Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway

British Journal of Nutrition

Volumn 109, Issue 7, 2013, Pages 1188-1195

  Granci, Virginie ^a   Cai, Fang ^a   Lecumberri, Elena ^a   Clerc, Aurélie ^a   Dupertuis, Yves M ^a   Pichard, Claude ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

5 Fluorouracil; Apoptosis; Colorectal cancer; Fish oil; Irinotecan; Oxaliplatin

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; DOCOSAHEXAENOIC ACID; FISH OIL; FLUORESCENT DYE; FLUOROURACIL; ICOSAPENTAENOIC ACID; IRINOTECAN; LIPOCORTIN 5; LIPOVENOES; OMEGA 3 FATTY ACID; OMEGAVEN; OXALIPLATIN; PROTEIN BAX; SOYBEAN OIL EMULSION;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CELL KILLING; CELL VIABILITY; CHEMOSENSITIZATION; COLORECTAL CARCINOMA; COLORIMETRY; CONTROLLED STUDY; DRUG POTENTIATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CAMPTOTHECIN; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; DIETARY SUPPLEMENTS; DRUG RESISTANCE, NEOPLASM; EMULSIONS; FATTY ACIDS, OMEGA-3; FISH OILS; FLUOROURACIL; FOOD-DRUG INTERACTIONS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; ORGANOPLATINUM COMPOUNDS;

EID: 84876124576     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S000711451200308X     Document Type: Article

References (35)

1. Jemal A, Center MM, DeSantis C, et al. (2010) Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 19, 1893-1907.
2. Goldberg RM, Sargent DJ, Morton RF, et al. (2004) A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22, 23-30.
3. Tournigand C, Andre T, Achille E, et al. (2004) FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 22, 229-237.
4. Andre N and Schmiegel W (2005) Chemoradiotherapy for colorectal cancer. Gut 54, 1194-1202.
5. Van Cutsem E, Nordlinger B, Adam R, et al. (2006) Towards a pan-European consensus on the treatment of patients with colorectal liver metastases. Eur J Cancer 42, 2212-2221.
6. Ramos S (2007) Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention. J Nutr Biochem 18, 427-442.
7. Ban JO, Yuk DY, Woo KS, et al. (2007) Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells. J Pharmacol Sci 104, 374-383.
8. Campbell SE, Stone WL, Lee S, et al. (2006) Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines. BMC Cancer 6, 13.
9. Carnesecchi S, Langley K, Exinger F, et al. (2002) Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-fluorouracil treatment. J Pharmacol Exp Ther 301, 625-630.
10. Huang HP, Shih YW, Chang YC, et al. (2008) Chemoinhibitory effect of mulberry anthocyanins on melanoma metastasis involved in the Ras/PI3K pathway. J Agric Food Chem 56, 9286-9293.
11. Kunnumakkara AB, Diagaradjane P, Guha S, et al. (2008) Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factorkappaB- regulated gene products. Clin Cancer Res 14, 2128-2136.
12. Lin Y, Shi R, Wang X, et al. (2008) Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets 8, 634-646.
13. Geelen A, Schouten JM, Kamphuis C, et al. (2007) Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies. Am J Epidemiol 166, 1116-1125.
14. Dupertuis YM, Meguid MM and Pichard C (2007) Colon cancer therapy: new perspectives of nutritional manipulations using polyunsaturated fatty acids. Curr Opin Clin Nutr Metab Care 10, 427-432.
15. Dupertuis YM, Benais-Pont G, Buchegger F, et al. (2007) Effect of an immunonutrient mix on human colorectal adenocarcinoma cell growth and viability. Nutrition 23, 672-680.
16. Kang KS, Wang P, Yamabe N, et al. (2010) Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation. PLoS One 5, e10296.
17. Wu M, Harvey KA, Ruzmetov N, et al. (2005) Omega-3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase-mediated pathway. Int J Cancer 117, 340-348.
18. Bathen TF, Holmgren K, Lundemo AG, et al. (2008) Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice. Anticancer Res 28, 3717-3723.
19. Benais-Pont G, Dupertuis YM, Kossovsky MP, et al. (2006) Omega-3 polyunsaturated fatty acids and ionizing radiation: combined cytotoxicity on human colorectal adenocarcinoma cells. Nutrition 22, 931-939.
20. Shaikh IA, Brown I, Schofield AC, et al. (2008) Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway. Prostate 68, 1635-1646.
21. Vaculova A, Hofmanova J, Andera L, et al. (2005) TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. Cancer Lett 229, 43-48.
22. Calviello G, Di Nicuolo F, Serini S, et al. (2005) Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. Cancer Chemother Pharmacol 55, 12-20.
23. Zhuo Z, Zhang L, Mu Q, et al. (2009) The effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells. In vitro Cell Dev Biol Anim 45, 69-74.
24. Xue H, Sawyer MB, Field CJ, et al. (2007) Nutritional modulation of antitumor efficacy and diarrhea toxicity related to irinotecan chemotherapy in rats bearing the ward colon tumor. Clin Cancer Res 13, 7146-7154.
25. Cockbain AJ, Toogood GJ and Hull MA (2012) Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer. Gut 61, 135-149.
26. Hajjaji N, Besson P and Bougnoux P (2012) Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats. Cancer Chemother Pharmacol 70, 17-23.
27. Campbell SE, Rudder B, Phillips RB, et al. (2011) g-Tocotrienol induces growth arrest through a novel pathway with TGFbeta2 in prostate cancer. Free Rad Biol Med 50, 1344-1354.
28. Violette S, Poulain L, Dussaulx E, et al. (2002) Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 status. Int J Cancer 98, 498-504.
29. Nehls O, Okech T, Hsieh CJ, et al. (2007) Studies on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of proapoptotic BAX. Br J Cancer 96, 1409-1418.
30. Wang S and El-Deiry WS (2003) Requirement of p53 targets in chemosensitization of colonic carcinoma to death ligand therapy. Proc Natl Acad Sci U S A 100, 15095-15100.
31. Gourdier I, Crabbe L, Andreau K, et al. (2004) Oxaliplatininduced mitochondrial apoptotic response of colon carcinoma cells does not require nuclear DNA. Oncogene 23, 7449-7457.
32. Kroemer G (2003) The mitochondrial permeability transition pore complex as a pharmacological target. An introduction. Curr Med Chem 10, 1469-1472.
33. Ng Y, Barhoumi R, Tjalkens RB, et al. (2005) The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. Carcinogenesis 26, 1914-1921.
34. Bougnoux P, Chajes V, Germain E, et al. (1999) Cytotoxic drug efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. Lipids 34, S109.
35. Murphy RA, Mourtzakis M, Chu QS, et al. (2011) Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer 117, 3774-3780.