Analysis of small molecule ligands targeting the HIV-1 matrix protein-RNA binding site

Journal of Biological Chemistry

Volumn 288, Issue 1, 2013, Pages 666-676

  Alfadhli, Ayna ^a   McNett, Henry ^a   Eccles, Jacob ^a   Tsagli, Seyram ^a   Noviello, Colleen ^a   Sloan, Rachel ^a   López, Claudia S ^a   Peyton, David H ^b   Barklis, Eric ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5-BISPHOSPHATE; ANTIVIRALS; CELLULAR MEMBRANES; MATRIX DOMAINS; RNA BINDING; SMALL MOLECULES;

CELL CULTURE; CELL MEMBRANES; MOLECULES; PHOSPHOLIPIDS; PROTEINS; RNA;

BINDING SITES;

2 (2 CHLORO 6 METHYLPHENYL) 4 (CYCLOPROPYLMETHYL) 1,2,4 THIADIAZOLANE 3,5 DIONE; 2 (3,5 DIMETHYLISOXAZOL 4 YL) 4 (4 FLUOROPHENYL) 1,2,4 THIADIAZOLANE 3,5 DIONE; 2,3 DICHLORO 1,4 DIHYDRONAPTHALENE 1,4 DIONE; 4 (CYCLOPROPYLMETHYL) 2 (3,5 DIMETHYLISOXAZOL 4 YL) 1,2,4 THIADIAZOLANE 3,5 DIONE; 4 METHYL 2 (1NAPHTHYL) 1,2,4 THIADIAZOLANE 3,5 DIONE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MATRIX PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PIOGLITAZONE; ROSIGLITAZONE; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANISOTROPY; ANTIVIRAL ACTIVITY; ARTICLE; BINDING COMPETITION; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; FLUORESCENCE ANALYSIS; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN RNA BINDING; PROTEIN TARGETING; TOXICITY TESTING; VIRUS REPLICATION; VIRUS VIRULENCE;

ANTI-HIV AGENTS; BINDING SITES; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HIV-1; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, FLUORESCENCE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHOLIPIDS; PROTEIN BINDING; RETROVIRIDAE; RNA; THIADIAZOLES;

HUMAN IMMUNODEFICIENCY VIRUS 1; PHOS;

EID: 84872078381     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.399865     Document Type: Article

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