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Volumn 12, Issue 11, 2013, Pages 972-981

Effects of chromatin decondensation on alternative NHEJ

Author keywords

Backup NHEJ; Chromatin condensation; DNA double strand breaks (DSBs); DNA methylation; Ionizing radiation (IR); Non homologous end joining

Indexed keywords

5 AZA 2' DEOXYCYTIDINE;

EID: 84887138190     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.08.004     Document Type: Article
Times cited : (4)

References (81)
  • 1
    • 79551562850 scopus 로고    scopus 로고
    • Chromatin dynamics during repair of chromosomal DNA double-strand breaks
    • Sinha M., Peterson C.L. Chromatin dynamics during repair of chromosomal DNA double-strand breaks. Epigenomics 2009, 1(2):371-385.
    • (2009) Epigenomics , vol.1 , Issue.2 , pp. 371-385
    • Sinha, M.1    Peterson, C.L.2
  • 2
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: signaling, repair and the cancer connection
    • Khanna K.K., Jackson S.P. DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics 2001, 27(3):247-254.
    • (2001) Nature Genetics , vol.27 , Issue.3 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 3
    • 0037039463 scopus 로고    scopus 로고
    • UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mre11 relocalization
    • Limoli C.L., et al. UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma-H2AX formation, and Mre11 relocalization. Proceedings of the National Academy of Sciences of the United States of America 2002, 99(1):233-238.
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , Issue.1 , pp. 233-238
    • Limoli, C.L.1
  • 4
    • 29244437908 scopus 로고    scopus 로고
    • The role of double-strand break repair - insights from human genetics
    • O'Driscoll M., Jeggo P.A. The role of double-strand break repair - insights from human genetics. Nature Reviews: Genetics 2006, 7(1):45-54.
    • (2006) Nature Reviews: Genetics , vol.7 , Issue.1 , pp. 45-54
    • O'Driscoll, M.1    Jeggo, P.A.2
  • 5
    • 78649449767 scopus 로고    scopus 로고
    • The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax
    • Goodarzi A.A., Jeggo P., Lobrich M. The influence of heterochromatin on DNA double strand break repair: getting the strong, silent type to relax. DNA Repair 2010, 9(12):1273-1282.
    • (2010) DNA Repair , vol.9 , Issue.12 , pp. 1273-1282
    • Goodarzi, A.A.1    Jeggo, P.2    Lobrich, M.3
  • 6
    • 84886806613 scopus 로고    scopus 로고
    • DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice
    • in press
    • Schipler A., Iliakis G. DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Research 2013, in press. 10.1093/nar/gkt556.
    • (2013) Nucleic Acids Research
    • Schipler, A.1    Iliakis, G.2
  • 7
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber M.R. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annual Review of Biochemistry 2010, 79:181-211.
    • (2010) Annual Review of Biochemistry , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 8
    • 11244277456 scopus 로고    scopus 로고
    • Backup pathways of NHEJ are suppressed by DNA-PK
    • Perrault R., et al. Backup pathways of NHEJ are suppressed by DNA-PK. Journal of Cellular Biochemistry 2004, 92:781-794.
    • (2004) Journal of Cellular Biochemistry , vol.92 , pp. 781-794
    • Perrault, R.1
  • 9
    • 2642570858 scopus 로고    scopus 로고
    • Mechanisms of DNA double strand break repair and chromosome aberration formation
    • Iliakis G., et al. Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenetic and Genome Research 2004, 104:14-20.
    • (2004) Cytogenetic and Genome Research , vol.104 , pp. 14-20
    • Iliakis, G.1
  • 10
    • 46249131123 scopus 로고    scopus 로고
    • Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair
    • Bennardo N., et al. Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genetics 2008, 4(6):e1000110.
    • (2008) PLoS Genetics , vol.4 , Issue.6
    • Bennardo, N.1
  • 11
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical end-joining pathway
    • Yan C.T., et al. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature 2007, 449:478-482.
    • (2007) Nature , vol.449 , pp. 478-482
    • Yan, C.T.1
  • 12
    • 78049446968 scopus 로고    scopus 로고
    • The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
    • Mansour W.Y., Rhein T., Dahm-Daphi J. The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies. Nucleic Acids Research 2010, 38(18):6065-6077.
