메뉴 건너뛰기




Volumn 26, Issue , 2014, Pages 71-78

Microbial production of antioxidant food ingredients via metabolic engineering

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; ESCHERICHIA COLI; FOOD ADDITIVES; FOOD MICROBIOLOGY; METABOLISM; METABOLITES;

EID: 84887242219     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2013.10.004     Document Type: Review
Times cited : (79)

References (64)
  • 1
    • 79952442409 scopus 로고    scopus 로고
    • Free radicals and antioxidants - quo vadis?
    • Halliwell B. Free radicals and antioxidants - quo vadis?. Trends Pharmacol Sci 2011, 32:125-130.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 125-130
    • Halliwell, B.1
  • 2
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A 1993, 90:7915-7922.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 4
    • 84858069261 scopus 로고    scopus 로고
    • Antioxidant activity of food constituents: an overview
    • Gulcin I. Antioxidant activity of food constituents: an overview. Arch Toxicol 2012, 86:345-391.
    • (2012) Arch Toxicol , vol.86 , pp. 345-391
    • Gulcin, I.1
  • 6
    • 1642576078 scopus 로고    scopus 로고
    • Reconstitution of the entry point of plant phenylpropanoid metabolism in yeast (Saccharomyces cerevisiae): implications for control of metabolic flux into the phenylpropanoid pathway
    • Ro D.K., Douglas C.J. Reconstitution of the entry point of plant phenylpropanoid metabolism in yeast (Saccharomyces cerevisiae): implications for control of metabolic flux into the phenylpropanoid pathway. J Biol Chem 2004, 279:2600-2607.
    • (2004) J Biol Chem , vol.279 , pp. 2600-2607
    • Ro, D.K.1    Douglas, C.J.2
  • 7
    • 33847252518 scopus 로고    scopus 로고
    • Production of p-hydroxycinnamic acid from glucose in Saccharomyces cerevisiae and Escherichia coli by expression of heterologous genes from plants and fungi
    • Vannelli T., Wei Qi W., Sweigard J., Gatenby A.A., Sariaslani F.S. Production of p-hydroxycinnamic acid from glucose in Saccharomyces cerevisiae and Escherichia coli by expression of heterologous genes from plants and fungi. Metab Eng 2007, 9:142-151.
    • (2007) Metab Eng , vol.9 , pp. 142-151
    • Vannelli, T.1    Wei Qi, W.2    Sweigard, J.3    Gatenby, A.A.4    Sariaslani, F.S.5
  • 8
    • 84870293949 scopus 로고    scopus 로고
    • Artificial biosynthesis of phenylpropanoic acids in a tyrosine overproducing Escherichia coli strain
    • Kang S.Y., Choi O., Lee J.K., Hwang B.Y., Uhm T.B., Hong Y.S. Artificial biosynthesis of phenylpropanoic acids in a tyrosine overproducing Escherichia coli strain. Microb Cell Fact 2012, 11:153.
    • (2012) Microb Cell Fact , vol.11 , pp. 153
    • Kang, S.Y.1    Choi, O.2    Lee, J.K.3    Hwang, B.Y.4    Uhm, T.B.5    Hong, Y.S.6
  • 9
    • 81055140628 scopus 로고    scopus 로고
    • Biosynthesis of plant-specific phenylpropanoids by construction of an artificial biosynthetic pathway in Escherichia coli
    • Choi O., Wu C.Z., Kang S.Y., Ahn J.S., Uhm T.B., Hong Y.S. Biosynthesis of plant-specific phenylpropanoids by construction of an artificial biosynthetic pathway in Escherichia coli. J Ind Microbiol Biotechnol 2011, 38:1657-1665.
    • (2011) J Ind Microbiol Biotechnol , vol.38 , pp. 1657-1665
    • Choi, O.1    Wu, C.Z.2    Kang, S.Y.3    Ahn, J.S.4    Uhm, T.B.5    Hong, Y.S.6
  • 10
    • 33645235844 scopus 로고    scopus 로고
    • Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis
    • Berner M., Krug D., Bihlmaier C., Vente A., Muller R., Bechthold A. Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol 2006, 188:2666-2673.
    • (2006) J Bacteriol , vol.188 , pp. 2666-2673
    • Berner, M.1    Krug, D.2    Bihlmaier, C.3    Vente, A.4    Muller, R.5    Bechthold, A.6
  • 11
    • 84938746622 scopus 로고    scopus 로고
    • Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex
    • Lin Y., Yan Y. Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex. Microb Cell Fact 2012, 11:42.
