-
1
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T (2001) Oncogenic kinase signalling. Nature 411: 355-365.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
2
-
-
9444287030
-
Common and distinct elements in cellular signaling via EGF and FGF receptors
-
Schlessinger J (2004) Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 306: 1506-1507.
-
(2004)
Science
, vol.306
, pp. 1506-1507
-
-
Schlessinger, J.1
-
3
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (2002) The protein kinase complement of the human genome. Science 298: 1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
5
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall CJ (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80: 179-185.
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
7
-
-
0032931259
-
The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation
-
Cook SJ, Aziz N, McMahon M (1999) The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation. Mol Cell Biol 19: 330-341.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 330-341
-
-
Cook, S.J.1
Aziz, N.2
McMahon, M.3
-
8
-
-
0032521642
-
The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic
-
Tombes RM, Auer KL, Mikkelsen R, Valerie K, Wymann MP, et al. (1998) The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or chronic. Biochem J 330 (Pt 3): 1451-1460.
-
(1998)
Biochem J
, vol.330
, Issue.PART 3
, pp. 1451-1460
-
-
Tombes, R.M.1
Auer, K.L.2
Mikkelsen, R.3
Valerie, K.4
Wymann, M.P.5
-
9
-
-
0026486878
-
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
-
Traverse S, Gomez N, Paterson H, Marshall C, Cohen P (1992) Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem J 288 (Pt 2): 351-355.
-
(1992)
Biochem J
, vol.288
, Issue.PART 2
, pp. 351-355
-
-
Traverse, S.1
Gomez, N.2
Paterson, H.3
Marshall, C.4
Cohen, P.5
-
10
-
-
17344362384
-
Prediction and validation of the distinct dynamics of transient and sustained ERK activation
-
Sasagawa S, Ozaki Y, Fujita K, Kuroda S (2005) Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat Cell Biol 7: 365-373.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 365-373
-
-
Sasagawa, S.1
Ozaki, Y.2
Fujita, K.3
Kuroda, S.4
-
11
-
-
0031903330
-
NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating
-
Yaka R, Gamliel A, Gurwitz D, Stein R (1998) NGF induces transient but not sustained activation of ERK in PC12 mutant cells incapable of differentiating. J Cell Biochem 70: 425-432.
-
(1998)
J Cell Biochem
, vol.70
, pp. 425-432
-
-
Yaka, R.1
Gamliel, A.2
Gurwitz, D.3
Stein, R.4
-
12
-
-
0034722894
-
Development of anticancer drugs targeting the MAP kinase pathway
-
Sebolt-Leopold JS (2000) Development of anticancer drugs targeting the MAP kinase pathway. Oncogene 19: 6594-6599.
-
(2000)
Oncogene
, vol.19
, pp. 6594-6599
-
-
Sebolt-Leopold, J.S.1
-
13
-
-
20444411533
-
The Silicon Cell initiative: Working towards a detailed kinetic description at the cellular level
-
Snoep JL (2005) The Silicon Cell initiative: working towards a detailed kinetic description at the cellular level. Curr Opin Biotechnol 16: 336-343.
-
(2005)
Curr Opin Biotechnol
, vol.16
, pp. 336-343
-
-
Snoep, J.L.1
-
14
-
-
0037079054
-
Computational systems biology
-
Kitano H (2002) Computational systems biology. Nature 420: 206-210.
-
(2002)
Nature
, vol.420
, pp. 206-210
-
-
Kitano, H.1
-
15
-
-
0034613112
-
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells
-
Brightman FA, Fell DA (2000) Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells. FEBS Lett 482: 169-174.
-
(2000)
FEBS Lett
, vol.482
, pp. 169-174
-
-
Brightman, F.A.1
Fell, D.A.2
-
16
-
-
24644456999
-
Control of MAPK signalling: From complexity to what really matters
-
Hornberg JJ, Binder B, Bruggeman FJ, Schoeberl B, Heinrich R, et al. (2005) Control of MAPK signalling: from complexity to what really matters. Oncogene 24: 5533-5542.