    • (2010) Nucleic Acids Research , vol.38 , Issue.18 , pp. 6065-6077
    • Mansour, W.Y.1    Rhein, T.2    Dahm-Daphi, J.3
  • 13
    • 79956215808 scopus 로고    scopus 로고
    • Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways
    • Mladenov E., Iliakis G. Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mutation Research 2011, 711:61-72.
    • (2011) Mutation Research , vol.711 , pp. 61-72
    • Mladenov, E.1    Iliakis, G.2
  • 14
    • 2642570858 scopus 로고    scopus 로고
    • Mechanisms of DNA double strand break repair and chromosome aberration formation
    • Iliakis G., et al. Mechanisms of DNA double strand break repair and chromosome aberration formation. Cytogenetic and Genome Research 2004, 104(1-4):14-20.
    • (2004) Cytogenetic and Genome Research , vol.104 , Issue.1-4 , pp. 14-20
    • Iliakis, G.1
  • 15
    • 69949173301 scopus 로고    scopus 로고
    • Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence
    • Iliakis G. Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence. Radiotherapy and Oncology 2009, 92(3):310-315.
    • (2009) Radiotherapy and Oncology , vol.92 , Issue.3 , pp. 310-315
    • Iliakis, G.1
  • 16
    • 20144363082 scopus 로고    scopus 로고
    • DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
    • Wang H., et al. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Research 2005, 65(10):4020-4030.
    • (2005) Cancer Research , vol.65 , Issue.10 , pp. 4020-4030
    • Wang, H.1
  • 17
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • Wang M., et al. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Research 2006, 34(21):6170-6182.
    • (2006) Nucleic Acids Research , vol.34 , Issue.21 , pp. 6170-6182
    • Wang, M.1
  • 18
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert M., Salles B., Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. The Journal of Biological Chemistry 2004, 279(53):55117-55126.
    • (2004) The Journal of Biological Chemistry , vol.279 , Issue.53 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 19
    • 41149176120 scopus 로고    scopus 로고
    • Histone H1 functions as a stimulatory factor in backup pathways of NHEJ
    • Rosidi B., et al. Histone H1 functions as a stimulatory factor in backup pathways of NHEJ. Nucleic Acids Research 2008, 36(5):1610-1623.
    • (2008) Nucleic Acids Research , vol.36 , Issue.5 , pp. 1610-1623
    • Rosidi, B.1
  • 20
    • 79956215808 scopus 로고    scopus 로고
    • Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways
    • Mladenov E., Iliakis G. Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mutation Research 2011, 711(1-2):61-72.
    • (2011) Mutation Research , vol.711 , Issue.1-2 , pp. 61-72
    • Mladenov, E.1    Iliakis, G.2
  • 21
    • 37549006429 scopus 로고    scopus 로고
    • Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2
    • Wu W., et al. Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2. DNA Repair 2008, 7(2):329-338.
    • (2008) DNA Repair , vol.7 , Issue.2 , pp. 329-338
    • Wu, W.1
  • 22
    • 55249102702 scopus 로고    scopus 로고
    • Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells with defects in the classical pathway of NHEJ
    • Wu W., et al. Enhanced use of backup pathways of NHEJ in G2 in Chinese hamster mutant cells with defects in the classical pathway of NHEJ. Radiation Research 2008, 170(4):512-520.
    • (2008) Radiation Research , vol.170 , Issue.4 , pp. 512-520
    • Wu, W.1
  • 24
    • 78650850519 scopus 로고    scopus 로고
    • Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors
    • Singh S.K., et al. Widespread dependence of backup NHEJ on growth state: ramifications for the use of DNA-PK inhibitors. International Journal of Radiation Oncology, Biology, Physics 2011, 79(2):540-548.
    • (2011) International Journal of Radiation Oncology, Biology, Physics , vol.79 , Issue.2 , pp. 540-548
    • Singh, S.K.1
  • 25
    • 84865647966 scopus 로고    scopus 로고
    • Inhibition of B-NHEJ in plateau-phase cells is not a direct consequence of suppressed growth factor signaling
    • Singh S.K., et al. Inhibition of B-NHEJ in plateau-phase cells is not a direct consequence of suppressed growth factor signaling. International Journal of Radiation Oncology, Biology, Physics 2012, 84:e237-e243.