    • (2012) Microb Cell Fact , vol.11 , pp. 42
    • Lin, Y.1    Yan, Y.2
  • 12
    • 84895567367 scopus 로고    scopus 로고
    • Catalytic activity of the two-component flavin-dependent monooxygenase from Pseudomonas aeruginosa toward cinnamic acid derivatives
    • Furuya T., Kino K. Catalytic activity of the two-component flavin-dependent monooxygenase from Pseudomonas aeruginosa toward cinnamic acid derivatives. Appl Microbiol Biotechnol 2013, 10.1007/s00253-013-4958-y.
    • (2013) Appl Microbiol Biotechnol
    • Furuya, T.1    Kino, K.2
  • 13
    • 84886239741 scopus 로고    scopus 로고
    • Caffeic acid production enhancement by engineering a phenylalanine over-producing Escherichia coli
    • Huang Q., Lin Y., Yan Y. Caffeic acid production enhancement by engineering a phenylalanine over-producing Escherichia coli. Biotechnol Bioeng 2013, 10.1002/bit.24988.
    • (2013) Biotechnol Bioeng
    • Huang, Q.1    Lin, Y.2    Yan, Y.3
  • 14
    • 84876676603 scopus 로고    scopus 로고
    • Engineering E. coli for caffeic acid biosynthesis from renewable sugars
    • Zhang H., Stephanopoulos G. Engineering E. coli for caffeic acid biosynthesis from renewable sugars. Appl Microbiol Biotechnol 2013, 97:3333-3341.
    • (2013) Appl Microbiol Biotechnol , vol.97 , pp. 3333-3341
    • Zhang, H.1    Stephanopoulos, G.2
  • 15
    • 84873254986 scopus 로고    scopus 로고
    • Production of hydroxycinnamoyl-shikimates and chlorogenic acid in Escherichia coli: production of hydroxycinnamic acid conjugates
    • Kim B.G., Jung W.D., Mok H., Ahn J.H. Production of hydroxycinnamoyl-shikimates and chlorogenic acid in Escherichia coli: production of hydroxycinnamic acid conjugates. Microb Cell Fact 2013, 12:15.
    • (2013) Microb Cell Fact , vol.12 , pp. 15
    • Kim, B.G.1    Jung, W.D.2    Mok, H.3    Ahn, J.H.4
  • 16
    • 0037545559 scopus 로고    scopus 로고
    • Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster
    • Hwang E.I., Kaneko M., Ohnishi Y., Horinouchi S. Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster. Appl Environ Microbiol 2003, 69:2699-2706.
    • (2003) Appl Environ Microbiol , vol.69 , pp. 2699-2706
    • Hwang, E.I.1    Kaneko, M.2    Ohnishi, Y.3    Horinouchi, S.4
  • 17
    • 20444422841 scopus 로고    scopus 로고
    • Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae
    • Jiang H., Wood K.V., Morgan J.A. Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae. Appl Environ Microbiol 2005, 71:2962-2969.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 2962-2969
    • Jiang, H.1    Wood, K.V.2    Morgan, J.A.3
  • 18
    • 25144431998 scopus 로고    scopus 로고
    • Biosynthesis of natural flavanones in Saccharomyces cerevisiae
    • Yan Y., Kohli A., Koffas M.A. Biosynthesis of natural flavanones in Saccharomyces cerevisiae. Appl Environ Microbiol 2005, 71:5610-5613.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 5610-5613
    • Yan, Y.1    Kohli, A.2    Koffas, M.A.3
  • 20
    • 34250849659 scopus 로고    scopus 로고
    • Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli
    • Leonard E., Lim K.H., Saw P.N., Koffas M.A. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. Appl Environ Microbiol 2007, 73:3877-3886.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 3877-3886
    • Leonard, E.1    Lim, K.H.2    Saw, P.N.3    Koffas, M.A.4
  • 21
    • 42549160614 scopus 로고    scopus 로고
    • Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids
    • Leonard E., Yan Y., Fowler Z.L., Li Z., Lim C.G., Lim K.H., Koffas M.A. Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids. Mol Pharm 2008, 5:257-265.
    • (2008) Mol Pharm , vol.5 , pp. 257-265
    • Leonard, E.1    Yan, Y.2    Fowler, Z.L.3    Li, Z.4    Lim, C.G.5    Lim, K.H.6    Koffas, M.A.7
  • 22
    • 80052021573 scopus 로고    scopus 로고
    • Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA
    • Xu P., Ranganathan S., Fowler Z.L., Maranas C.D., Koffas M.A. Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. Metab Eng 2011, 13:578-587.
