메뉴 건너뛰기




Volumn 38, Issue 4, 2009, Pages 301-311

Evaluation of intestinal absorption and mucosal toxicity using two promoters. II. Rat instillation and perfusion studies

Author keywords

Absorption promotion; Epithelial transport; Melittin; Oral macromolecule delivery; Sodium caprate

Indexed keywords

CARBON 14; DECANOATE SODIUM; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MANNITOL; MELITTIN; PENETRATION ENHANCING AGENT; SODIUM DERIVATIVE; SUGAR; UNCLASSIFIED DRUG;

EID: 70349838243     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.07.011     Document Type: Article
Times cited : (34)

References (81)
  • 2
    • 0027174290 scopus 로고
    • Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route
    • Anderberg E.K., Lindmark T., and Artursson P. Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm. Res. 10 (1993) 857-864
    • (1993) Pharm. Res. , vol.10 , pp. 857-864
    • Anderberg, E.K.1    Lindmark, T.2    Artursson, P.3
  • 3
    • 0033816196 scopus 로고    scopus 로고
    • Intestinal permeation enhancers
    • Aungst B.J. Intestinal permeation enhancers. J. Pharm. Sci. 89 (2000) 429-442
    • (2000) J. Pharm. Sci. , vol.89 , pp. 429-442
    • Aungst, B.J.1
  • 5
    • 0031422605 scopus 로고    scopus 로고
    • Heparin absorption across the intestine: effects of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers
    • Brayden D., Creed E., O'Connell A., Leipold H., Agarwal R., and Leone-Bay A. Heparin absorption across the intestine: effects of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate in rat in situ intestinal instillations and in Caco-2 monolayers. Pharm. Res. 14 (1997) 1772-1779
    • (1997) Pharm. Res. , vol.14 , pp. 1772-1779
    • Brayden, D.1    Creed, E.2    O'Connell, A.3    Leipold, H.4    Agarwal, R.5    Leone-Bay, A.6
  • 6
    • 0033604485 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of effects of sodium caprate on enteral peptide absorption and on mucosal morphology
    • Chao A.C., Nguyen J.V., Broughall M., Griffin A., Fix J.A., and Daddona P.E. In vitro and in vivo evaluation of effects of sodium caprate on enteral peptide absorption and on mucosal morphology. Int. J. Pharm. 191 (1999) 15-24
    • (1999) Int. J. Pharm. , vol.191 , pp. 15-24
    • Chao, A.C.1    Nguyen, J.V.2    Broughall, M.3    Griffin, A.4    Fix, J.A.5    Daddona, P.E.6
  • 8
    • 0038344743 scopus 로고    scopus 로고
    • Improvement of norfloxacin oral bioavailability by EDTA and sodium caprate
    • Dos Santos I., Fawaz F., Lagueny A.M., and Bonini F. Improvement of norfloxacin oral bioavailability by EDTA and sodium caprate. Int. J. Pharm. 260 (2003) 1-4
    • (2003) Int. J. Pharm. , vol.260 , pp. 1-4
    • Dos Santos, I.1    Fawaz, F.2    Lagueny, A.M.3    Bonini, F.4
  • 9
    • 0032522492 scopus 로고    scopus 로고
    • Effect of a weak electrolyte on the critical micellar concentration of sodium dodecyl sulfate
    • Esposito C., Colicchio P., Facchiano A., and Ragone R. Effect of a weak electrolyte on the critical micellar concentration of sodium dodecyl sulfate. J. Colloid Interface Sci. 200 (1998) 310-312
    • (1998) J. Colloid Interface Sci. , vol.200 , pp. 310-312
    • Esposito, C.1    Colicchio, P.2    Facchiano, A.3    Ragone, R.4
  • 10
    • 0030938926 scopus 로고    scopus 로고
    • Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
    • Fasano A., and Uzzau S. Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model. J. Clin. Invest. 99 (1997) 1158-1164
    • (1997) J. Clin. Invest. , vol.99 , pp. 1158-1164
    • Fasano, A.1    Uzzau, S.2
  • 12
    • 15044359147 scopus 로고    scopus 로고
