Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography

ACS Chemical Biology

Volumn 8, Issue 5, 2013, Pages 1074-1082

  Goudreau, Nathalie ^a   Lemke, Christopher T ^a   Faucher, Anne Marie ^a,b   Grand Maiître, Chantal ^a   Goulet, Sylvie ^a   Lacoste, Jean Eric ^a   Rancourt, Jean ^a   Malenfant, Eric ^a   Mercier, Jean François ^a   Titolo, Steve ^a,c   Mason, Stephen W ^a,d  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c AL G Technologies   (Canada)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; BENZODIAZEPINE; CAPSID PROTEIN; CYCLOPHILIN A; GAG PROTEIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZIMIDAZOLE;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; ROUS SARCOMA ONCOVIRUS; VIRUS CAPSID; VIRUS INFECTIVITY; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; CHEMISTRY; GENETIC POLYMORPHISM; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; BENZIMIDAZOLES; BINDING SITES; BINDING, COMPETITIVE; CAPSID PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYCLOPHILIN A; HIV-1; MAGNETIC RESONANCE SPECTROSCOPY; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878048393     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400075f     Document Type: Article

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