    • (2012) International Journal of Radiation Oncology, Biology, Physics , vol.84
    • Singh, S.K.1
  • 26
    • 77951648256 scopus 로고    scopus 로고
    • Chromatin condensation modulates access and binding of nuclear proteins
    • Martin R.M., Cardoso M.C. Chromatin condensation modulates access and binding of nuclear proteins. FASEB Journal 2010, 24(4):1066-1072.
    • (2010) FASEB Journal , vol.24 , Issue.4 , pp. 1066-1072
    • Martin, R.M.1    Cardoso, M.C.2
  • 27
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. Chromatin modifications and their function. Cell 2007, 128(4):693-705.
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 28
    • 4444289406 scopus 로고    scopus 로고
    • ATP-dependent nucleosome remodelling: factors and functions
    • Eberharter A., Becker P.B. ATP-dependent nucleosome remodelling: factors and functions. Journal of Cell Science 2004, 117(Pt 17):3707-3711.
    • (2004) Journal of Cell Science , vol.117 , Issue.PART 17 , pp. 3707-3711
    • Eberharter, A.1    Becker, P.B.2
  • 29
    • 33745790132 scopus 로고    scopus 로고
    • Chromatin remodelling: the industrial revolution of DNA around histones
    • Saha A., Wittmeyer J., Cairns B.R. Chromatin remodelling: the industrial revolution of DNA around histones. Nature Reviews: Molecular Cell Biology 2006, 7(6):437-447.
    • (2006) Nature Reviews: Molecular Cell Biology , vol.7 , Issue.6 , pp. 437-447
    • Saha, A.1    Wittmeyer, J.2    Cairns, B.R.3
  • 31
    • 79955471128 scopus 로고    scopus 로고
    • Characterization of Eu- and heterochromatin of citrus with a focus on the condensation behavior of 45S rDNA chromatin
    • Marques A., et al. Characterization of Eu- and heterochromatin of citrus with a focus on the condensation behavior of 45S rDNA chromatin. Cytogenetic and Genome Research 2011, 134(1):72-82.
    • (2011) Cytogenetic and Genome Research , vol.134 , Issue.1 , pp. 72-82
    • Marques, A.1
  • 32
    • 34250820438 scopus 로고    scopus 로고
    • Chromatin dynamics and the preservation of genetic information
    • Downs J.A., Nussenzweig M.C., Nussenzweig A. Chromatin dynamics and the preservation of genetic information. Nature 2007, 447(7147):951-958.
    • (2007) Nature , vol.447 , Issue.7147 , pp. 951-958
    • Downs, J.A.1    Nussenzweig, M.C.2    Nussenzweig, A.3
  • 34
    • 53349171467 scopus 로고    scopus 로고
    • Standardizing data
    • Sorg U.R. Standardizing data. Nature Cell Biology 2008, 10(10):1123-1124.
    • (2008) Nature Cell Biology , vol.10 , Issue.10 , pp. 1123-1124
    • Sorg, U.R.1
  • 35
    • 75949122330 scopus 로고    scopus 로고
    • 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
    • Noon A.T., et al. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nature Cell Biology 2010, 12(2):177-184.
    • (2010) Nature Cell Biology , vol.12 , Issue.2 , pp. 177-184
    • Noon, A.T.1
  • 36
    • 47349107760 scopus 로고    scopus 로고
    • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    • Goodarzi A.A., et al. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Molecular Cell 2008, 31(2):167-177.
    • (2008) Molecular Cell , vol.31 , Issue.2 , pp. 167-177
    • Goodarzi, A.A.1
  • 37
    • 0023132251 scopus 로고
    • Persistent and heritable structural damage induced in heterochromatic DNA from rat liver by N-nitrosodimethylamine
    • Ward E.J., Stewart B.W. Persistent and heritable structural damage induced in heterochromatic DNA from rat liver by N-nitrosodimethylamine. Biochemistry 1987, 26(6):1709-1717.
    • (1987) Biochemistry , vol.26 , Issue.6 , pp. 1709-1717
    • Ward, E.J.1    Stewart, B.W.2
  • 38
    • 33644984490 scopus 로고    scopus 로고
    • A new description of cellular quiescence
    • Coller H.A., Sang L., Roberts J.M. A new description of cellular quiescence. PLoS Biology 2006, 4(3):e83.