    • Improvement of absorption enhancing effects of n-dodecyl-beta-d-maltopyranoside by its colon-specific delivery using chitosan capsules
    • Fetih G., Lindberg S., Itoh K., Okada N., Fujita T., Habib F., Artersson P., Attia M., and Yamamoto A. Improvement of absorption enhancing effects of n-dodecyl-beta-d-maltopyranoside by its colon-specific delivery using chitosan capsules. Int. J. Pharm. 293 (2005) 127-135
    • (2005) Int. J. Pharm. , vol.293 , pp. 127-135
    • Fetih, G.1    Lindberg, S.2    Itoh, K.3    Okada, N.4    Fujita, T.5    Habib, F.6    Artersson, P.7    Attia, M.8    Yamamoto, A.9
  • 14
    • 70349800732 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of daily oral antisense oligonucleotide, ISIS 301012 in mice and dogs for 13 weeks
    • Geary R., Yu R., Kim T.-W., Levin A., Dokka S., Tillman L.G., and Hardee G. Pharmacokinetics and tolerability of daily oral antisense oligonucleotide, ISIS 301012 in mice and dogs for 13 weeks. AAPS J. 7 (2005) S2
    • (2005) AAPS J. , vol.7
    • Geary, R.1    Yu, R.2    Kim, T.-W.3    Levin, A.4    Dokka, S.5    Tillman, L.G.6    Hardee, G.7
  • 15
    • 70349828289 scopus 로고    scopus 로고
    • A phase I study of orally administered ISIS 301012 for the reduction of ApoB-100 and LDL-cholesterol
    • Hardee G., Geary R., Tillman L.G., Bradley J., Su J., Dokka S., and Wedel M. A phase I study of orally administered ISIS 301012 for the reduction of ApoB-100 and LDL-cholesterol. AAPS J. 8 (2006) S1
    • (2006) AAPS J. , vol.8
    • Hardee, G.1    Geary, R.2    Tillman, L.G.3    Bradley, J.4    Su, J.5    Dokka, S.6    Wedel, M.7
  • 16
    • 0038546904 scopus 로고    scopus 로고
    • The colon as a possible target for orally administered peptide and protein drugs
    • Haupt S., and Rubinstein A. The colon as a possible target for orally administered peptide and protein drugs. Crit. Rev. Ther. Drug Carrier Syst. 19 (2002) 499-551
    • (2002) Crit. Rev. Ther. Drug Carrier Syst. , vol.19 , pp. 499-551
    • Haupt, S.1    Rubinstein, A.2
  • 17
    • 0035192016 scopus 로고    scopus 로고
    • Estimation of absorption enhancement by medium-chain fatty acids in rat large intestine
    • Higaki K., Yata T., Sone M., Ogawara K., and Kimura T. Estimation of absorption enhancement by medium-chain fatty acids in rat large intestine. Res. Commun. Mol. Pathol. Pharmacol. 109 (2001) 231-240
    • (2001) Res. Commun. Mol. Pathol. Pharmacol. , vol.109 , pp. 231-240
    • Higaki, K.1    Yata, T.2    Sone, M.3    Ogawara, K.4    Kimura, T.5
  • 18
    • 59349115917 scopus 로고    scopus 로고
    • 2008 FDA drug approvals
    • Hughes B. 2008 FDA drug approvals. Nat. Rev. Drug Discov. 8 (2009) 93-96
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 93-96
    • Hughes, B.1
  • 19
    • 16244421697 scopus 로고    scopus 로고
    • Absorption-enhancing effect of glycyrrhizin induced in the presence of capric acid
    • Imai T., Sakai M., Ohtake H., Azuma H., and Otagiri M. Absorption-enhancing effect of glycyrrhizin induced in the presence of capric acid. Int. J. Pharm. 294 (2005) 11-21
    • (2005) Int. J. Pharm. , vol.294 , pp. 11-21
    • Imai, T.1    Sakai, M.2    Ohtake, H.3    Azuma, H.4    Otagiri, M.5
  • 20
    • 0023603431 scopus 로고
    • Enhancement of jejunal and colonic absorption of fosfomycin by promoters in the rat
    • Ishizawa T., Hayashi M., and Awazu S. Enhancement of jejunal and colonic absorption of fosfomycin by promoters in the rat. J. Pharm. Pharmacol. 39 (1987) 892-895
    • (1987) J. Pharm. Pharmacol. , vol.39 , pp. 892-895
    • Ishizawa, T.1    Hayashi, M.2    Awazu, S.3
  • 21
    • 0032968755 scopus 로고    scopus 로고
