Identification of a Small-Molecule Inhibitor of HIV-1 Assembly that Targets the Phosphatidylinositol (4,5)-bisphosphate Binding Site of the HIV-1 Matrix Protein

ChemMedChem

Volumn 8, Issue 3, 2013, Pages 426-432

  Zentner, Isaac ^a   Sierra, Luz Jeannette ^a   Fraser, Ayesha K ^a   Maciunas, Lina ^a   Mankowski, Marie K ^b   Vinnik, Andrei ^c   Fedichev, Peter ^c   Ptak, Roger G ^b   Martín García, Julio ^a   Cocklin, Simon ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c QuantumLead   (Russian Federation)

Author keywords

Antiviral agents; HIV 1; Matrix proteins; Phosphatidylinositol 4,5 bisphosphates; Virtual screening

Indexed keywords

2[4((3(4 FLUOROPHENYL) 1,2,4 OXADIAZOL 5 YL) METHYL)] 1 PIPERAZINYL N (4 METHYLPHENYL) ACETAMIDE; 3(2 ETHOXYPHENYL) 5[(4(4 NITROPHENYL) PIPERAZIN 1 YL) METHYL] 1,2,4 OXADIAZOLE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MATRIX PROTEIN; N [4 ETHOXY 3(1 PIPERIDINYLSULFONYL) PHENYL] 2 (IMIDAZO [2,1 B][1,3] THIAZOL 6 YL) ACETAMIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IN VITRO STUDY; LIFE CYCLE STAGE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VIRUS ASSEMBLY; VIRUS REPLICATION;

ACETANILIDES; ANTI-HIV AGENTS; BINDING SITES; CELLS, CULTURED; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HEK293 CELLS; HIV ANTIGENS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MOLECULAR DOCKING SIMULATION; OXADIAZOLES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; VIRUS REPLICATION;

EID: 84874297767     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200577     Document Type: Article

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