메뉴 건너뛰기




Volumn 34, Issue 8, 2012, Pages 1405-1414

Pathway engineering strategies for production of beneficial carotenoids in microbial hosts

Author keywords

Carotene; Astaxanthin; Carotenoid; Lycopene; Metabolic engineering; Zeaxanthin

Indexed keywords

ASTAXANTHIN; CANTHAXANTHIN; CAROTENOID; CAROTENOID BIOSYNTHESIS; CAROTENOID PRODUCTION; COMPLEX PROCESSES; EXPRESSION LEVELS; HEALTH BENEFITS; HUMAN HEALTH; LYCOPENES; METABOLIC ENGINEERING APPROACH; VITAMIN A; ZEAXANTHIN;

EID: 84864383168     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-012-0921-8     Document Type: Review
Times cited : (78)

References (44)
  • 2
    • 33645917351 scopus 로고    scopus 로고
    • The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of beta-carotene into astaxanthin and other xanthophylls
    • Alvarez V, Rodríguez-Sáiz M, de la Fuente JL, Gudiña EJ, Godio RP, Martín JF, Barredo JL (2006) The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of beta-carotene into astaxanthin and other xanthophylls. Fungal Genet Biol 4: 261-272.
    • (2006) Fungal Genet Biol , vol.4 , pp. 261-272
    • Alvarez, V.1    Rodríguez-Sáiz, M.2    de la Fuente, J.L.3    Gudiña, E.J.4    Godio, R.P.5    Martín, J.F.6    Barredo, J.L.7
  • 3
    • 84862302788 scopus 로고    scopus 로고
    • Construction of new Pichia pastoris X-33 strains for production of lycopene and β-carotene
    • doi:10.1007/s00253-011-3764-7
    • Araya-Garay JM, Feijoo-Siota L, Rosa-Dos-Santos F, Veiga-Crespo P, Villa TG (2011) Construction of new Pichia pastoris X-33 strains for production of lycopene and β-carotene. Appl Microbiol Biotechnol 93(6): 2483-2492. doi: 10. 1007/s00253-011-3764-7.
    • (2011) Appl Microbiol Biotechnol , vol.93 , Issue.6 , pp. 2483-2492
    • Araya-Garay, J.M.1    Feijoo-Siota, L.2    Rosa-Dos-santos, F.3    Veiga-Crespo, P.4    Villa, T.G.5
  • 5
    • 84874192632 scopus 로고    scopus 로고
    • BCC Research
    • BCC Research (2011) The Global Market for Carotenoids (FOD025D). http://www. bccresearch. com/report/carotenoids-global-market-fod025d. html.
    • (2011) The Global Market for Carotenoids (FOD025D)
  • 7
    • 69249212276 scopus 로고    scopus 로고
    • Metabolic engineering of Pichia pastoris X-33 for lycopene production
    • Bhatayaa A, Schmidt-Dannerta C, Leeb PC (2009) Metabolic engineering of Pichia pastoris X-33 for lycopene production. Process Biochem 44: 1095-1102.
    • (2009) Process Biochem , vol.44 , pp. 1095-1102
    • Bhatayaa, A.1    Schmidt-Dannerta, C.2    Leeb, P.C.3
  • 8
    • 79952763038 scopus 로고    scopus 로고
    • Engineering of geranylgeranyl pyrophosphate synthase levels and physiological conditions for enhanced carotenoid and astaxanthin synthesis in Xanthophyllomyces dendrorhous
    • Breitenbach J, Visser H, Verdoes JC, van Ooyen AJ, Sandmann G (2011) Engineering of geranylgeranyl pyrophosphate synthase levels and physiological conditions for enhanced carotenoid and astaxanthin synthesis in Xanthophyllomyces dendrorhous. Biotechnol Lett 33: 755-761.
    • (2011) Biotechnol Lett , vol.33 , pp. 755-761
    • Breitenbach, J.1    Visser, H.2    Verdoes, J.C.3    van Ooyen, A.J.4    Sandmann, G.5
  • 9
    • 80053180380 scopus 로고    scopus 로고
    • Elucidation of the pathway to astaxanthin in the flowers of Adonis aestivalis
    • Cunningham FX Jr, Gantt E (2011) Elucidation of the pathway to astaxanthin in the flowers of Adonis aestivalis. Plant Cell 23: 3055-3069.
    • (2011) Plant Cell , vol.23 , pp. 3055-3069
    • Cunningham Jr., F.X.1    Gantt, E.2
  • 10
    • 0027397668 scopus 로고
    • Antioxidant status and neovascular age-related macular degeneration
    • Eye Disease Case-Control Study Group
    • Eye Disease Case-Control Study Group (1993) Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol 111: 104-109.
    • (1993) Arch Ophthalmol , vol.111 , pp. 104-109