-
(2005)
Oncogene
, vol.24
, pp. 5533-5542
-
-
Hornberg, J.J.1
Binder, B.2
Bruggeman, F.J.3
Schoeberl, B.4
Heinrich, R.5
-
17
-
-
23844494402
-
The duration, magnitude and compartmentalization of ERK MAP kinase activity: Mechanisms for providing signaling specificity
-
Ebisuya M, Kondoh K, Nishida E (2005) The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. J Cell Sci 118: 2997-3002.
-
(2005)
J Cell Sci
, vol.118
, pp. 2997-3002
-
-
Ebisuya, M.1
Kondoh, K.2
Nishida, E.3
-
18
-
-
0034914737
-
A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model
-
Asthagiri AR, Lauffenburger DA (2001) A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model. Biotechnol Prog 17: 227-239.
-
(2001)
Biotechnol Prog
, vol.17
, pp. 227-239
-
-
Asthagiri, A.R.1
Lauffenburger, D.A.2
-
19
-
-
0037047611
-
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
-
Bhalla US, Ram PT, Iyengar R (2002) MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297: 1018-1023.
-
(2002)
Science
, vol.297
, pp. 1018-1023
-
-
Bhalla, U.S.1
Ram, P.T.2
Iyengar, R.3
-
20
-
-
33846042014
-
Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades
-
Markevich NI, Tsyganov MA, Hoek JB, Kholodenko BN (2006) Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades. Mol Syst Biol 2: 61.
-
(2006)
Mol Syst Biol
, vol.2
, pp. 61
-
-
Markevich, N.I.1
Tsyganov, M.A.2
Hoek, J.B.3
Kholodenko, B.N.4
-
21
-
-
39349111646
-
Bistable MAP kinase activity: A plausible mechanism contributing to maintenance of late long-term potentiation
-
Smolen P, Baxter DA, Byrne JH (2008) Bistable MAP kinase activity: a plausible mechanism contributing to maintenance of late long-term potentiation. Am J Physiol Cell Physiol 294: C503-515.
-
(2008)
Am J Physiol Cell Physiol
, vol.294
-
-
Smolen, P.1
Baxter, D.A.2
Byrne, J.H.3
-
22
-
-
0036532226
-
Self-perpetuating states in signal transduction: Positive feedback, double-negative feedback and bistability
-
Ferrell JE Jr (2002) Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability. Curr Opin Cell Biol 14: 140-148.
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 140-148
-
-
Ferrell Jr, J.E.1
-
23
-
-
0033555859
-
Emergent properties of networks of biological signaling pathways
-
Bhalla US, Iyengar R (1999) Emergent properties of networks of biological signaling pathways. Science 283: 381-387.
-
(1999)
Science
, vol.283
, pp. 381-387
-
-
Bhalla, U.S.1
Iyengar, R.2
-
24
-
-
33646852421
-
Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes
-
Fujioka A, Terai K, Itoh RE, Aoki K, Nakamura T, et al. (2006) Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem 281: 8917-8926.
-
(2006)
J Biol Chem
, vol.281
, pp. 8917-8926
-
-
Fujioka, A.1
Terai, K.2
Itoh, R.E.3
Aoki, K.4
Nakamura, T.5
-
25
-
-
1342265607
-
Experimental Design in Systems Biology, Based on Parameter Sensitivity Analysis Using a Monte Carlo Method: A Case Study for the TNF{alpha}-Mediated NF-{kappa} B Signal Transduction Pathway
-
Cho KH, Shin SY, Kolch W, Wolkenhauer O (2003) Experimental Design in Systems Biology, Based on Parameter Sensitivity Analysis Using a Monte Carlo Method: A Case Study for the TNF{alpha}-Mediated NF-{kappa} B Signal Transduction Pathway. SIMULATION: Transactions of The Society for Modeling and Simulation International 79: 726-739.
-
(2003)
SIMULATION: Transactions of The Society for Modeling and Simulation International
, vol.79
, pp. 726-739
-
-
Cho, K.H.1
Shin, S.Y.2
Kolch, W.3
Wolkenhauer, O.4
-
26
-
-
84887213316
-
-
Saltelli A, Tarantola S, Campolongo F, M. R (2004) Sensitivity Analysis in Practice: A Guide to Assessing Scientific Models John Wiley & Sons, Ltd. 232 p.
