Docosahexaenoic acid activates some SREBP-2 targets Independent of cholesterol and ER stress in SW620 colon cancer cells

Lipids

Volumn 44, Issue 8, 2009, Pages 673-683

  Størvold, Gro Leite ^a   Fleten, Karianne Giller ^a   Olsen, Cathrine Goberg ^a   Follestad, Turid ^a   Krokan, Hans Einar ^a   Schønberg, Svanhild Arentz ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Cholesterol biosynthesis; EIF2 ; ER stress; SREBP 2; Transcriptional regulation

Indexed keywords

DOCOSAHEXAENOIC ACID; INITIATION FACTOR 2ALPHA; OLEIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; THAPSIGARGIN;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CHOLESTEROL SYNTHESIS; COLON CANCER; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN PHOSPHORYLATION;

ADENOCARCINOMA; CELL CYCLE; CELL LINE, TUMOR; CHOLESTEROL; COLONIC NEOPLASMS; DOCOSAHEXAENOIC ACIDS; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; OLEIC ACID; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STRESS, PHYSIOLOGICAL;

EID: 68349106921     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-009-3324-4     Document Type: Article

References (53)

1. MS Brown JL Goldstein 1997 The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 89 331 340
2. I Shimomura H Shimano JD Horton JL Goldstein MS Brown 1997 Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells J Clin Invest 99 838 845
3. JD Horton JL Goldstein MS Brown 2002 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 1125 1131
4. JT Pai O Guryev MS Brown JL Goldstein 1998 Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins J Biol Chem 273 26138 26148
5. MS Brown JL Goldstein 1999 A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood Proc Natl Acad Sci USA 96 11041 11048
6. X Hua A Nohturfft JL Goldstein MS Brown 1996 Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein Cell 87 415 426
7. JL Goldstein RA Bose-Boyd MS Brown 2006 Protein sensors for membrane sterols Cell 124 35 46
8. LP Sun L Li JL Goldstein MS Brown 2005 Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro J Biol Chem 280 26483 26490
9. H Shimano 2001 Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes Prog Lipid Res 40 439 452
10. M Amemiya-Kudo H Shimano AH Hasty N Yahagi T Yoshikawa T Matsuzaka H Okazaki Y Tamura Y Iizuka K Ohashi J Osuga K Harada T Gotoda R Sato S Kimura S Ishibashi N Yamada 2002 Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes J Lipid Res 43 1220 1235
11. MT Bengoechea-Alonso J Ericsson 2007 SREBP in signal transduction: cholesterol metabolism and beyond Curr Opin Cell Biol 19 215 222
12. VC Hannah J Ou A Luong JL Goldstein MS Brown 2001 Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells J Biol Chem 276 4365 4372
13. DP Thewke SR Panini M Sinensky 1998 Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins J Biol Chem 273 21402 21407
14. TS Worgall SL Sturley T Seo TF Osborne RJ Deckelbaum 1998 Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein J Biol Chem 273 25537 25540
15. N Yahagi H Shimano AH Hasty M Amemiya-Kudo H Okazaki Y Tamura Y Iizuka F Shionoiri K Ohashi J Osuga K Harada T Gotoda R Nagai S Ishibashi N Yamada 1999 A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids J Biol Chem 274 35840 35844
16. J Xu MT Nakamura HP Cho SD Clarke 1999 Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats J Biol Chem 274 23577 23583
17. J Ou H Tu B Shan A Luk RA Bose-Boyd Y Bashmakov JL Goldstein MS Brown 2001 Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR Proc Natl Acad Sci USA 98 6027 6032
18. FJ Field E Born S Murthy SN Mathur 2002 Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport Biochem J 368 855 864
19. HJ Kim M Takahashi O Ezaki 1999 Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs J Biol Chem 274 25892 25898
20. C Le Jossic-Corcos C Gonthier I Zaghini E Logette I Shechter P Bournot 2005 Hepatic farnesyl diphosphate synthase expression is suppressed by polyunsaturated fatty acids Biochem J 385 787 794
21. JN Lee J Ye 2004 Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1 J Biol Chem 279 45257 45265
22. SM Colgan D Tang GH Werstuck RC Austin 2007 Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2 Int J Biochem Cell Biol 39 1843 1851
23. GH Werstuck SR Lentz S Dayal GS Hossain SK Sood YY Shi J Zhou N Maeda SK Krisans MR Malinow RC Austin 2001 Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways J Clin Invest 107 1263 1273
24. X Wang NG Zelenski J Yang J Sakai MS Brown JL Goldstein 1996 Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis EMBO J 15 1012 1020
25. M Schroder RJ Kaufman 2005 ER stress and the unfolded protein response Mutat Res 569 29 63
26. JW Brewer LM Hendershot CJ Sherr JA Diehl 1999 Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression Proc Natl Acad Sci USA 96 8505 8510
