med Chem
, vol.43
, pp. 4109-4117
-
-
Sotriffer, C.A.1
Ni, H.2
McCammon, J.A.3
-
16
-
-
29944442441
-
Preliminary mapping of a putative inhibitor-binding pocket for human immunodeficiency virus type 1 integrase inhibitors
-
1346808 16377678
-
Lee DJ Robinson WE Jr Preliminary mapping of a putative inhibitor-binding pocket for human immunodeficiency virus type 1 integrase inhibitors Antimicrob Agents Chemother 2006, 50:134-142 1346808 16377678
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 134-142
-
-
Lee, D.J.1
Robinson Jr., W.E.2
-
17
-
-
0037827778
-
Strategy to discriminate between high and low affinity bindings of human immunodeficiency virus, type 1 integrase to viral DNA
-
12626494
-
Zargarian L Benleumi MS Renisio JG Merad H Maroun RG Wieber F Mauffret O Porumb H Troalen F Fermandjian S Strategy to discriminate between high and low affinity bindings of human immunodeficiency virus, type 1 integrase to viral DNA J Biol Chem 2003, 278:19966-19973 12626494
-
(2003)
J Biol Chem
, vol.278
, pp. 19966-19973
-
-
Zargarian, L.1
Benleumi, M.S.2
Renisio, J.G.3
Merad, H.4
Maroun, R.G.5
Wieber, F.6
Mauffret, O.7
Porumb, H.8
Troalen, F.9
Fermandjian, S.10
-
18
-
-
13444269378
-
Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase
-
546573 15681450
-
Lu R Limon A Ghory HZ Engelman A Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase J Virol 2005, 79:2493-2505 546573 15681450
-
(2005)
J Virol
, vol.79
, pp. 2493-2505
-
-
Lu, R.1
Limon, A.2
Ghory, H.Z.3
Engelman, A.4
-
19
-
-
34248203565
-
Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor, GS-9137 (JTK-303)
-
[abstract 627] Los Angeles, CA February 25-28 2007
-
Jones G Ledford R Yu F Miller M Tsiang M McColl D Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor, GS-9137 (JTK-303) [abstract 627] 14th Conference on Retroviruses and Opportunistic Infections Los Angeles, CA 2007 February 25-28 2007.
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
-
-
Jones, G.1
Ledford, R.2
Yu, F.3
Miller, M.4
Tsiang, M.5
McColl, D.6
-
20
-
-
40549125135
-
Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase II study of elvitegravir (GS-9137)
-
Mccoll D Fransen S Gupta S Parking N Margot N Chuck S Cheng A Miller M Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase II study of elvitegravir (GS-9137) [abstract 9] Antivir Ther 2007:12
-
(2007)
Antivir Ther
, pp. 12
-
-
Mccoll, D.1
Fransen, S.2
Gupta, S.3
Parking, N.4
Margot, N.5
Chuck, S.6
Cheng, A.7
Miller, M.8
-
21
-
-
37249065868
-
Resistance to the HIV integrase inhibitor raltegravir: Analysis of protocol 005, a phase II study in patients with triple-class resistant HIV-1
-
[abstract 8]
-
Hazuda D Miller M Nguyen B Zhao J Resistance to the HIV integrase inhibitor raltegravir: Analysis of protocol 005, a phase II study in patients with triple-class resistant HIV-1 [abstract 8] Antivir Ther 2007:12
-
(2007)
Antivir Ther
, pp. 12
-
-
Hazuda, D.1
Miller, M.2
Nguyen, B.3
Zhao, J.4
-
22
-
-
28444445583
-
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
-
1297672 16260736
-
Cherepanov P Ambrosio AL Rahman S Ellenberger T Engelman A Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75 Proc Natl Acad Sci USA 2005, 102:17308-17313 1297672 16260736
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17308-17313
-
-
Cherepanov, P.1
Ambrosio, A.L.2
Rahman, S.3
Ellenberger, T.4
Engelman, A.5
-
23
-
-
23244433627
-
Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase
-
1182625 16051828
-
Lu R Ghory HZ Engelman A Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase J Virol 2005, 79:10356-10368 1182625 16051828
-
(2005)
J Virol
, vol.79
, pp. 10356-10368
-
-
Lu, R.1
Ghory, H.Z.2
Engelman, A.3
-
24
-
-
52749085178
-
Isentress
-
Merck
-
Merck Isentress Package Insert 2007
-
(2007)
Package Insert
-
-
-
25
-
-
52749089231
-