    • (2011) Metab Eng , vol.13 , pp. 578-587
    • Xu, P.1    Ranganathan, S.2    Fowler, Z.L.3    Maranas, C.D.4    Koffas, M.A.5
  • 23
    • 79958715193 scopus 로고    scopus 로고
    • Optimization of a heterologous pathway for the production of flavonoids from glucose
    • Santos C.N., Koffas M., Stephanopoulos G. Optimization of a heterologous pathway for the production of flavonoids from glucose. Metab Eng 2011, 13:392-400.
    • (2011) Metab Eng , vol.13 , pp. 392-400
    • Santos, C.N.1    Koffas, M.2    Stephanopoulos, G.3
  • 24
    • 84872221971 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy
    • Wu J., Du G., Zhou J., Chen J. Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy. Metab Eng 2013, 16:48-55.
    • (2013) Metab Eng , vol.16 , pp. 48-55
    • Wu, J.1    Du, G.2    Zhou, J.3    Chen, J.4
  • 26
    • 35748974224 scopus 로고    scopus 로고
    • Biosynthesis of 5-deoxyflavanones in microorganisms
    • Yan Y., Huang L., Koffas M.A. Biosynthesis of 5-deoxyflavanones in microorganisms. Biotechnol J 2007, 2:1250-1262.
    • (2007) Biotechnol J , vol.2 , pp. 1250-1262
    • Yan, Y.1    Huang, L.2    Koffas, M.A.3
  • 28
    • 29144455444 scopus 로고    scopus 로고
    • Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae
    • Leonard E., Yan Y., Lim K.H., Koffas M.A. Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae. Appl Environ Microbiol 2005, 71:8241-8248.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 8241-8248
    • Leonard, E.1    Yan, Y.2    Lim, K.H.3    Koffas, M.A.4
  • 29
    • 36649037393 scopus 로고    scopus 로고
    • Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli
    • Leonard E., Koffas M.A. Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli. Appl Environ Microbiol 2007, 73:7246-7251.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 7246-7251
    • Leonard, E.1    Koffas, M.A.2
  • 30
    • 36348979910 scopus 로고    scopus 로고
    • Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion
    • Chemler J.A., Lock L.T., Koffas M.A., Tzanakakis E.S. Standardized biosynthesis of flavan-3-ols with effects on pancreatic beta-cell insulin secretion. Appl Microbiol Biotechnol 2007, 77:797-807.
    • (2007) Appl Microbiol Biotechnol , vol.77 , pp. 797-807
    • Chemler, J.A.1    Lock, L.T.2    Koffas, M.A.3    Tzanakakis, E.S.4
  • 31
  • 32
    • 42549160385 scopus 로고    scopus 로고
    • High-yield anthocyanin biosynthesis in engineered Escherichia coli
    • Yan Y., Li Z., Koffas M.A. High-yield anthocyanin biosynthesis in engineered Escherichia coli. Biotechnol Bioeng 2008, 100:126-140.
    • (2008) Biotechnol Bioeng , vol.100 , pp. 126-140
    • Yan, Y.1    Li, Z.2    Koffas, M.A.3
  • 33
    • 4644270018 scopus 로고    scopus 로고
    • An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases
    • Austin M.B., Bowman M.E., Ferrer J.L., Schroder J., Noel J.P. An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. Chem Biol 2004, 11:1179-1194.
    • (2004) Chem Biol , vol.11 , pp. 1179-1194
    • Austin, M.B.1    Bowman, M.E.2    Ferrer, J.L.3    Schroder, J.4    Noel, J.P.5
  • 36
    • 77952268311 scopus 로고    scopus 로고
    • Considerable increase in resveratrol production by recombinant industrial yeast strains with use of rich medium
    • Sydor T., Schaffer S., Boles E. Considerable increase in resveratrol production by recombinant industrial yeast strains with use of rich medium. Appl Environ Microbiol 2010, 76:3361-3363.
    • (2010) Appl Environ Microbiol , vol.76 , pp. 3361-3363
    • Sydor, T.1    Schaffer, S.2    Boles, E.3
  • 38
    • 33645779318 scopus 로고    scopus 로고
    • Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli
    • Watts K.T., Lee P.C., Schmidt-Dannert C. Biosynthesis of plant-specific stilbene polyketides in metabolically engineered Escherichia coli. BMC Biotechnol 2006, 6:22.
    • (2006) BMC Biotechnol , vol.6 , pp. 22
    • Watts, K.T.1    Lee, P.C.2    Schmidt-Dannert, C.3
  • 39
    • 53449086128 scopus 로고    scopus 로고
    • Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway
    • Katsuyama Y., Matsuzawa M., Funa N., Horinouchi S. Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway. Microbiology 2008, 154:2620-2628.