  • 13
    • 3042694925 scopus 로고    scopus 로고
    • Prospective study of plasma carotenoids and tocopherols in relation to risk of ischemic stroke
    • Hak AE, Ma J, Powell CB, Campos H, Gaziano JM, Willett WC, Stampfer MJ (2004) Prospective study of plasma carotenoids and tocopherols in relation to risk of ischemic stroke. Stroke 35: 1584-1588.
    • (2004) Stroke , vol.35 , pp. 1584-1588
    • Hak, A.E.1    Ma, J.2    Powell, C.B.3    Campos, H.4    Gaziano, J.M.5    Willett, W.C.6    Stampfer, M.J.7
  • 14
    • 34547609909 scopus 로고    scopus 로고
    • The non-mevalonate pathway of isoprenoid precursor biosynthesis
    • Hunter WN (2007) The non-mevalonate pathway of isoprenoid precursor biosynthesis. J Biol Chem 282: 21573-21577.
    • (2007) J Biol Chem , vol.282 , pp. 21573-21577
    • Hunter, W.N.1
  • 15
    • 33644756597 scopus 로고    scopus 로고
    • Defining the primary route for lutein synthesis in plants: the role of Arabidopsis carotenoid beta-ring hydroxylase CYP97A3
    • Kim J, DellaPenna D (2006) Defining the primary route for lutein synthesis in plants: the role of Arabidopsis carotenoid beta-ring hydroxylase CYP97A3. Proc Natl Acad Sci USA 103: 3474-3479.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 3474-3479
    • Kim, J.1    Dellapenna, D.2
  • 16
    • 79954741746 scopus 로고    scopus 로고
    • Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli
    • Kim YS, Lee JH, Kim NH, Yeom SJ, Kim SW, Oh DK (2011) Increase of lycopene production by supplementing auxiliary carbon sources in metabolically engineered Escherichia coli. Appl Microbiol Biotechnol 90: 489-497.
    • (2011) Appl Microbiol Biotechnol , vol.90 , pp. 489-497
    • Kim, Y.S.1    Lee, J.H.2    Kim, N.H.3    Yeom, S.J.4    Kim, S.W.5    Oh, D.K.6
  • 17
    • 28544439691 scopus 로고    scopus 로고
    • Carotenoid actions and their relation to health and disease
    • Krinsky NI, Johnson EJ (2005) Carotenoid actions and their relation to health and disease. Mol Aspects Med 26: 459-516.
    • (2005) Mol Aspects Med , vol.26 , pp. 459-516
    • Krinsky, N.I.1    Johnson, E.J.2
  • 18
    • 0034700150 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
    • Lange BM, Rujan T, Martin W, Croteau R (2000) Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proc Natl Acad Sci USA 97: 13172-13177.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13172-13177
    • Lange, B.M.1    Rujan, T.2    Martin, W.3    Croteau, R.4
  • 19
    • 79955103635 scopus 로고    scopus 로고
    • Engineering of a plasmid-free Escherichia coli strain for improved in vivo biosynthesis of astaxanthin
    • Lemuth K, Steuer K, Albermann C (2011) Engineering of a plasmid-free Escherichia coli strain for improved in vivo biosynthesis of astaxanthin. Microb Cell Fact 10: 29.
    • (2011) Microb Cell Fact , vol.10 , pp. 29
    • Lemuth, K.1    Steuer, K.2    Albermann, C.3
  • 20
    • 34547660107 scopus 로고    scopus 로고
    • Biosynthesis, accumulation and emission of carotenoids, alpha-tocopherol, plastoquinone, and isoprene in leaves under high photosynthetic irradiance
    • Lichtenthaler HK (2007) Biosynthesis, accumulation and emission of carotenoids, alpha-tocopherol, plastoquinone, and isoprene in leaves under high photosynthetic irradiance. Photosynth Res 92: 163-179.
    • (2007) Photosynth Res , vol.92 , pp. 163-179
    • Lichtenthaler, H.K.1
  • 22
    • 0038391517 scopus 로고    scopus 로고
    • Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
    • Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD (2003) Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nature 21: 796-802.
    • (2003) Nature , vol.21 , pp. 796-802
    • Martin, V.J.1    Pitera, D.J.2    Withers, S.T.3    Newman, J.D.4    Keasling, J.D.5
  • 23
    • 0029945201 scopus 로고    scopus 로고