Resistance mutations in HIV-1 selected with raltegravir or elvitegravir confer reduced susceptibility to a diverse panel of integrase inhibitors
-
[abstract 9]
-
Goethals O Clayton R Wagemans E Van Gindere M Cummings M Geluykens P Dockx K Smits V Meersseman G Jochmans D Hallenberger S Hertogs K Resistance mutations in HIV-1 selected with raltegravir or elvitegravir confer reduced susceptibility to a diverse panel of integrase inhibitors [abstract 9] Antivr Ther 2008, 13(Suppl 3):A11
-
(2008)
Antivr Ther
, vol.13
, Issue.SUPPL. 3
-
-
Goethals, O.1
Clayton, R.2
Wagemans, E.3
Van Gindere, M.4
Cummings, M.5
Geluykens, P.6
Dockx, K.7
Smits, V.8
Meersseman, G.9
Jochmans, D.10
Hallenberger, S.11
Hertogs, K.12
-
26
-
-
0037334017
-
An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA
-
149511 12610159
-
Harper AL Sudol M Katzman M An amino acid in the central catalytic domain of three retroviral integrases that affects target site selection in nonviral DNA J Virol 2003, 77:3838-3845 149511 12610159
-
(2003)
J Virol
, vol.77
, pp. 3838-3845
-
-
Harper, A.L.1
Sudol, M.2
Katzman, M.3
-
27
-
-
29744433678
-
Division of labor within human immunodeficiency virus integrase complexes: Determinants of catalysis and target DNA capture
-
1316026 16306609
-
Diamond TL Bushman FD Division of labor within human immunodeficiency virus integrase complexes: Determinants of catalysis and target DNA capture J Virol 2005, 79:15376-15387 1316026 16306609
-
(2005)
J Virol
, vol.79
, pp. 15376-15387
-
-
Diamond, T.L.1
Bushman, F.D.2
-
28
-
-
12944270496
-
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
-
17185 11016953
-
Espeseth AS Felock P Wolfe A Witmer M Grobler J Anthony N Egbertson M Melamed JY Young S Hamill T Cole JL Hazuda DJ HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase Proc Natl Acad Sci USA 2000, 97:11244-11249 17185 11016953
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 11244-11249
-
-
Espeseth, A.S.1
Felock, P.2
Wolfe, A.3
Witmer, M.4
Grobler, J.5
Anthony, N.6
Egbertson, M.7
Melamed, J.Y.8
Young, S.9
Hamill, T.10
Cole, J.L.11
Hazuda, D.J.12
-
29
-
-
0034887472
-
In vitro human immunodeficiency virus type 1 integrase assays
-
11494874
-
Marchand C Neamati N Pommier Y In vitro human immunodeficiency virus type 1 integrase assays Methods Enzymol 2001, 340:624-633 11494874
-
(2001)
Methods Enzymol
, vol.340
, pp. 624-633
-
-
Marchand, C.1
Neamati, N.2
Pommier, Y.3
-
30
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
10649997
-
Hazuda DJ Felock P Witmer M Wolfe A Stillmock K Grobler JA Espeseth A Gabryelski L Schleif W Blau C Miller MD Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells Science 2000, 287:646-650 10649997
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
Espeseth, A.7
Gabryelski, L.8
Schleif, W.9
Blau, C.10
Miller, M.D.11
-
31
-
-
3843108916
-
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
-
509174 15277684
-
Hazuda DJ Anthony NJ Gomez RP Jolly SM Wai JS Zhuang L Fisher TE Embrey M Guare JP Jr Egbertson MS Vocca JP Huff JR Felock PJ Witmer MV Stillmock KA Danovich R Grobler J Miller MD Espeseth AS Jin L Chen I Lin JH Kassahun K Ellis JD Wong BK Xu Wei Pearson PG Schleif WA Cortese R Emini E Summa V Holloway K Young SD Coffin JM A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase Proc Natl Acad Sci USA 2004, 101:11233-11238 509174 15277684
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 11233-11238
-
-
Hazuda, D.J.1
Anthony, N.J.2
Gomez, R.P.3
Jolly, S.M.4
Wai, J.S.5
Zhuang, L.6
Fisher, T.E.7
Embrey, M.8
Guare Jr., J.P.9
Egbertson, M.S.10
Vocca, J.P.11
Huff, J.R.12
Felock, P.J.13
Witmer, M.V.14
Stillmock, K.A.15
Danovich, R.16
Grobler, J.17
Miller, M.D.18
Espeseth, A.S.19
Jin, L.20
Chen, I.21
Lin, J.H.22
Kassahun, K.23
Ellis, J.D.24
Wong, B.K.25
Xu, W.26
Pearson, P.G.27
Schleif, W.A.28
Cortese, R.29
Emini, E.30
Summa, V.31
Holloway, K.32
Young, S.D.33
Coffin, J.M.34
more..