    • (2008) Microbiology , vol.154 , pp. 2620-2628
    • Katsuyama, Y.1    Matsuzawa, M.2    Funa, N.3    Horinouchi, S.4
  • 40
    • 84878364563 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of plant-specific coumarins in bacteria
    • Lin Y., Sun X., Yuan Q., Yan Y. Combinatorial biosynthesis of plant-specific coumarins in bacteria. Metab Eng 2013, 18:69-77.
    • (2013) Metab Eng , vol.18 , pp. 69-77
    • Lin, Y.1    Sun, X.2    Yuan, Q.3    Yan, Y.4
  • 41
    • 0025630190 scopus 로고
    • Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli
    • Misawa N., Nakagawa M., Kobayashi K., Yamano S., Izawa Y., Nakamura K., Harashima K. Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli. J Bacteriol 1990, 172:6704-6712.
    • (1990) J Bacteriol , vol.172 , pp. 6704-6712
    • Misawa, N.1    Nakagawa, M.2    Kobayashi, K.3    Yamano, S.4    Izawa, Y.5    Nakamura, K.6    Harashima, K.7
  • 42
    • 0028817748 scopus 로고
    • Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level
    • Misawa N., Satomi Y., Kondo K., Yokoyama A., Kajiwara S., Saito T., Ohtani T., Miki W. Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level. J Bacteriol 1995, 177:6575-6584.
    • (1995) J Bacteriol , vol.177 , pp. 6575-6584
    • Misawa, N.1    Satomi, Y.2    Kondo, K.3    Yokoyama, A.4    Kajiwara, S.5    Saito, T.6    Ohtani, T.7    Miki, W.8
  • 43
    • 0030970352 scopus 로고    scopus 로고
    • Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli
    • Kajiwara S., Fraser P.D., Kondo K., Misawa N. Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli. Biochem J 1997, 324(Pt 2):421-426.
    • (1997) Biochem J , vol.324 , Issue.PART 2 , pp. 421-426
    • Kajiwara, S.1    Fraser, P.D.2    Kondo, K.3    Misawa, N.4
  • 44
    • 0035916370 scopus 로고    scopus 로고
    • Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production
    • Kim S.W., Keasling J.D. Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production. Biotechnol Bioeng 2001, 72:408-415.
    • (2001) Biotechnol Bioeng , vol.72 , pp. 408-415
    • Kim, S.W.1    Keasling, J.D.2
  • 45
    • 62849084758 scopus 로고    scopus 로고
    • Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli
    • Yoon S.H., Lee S.H., Das A., Ryu H.K., Jang H.J., Kim J.Y., Oh D.K., Keasling J.D., Kim S.W. Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli. J Biotechnol 2009, 140:218-226.
    • (2009) J Biotechnol , vol.140 , pp. 218-226
    • Yoon, S.H.1    Lee, S.H.2    Das, A.3    Ryu, H.K.4    Jang, H.J.5    Kim, J.Y.6    Oh, D.K.7    Keasling, J.D.8    Kim, S.W.9
  • 46
    • 0035128694 scopus 로고    scopus 로고
    • Precursor balancing for metabolic engineering of lycopene production in Escherichia coli
    • Farmer W.R., Liao J.C. Precursor balancing for metabolic engineering of lycopene production in Escherichia coli. Biotechnol Prog 2001, 17:57-61.
    • (2001) Biotechnol Prog , vol.17 , pp. 57-61
    • Farmer, W.R.1    Liao, J.C.2
  • 47
    • 0034024497 scopus 로고    scopus 로고
    • Improving lycopene production in Escherichia coli by engineering metabolic control
    • Farmer W.R., Liao J.C. Improving lycopene production in Escherichia coli by engineering metabolic control. Nat Biotechnol 2000, 18:533-537.
    • (2000) Nat Biotechnol , vol.18 , pp. 533-537
    • Farmer, W.R.1    Liao, J.C.2
  • 48
    • 22844452835 scopus 로고    scopus 로고
    • Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets
    • Alper H., Miyaoku K., Stephanopoulos G. Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets. Nat Biotechnol 2005, 23:612-616.
    • (2005) Nat Biotechnol , vol.23 , pp. 612-616
    • Alper, H.1    Miyaoku, K.2    Stephanopoulos, G.3
  • 50
    • 34547109364 scopus 로고    scopus 로고
    • Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli
    • Jin Y.S., Stephanopoulos G. Multi-dimensional gene target search for improving lycopene biosynthesis in Escherichia coli. Metab Eng 2007, 9:337-347.