27. SA Schonberg AG Lundemo T Fladvad K Holmgren H Bremseth A Nilsen O Gederaas KE Tvedt KW Egeberg HE Krokan 2006 Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1 FEBS J 273 2749 2765
28. CH Jakobsen GL Storvold H Bremseth T Follestad K Sand M Mack KS Olsen AG Lundemo JG Iversen HE Krokan SM Schonberg 2008 DHA induces ER stress and growth arrest in human colon cancer cells-associations with cholesterol and calcium homeostasis J Lipid Res 49 2089 2100
29. RA Irizarry BM Bolstad F Collin LM Cope B Hobbs TP Speed 2003 Summaries of Affymetrix GeneChip probe level data Nucleic Acids Res 31 e15
30. BM Bolstad RA Irizarry M Astrand TP Speed 2003 A comparison of normalization methods for high density oligonucleotide array data based on variance and bias Bioinformatics 19 185 193
31. Smyth GK (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: Article 3
32. Y Benjamini Y Hochberg 1995 Controlling the false discovery rate - practical and powerful approach to multiple testing J Royal Statistical Soc 57 289 300
33. RC Gentleman VJ Carey DM Bates B Bolstad M Dettling S Dudoit B Ellis L Gautier Y Ge J Gentry K Hornik T Hothorn W Huber S Iacus R Irizarry F Leisch C Li M Maechler AJ Rossini G Sawitzki C Smith G Smyth L Tierney JY Yang J Zhang 2004 Bioconductor: open software development for computational biology and bioinformatics Genome Biol 5 R80
34. Robichon C, Varret M, Le L, X, Lasnier F, Hajduch E, Ferre P, Dugail I (2006) DnaJA4 is a SREBP-regulated chaperone involved in the cholesterol biosynthesis pathway. Biochim Biophys Acta 1761:1107-1113
35. HP Harding Y Zhang S Khersonsky S Marciniak D Scheuner RJ Kaufman N Javitt YT Chang D Ron 2005 Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression Cell Metab 2 361 371
36. JD Horton NA Shah JA Warrington NN Anderson SW Park MS Brown JL Goldstein 2003 Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes Proc Natl Acad Sci USA 100 12027 12032
37. Y Sakakura H Shimano H Sone A Takahashi N Inoue H Toyoshima S Suzuki N Yamada 2001 Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis Biochem Biophys Res Commun 286 176 183
38. L Liscum RM Ruggiero JR Faust 1989 The intracellular transport of low density lipoprotein-derived cholesterol is defective in Niemann-Pick type C fibroblasts J Cell Biol 108 1625 1636
39. J Martinez-Botas Y Suarez AJ Ferruelo D Gomez-Coronado MA Lasuncion 1999 Cholesterol starvation decreases p34(cdc2) kinase activity and arrests the cell cycle at G2 FASEB J 13 1359 1370
40. L Zeng M Lu K Mori S Luo AS Lee Y Zhu JY Shyy 2004 ATF6 modulates SREBP2-mediated lipogenesis EMBO J 23 950 958
41. S Gill R Chow AJ Brown 2008 Sterol regulators of cholesterol homeostasis and beyond: the oxysterol hypothesis revisited and revised Prog Lipid Res 47 391 404
42. JE Metherall K Waugh H Li 1996 Progesterone inhibits cholesterol biosynthesis in cultured cells. Accumulation of cholesterol precursors J Biol Chem 271 2627 2633
43. A Sundqvist MT Bengoechea-Alonso X Ye V Lukiyanchuk J Jin JW Harper J Ericsson 2005 Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7) Cell Metab 1 379 391
44. R Raghow C Yellaturu X Deng EA Park MB Elam 2008 SREBPs: the crossroads of physiological and pathological lipid homeostasis Trends Endocrinol Metab 19 65 73
45. V Giandomenico M Simonsson E Gronroos J Ericsson 2003 Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors Mol Cell Biol 23 2587 2599 (Pubitemid 36351037)
46. M Teran-Garcia C Rufo MT Nakamura TF Osborne SD Clarke 2002 NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription Biochem Biophys Res Commun 290 1295 1299
47. Y Wang PM Rogers C Su G Varga KR Stayrook TP Burris 2008 Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha J Biol Chem 283 26332 26339
48. JM Dietschy SD Turley DK Spady 1993 Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans J Lipid Res 34 1637 1659
49. KN Rao 1995 The significance of the cholesterol biosynthetic pathway in cell growth and carcinogenesis (review) Anticancer Res 15 309 314
50. E Sugiyama Y Ishikawa Y Li T Kagai M Nobayashi N Tanaka Y Kamijo S Yokoyama A Hara T Aoyama 2008 Eicosapentaenoic acid lowers plasma and liver cholesterol levels in the presence of peroxisome proliferators-activated receptor alpha Life Sci 83 19 28
51. F Natali L Siculella S Salvati GV Gnoni 2007 Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells J Lipid Res 48 1966 1975
52. K Brusselmans L Timmermans ST Van de PP Van Veldhoven G Guan I Shechter F Claessens G Verhoeven JV Swinnen 2007 Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation J Biol Chem 282 18777 18785
53. R Kaneko N Tsuji K Asanuma H Tanabe D Kobayashi N Watanabe 2007 Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer J Biol Chem 282 19273 19281