    • Surfactants in membrane solubilisation
    • Jones M.N. Surfactants in membrane solubilisation. Int. J. Pharm. 177 (1999) 137-159
    • (1999) Int. J. Pharm. , vol.177 , pp. 137-159
    • Jones, M.N.1
  • 22
    • 0030001341 scopus 로고    scopus 로고
    • A novel method for the preclinical assessment of rectal irritation
    • Kinouchi Y., Takeichi Y., and Yata N. A novel method for the preclinical assessment of rectal irritation. J. Pharm. Pharmacol. 48 (1996) 310-315
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 310-315
    • Kinouchi, Y.1    Takeichi, Y.2    Yata, N.3
  • 23
    • 0018850819 scopus 로고
    • Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes
    • Komiya I., Park J.Y., Kamani A., Ho N.F.H., and Higuchi W.I. Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes. Int. J. Pharm. 4 (1980) 249-262
    • (1980) Int. J. Pharm. , vol.4 , pp. 249-262
    • Komiya, I.1    Park, J.Y.2    Kamani, A.3    Ho, N.F.H.4    Higuchi, W.I.5
  • 25
    • 33748363100 scopus 로고    scopus 로고
    • A novel strategy for a drug delivery system using a claudin modulator
    • Kondoh M., Takahashi A., Fujii M., Yagi K., and Watanabe Y. A novel strategy for a drug delivery system using a claudin modulator. Biol. Pharm. Bull. 29 (2006) 1783-1789
    • (2006) Biol. Pharm. Bull. , vol.29 , pp. 1783-1789
    • Kondoh, M.1    Takahashi, A.2    Fujii, M.3    Yagi, K.4    Watanabe, Y.5
  • 26
    • 0026329336 scopus 로고
    • Mucosal penetration enhancers for facilitation of peptide and protein drug absorption
    • Lee V.H., Yamamoto A., and Kompella U.B. Mucosal penetration enhancers for facilitation of peptide and protein drug absorption. Crit. Rev. Ther. Drug Carrier Syst. 8 (1991) 91-192
    • (1991) Crit. Rev. Ther. Drug Carrier Syst. , vol.8 , pp. 91-192
    • Lee, V.H.1    Yamamoto, A.2    Kompella, U.B.3
  • 27
    • 0036229948 scopus 로고    scopus 로고
    • The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans
    • Lennernas H., Gjellan K., Hallgren R., and Graffner C. The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans. J. Pharm. Pharmacol. 54 (2002) 499-508
    • (2002) J. Pharm. Pharmacol. , vol.54 , pp. 499-508
    • Lennernas, H.1    Gjellan, K.2    Hallgren, R.3    Graffner, C.4
  • 28
    • 33748641168 scopus 로고    scopus 로고
    • Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET
    • Leonard T.W., Lynch J., McKenna M.J., and Brayden D.J. Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET. Expert Opin. Drug Deliv. 3 (2006) 685-962
    • (2006) Expert Opin. Drug Deliv. , vol.3 , pp. 685-962
    • Leonard, T.W.1    Lynch, J.2    McKenna, M.J.3    Brayden, D.J.4
  • 29
    • 0031885344 scopus 로고    scopus 로고
    • Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells
    • Lindmark T., Kimura Y., and Artursson P. Absorption enhancement through intracellular regulation of tight junction permeability by medium chain fatty acids in Caco-2 cells. J. Pharmacol. Exp. Ther. 284 (1998) 362-369
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 362-369
    • Lindmark, T.1    Kimura, Y.2    Artursson, P.3
  • 30
    • 0030749435 scopus 로고    scopus 로고
    • Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate
    • Lindmark T., Söderholm J.D., Olaison G., Alván G., Ocklind G., and Artursson P. Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate. Pharm. Res. 14 (1997) 930-935
    • (1997) Pharm. Res. , vol.14 , pp. 930-935
    • Lindmark, T.1    Söderholm, J.D.2    Olaison, G.3    Alván, G.4    Ocklind, G.5    Artursson, P.6
  • 31
    • 0028836246 scopus 로고
    • Mechanism of colonic permeation of inulin: is rat colon more permeable than small intestine?
