Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Gelsomino, Giada ^a   Corsetto, Paola A ^b   Campia, Ivana ^a   Montorfano, Gigliola ^b   Kopecka, Joanna ^a   Castella, Barbara ^c   Gazzano, Elena ^a   Ghigo, Dario ^a   Rizzo, Angela M ^b   Riganti, Chiara ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

ATP binding cassette transporters; Cholesterol; Detergent resistant membranes; Multidrug resistance; Omega 3 polyunsaturated fatty acids

Indexed keywords

CHOLESTEROL; DOCOSAHEXAENOIC ACID; DOXORUBICIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ICOSAPENTAENOIC ACID; IRINOTECAN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; OMEGA 3 FATTY ACID; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN PROTEIN LIGASE E3 TRC 8; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CELL MEMBRANE; CELL POPULATION; CELL SURFACE; CELL VIABILITY; CHEMOSENSITIZATION; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; COLON CANCER; CONTROLLED STUDY; DETERGENT RESISTANT MEMBRANE; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOPRECIPITATION; LIPID COMPOSITION; PHAGOCYTOSIS; PROTEIN EXPRESSION; UBIQUITINATION; BIOSYNTHESIS; COLONIC NEOPLASMS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; HT 29 CELL LINE; IMMUNOLOGY; METABOLISM; MULTIDRUG RESISTANCE; PHOSPHORYLATION; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL MEMBRANE; CHOLESTEROL; COLONIC NEOPLASMS; DOCOSAHEXAENOIC ACIDS; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; EICOSAPENTAENOIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; P-GLYCOPROTEIN; PHOSPHORYLATION; UBIQUITINATION;

EID: 84887384756     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-137     Document Type: Article

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