Arginine-rich peptides destabilize the plasma membrane, consistent with a pore formation translocation mechanism of cell-penetrating peptides

Biophysical Journal

Volumn 97, Issue 7, 2009, Pages 1917-1925

  Herce, H D ^a,b   Garcia, A E ^a,b   Litt, J ^b,c   Kane, R S ^b,c   Martin, P ^d   Enrique, N ^d   Rebolledo, A ^d   Milesi, V ^d  

^a Research Rensselaer Polytechnic Institute   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^d UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CELL PENETRATING PEPTIDE; PEPTIDE DERIVATIVE; TRANSACTIVATOR PROTEIN;

ARTICLE; CELL MEMBRANE; CHANNEL GATING; CONTROLLED STUDY; HUMAN; HUMAN CELL; ION CURRENT; LIPID BILAYER; MEMBRANE STABILIZATION; MOLECULAR DYNAMICS; OSTEOSARCOMA CELL; PHOSPHOLIPID BILAYER; PROTEIN BINDING; PROTEIN TRANSPORT; SIMULATION; SMOOTH MUSCLE FIBER;

ANIMALS; ARGININE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; ELECTRIC CONDUCTIVITY; GENE PRODUCTS, TAT; HUMAN IMMUNODEFICIENCY VIRUS PROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; POROSITY; PROTEIN TRANSPORT; SALTS; WATER;

EID: 70350023192     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2009.05.066     Document Type: Article

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