MRP1 and glucosylceramide are coordinately over expressed and enriched in rafts during multidrug resistance acquisition in colon cancer cells

International Journal of Cancer

Volumn 110, Issue 4, 2004, Pages 511-522

  Klappe, Karin ^a   Hinrichs, John W J ^a   Kroesen, Bart Jan ^b   Sietsma, Hannie ^b   Kok, Jan Willem ^a,c  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Detergent insoluble glycosphingolipid enriched membrane domains; Glucosylceramide; MRP1; Multidrug resistance; Sphingolipids

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE; COLCHICINE; GLUCOSYLCERAMIDE; LUBROL; MULTIDRUG RESISTANCE PROTEIN 1; SPHINGOLIPID; VERLUKAST;

ARTICLE; CANCER SCREENING; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME INHIBITION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIPID METABOLISM; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAFT; SENSITIVITY ANALYSIS;

APOPTOSIS; COLCHICINE; COLONIC NEOPLASMS; DRUG RESISTANCE, NEOPLASM; GLUCOSYLCERAMIDES; GLUCOSYLTRANSFERASES; HT29 CELLS; HUMANS; MEMBRANE MICRODOMAINS; P-GLYCOPROTEIN; SPHINGOLIPIDS;

EID: 2442675466     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20140     Document Type: Article

References (37)

1. Nooter K, Stoter G. Molecular mechanisms of multidrug resistance in cancer chemotherapy. Pathol Res Pract 1996;192:768-80.
2. Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Rev Cancer 2002;2:48-58.
3. Klein I, Sarkadi B, Varadi A. An inventory of the human ABC proteins. Biochim Biophys Acta 1999;1461:237-62.
4. Hrycyna CA. Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance. Semin Cell Dev Biol 2001;12:247-56.
5. Roepe PD. The role of the MDR protein in altered drug translocation across tumor cell membranes. Biochim Biophys Acta 1995;1241:385-405.
6. Hipfner DR, Deeley, RG, Cole SPC. Structural, mechanistic and clinical aspects of MRP1. Biochim Biophys Acta 1999;1461:359-376.
7. Renes J, De Vries EG, Jansen PL, Muller M. The (patho)physiological functions of the MRP family. Drug Resist Updat 2000;3:289-302.
8. Lavie Y, Cao H, Bursten SL, Giuliano AE, Cabot MC. Accumulation of glucosylceramides in multidrug-resistant cancer cells. J Biol Chem 1996;271:19530-6.
9. Sietsma H, Veldman RJ, Kok JW. The involvement of sphingolipids in multidrug resistance. J Membrane Biol 2001;181:153-62.
10. Lucci A, Cho WI, Han TY, Giuliano AE, Morton DL, Cabot MC Glucosylceramide: a marker for multiple-drug resistant cancers. Anticancer Res 1998;18:475-80.
11. Borst P, Zelcer N, van Helvoort A. ABC transporters in lipid transport. Biochim Biophys Acta 2000;1486:128-44.
12. Veldman RJ, Sietsma H, Klappe K, Hoekstra D, Kok JW. Inhibition of P-glycoprotein activity and chemosensitization of multidrug-resistant ovarian carcinoma 2780AD cells by hexanoylglucosylceramide. Biochem Biophys Res Commun 1999;266:492-6.
13. Lavie Y, Fiucci G, Liscovitch M. Upregulation of caveolae and caveolar constituents in multidrug-resistant cancer cells. J Biol Chem 1998;273:32380-3.
14. Lavie Y, Liscovitch M. Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences. Glycoconj J 2000;17:253-9.
15. Hannun YA, Luberto C. Ceramide in the eukaryotic stress response. Trends Cell Biol 2000;10:73-80.
16. Senchenkov A, Litval DA, Cabot MC. Targeting ceramide metabolism: a strategy for overcoming drug resistance. J Natl Cancer Inst 2001;93:347-57.
17. Liu YY, Han TY, Giuliano AE, Cabot MC. Expression of glucosyl-ceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells. J Biol Chem 1999;274:1140-6.
18. Liu YY, Han TY, Giuliano AE, Hansen N, Cabot MC. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance. J Biol Chem 2000;275:7138-43.
19. Kok JW, Veldman RJ, Klappe K, Koning H, Filipeanu CM, Muller M. Differential expression of sphingolipids in MRPI overexpressing HT29 cells. Int J Cancer 2000;87:172-8.
20. Kok JW, Hoekstra D. Fluorescent lipid analogues: Applications in cell and membrane biology. In: Mason WT. Fluorescent and luminescent probes for biological activity. London: Academic Press, 1999:136-55.
21. Carmichael J, Degraff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987;47:936-42.
22. Van de Kolk DM, De Vries EGE, Konings JA, Van den Berg E, Muller M, Vellenga E. Activity and expression of the multidrug resistance proteins MRP1 and MRP2 in acute myeloid leukemia cells, and normal hematopoietic CD34+ peripheral blood cells. Clin Canc Res 1998;4:1727-36.
23. Lisanti MP, Tang Z, Scherer PE, Sargiacomo M. Caveolae purification and glycosylphosphatidylinositol-linked protein sorting in polarized epithelia. Methods Enzymol 1995;250:655-68.
24. Babia T, Veldman RJ, Hoekstra D, Kok JW. Modulation of carcino-embryonic antigen release by glucosylceramide. Implications for HT29 cell differentiation. Eur J Biochem 1998;258:233-42.
25. Bligh EJ, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-7.
26. Veldman RJ, Klappe K, Hoekstra D, Kok, JW. Metabolism and apoptotic properties of elevated ceramide in HT29rev cells. Biochem J 1998;331:563-9.
27. Böttcher CJF, Van Gent CM, Pries C. A rapid and sensitive submicro phosphorus determination. Anal Chim Acta 1961;24:203-4.
28. Preiss J, Loomis CR, Bishop WR, Stein R, Niedel JE, Bell RM. Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J Biol Chem 1986;261:8597-600.
29. Le Bivic A, Quaroni A, Nichols B, Rodriquez-Boulan E. Biogenetic pathways of plasma membrane proteins in Caco-2, a human intestinal epithelial cell line. J Cell Biol 1990;111:1351-61.
30. Marks DL, Wu KW, Paul P, Kamisaka Y, Watanabe R, Pagano RE. Olgomerization and topology of the Golgi membrane protein glucosylceramide synthase. J Biol Chem 1999;274:451-6.
31. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
32. Towbin H, Staehalin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4.
33. Roelofsen H, Vos TA, Schippers IJ, Kuipers F, Koning H, Moshage H, Jansen PLM, Muller M. Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells. Gastroenterology 1997;112:511-21.
34. Veldman RJ, Klappe K, Hinrichs J, Hummel I, Van der Schaaf G, Sietsma H, Kok JW. Altered sphingolipid metabolism in multidrug resistant ovarian cancer cells is due to uncoupling of glycolipid biosynthesis in the Golgi apparatus. FASEB J 2002;10.1096/fj.01-0863com.
35. Hinrichs JWJ, Klappe K, Hummel I, Kok, JW. ABC transporters are enriched in non-caveolar DIGs in human multidrug resistant cancer cells. J Biol Chem, in press.
36. Malisan F, Testi R. GD3 ganglioside and apoptosis. Biochim Biophys Acta 2002;1585:179-87.
37. Dijkhuis A-J, Douwes J, Kamps W, Sietsma H, Kok JW. Differential expression of sphingolipids in P-glycoprotein or multidrug resistance-related protein 1 expressing human neuroblastoma cell lines. FEBS Lett 2003;548:28-32.