    • Ma T.Y., Hollander D., Erickson R.A., Truong H., Nguyen H., and Krugliak P. Mechanism of colonic permeation of inulin: is rat colon more permeable than small intestine?. Gastroenterology 108 (1995) 12-20
    • (1995) Gastroenterology , vol.108 , pp. 12-20
    • Ma, T.Y.1    Hollander, D.2    Erickson, R.A.3    Truong, H.4    Nguyen, H.5    Krugliak, P.6
  • 32
    • 34249889326 scopus 로고    scopus 로고
    • Melittin as an epithelial permeability enhancer I: investigation of its mechanism of action in Caco-2 monolayers
    • Maher S., Feighery L., Brayden D.J., and McClean S. Melittin as an epithelial permeability enhancer I: investigation of its mechanism of action in Caco-2 monolayers. Pharm. Res. 24 (2007) 1336-1345
    • (2007) Pharm. Res. , vol.24 , pp. 1336-1345
    • Maher, S.1    Feighery, L.2    Brayden, D.J.3    McClean, S.4
  • 33
    • 34249872197 scopus 로고    scopus 로고
    • Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae
    • Maher S., Feighery L., Brayden D.J., and McClean S. Melittin as a permeability enhancer II: in vitro investigations in human mucus secreting intestinal monolayers and rat colonic mucosae. Pharm. Res. 24 (2007) 1346-1356
    • (2007) Pharm. Res. , vol.24 , pp. 1346-1356
    • Maher, S.1    Feighery, L.2    Brayden, D.J.3    McClean, S.4
  • 34
    • 70349843043 scopus 로고    scopus 로고
    • Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in Isolated rat and human colonic mucosae
    • in press
    • Maher, S., Kennelly, R., Bzik, V., Baird, A.W., Wang, X., Winter, D., Brayden, D.J., 2009. Evaluation of intestinal absorption enhancement and local mucosal toxicity of two promoters. I. Studies in Isolated rat and human colonic mucosae. Eur. J. Pharm. Sci., in press.
    • (2009) Eur. J. Pharm. Sci
    • Maher, S.1    Kennelly, R.2    Bzik, V.3    Baird, A.W.4    Wang, X.5    Winter, D.6    Brayden, D.J.7
  • 35
    • 33645119895 scopus 로고    scopus 로고
    • Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro
    • Maher S., and McClean S. Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro. Biochem. Pharmacol. 71 (2006) 1289-1298
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1289-1298
    • Maher, S.1    McClean, S.2
  • 36
    • 38949175466 scopus 로고    scopus 로고
    • Melittin exhibits necrotic cytotoxicity in gastrointestinal cells which is attenuated by cholesterol
    • Maher S., and McClean S. Melittin exhibits necrotic cytotoxicity in gastrointestinal cells which is attenuated by cholesterol. Biochem. Pharmacol. 75 (2008) 1104-1114
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 1104-1114
    • Maher, S.1    McClean, S.2
  • 37
    • 0242403355 scopus 로고    scopus 로고
    • Diversity of restitution after deoxycholic acid-induced small intestinal mucosal injury in the rat
    • Masuda K., Ikeda H., Kasai K., Fukuzawa Y., Nishimaki H., Takeo T., and Itoh G. Diversity of restitution after deoxycholic acid-induced small intestinal mucosal injury in the rat. Dig. Dis. Sci. 48 (2003) 2108-2115
    • (2003) Dig. Dis. Sci. , vol.48 , pp. 2108-2115
    • Masuda, K.1    Ikeda, H.2    Kasai, K.3    Fukuzawa, Y.4    Nishimaki, H.5    Takeo, T.6    Itoh, G.7
  • 39
    • 0037381429 scopus 로고    scopus 로고
    • Combinatorial use of sodium laurate with taurine or l-glutamine enhances colonic absorption of rebamipide, poorly absorbable antiulcer drug, without any serious histopathological mucosal damages
    • Miyake M., Oka Y., Minami T., Toguchi H., Odomi M., Ogawara K., Higaki K., and Kimura T. Combinatorial use of sodium laurate with taurine or l-glutamine enhances colonic absorption of rebamipide, poorly absorbable antiulcer drug, without any serious histopathological mucosal damages. J. Pharm. Sci. 92 (2003) 911-921