    • Beta-carotene, carotenoids, and disease prevention in humans
    • Mayne ST (1996) Beta-carotene, carotenoids, and disease prevention in humans. FASEB J 10: 690-701.
    • (1996) FASEB J , vol.10 , pp. 690-701
    • Mayne, S.T.1
  • 24
    • 79957660778 scopus 로고    scopus 로고
    • Carotenoid β-ring hydroxylase and ketolase from marine bacteria-promiscuous enzymes for synthesizing functional xanthophylls
    • Misawa N (2011) Carotenoid β-ring hydroxylase and ketolase from marine bacteria-promiscuous enzymes for synthesizing functional xanthophylls. Drugs 9: 757-771.
    • (2011) Drugs , vol.9 , pp. 757-771
    • Misawa, N.1
  • 25
    • 79960807863 scopus 로고    scopus 로고
    • The biosynthesis of isoprenoids and the mechanisms regulating it in plants
    • Okada K (2011) The biosynthesis of isoprenoids and the mechanisms regulating it in plants. Biosci Biotechnol Biochem 75: 1219-1225.
    • (2011) Biosci Biotechnol Biochem , vol.75 , pp. 1219-1225
    • Okada, K.1
  • 26
    • 33847309176 scopus 로고    scopus 로고
    • Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli
    • Pitera DJ, Paddon CJ, Newman JD, Keasling JD (2007) Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab Eng 9: 193-207.
    • (2007) Metab Eng , vol.9 , pp. 193-207
    • Pitera, D.J.1    Paddon, C.J.2    Newman, J.D.3    Keasling, J.D.4
  • 27
    • 77955125017 scopus 로고    scopus 로고
    • Regulation must be revolutionized
    • Potrykus I (2010) Regulation must be revolutionized. Nature 466: 561.
    • (2010) Nature , vol.466 , pp. 561
    • Potrykus, I.1
  • 28
    • 78349234191 scopus 로고    scopus 로고
    • The 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products
    • Sabirova JS, Haddouche R, van Bogaert IN, Mulaa F, Verstraete W, Timmis KN, Schmidt-Dannert C, Nicaud JM, Soetaert W (2011) The 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products. Microb Biotechnol 4: 47-54.
    • (2011) Microb Biotechnol , vol.4 , pp. 47-54
    • Sabirova, J.S.1    Haddouche, R.2    van Bogaert, I.N.3    Mulaa, F.4    Verstraete, W.5    Timmis, K.N.6    Schmidt-Dannert, C.7    Nicaud, J.M.8    Soetaert, W.9
  • 29
    • 67650841831 scopus 로고    scopus 로고
    • Characterization of cyanobacterial beta-carotene ketolase and hydroxylase genes in Escherichia coli, and their application for astaxanthin biosynthesis
    • Scaife MA, Burja AM, Wright PC (2009) Characterization of cyanobacterial beta-carotene ketolase and hydroxylase genes in Escherichia coli, and their application for astaxanthin biosynthesis. Biotechnol Bioeng 103: 944-955.
    • (2009) Biotechnol Bioeng , vol.103 , pp. 944-955
    • Scaife, M.A.1    Burja, A.M.2    Wright, P.C.3
  • 31
    • 33947414897 scopus 로고    scopus 로고
    • Use of transposon promoter-probe vectors in the metabolic engineering of the obligate methanotroph Methylomonas sp. strain 16a for enhanced C40 carotenoid synthesis
    • Sharpe PL, Dicosimo D, Bosak MD, Knoke K, Tao L, Cheng Q, Ye RW (2007) Use of transposon promoter-probe vectors in the metabolic engineering of the obligate methanotroph Methylomonas sp. strain 16a for enhanced C40 carotenoid synthesis. Appl Environ Microbiol 73: 1721-1728.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 1721-1728
    • Sharpe, P.L.1    Dicosimo, D.2    Bosak, M.D.3    Knoke, K.4    Tao, L.5    Cheng, Q.6    Ye, R.W.7
  • 32
    • 33749451187 scopus 로고    scopus 로고
    • Engineering a beta-carotene ketolase for astaxanthin production
    • Tao L, Wilczek J, Odom JM, Cheng Q (2006) Engineering a beta-carotene ketolase for astaxanthin production. Metab Eng 8: 523-531.
    • (2006) Metab Eng , vol.8 , pp. 523-531
    • Tao, L.1    Wilczek, J.2    Odom, J.M.3    Cheng, Q.4
  • 33
    • 33847174099 scopus 로고    scopus 로고
    • Expression of bacterial hemoglobin genes to improve astaxanthin production in a methanotrophic bacterium Methylomonas sp