    • (2006) PLoS Biology , vol.4 , Issue.3
    • Coller, H.A.1    Sang, L.2    Roberts, J.M.3
  • 39
    • 0016774008 scopus 로고
    • The messenger RNA sequences in growing and resting mouse fibroblasts
    • Williams J.G., Penman S. The messenger RNA sequences in growing and resting mouse fibroblasts. Cell 1975, 6(2):197-206.
    • (1975) Cell , vol.6 , Issue.2 , pp. 197-206
    • Williams, J.G.1    Penman, S.2
  • 40
    • 0023765743 scopus 로고
    • Genes specifically expressed at growth arrest of mammalian cells
    • Schneider C., King R.M., Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell 1988, 54(6):787-793.
    • (1988) Cell , vol.54 , Issue.6 , pp. 787-793
    • Schneider, C.1    King, R.M.2    Philipson, L.3
  • 41
    • 0027616598 scopus 로고
    • Preferential gene expression in quiescent human lung fibroblasts
    • Coppock D., et al. Preferential gene expression in quiescent human lung fibroblasts. Cell Growth & Differentiation 1993, 4(6):483-493.
    • (1993) Cell Growth & Differentiation , vol.4 , Issue.6 , pp. 483-493
    • Coppock, D.1
  • 42
    • 84867621675 scopus 로고    scopus 로고
    • Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin
    • Manova V., Singh S.K., Iliakis G. Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin. Genome Integrity 2012, 3(1):4.
    • (2012) Genome Integrity , vol.3 , Issue.1 , pp. 4
    • Manova, V.1    Singh, S.K.2    Iliakis, G.3
  • 43
    • 0022386794 scopus 로고
    • Effects of osmotic shocks on the ultrastructure of different tissues and cell types
    • Delpire E., et al. Effects of osmotic shocks on the ultrastructure of different tissues and cell types. Experimental Cell Research 1985, 160(1):106-116.
    • (1985) Experimental Cell Research , vol.160 , Issue.1 , pp. 106-116
    • Delpire, E.1
  • 44
    • 55149112815 scopus 로고    scopus 로고
    • Chromatin structure influences the sensitivity of DNA to gamma-radiation
    • Falk M., Lukasova E., Kozubek S. Chromatin structure influences the sensitivity of DNA to gamma-radiation. Biochimica et Biophysica Acta 2008, 1783(12):2398-2414.
    • (2008) Biochimica et Biophysica Acta , vol.1783 , Issue.12 , pp. 2398-2414
    • Falk, M.1    Lukasova, E.2    Kozubek, S.3
  • 45
    • 0028947749 scopus 로고
    • The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes
    • Haaf T. The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes. Pharmacology & Therapeutics 1995, 65(1):19-46.
    • (1995) Pharmacology & Therapeutics , vol.65 , Issue.1 , pp. 19-46
    • Haaf, T.1
  • 46
    • 0037068379 scopus 로고    scopus 로고
    • 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy
    • Christman J.K. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 2002, 21(35):5483-5495.
    • (2002) Oncogene , vol.21 , Issue.35 , pp. 5483-5495
    • Christman, J.K.1
  • 47
    • 0037383398 scopus 로고    scopus 로고
    • Endogenous assays of DNA methyltransferases: evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo
    • Liu K., et al. Endogenous assays of DNA methyltransferases: evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo. Molecular and Cellular Biology 2003, 23(8):2709-2719.
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.8 , pp. 2709-2719
    • Liu, K.1
  • 48
    • 0842347353 scopus 로고    scopus 로고
    • Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation
    • Weisenberger D.J., et al. Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation. Molecular Cancer Research 2004, 2(1):62-72.
    • (2004) Molecular Cancer Research , vol.2 , Issue.1 , pp. 62-72
    • Weisenberger, D.J.1
  • 49
    • 37849026412 scopus 로고    scopus 로고
    • DNA methylation inhibitor 5-aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B
    • Palii S.S., et al. DNA methylation inhibitor 5-aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Molecular and Cellular Biology 2008, 28(2):752-771.