    • (2007) Metab Eng , vol.9 , pp. 337-347
    • Jin, Y.S.1    Stephanopoulos, G.2
  • 51
  • 52
    • 79954741746 scopus 로고    scopus 로고
    • Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli
    • Kim Y.S., Lee J.H., Kim N.H., Yeom S.J., Kim S.W., Oh D.K. Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. Appl Microbiol Biotechnol 2011, 90:489-497.
    • (2011) Appl Microbiol Biotechnol , vol.90 , pp. 489-497
    • Kim, Y.S.1    Lee, J.H.2    Kim, N.H.3    Yeom, S.J.4    Kim, S.W.5    Oh, D.K.6
  • 53
    • 84872811004 scopus 로고    scopus 로고
    • Increase in the production of beta-carotene in recombinant Escherichia coli cultured in a chemically defined medium supplemented with amino acids
    • Nam H.K., Choi J.G., Lee J.H., Kim S.W., Oh D.K. Increase in the production of beta-carotene in recombinant Escherichia coli cultured in a chemically defined medium supplemented with amino acids. Biotechnol Lett 2013, 35:265-271.
    • (2013) Biotechnol Lett , vol.35 , pp. 265-271
    • Nam, H.K.1    Choi, J.G.2    Lee, J.H.3    Kim, S.W.4    Oh, D.K.5
  • 54
    • 84864383168 scopus 로고    scopus 로고
    • Pathway engineering strategies for production of beneficial carotenoids in microbial hosts
    • Ye V.M., Bhatia S.K. Pathway engineering strategies for production of beneficial carotenoids in microbial hosts. Biotechnol Lett 2012, 34:1405-1414.
    • (2012) Biotechnol Lett , vol.34 , pp. 1405-1414
    • Ye, V.M.1    Bhatia, S.K.2
  • 56
    • 33747754525 scopus 로고    scopus 로고
    • Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway
    • Zahiri H.S., Yoon S.H., Keasling J.D., Lee S.H., Won Kim S., Yoon S.C., Shin Y.C. Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway. Metab Eng 2006, 8:406-416.
    • (2006) Metab Eng , vol.8 , pp. 406-416
    • Zahiri, H.S.1    Yoon, S.H.2    Keasling, J.D.3    Lee, S.H.4    Won Kim, S.5    Yoon, S.C.6    Shin, Y.C.7
  • 59
    • 77950899704 scopus 로고    scopus 로고
    • Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine
    • Zhang K., Li H., Cho K.M., Liao J.C. Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine. Proc Natl Acad Sci U S A 2010, 107:6234-6239.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6234-6239
    • Zhang, K.1    Li, H.2    Cho, K.M.3    Liao, J.C.4
  • 61
    • 84877804801 scopus 로고    scopus 로고
    • Modular optimization of mutilple-gene pathways for fatty acids production in E. coli
    • Xu P., Gu Q., Wang W., Wong L., Bower A.G., Collins C.H., Koffas M.A. Modular optimization of mutilple-gene pathways for fatty acids production in E. coli. Nat Commun 2013, 10.1038/ncomms2425.
    • (2013) Nat Commun
    • Xu, P.1    Gu, Q.2    Wang, W.3    Wong, L.4    Bower, A.G.5    Collins, C.H.6    Koffas, M.A.7
  • 62
    • 84873596341 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs
    • Na D., Yoo S.M., Chung H., Park H., Park J.H., Lee S.Y. Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs. Nat Biotechnol 2013, 31:170-174.
    • (2013) Nat Biotechnol , vol.31 , pp. 170-174
    • Na, D.1    Yoo, S.M.2    Chung, H.3    Park, H.4    Park, J.H.5    Lee, S.Y.6
  • 63
    • 84877256074 scopus 로고    scopus 로고
    • Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols
    • Avalos J.L., Fink G.R., Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nat Biotechnol 2013, 31:335-341.
    • (2013) Nat Biotechnol , vol.31 , pp. 335-341
    • Avalos, J.L.1    Fink, G.R.2    Stephanopoulos, G.3
  • 64
    • 77950930053 scopus 로고    scopus 로고
    • A versatile microbial system for biosynthesis of novel polyphenols with altered estrogen receptor binding activity
    • Chemler J.A., Lim C.G., Daiss J.L., Koffas M.A. A versatile microbial system for biosynthesis of novel polyphenols with altered estrogen receptor binding activity. Chem Biol 2010, 17:392-401.
    • (2010) Chem Biol , vol.17 , pp. 392-401
    • Chemler, J.A.1    Lim, C.G.2    Daiss, J.L.3    Koffas, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.