-
32
-
-
33846916481
-
A potent and orally active HIV-1 integrase inhibitor
-
17194584
-
Egbertson MS Moritz HM Melamed JY Han W Perlow DS Kuo MS Embrey M Vacca JP Zrada MM Cortes AR Wallace A Leonard Y Hazuda DJ Miller MD Felock PJ Stillmock KA Witmer MV Schleif W Gabryelski LJ Moyer G Ellis JD Jin L Xu W Braun MP Kassahun K Tsou NN Young SD A potent and orally active HIV-1 integrase inhibitor Bioorg Med Chem Lett 2007, 17:1392-1398 17194584
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 1392-1398
-
-
Egbertson, M.S.1
Moritz, H.M.2
Melamed, J.Y.3
Han, W.4
Perlow, D.S.5
Kuo, M.S.6
Embrey, M.7
Vacca, J.P.8
Zrada, M.M.9
Cortes, A.R.10
Wallace, A.11
Leonard, Y.12
Hazuda, D.J.13
Miller, M.D.14
Felock, P.J.15
Stillmock, K.A.16
Witmer, M.V.17
Schleif, W.18
Gabryelski, L.J.19
Moyer, G.20
Ellis, J.D.21
Jin, L.22
Xu, W.23
Braun, M.P.24
Kassahun, K.25
Tsou, N.N.26
Young, S.D.27
more..
-
33
-
-
52749095782
-
Broad Anti-Retroviral Activity and Resistance Profile of a Novel Human Immunodeficiency Virus Integrase Inhibitor, Elvitegravir (JTK-303/ GS-9137)
-
2224569 17977962
-
Shimura K Kodama E Sakagami Y Matsuzaki Y Watanabe W Yamataka K Watanabe Y Ohata Y Doi S Sato M Kano M Ikeda S Matsuoka M Broad Anti-Retroviral Activity and Resistance Profile of a Novel Human Immunodeficiency Virus Integrase Inhibitor, Elvitegravir (JTK-303/GS-9137) J Virol 2007 2224569 17977962
-
(2007)
J Virol
-
-
Shimura, K.1
Kodama, E.2
Sakagami, Y.3
Matsuzaki, Y.4
Watanabe, W.5
Yamataka, K.6
Watanabe, Y.7
Ohata, Y.8
Doi, S.9
Sato, M.10
Kano, M.11
Ikeda, S.12
Matsuoka, M.13
-
34
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
17434401
-
Grinsztejn B Nguyen BY Katlama C Gatell JM Lazzarin A Vittecoq D Gonzalez CJ Chen J Harvey CM Isaacs RD Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial Lancet 2007, 369:1261-1269 17434401
-
(2007)
Lancet
, vol.369
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.Y.2
Katlama, C.3
Gatell, J.M.4
Lazzarin, A.5
Vittecoq, D.6
Gonzalez, C.J.7
Chen, J.8
Harvey, C.M.9
Isaacs, R.D.10
-
35
-
-
34748860363
-
Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
-
17721395
-
Markowitz M Nguyen BY Gotuzzo E Mendo F Ratanasuwan W Kovacs C Prada G Morales-Ramirez JO Crumpacker CS Isaacs RD Gilde LR Wan H Miller MD Wenning LA Teppler H Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study J Acquir Immune Defic Syndr 2007, 46:125-133 17721395
-
(2007)
J Acquir Immune Defic Syndr
, vol.46
, pp. 125-133
-
-
Markowitz, M.1
Nguyen, B.Y.2
Gotuzzo, E.3
Mendo, F.4
Ratanasuwan, W.5
Kovacs, C.6
Prada, G.7
Morales-Ramirez, J.O.8
Crumpacker, C.S.9
Isaacs, R.D.10
Gilde, L.R.11
Wan, H.12
Miller, M.D.13
Wenning, L.A.14
Teppler, H.15
-
36
-
-
34248205567
-
Results of the BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518 a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
-
Steigbigel R Kumar P Eron J Schechter M Markowitz M Loutfy MR Zhao J Isaacs R Nguyen-Ba N Teppler H Results of the BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518 a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus 14th Conference on Retroviruses and Opportunistic Infections 2007:104
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
, pp. 104