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.2 , pp. 752-771
    • Palii, S.S.1
  • 50
    • 0033634973 scopus 로고    scopus 로고
    • DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway
    • Frank K.M., et al. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Molecular Cell 2000, 5(6):993-1002.
    • (2000) Molecular Cell , vol.5 , Issue.6 , pp. 993-1002
    • Frank, K.M.1
  • 51
    • 80455149665 scopus 로고    scopus 로고
    • Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair
    • Singh S.K., et al. Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair. Nucleic Acids Research 2011, 39(19):8416-8429.
    • (2011) Nucleic Acids Research , vol.39 , Issue.19 , pp. 8416-8429
    • Singh, S.K.1
  • 52
    • 0025739820 scopus 로고
    • Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells
    • Metzger L., Iliakis G. Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells. International Journal of Radiation Biology 1991, 59(6):1325-1339.
    • (1991) International Journal of Radiation Biology , vol.59 , Issue.6 , pp. 1325-1339
    • Metzger, L.1    Iliakis, G.2
  • 53
    • 0026504941 scopus 로고
    • Influence of chromatin structure on the induction of DNA double strand breaks by ionizing radiation
    • Elia M.C., Bradley M.O. Influence of chromatin structure on the induction of DNA double strand breaks by ionizing radiation. Cancer Research 1992, 52:1580-1586.
    • (1992) Cancer Research , vol.52 , pp. 1580-1586
    • Elia, M.C.1    Bradley, M.O.2
  • 54
    • 84875484920 scopus 로고    scopus 로고
    • DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates
    • Paul K., et al. DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates. PLoS ONE 2013, 8(3):e59505.
    • (2013) PLoS ONE , vol.8 , Issue.3
    • Paul, K.1
  • 55
    • 34848828539 scopus 로고    scopus 로고
    • Low levels of DNA ligases III and IV sufficient for effective NHEJ
    • Windhofer F., Wu W., Iliakis G. Low levels of DNA ligases III and IV sufficient for effective NHEJ. Journal of Cellular Physiology 2007, 213(2):475-483.
    • (2007) Journal of Cellular Physiology , vol.213 , Issue.2 , pp. 475-483
    • Windhofer, F.1    Wu, W.2    Iliakis, G.3
  • 56
    • 33846475536 scopus 로고    scopus 로고
    • Chromatin modifications and DNA double-strand breaks: the current state of play
    • Karagiannis T.C., El-Osta A. Chromatin modifications and DNA double-strand breaks: the current state of play. Leukemia 2007, 21(2):195-200.
    • (2007) Leukemia , vol.21 , Issue.2 , pp. 195-200
    • Karagiannis, T.C.1    El-Osta, A.2
  • 57
    • 0034175813 scopus 로고    scopus 로고
    • Stimulation of V(D)J recombination by histone acetylation
    • McBlane F., Boyes J. Stimulation of V(D)J recombination by histone acetylation. Current Biology 2000, 10(8):483-486.
    • (2000) Current Biology , vol.10 , Issue.8 , pp. 483-486
    • McBlane, F.1    Boyes, J.2
  • 58
    • 55249116558 scopus 로고    scopus 로고
    • Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
    • Kinner A., et al. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Research 2008, 36(17):5678-5694.
    • (2008) Nucleic Acids Research , vol.36 , Issue.17 , pp. 5678-5694
    • Kinner, A.1
  • 59
    • 62849083222 scopus 로고    scopus 로고
    • The emerging role of nuclear architecture in DNA repair and genome maintenance
    • Misteli T., Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nature Reviews: Molecular Cell Biology 2009, 10(4):243-254.
    • (2009) Nature Reviews: Molecular Cell Biology , vol.10 , Issue.4 , pp. 243-254
    • Misteli, T.1    Soutoglou, E.2
  • 60
    • 0033538132 scopus 로고    scopus 로고
    • Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations
    • Rothkamm K., Lobrich M. Misrejoining of DNA double-strand breaks in primary and transformed human and rodent cells: a comparison between the HPRT region and other genomic locations. Mutation Research 1999, 433(3):193-205.