    • (2003) J. Pharm. Sci. , vol.92 , pp. 911-921
    • Miyake, M.1    Oka, Y.2    Minami, T.3    Toguchi, H.4    Odomi, M.5    Ogawara, K.6    Higaki, K.7    Kimura, T.8
  • 40
    • 0026651731 scopus 로고
    • Effects of salicylate and other enhancers on rectal absorption of erythropoietin in rats
    • Mizuno A., Ueda M., and Kawanishi G. Effects of salicylate and other enhancers on rectal absorption of erythropoietin in rats. J. Pharm. Pharmacol. 44 (1992) 570-573
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 570-573
    • Mizuno, A.1    Ueda, M.2    Kawanishi, G.3
  • 41
    • 0024426122 scopus 로고
    • Villus contraction aids repair of intestinal epithelium after injury
    • Moore R., Carlson S., and Madara J.L. Villus contraction aids repair of intestinal epithelium after injury. Am. J. Physiol. 257 (1989) G274-G283
    • (1989) Am. J. Physiol. , vol.257
    • Moore, R.1    Carlson, S.2    Madara, J.L.3
  • 42
    • 0037417735 scopus 로고    scopus 로고
    • Thermodynamic and kinetic stability. Properties of micelles and vesicles formed by the decanoic acid/decanoate system
    • Morigaki K., Walde P., Misran M., and Robinson B.H. Thermodynamic and kinetic stability. Properties of micelles and vesicles formed by the decanoic acid/decanoate system. Colloids Surf. A: Phys. Eng. Aspects 213 (2003) 37-44
    • (2003) Colloids Surf. A: Phys. Eng. Aspects , vol.213 , pp. 37-44
    • Morigaki, K.1    Walde, P.2    Misran, M.3    Robinson, B.H.4
  • 43
    • 16344384909 scopus 로고    scopus 로고
    • Elucidation of the transport pathway in hairless rat skin enhanced by low-frequency sonophoresis based on the solute-water transport relationship and confocal microscopy
    • Morimoto Y., Mutoh M., Ueda H., Fang L., Hirayama K., Atobe M., and Kobayashi D. Elucidation of the transport pathway in hairless rat skin enhanced by low-frequency sonophoresis based on the solute-water transport relationship and confocal microscopy. J. Control. Release 103 (2005) 587-597
    • (2005) J. Control. Release , vol.103 , pp. 587-597
    • Morimoto, Y.1    Mutoh, M.2    Ueda, H.3    Fang, L.4    Hirayama, K.5    Atobe, M.6    Kobayashi, D.7
  • 45
    • 30844439844 scopus 로고    scopus 로고
    • Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels
    • Motlekar N.A., Srivenugopal K.S., Wachtel M.S., and Youan B.B. Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels. J. Drug Target. 13 (2005) 573-583
    • (2005) J. Drug Target. , vol.13 , pp. 573-583
    • Motlekar, N.A.1    Srivenugopal, K.S.2    Wachtel, M.S.3    Youan, B.B.4
  • 46
    • 0026722203 scopus 로고
    • The colon as a site for drug delivery
    • Mrsny R.J. The colon as a site for drug delivery. J. Control. Release 22 (1992) 15-34
    • (1992) J. Control. Release , vol.22 , pp. 15-34
    • Mrsny, R.J.1
  • 47
    • 27644461045 scopus 로고    scopus 로고
    • Modification of epithelial tight junction integrity to enhance transmucosal absorption
    • Mrsny R.J. Modification of epithelial tight junction integrity to enhance transmucosal absorption. Crit. Rev. Ther. Drug Carrier Syst. 22 (2005) 331-418
    • (2005) Crit. Rev. Ther. Drug Carrier Syst. , vol.22 , pp. 331-418
    • Mrsny, R.J.1
  • 48
    • 38049129684 scopus 로고    scopus 로고
    • Evaluation of mucosal damage and recovery in the gastrointestinal tract of rats by a penetration enhancer
    • Narkar Y., Burnette R., Bleher R., Albrecht R., Kandela A., and Robinson J.R. Evaluation of mucosal damage and recovery in the gastrointestinal tract of rats by a penetration enhancer. Pharm. Res. 25 (2008) 25-38
    • (2008) Pharm. Res. , vol.25 , pp. 25-38
    • Narkar, Y.1    Burnette, R.2    Bleher, R.3    Albrecht, R.4    Kandela, A.5    Robinson, J.R.6