-
-
Steigbigel, R.1
Kumar, P.2
Eron, J.3
Schechter, M.4
Markowitz, M.5
Loutfy, M.R.6
Zhao, J.7
Isaacs, R.8
Nguyen-Ba, N.9
Teppler, H.10
-
37
-
-
34248177765
-
Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518 a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
-
[abstract 105aLB]
-
Cooper D Gatell AJ Rockstroh J Katlama C Yeni P Lazzarin A Chen J Isaacs R Teppler H Nguyen BY Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518 a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus [abstract 105aLB] 14th Conference on Retroviruses and Opportunistic Infections 2007:103
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
, pp. 103
-
-
Cooper, D.1
Gatell, A.J.2
Rockstroh, J.3
Katlama, C.4
Yeni, P.5
Lazzarin, A.6
Chen, J.7
Isaacs, R.8
Teppler, H.9
Nguyen, B.Y.10
-
38
-
-
33748113778
-
Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients
-
16936557
-
DeJesus E Berger D Markowitz M Cohen C Hawkins T Ruane P Elion R Farthing C Zhong L Cheng AK Mccoll D Kearney BP Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients J Acquir Immune Defic Syndr 2006, 43:1-5 16936557
-
(2006)
J Acquir Immune Defic Syndr
, vol.43
, pp. 1-5
-
-
DeJesus, E.1
Berger, D.2
Markowitz, M.3
Cohen, C.4
Hawkins, T.5
Ruane, P.6
Elion, R.7
Farthing, C.8
Zhong, L.9
Cheng, A.K.10
Mccoll, D.11
Kearney, B.P.12
-
39
-
-
34248199833
-
The HIV-1 integrase inhibitor GS-9137 demonstrates potent antiretroviral activity in treatment-experienced patients
-
[abstract 143LB]
-
Zolopa A Mullen M Berger D Ruane P Hawkins T Zhong L Chuck S Enejosa J Kearnery B Cheng A The HIV-1 integrase inhibitor GS-9137 demonstrates potent antiretroviral activity in treatment-experienced patients [abstract 143LB] 14th Conference on Retroviruses and Opportunistic Infections 2007
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
-
-
Zolopa, A.1
Mullen, M.2
Berger, D.3
Ruane, P.4
Hawkins, T.5
Zhong, L.6
Chuck, S.7
Enejosa, J.8
Kearnery, B.9
Cheng, A.10
-
40
-
-
0037076324
-
Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
-
124459 11997448
-
Grobler JA Stillmock K Hu B Witmer M Felock P Espeseth AS Wolfe A Egbertson M Bourgeois M Melamed J Wai JS Young S Vacca J Hazuda DJ Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes Proc Natl Acad Sci USA 2002, 99:6661-6666 124459 11997448
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 6661-6666
-
-
Grobler, J.A.1
Stillmock, K.2
Hu, B.3
Witmer, M.4
Felock, P.5
Espeseth, A.S.6
Wolfe, A.7
Egbertson, M.8
Bourgeois, M.9
Melamed, J.10
Wai, J.S.11
Young, S.12
Vacca, J.13
Hazuda, D.J.14
-
41
-
-
7744240084
-
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
-
15577623
-
Fikkert V Hombrouck A Van Remoortel B De Maeyer M Pannecouque C De Clercq E Debyser Z Witvrouw M Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360 AIDS 2004, 18:2019-2028 15577623
-
(2004)
AIDS
, vol.18
, pp. 2019-2028
-
-
Fikkert, V.1
Hombrouck, A.2
Van Remoortel, B.3
De Maeyer, M.4
Pannecouque, C.5
De Clercq, E.6
Debyser, Z.7
Witvrouw, M.8
-
42
-
-
44449155764
-
Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137
-
18378713
-
Hombrouck A Voet A Van Remoortel B Desadeleer C De Maeyer M Debyser Z Witvrouw M Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137 Antimicrob Agents Chemother 2008, 52:2069-2078 18378713