    • Tao L, Sedkova N, Yao H, Ye RW, Sharpe PL, Cheng Q (2007) Expression of bacterial hemoglobin genes to improve astaxanthin production in a methanotrophic bacterium Methylomonas sp. Appl Microbiol Biotechnol 74: 625-633.
    • (2007) Appl Microbiol Biotechnol , vol.74 , pp. 625-633
    • Tao, L.1    Sedkova, N.2    Yao, H.3    Ye, R.W.4    Sharpe, P.L.5    Cheng, Q.6
  • 34
    • 77449126022 scopus 로고    scopus 로고
    • Lipid composition of the mucoraceous fungus Blakeslea trispora under lycopene formation-stimulating conditions
    • Tereshina VM, Memorskaya AS, Feofilova EP (2010) Lipid composition of the mucoraceous fungus Blakeslea trispora under lycopene formation-stimulating conditions. Microbiology 79: 34-39.
    • (2010) Microbiology , vol.79 , pp. 34-39
    • Tereshina, V.M.1    Memorskaya, A.S.2    Feofilova, E.P.3
  • 35
    • 70449396286 scopus 로고    scopus 로고
    • Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance
    • Ukibe K, Hashida K, Yoshida N, Takagi H (2009) Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance. Appl Environ Microbiol 75: 7205-7211.
    • (2009) Appl Environ Microbiol , vol.75 , pp. 7205-7211
    • Ukibe, K.1    Hashida, K.2    Yoshida, N.3    Takagi, H.4
  • 36
    • 34447543117 scopus 로고    scopus 로고
    • High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous
    • Verwaal R, Wang J, Meijnen JP, Visser H, Sandmann G, van den Berg JA, van Ooyen AJ (2007) High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous. Appl Environ Microbiol 73: 4342-4350.
    • (2007) Appl Environ Microbiol , vol.73 , pp. 4342-4350
    • Verwaal, R.1    Wang, J.2    Meijnen, J.P.3    Visser, H.4    Sandmann, G.5    van den Berg, J.A.6    van Ooyen, A.J.7
  • 39
    • 85007940083 scopus 로고
    • Metabolic engineering for production of beta-carotene and lycopene in Saccharomyces cerevisiae
    • Yamano S, Ishii T, Nakagawa M, Ikenaga H, Misawa N (1994) Metabolic engineering for production of beta-carotene and lycopene in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 58: 1112-1114.
    • (1994) Biosci Biotechnol Biochem , vol.58 , pp. 1112-1114
    • Yamano, S.1    Ishii, T.2    Nakagawa, M.3    Ikenaga, H.4    Misawa, N.5
  • 40
    • 84856972996 scopus 로고    scopus 로고
    • Enhancement of β-carotene production by over-expression of HMG-CoA reductase coupled with addition of ergosterol biosynthesis inhibitors in recombinant Saccharomyces cerevisiae
    • doi:10.1007/s00284-011-0044-9
    • Yan GL, Wen KR, Duan CQ (2011) Enhancement of β-carotene production by over-expression of HMG-CoA reductase coupled with addition of ergosterol biosynthesis inhibitors in recombinant Saccharomyces cerevisiae. Curr Microbiol 64(2): 159-163. doi: 10. 1007/s00284-011-0044-9.
    • (2011) Curr Microbiol , vol.64 , Issue.2 , pp. 159-163
    • Yan, G.L.1    Wen, K.R.2    Duan, C.Q.3
  • 41
    • 84855598579 scopus 로고    scopus 로고
    • Metabolic engineering of clinically important molecules: omega-3 fatty acids, artemisinin, and taxol
    • Ye VM, Bhatia SK (2012) Metabolic engineering of clinically important molecules: omega-3 fatty acids, artemisinin, and taxol. Biotechnol J 7: 20-33.
    • (2012) Biotechnol J , vol.7 , pp. 20-33
    • Ye, V.M.1    Bhatia, S.K.2
  • 42
    • 33748803584 scopus 로고    scopus 로고
    • Mutational and functional analysis of the beta-carotene ketolase involved in the production of canthaxanthin and astaxanthin
    • Ye RW, Stead KJ, Yao H, He H (2006) Mutational and functional analysis of the beta-carotene ketolase involved in the production of canthaxanthin and astaxanthin. Appl Environ Microbiol 72: 5829-5837.
    • (2006) Appl Environ Microbiol , vol.72 , pp. 5829-5837
    • Ye, R.W.1    Stead, K.J.2    Yao, H.3    He, H.4
  • 44


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.