-
Saltelli A, Tarantola S, Campolongo F, M. R (2004) Sensitivity Analysis in Practice: A Guide to Assessing Scientific Models John Wiley & Sons, Ltd. 232 p.
-
-
-
-
28
-
-
4444322221
-
-
Stelling J, Gilles ED, Doyle FJ 3rd (2004) Robustness properties of circadian clock architectures. Proc Natl Acad Sci U S A 101: 13210-13215.
-
Stelling J, Gilles ED, Doyle FJ 3rd (2004) Robustness properties of circadian clock architectures. Proc Natl Acad Sci U S A 101: 13210-13215.
-
-
-
-
29
-
-
0015231849
-
Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems
-
Savageau MA (1971) Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems. Nature 229: 542-544.
-
(1971)
Nature
, vol.229
, pp. 542-544
-
-
Savageau, M.A.1
-
30
-
-
0038311995
-
Ras family signaling: Therapeutic targeting
-
Cox AD, Der CJ (2002) Ras family signaling: therapeutic targeting. Cancer Biol Ther 1: 599-606.
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 599-606
-
-
Cox, A.D.1
CJ, D.2
-
31
-
-
0034284027
-
Targeting the Ras signaling pathway: A rational, mechanism-based treatment for hematologic malignancies?
-
Reuter CW, Morgan MA, Bergmann L (2000) Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood 96: 1655-1669.
-
(2000)
Blood
, vol.96
, pp. 1655-1669
-
-
Reuter, C.W.1
Morgan, M.A.2
Bergmann, L.3
-
32
-
-
0036306889
-
Transient and sustained ERK phosphorylation and nuclear translocation in growth control
-
Adachi T, Kar S, Wang M, Carr BI (2002) Transient and sustained ERK phosphorylation and nuclear translocation in growth control. J Cell Physiol 192: 151-159.
-
(2002)
J Cell Physiol
, vol.192
, pp. 151-159
-
-
Adachi, T.1
Kar, S.2
Wang, M.3
Carr, B.I.4
-
33
-
-
11444260258
-
Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control
-
Hornberg JJ, Bruggeman FJ, Binder B, Geest CR, de Vaate AJ, et al. (2005) Principles behind the multifarious control of signal transduction. ERK phosphorylation and kinase/phosphatase control. Febs J 272: 244-258.
-
(2005)
Febs J
, vol.272
, pp. 244-258
-
-
Hornberg, J.J.1
Bruggeman, F.J.2
Binder, B.3
Geest, C.R.4
de Vaate, A.J.5
-
34
-
-
36248988538
-
Ligand-dependent responses of the ErbB signaling network: Experimental and modeling analyses
-
Birtwistle MR, Hatakeyama M, Yumoto N, Ogunnaike BA, Hoek JB, et al. (2007) Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses. Mol Syst Biol 3: 144.
-
(2007)
Mol Syst Biol
, vol.3
, pp. 144
-
-
Birtwistle, M.R.1
Hatakeyama, M.2
Yumoto, N.3
Ogunnaike, B.A.4
Hoek, J.B.5
-
35
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
36
-
-
0037076425
-
Agent-based modeling: Methods and techniques for simulating human systems
-
Bonabeau E (2002) Agent-based modeling: methods and techniques for simulating human systems. Proc Natl Acad Sci U S A 99 Suppl 3: 7280-7287.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.SUPPL. 3
, pp. 7280-7287
-
-
Bonabeau, E.1
-
37
-
-
33750974791
-
Development of a three-dimensional multiscale agent-based tumor model: Simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer
-
Zhang L, Athale CA, Deisboeck TS (2007) Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer. J Theor Biol 244: 96-107.
-
(2007)
J Theor Biol
, vol.244
, pp. 96-107
-
-
Zhang, L.1
Athale, C.A.2
Deisboeck, T.S.3
|