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 2069-2078
-
-
Hombrouck, A.1
Voet, A.2
Van Remoortel, B.3
Desadeleer, C.4
De Maeyer, M.5
Debyser, Z.6
Witvrouw, M.7
-
43
-
-
52749091840
-
In vitro resistance selection studies using raltegravir: A novel inhibitor of HIV-1 integrase
-
Richmond VA, November 11 - 14, 2007
-
Witmer M Danovich R Ke Y Day A Gabryelski L Ecto L McKenna P Miller M Hazuda D In vitro resistance selection studies using raltegravir: A novel inhibitor of HIV-1 integrase 8th Annual Symposium on Antiviral Drug Resistance, Richmond VA, November 11 - 14, 2007 2007
-
(2007)
8th Annual Symposium on Antiviral Drug Resistance
-
-
Witmer, M.1
Danovich, R.2
Ke, Y.3
Day, A.4
Gabryelski, L.5
Ecto, L.6
McKenna, P.7
Miller, M.8
Hazuda, D.9
-
44
-
-
42049119625
-
Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
-
2292515 18227187
-
Malet I Delelis O Valantin MA Montes B Soulie C Wirden M Tchertanov L Peytavin G Reynes J Mouscadet JF Katlama C Calvez V Marcelin AG Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro Antimicrob Agents Chemother 2008, 52:1351-1358 2292515 18227187
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 1351-1358
-
-
Malet, I.1
Delelis, O.2
Valantin, M.A.3
Montes, B.4
Soulie, C.5
Wirden, M.6
Tchertanov, L.7
Peytavin, G.8
Reynes, J.9
Mouscadet, J.F.10
Katlama, C.11
Calvez, V.12
Marcelin, A.G.13
-
45
-
-
52749085595
-
Longitudinal analysis of resistance to the HIV-1 integrase inhibitor raltebravir: Results from P005, a phase 2 study in treatment expreienced patients
-
[abstract 6]
-
Miller MD Danovich RM Ke Y Witmer MV Zhao J Harvey C Nguyen BY Hazuda DJ Longitudinal analysis of resistance to the HIV-1 integrase inhibitor raltebravir: Results from P005, a phase 2 study in treatment expreienced patients [abstract 6] Antivir Ther 2008, 13(Suppl 3):A8
-
(2008)
Antivir Ther
, vol.13
, Issue.SUPPL. 3
-
-
Miller, M.D.1
Danovich, R.M.2
Ke, Y.3
Witmer, M.V.4
Zhao, J.5
Harvey, C.6
Nguyen, B.Y.7
Hazuda, D.J.8
-
46
-
-
52749097450
-
Integrase inhibitor resistance involves complex interactions among primary and secondary resistance mutations: A novel mutation L68V/I associates with E92Q and increases resistance
-
[abstact 13]
-
Goodman D Hluhanich R Waters J Margot NA Fransen S Gupta S Huang W Parkin N Borroto-Esoda K Svarovskaia ES Miller MD McColl DJ Integrase inhibitor resistance involves complex interactions among primary and secondary resistance mutations: A novel mutation L68V/I associates with E92Q and increases resistance [abstact 13] Antviral Ther 2008, 13(Suppl 3):A15
-
(2008)
Antviral Ther
, vol.13
, Issue.SUPPL. 3
-
-
Goodman, D.1
Hluhanich, R.2
Waters, J.3
Margot, N.A.4
Fransen, S.5
Gupta, S.6
Huang, W.7
Parkin, N.8
Borroto-Esoda, K.9
Svarovskaia, E.S.10
Miller, M.D.11
McColl, D.J.12
-
47
-
-
52749083694
-
Virological and immunological outcomes in a cohort of patients failing integrase inhibitors
-
[abstract 10]
-
Hatano H Lampiris H Huang W Hoh R Gupta S Fransen S Martin JN Petropoulos CJ Deeks SG Virological and immunological outcomes in a cohort of patients failing integrase inhibitors [abstract 10] Antivir Ther 2008, 13(Suppl 3):A12