  • 49
    • 0001334658 scopus 로고    scopus 로고
    • Design principles for orally bioavailable drugs
    • Navia M.A., and Chaturvedi P.R. Design principles for orally bioavailable drugs. Drug Discov. Today 1 (1996) 179-189
    • (1996) Drug Discov. Today , vol.1 , pp. 179-189
    • Navia, M.A.1    Chaturvedi, P.R.2
  • 50
    • 0021966760 scopus 로고
    • Studies on the promoting effects of carboxylic acid derivatives on the rectal absorption of beta-lactam antibiotics in rats
    • Nishimura K., Nozaki Y., Yoshimi A., Nakamura S., Kitagawa M., Kakeya N., and Kitao K. Studies on the promoting effects of carboxylic acid derivatives on the rectal absorption of beta-lactam antibiotics in rats. Chem. Pharm. Bull. 33 (1985) 282-291
    • (1985) Chem. Pharm. Bull. , vol.33 , pp. 282-291
    • Nishimura, K.1    Nozaki, Y.2    Yoshimi, A.3    Nakamura, S.4    Kitagawa, M.5    Kakeya, N.6    Kitao, K.7
  • 52
    • 34447282684 scopus 로고    scopus 로고
    • Melittin: a membrane-active peptide with diverse functions
    • Raghuraman H., and Chattopadhyay A. Melittin: a membrane-active peptide with diverse functions. Biosci. Rep. 27 (2007) 189-223
    • (2007) Biosci. Rep. , vol.27 , pp. 189-223
    • Raghuraman, H.1    Chattopadhyay, A.2
  • 54
    • 0036830625 scopus 로고    scopus 로고
    • Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs
    • Raoof A.A., Ramtoola Z., McKenna B., Yu R.Z., Hardee G., and Geary R.S. Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs. Eur. J. Pharm. Sci. 17 (2002) 131-138
    • (2002) Eur. J. Pharm. Sci. , vol.17 , pp. 131-138
    • Raoof, A.A.1    Ramtoola, Z.2    McKenna, B.3    Yu, R.Z.4    Hardee, G.5    Geary, R.S.6
  • 56
    • 27744448891 scopus 로고    scopus 로고
    • Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers
    • Sharma P., Varma M.V., Chawla H.P., and Panchagnula R. Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers. Farmaco 60 (2005) 884-893
    • (2005) Farmaco , vol.60 , pp. 884-893
    • Sharma, P.1    Varma, M.V.2    Chawla, H.P.3    Panchagnula, R.4
  • 57
    • 27744605985 scopus 로고    scopus 로고
    • In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies
    • Sharma P., Varma M.V., Chawla H.P., and Panchagnula R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Farmaco 60 (2005) 874-883
    • (2005) Farmaco , vol.60 , pp. 874-883
    • Sharma, P.1    Varma, M.V.2    Chawla, H.P.3    Panchagnula, R.4
  • 58
    • 0031183655 scopus 로고    scopus 로고
    • Effects of medium-chain fatty acids and their acylglycerols on the transport of penicillin V across Caco-2 cell monolayers
    • Shima M., Yohdoh K., Yamaguchi M., Kimura Y., Adachi S., and Matsuno R. Effects of medium-chain fatty acids and their acylglycerols on the transport of penicillin V across Caco-2 cell monolayers. Biosci. Biotechnol. Biochem. 61 (1997) 1150-1155
    • (1997) Biosci. Biotechnol. Biochem. , vol.61 , pp. 1150-1155
    • Shima, M.1    Yohdoh, K.2    Yamaguchi, M.3    Kimura, Y.4    Adachi, S.5    Matsuno, R.6
  • 59
    • 0022531027 scopus 로고
    • The interaction of melittin with calmodulin and its tryptic fragments
    • Steiner R.F., Marshall L., and Needleman D. The interaction of melittin with calmodulin and its tryptic fragments. Arch. Biochem. Biophys. 246 (1986) 286-300
    • (1986) Arch. Biochem. Biophys. , vol.246 , pp. 286-300
    • Steiner, R.F.1    Marshall, L.2    Needleman, D.3
  • 60
    • 34547680472 scopus 로고    scopus 로고
    • Enhancement of intestinal absorption of macromolecules by spermine in rats
    • Sugita Y., Takao K., Toyama Y., and Shirahata A. Enhancement of intestinal absorption of macromolecules by spermine in rats. Amino Acids 33 (2007) 253-260
