In vivo safety evaluation of polyarginine coated magnetic nanovectors

Molecular Pharmaceutics

Volumn 10, Issue 11, 2013, Pages 4099-4106

  Veiseh, Omid ^a   Kievit, Forrest M ^b   Liu, Vicki ^c   Fang, Chen ^d   Stephen, Zachary R ^a   Ellenbogen, Richard G ^b   Zhang, Miqin ^a,b  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c University of Washington   (United States)

^d USA   (United States)

Author keywords

cancer; gene therapy; iron oxide nanoparticle; nanotechnology; siRNA

Indexed keywords

MACROGOL; OLIGONUCLEOTIDE; POLYARGININE; POLYETHYLENEIMINE; SMALL INTERFERING RNA; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ARTICLE; CELL VIABILITY; CHEMICAL STRUCTURE; DRUG CLEARANCE; DRUG UPTAKE; ERYTHROCYTE AGGREGATION; FLUORESCENCE ANALYSIS; GENE DELIVERY SYSTEM; GENE SILENCING; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HYDRODYNAMICS; LIVER; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPLEEN; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

FERRIC COMPOUNDS; GENETIC THERAPY; NANOPARTICLES; NANOTECHNOLOGY; PEPTIDES; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RNA, SMALL INTERFERING;

EID: 84887387632     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4005468     Document Type: Article

References (34)