    • (1999) Mutation Research , vol.433 , Issue.3 , pp. 193-205
    • Rothkamm, K.1    Lobrich, M.2
  • 61
    • 0029948701 scopus 로고    scopus 로고
    • Induction of DNA double-strand breaks by ionizing radiation at the c-myc locus compared with the whole genome: a study using pulsed-field gel electrophoresis and gene probing
    • Sak A., et al. Induction of DNA double-strand breaks by ionizing radiation at the c-myc locus compared with the whole genome: a study using pulsed-field gel electrophoresis and gene probing. International Journal of Radiation Biology 1996, 69(6):679-685.
    • (1996) International Journal of Radiation Biology , vol.69 , Issue.6 , pp. 679-685
    • Sak, A.1
  • 62
    • 0344286677 scopus 로고    scopus 로고
    • Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts
    • Lobrich M., et al. Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts. Genes, Chromosomes & Cancer 2000, 27(1):59-68.
    • (2000) Genes, Chromosomes & Cancer , vol.27 , Issue.1 , pp. 59-68
    • Lobrich, M.1
  • 63
    • 0034916608 scopus 로고    scopus 로고
    • Radiation-induced chromosome aberrations in human euchromatic (17cen-p53) and heterochromatic (1cen-1q12) regions
    • Puerto S., et al. Radiation-induced chromosome aberrations in human euchromatic (17cen-p53) and heterochromatic (1cen-1q12) regions. Mutagenesis 2001, 16(4):291-296.
    • (2001) Mutagenesis , vol.16 , Issue.4 , pp. 291-296
    • Puerto, S.1
  • 64
    • 2642569241 scopus 로고    scopus 로고
    • Distribution of breakpoints induced by etoposide and X-rays along the CHO X chromosome
    • Martinez-Lopez W., et al. Distribution of breakpoints induced by etoposide and X-rays along the CHO X chromosome. Cytogenetic and Genome Research 2004, 104(1-4):182-187.
    • (2004) Cytogenetic and Genome Research , vol.104 , Issue.1-4 , pp. 182-187
    • Martinez-Lopez, W.1
  • 65
    • 44849111611 scopus 로고    scopus 로고
    • Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing
    • Zeng L., et al. Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing. Nature Structural & Molecular Biology 2008, 15(6):626-633.
    • (2008) Nature Structural & Molecular Biology , vol.15 , Issue.6 , pp. 626-633
    • Zeng, L.1
  • 66
    • 44449136965 scopus 로고    scopus 로고
    • HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
    • Ayoub N., et al. HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Nature 2008, 453(7195):682-686.
    • (2008) Nature , vol.453 , Issue.7195 , pp. 682-686
    • Ayoub, N.1
  • 67
    • 33746601439 scopus 로고    scopus 로고
    • Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
    • Ziv Y., et al. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nature Cell Biology 2006, 8(8):870-876.
    • (2006) Nature Cell Biology , vol.8 , Issue.8 , pp. 870-876
    • Ziv, Y.1
  • 68
    • 33847270257 scopus 로고    scopus 로고
    • Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells
    • Lee Y.K., et al. Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells. The Journal of Biological Chemistry 2007, 282(3):1595-1606.
    • (2007) The Journal of Biological Chemistry , vol.282 , Issue.3 , pp. 1595-1606
    • Lee, Y.K.1
  • 69
    • 0030941116 scopus 로고    scopus 로고
    • Chromatin structure modulates DNA repair by photolyase in vivo
    • Suter B., Livingstone-Zatchej M., Thoma F. Chromatin structure modulates DNA repair by photolyase in vivo. The EMBO Journal 1997, 16(8):2150-2160.
    • (1997) The EMBO Journal , vol.16 , Issue.8 , pp. 2150-2160
    • Suter, B.1    Livingstone-Zatchej, M.2    Thoma, F.3
  • 70
    • 0037023774 scopus 로고    scopus 로고
    • Repair of active and silenced rDNA in yeast: the contributions of photolyase and transcription-couples nucleotide excision repair
    • Meier A., Livingstone-Zatchej M., Thoma F. Repair of active and silenced rDNA in yeast: the contributions of photolyase and transcription-couples nucleotide excision repair. The Journal of Biological Chemistry 2002, 277(14):11845-11852.