-
(2008)
Antivir Ther
, vol.13
, Issue.SUPPL. 3
-
-
Hatano, H.1
Lampiris, H.2
Huang, W.3
Hoh, R.4
Gupta, S.5
Fransen, S.6
Martin, J.N.7
Petropoulos, C.J.8
Deeks, S.G.9
-
48
-
-
52749089492
-
Virological evolution in HIV treatment-experienced patients with raltegravir-based salvage regimens
-
[abstract 11]
-
Katlama C Caby F Andrade R Schneider L Canestri A Ktorza N Tubiana R Valantin M Wirden M Mallet I Calvez V Virological evolution in HIV treatment-experienced patients with raltegravir-based salvage regimens [abstract 11] Antivir Ther 2008, 13(Suppl 3):A13
-
(2008)
Antivir Ther
, vol.13
, Issue.SUPPL. 3
-
-
Katlama, C.1
Caby, F.2
Andrade, R.3
Schneider, L.4
Canestri, A.5
Ktorza, N.6
Tubiana, R.7
Valantin, M.8
Wirden, M.9
Mallet, I.10
Calvez, V.11
-
49
-
-
52749088973
-
Mutational patterns in the HIV-1 integrase related to virological failures on raltegravir-containing regimens
-
[abstract 12]
-
Da Silva D Pellgrin I Anies G Breilh D Wittkop L Morlat P Dupon M Neau D Pellegrin J Fleury H Masquelier B Mutational patterns in the HIV-1 integrase related to virological failures on raltegravir-containing regimens [abstract 12] Antivir Ther 2008, 13(Suppl 3):A14
-
(2008)
Antivir Ther
, vol.13
, Issue.SUPPL. 3
-
-
Da Silva, D.1
Pellgrin, I.2
Anies, G.3
Breilh, D.4
Wittkop, L.5
Morlat, P.6
Dupon, M.7
Neau, D.8
Pellegrin, J.9
Fleury, H.10
Masquelier, B.11
-
50
-
-
52749091739
-
Virological response and resistance in multi-experienced patients treated with raltegravir
-
[abstract 18]
-
Ceccherini-Silberstein F Armenia D D'Arrigo R Micheli V Fabeni L Meraviglia P Capetti a Zaccarelli M Trotta MP Narciso P Antinori A Perno CF Virological response and resistance in multi-experienced patients treated with raltegravir [abstract 18] Antivir Ther 2008, 13(Suppl 3):A20
-
(2008)
Antivir Ther
, vol.13
, Issue.SUPPL. 3
-
-
Ceccherini-Silberstein, F.1
Armenia, D.2
D'Arrigo, R.3
Micheli, V.4
Fabeni, L.5
Meraviglia, P.6
Capetti, A.7
Zaccarelli, M.8
Trotta, M.P.9
Narciso, P.10
Antinori, A.11
Perno, C.F.12
-
51
-
-
34147128555
-
In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate
-
1847836 17374162
-
Savarino A In-Silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate Retrovirology 2007, 4:21 1847836 17374162
-
(2007)
Retrovirology
, vol.4
, pp. 21
-
-
Savarino, A.1
-
52
-
-
52749088638
-
Loss of raltegravir susceptibility in treated patients is conferred by multiple non-overlapping genetic pathways
-
[abstract 7]
-
Fransen S Gupta S Danovich R Hazuda DJ Miller M Witmer M Petropoulos CJ Parkin N Huang W Loss of raltegravir susceptibility in treated patients is conferred by multiple non-overlapping genetic pathways [abstract 7] Antivir Ther 2008, 13(Suppl 3):A9
-
(2008)
Antivir Ther
, vol.13
, Issue.SUPPL. 3
-
-
Fransen, S.1
Gupta, S.2
Danovich, R.3
Hazuda, D.J.4
Miller, M.5
Witmer, M.6
Petropoulos, C.J.7
Parkin, N.8
Huang, W.9
-
53
-
-
48449089625
-
In vitro cross-resistance studies of five different classes of integrase inhibitors in recombinant HIV-1
-
[abstract 1]
-
Ren C May S Miletti T Bedard J In vitro cross-resistance studies of five different classes of integrase inhibitors in recombinant HIV-1 [abstract 1] Antivir Ther 2007, 12:S3
