A permeation enhancer for increasing transport of therapeutic macromolecules across the intestine

Journal of Controlled Release

Volumn 172, Issue 2, 2013, Pages 541-549

  Gupta, Vivek ^a   Hwang, Byeong Hee ^a   Doshi, Nishit ^a   Mitragotri, Samir ^a  

^a University of California   (United States)

Author keywords

Caco 2; Calcitonin; Chemical permeation enhancer; Dimethyl palmitoyl ammonio propanesulfonate (PPS); Oral; Zwitterionic surfactant

Indexed keywords

CACO-2; CALCITONIN; DIMETHYL PALMITOYL AMMONIO PROPANESULFONATE (PPS); ORAL; PERMEATION ENHANCERS; ZWITTERIONIC SURFACTANTS;

BIOCHEMISTRY; TOXICITY;

MACROMOLECULES;

BOVINE INSULIN; CALCIUM; DIMETHYL PALMITOYL AMMONIO PROPANESULFONATE; FLUORESCEIN ISOTHIOCYANATE; PENETRATION ENHANCING AGENT; SALCATONIN; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALCIUM BLOOD LEVEL; CELL SURVIVAL; CELL VIABILITY; COLORECTAL CARCINOMA; CONFOCAL LASER MICROSCOPY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HALF LIFE; DRUG PENETRATION; DRUG SAFETY; DRUG TRANSPORT; ELECTRIC RESISTANCE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MACROMOLECULE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TIME TO MAXIMUM PLASMA CONCENTRATION;

CACO-2; CALCITONIN; CHEMICAL PERMEATION ENHANCER; DIMETHYL PALMITOYL AMMONIO PROPANESULFONATE (PPS); ORAL; ZWITTERIONIC SURFACTANT;

ALKANESULFONIC ACIDS; ANIMALS; CACO-2 CELLS; CALCITONIN; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HUMANS; INSULIN; INTESTINAL ABSORPTION; INTESTINES; MALE; PERMEABILITY; PHARMACEUTICAL VEHICLES; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINES;

EID: 84887098750     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.05.002     Document Type: Article

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