    • (2002) The Journal of Biological Chemistry , vol.277 , Issue.14 , pp. 11845-11852
    • Meier, A.1    Livingstone-Zatchej, M.2    Thoma, F.3
  • 71
    • 0033678508 scopus 로고    scopus 로고
    • DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease
    • El-Osta A., Wolffe A.P. DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease. Gene Expression 2000, 9(1/2):63-75.
    • (2000) Gene Expression , vol.9 , Issue.1-2 , pp. 63-75
    • El-Osta, A.1    Wolffe, A.P.2
  • 72
    • 0022351169 scopus 로고
    • DNA hypomethylation causes an increase in DNase-I sensitivity and an advance in the time of replication of the entire inactive X chromosome
    • Jablonka E., et al. DNA hypomethylation causes an increase in DNase-I sensitivity and an advance in the time of replication of the entire inactive X chromosome. Chromosoma 1985, 93(2):152-156.
    • (1985) Chromosoma , vol.93 , Issue.2 , pp. 152-156
    • Jablonka, E.1
  • 73
    • 0037154972 scopus 로고    scopus 로고
    • Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects
    • Richards E.J., Elgin S.C. Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects. Cell 2002, 108(4):489-500.
    • (2002) Cell , vol.108 , Issue.4 , pp. 489-500
    • Richards, E.J.1    Elgin, S.C.2
  • 74
    • 0037992395 scopus 로고    scopus 로고
    • The structure of DNA in the nucleosome core
    • Richmond T.J., Davey C.A. The structure of DNA in the nucleosome core. Nature 2003, 423(6936):145-150.
    • (2003) Nature , vol.423 , Issue.6936 , pp. 145-150
    • Richmond, T.J.1    Davey, C.A.2
  • 75
    • 0345097650 scopus 로고    scopus 로고
    • Is a small number of charge neutralizations sufficient to bend nucleosome core DNA onto its superhelical ramp?
    • Manning G.S. Is a small number of charge neutralizations sufficient to bend nucleosome core DNA onto its superhelical ramp?. Journal of the American Chemical Society 2003, 125(49):15087-15092.
    • (2003) Journal of the American Chemical Society , vol.125 , Issue.49 , pp. 15087-15092
    • Manning, G.S.1
  • 76
    • 84867621675 scopus 로고    scopus 로고
    • Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin
    • Manova V., Singh S., Iliakis G. Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin. Genome Integrity 2012, 3(1):4.
    • (2012) Genome Integrity , vol.3 , Issue.1 , pp. 4
    • Manova, V.1    Singh, S.2    Iliakis, G.3
  • 77
    • 39849097680 scopus 로고    scopus 로고
    • Resistance to therapy caused by intragenic deletion in BRCA2
    • Edwards S.L., et al. Resistance to therapy caused by intragenic deletion in BRCA2. Nature 2008, 451(7182):1111-1115.
    • (2008) Nature , vol.451 , Issue.7182 , pp. 1111-1115
    • Edwards, S.L.1
  • 78
    • 0141634051 scopus 로고    scopus 로고
    • Origins of chromosome translocations in childhood leukaemia
    • Greaves M.F., Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nature Reviews: Cancer 2003, 3(9):639-649.
    • (2003) Nature Reviews: Cancer , vol.3 , Issue.9 , pp. 639-649
    • Greaves, M.F.1    Wiemels, J.2
  • 79
    • 77955419733 scopus 로고    scopus 로고
    • The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres
    • Rai R., et al. The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. The EMBO Journal 2010, 29(15):2598-2610.
    • (2010) The EMBO Journal , vol.29 , Issue.15 , pp. 2598-2610
    • Rai, R.1
  • 80
    • 84879953282 scopus 로고    scopus 로고
    • DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy
    • (Article 113)
    • Mladenov E., et al. DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy. Frontiers in Oncology 2013, 3. (Article 113).
    • (2013) Frontiers in Oncology , vol.3
    • Mladenov, E.1
  • 81
    • 84964045835 scopus 로고    scopus 로고
    • Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer
    • Dueva R., Iliakis G. Alternative pathways of non-homologous end joining (NHEJ) in genomic instability and cancer. Translational Cancer Research 2013, 2(3):163-177.
    • (2013) Translational Cancer Research , vol.2 , Issue.3 , pp. 163-177
    • Dueva, R.1    Iliakis, G.2


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