-
(2007)
Antivir Ther
, vol.12
-
-
Ren, C.1
May, S.2
Miletti, T.3
Bedard, J.4
-
54
-
-
34248144345
-
In vitro antiviral activity and resistance profile of a novel HIV integrase inhibitor JTK-303/GS-9137
-
Kodama E Shimura K Sakagami Y Matsuzaki Y Watanabe W Yamataka K Sato M Kano M Ikeda S Matsuoka M In vitro antiviral activity and resistance profile of a novel HIV integrase inhibitor JTK-303/GS-9137 ICAAC 2006
-
(2006)
ICAAC
-
-
Kodama, E.1
Shimura, K.2
Sakagami, Y.3
Matsuzaki, Y.4
Watanabe, W.5
Yamataka, K.6
Sato, M.7
Kano, M.8
Ikeda, S.9
Matsuoka, M.10
-
55
-
-
34248197441
-
Frequency of naturally occurring polymorphisms associated with resistance to integrase inhibitors in a recently infected cohort
-
[abstract 625]
-
Low A Mohri H Markowitz M Frequency of naturally occurring polymorphisms associated with resistance to integrase inhibitors in a recently infected cohort [abstract 625] 14th Conference on Retroviruses and Opportunistic Infections 2007
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
-
-
Low, A.1
Mohri, H.2
Markowitz, M.3
-
58
-
-
48449088969
-
Specific mutations related to resistance to HIV-1 integrase inhibitors are associated with reverse transcriptase mutations in HAART-treated patients
-
[abstract 4]
-
Ceccherini-Silberstein F Malet I Fabeni L Svicher V Gori C Dimonte S Bono S Artese A D'Arrigo R Katlama C Antinori A Monforte A Calvez V Marcelin AG Perno CF Specific mutations related to resistance to HIV-1 integrase inhibitors are associated with reverse transcriptase mutations in HAART-treated patients [abstract 4] Antivir Ther 2007, 12:S6
-
(2007)
Antivir Ther
, vol.12
-
-
Ceccherini-Silberstein, F.1
Malet, I.2
Fabeni, L.3
Svicher, V.4
Gori, C.5
Dimonte, S.6
Bono, S.7
Artese, A.8
D'Arrigo, R.9
Katlama, C.10
Antinori, A.11
Monforte, A.12
Calvez, V.13
Marcelin, A.G.14
Perno, C.F.15
-
59
-
-
52749083002
-
Low level of baseline resistance to integrase inhibitors L731,988 and L870,810 in randomly selected subtype B and non-B HIV-1 strains
-
[abstract 5]
-
Van Baelen K Clynhens M Rondelez E Van Eygen V Zegel Van den P Vermeiren H Vandenbroucke I Stuyver L Low level of baseline resistance to integrase inhibitors L731,988 and L870,810 in randomly selected subtype B and non-B HIV-1 strains [abstract 5] Antivir Ther 2008, 12:S7
-
(2008)
Antivir Ther
, vol.12
-
-
Van Baelen, K.1
Clynhens, M.2
Rondelez, E.3
Van Eygen, V.4
Zegel, P.5
Vermeiren, H.6
Vandenbroucke, I.7
Stuyver, L.8
-
60
-
-
31344462038
-
Identfication of HIV-derived, HLA class I restricted CTL epitopes: Insights into TCR repertoire, CTL escape and viral fitness
-
Los Alamos: Los Alamos National Laboratory, Theoretical Biology and Biophysics Korbert BTBC, Haynes BF, Koup R, Moore JP, Walker BD, Watkins DI
-
Frahm N Linde C Brander C Identfication of HIV-derived, HLA class I restricted CTL epitopes: Insights into TCR repertoire, CTL escape and viral fitness HIV Molecular Immunology 2006/2007 Los Alamos: Los Alamos National Laboratory, Theoretical Biology and Biophysics Korbert BTBC, Haynes BF, Koup R, Moore JP, Walker BD, Watkins DI 2007 3-28
-
(2007)
HIV Molecular Immunology 2006/2007
, pp. 3-28
-
-
Frahm, N.1
Linde, C.2
Brander, C.3
|