1. Davidson, B. L.; McCray, P. B., Jr. Current prospects for RNA interference-based therapies Nat. Rev. Genet. 2011, 12, 329-40
2. Petrocca, F.; Lieberman, J. Promise and challenge of RNA interference-based therapy for cancer J. Clin. Oncol. 2011, 29, 747-54
3. Pecot, C. V.; Calin, G. A.; Coleman, R. L.; Lopez-Berestein, G.; Sood, A. K. RNA interference in the clinic: challenges and future directions Nat. Rev. Cancer 2011, 11, 59-67
4. Pan, X.; Thompson, R.; Meng, X.; Wu, D.; Xu, L. Tumor-targeted RNA-interference: functional non-viral nanovectors Am. J. Cancer Res. 2011, 1, 25-42
5. Kievit, F. M.; Zhang, M. Cancer nanotheranostics: improving imaging and therapy by targeted delivery across biological barriers Adv. Mater. 2011, 23, H217-47
6. Veiseh, O.; Gunn, J. W.; Zhang, M. Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging Adv. Drug Delivery Rev. 2010, 62, 284-304
7. Kievit, F. M.; Zhang, M. Surface engineering of iron oxide nanoparticles for targeted cancer therapy Acc. Chem. Res. 2011, 44, 853-62
8. Veiseh, O.; Kievit, F. M.; Fang, C.; Mu, N.; Jana, S.; Leung, M. C.; Mok, H.; Ellenbogen, R. G.; Park, J. O.; Zhang, M. Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery Biomaterials 2010, 31, 8032-42
9. Veiseh, O.; Kievit, F. M.; Mok, H.; Ayesh, J.; Clark, C.; Fang, C.; Leung, M.; Arami, H.; Park, J. O.; Zhang, M. Cell transcytosing poly-arginine coated magnetic nanovector for safe and effective siRNA delivery Biomaterials 2011, 32, 5717-25
10. Kievit, F. M.; Veiseh, O.; Bhattarai, N.; Fang, C.; Gunn, J. W.; Lee, D.; Ellenbogen, R. G.; Olson, J. M.; Zhang, M. PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection Adv. Funct. Mater. 2009, 19, 2244-2251
11. Kievit, F. M.; Veiseh, O.; Fang, C.; Bhattarai, N.; Lee, D.; Ellenbogen, R. G.; Zhang, M. Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma ACS Nano 2010, 4, 4587-94
12. Mok, H.; Veiseh, O.; Fang, C.; Kievit, F. M.; Wang, F. Y.; Park, J. O.; Zhang, M. pH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells Mol. Pharmaceutics 2010, 7, 1930-9
13. Liu, G.; Xie, J.; Zhang, F.; Wang, Z.; Luo, K.; Zhu, L.; Quan, Q.; Niu, G.; Lee, S.; Ai, H.; Chen, X. N-Alkyl-PEI-Functionalized Iron Oxide Nanoclusters for Efficient siRNA Delivery Small 2011, 7, 2742-9
14. Lee, J. H.; Lee, K.; Moon, S. H.; Lee, Y.; Park, T. G.; Cheon, J. All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery Angew. Chem., Int. Ed. Engl. 2009, 48, 4174-9
15. Godbey, W. T.; Wu, K. K.; Mikos, A. G. Poly(ethylenimine) and its role in gene delivery J. Controlled Release 1999, 60, 149-160
16. Ogris, M.; Walker, G.; Blessing, T.; Kircheis, R.; Wolschek, M.; Wagner, E. Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes J. Controlled Release 2003, 91, 173-81
17. Burke, R. S.; Pun, S. H. Extracellular barriers to in Vivo PEI and PEGylated PEI polyplex-mediated gene delivery to the liver Bioconjugate Chem. 2008, 19, 693-704
18. Veiseh, O.; Kievit, F. M.; Gunn, J. W.; Ratner, B. D.; Zhang, M. A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells Biomaterials 2009, 30, 649-57
19. Fang, C.; Bhattarai, N.; Sun, C.; Zhang, M. Q. Functionalized Nanoparticles with Long-Term Stability in Biological Media Small 2009, 5, 1637-1641
20. Veiseh, O.; Sun, C.; Gunn, J.; Kohler, N.; Gabikian, P.; Lee, D.; Bhattarai, N.; Ellenbogen, R.; Sze, R.; Hallahan, A.; Olson, J.; Zhang, M. Optical and MRI multifunctional nanoprobe for targeting gliomas Nano Lett. 2005, 5, 1003-8
21. Authier, F.; Posner, B. I.; Bergeron, J. J. Endosomal proteolysis of internalized proteins FEBS Lett. 1996, 389, 55-60
22. Singh, N.; Agrawal, A.; Leung, A. K.; Sharp, P. A.; Bhatia, S. N. Effect of nanoparticle conjugation on gene silencing by RNA interference J. Am. Chem. Soc. 2010, 132, 8241-3
23. Longmire, M.; Choyke, P. L.; Kobayashi, H. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats Nanomedicine 2008, 3, 703-717
24. Zhou, T.; Jia, X.; Li, H.; Wang, J.; Zhang, H.; A, Y.; Zhang, Z. New tumor-targeted nanosized delivery carrier for oligonucleotides: characteristics in vitro and in vivo Int. J. Nanomed. 2011, 6, 1527-34
25. Goyal, R.; Tripathi, S. K.; Tyagi, S.; Sharma, A.; Ram, K. R.; Chowdhuri, D. K.; Shukla, Y.; Kumar, P.; Gupta, K. C. Linear PEI nanoparticles: efficient pDNA/siRNA carriers in vitro and in vivo Nanomedicine 2011, 8, 167-175
26. Herce, H. D.; Garcia, A. E.; Litt, J.; Kane, R. S.; Martin, P.; Enrique, N.; Rebolledo, A.; Milesi, V. Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides Biophys. J. 2009, 97, 1917-25
27. Moghimi, S. M.; Symonds, P.; Murray, J. C.; Hunter, A. C.; Debska, G.; Szewczyk, A. A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy Mol. Ther. 2005, 11, 990-5
28. Dobrovolskaia, M. A.; Patri, A. K.; Simak, J.; Hall, J. B.; Semberova, J.; De Paoli Lacerda, S. H.; McNeil, S. E. Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitro Mol. Pharmaceutics 2012, 9, 382-93
29. Dobrovolskaia, M. A.; Clogston, J. D.; Neun, B. W.; Hall, J. B.; Patri, A. K.; McNeil, S. E. Method for analysis of nanoparticle hemolytic properties in vitro Nano Lett. 2008, 8, 2180-7
30. Neun, B. W.; Dobrovolskaia, M. A. Method for analysis of nanoparticle hemolytic properties in vitro Methods Mol. Biol. 2011, 697, 215-24
31. Veiseh, O.; Kievit, F. M.; Ellenbogen, R. G.; Zhang, M. Cancer cell invasion: treatment and monitoring opportunities in nanomedicine Adv. Drug Delivery Rev. 2011, 63, 582-96
32. Loeb, W. F.; Das, S. R.; Harbour, L. S.; Turturro, A.; Bucci, T. J.; Clifford, C. B. Pathobiology of the aging mouse. In Clinical Biochemistry; Mohr, U.; Dungworth, D. L.; Capen, C. C.; Carlton, W. W.; Sunderberg, J. P.; Ward, J. M., Eds.; ILSI Press: Washington, DC, 1996; Vol. I, pp 3-19.
33. Wolford, S. T.; Schroer, R. A.; Gohs, F. X.; Gallo, P. P.; Brodeck, M.; Falk, H. B.; Ruhren, R. Reference range database for serum chemistry and hematology values in laboratory-animals J. Toxicol. Environ. Health 1986, 18, 161-188
34. Jain, N. C. Vetrinary Hematology; Lea & Febiger: Philadelphia, 1993.