    • (2007) Amino Acids , vol.33 , pp. 253-260
    • Sugita, Y.1    Takao, K.2    Toyama, Y.3    Shirahata, A.4
  • 61
    • 18044399674 scopus 로고    scopus 로고
    • 14C-PEG-3350 methods to determine water absorption in the rat single-pass intestinal perfusion model
    • 14C-PEG-3350 methods to determine water absorption in the rat single-pass intestinal perfusion model. AAPS PharmSci 3 (2001) E25
    • (2001) AAPS PharmSci , vol.3
    • Sutton, S.C.1    Rinaldi, M.T.2    Vukovinsky, K.E.3
  • 62
    • 0026571249 scopus 로고
    • Means to enhance penetration. (2) Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity
    • Swenson E., and Curatolo W.J. Means to enhance penetration. (2) Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity. Adv. Drug Deliv. Rev. 8 (1992) 39-92
    • (1992) Adv. Drug Deliv. Rev. , vol.8 , pp. 39-92
    • Swenson, E.1    Curatolo, W.J.2
  • 63
    • 0030919761 scopus 로고    scopus 로고
    • The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absorption through a paracellular pathway
    • Takahashi H., Shibasaki T., Takeshita K., Kaiho F., and Hayashi M. The enhancing mechanism of capric acid (C10) from a suppository on rectal drug absorption through a paracellular pathway. Biol. Pharm. Bull. 20 (1997) 446-448
    • (1997) Biol. Pharm. Bull. , vol.20 , pp. 446-448
    • Takahashi, H.1    Shibasaki, T.2    Takeshita, K.3    Kaiho, F.4    Hayashi, M.5
  • 64
    • 0028348099 scopus 로고
    • Pharmacokinetic analysis of the absorption enhancing action of decanoic acid and its derivatives in rats
    • Takahashi K., Murakami T., Kamata A., Yumoto R., Higashi Y., and Yata N. Pharmacokinetic analysis of the absorption enhancing action of decanoic acid and its derivatives in rats. Pharm. Res. 11 (1994) 388-392
    • (1994) Pharm. Res. , vol.11 , pp. 388-392
    • Takahashi, K.1    Murakami, T.2    Kamata, A.3    Yumoto, R.4    Higashi, Y.5    Yata, N.6
  • 65
    • 0027973670 scopus 로고
    • Decanoic acid induced enhancement of rectal absorption of hydrophilic compounds in rats
    • Takahashi K., Murakami T., Yumoto R., Hattori T., Higashi Y., and Yata N. Decanoic acid induced enhancement of rectal absorption of hydrophilic compounds in rats. Pharm. Res. 11 10 (1994) 1401-1404
    • (1994) Pharm. Res. , vol.11 , Issue.10 , pp. 1401-1404
    • Takahashi, K.1    Murakami, T.2    Yumoto, R.3    Hattori, T.4    Higashi, Y.5    Yata, N.6
  • 66
    • 0024993529 scopus 로고
    • Combinative improving effect of increased solubility and the use of absorption enhancers on the rectal absorption of uracil in beagle dogs
    • Takeichi Y., Baba K., Kinouchi Y., Iida Y., Umeno Y., Muranishi S., and Nakai Y. Combinative improving effect of increased solubility and the use of absorption enhancers on the rectal absorption of uracil in beagle dogs. Chem. Pharm. Bull. 38 (1990) 2547-2551
    • (1990) Chem. Pharm. Bull. , vol.38 , pp. 2547-2551
    • Takeichi, Y.1    Baba, K.2    Kinouchi, Y.3    Iida, Y.4    Umeno, Y.5    Muranishi, S.6    Nakai, Y.7
  • 67
    • 38349171887 scopus 로고    scopus 로고
    • Oral delivery of antisense oligonucleotides in man
    • Tillman L.G., Geary R.S., and Hardee G.E. Oral delivery of antisense oligonucleotides in man. J. Pharm. Sci. 97 (2008) 225-236
    • (2008) J. Pharm. Sci. , vol.97 , pp. 225-236
    • Tillman, L.G.1    Geary, R.S.2    Hardee, G.E.3
  • 68
    • 0024245937 scopus 로고
    • Enhancement of colonic drug absorption by the transcellular permeation route
    • Tomita M., Hayashi M., Horie T., Ishizawa T., and Awazu S. Enhancement of colonic drug absorption by the transcellular permeation route. Pharm. Res. 5 (1988) 786-789
    • (1988) Pharm. Res. , vol.5 , pp. 786-789
    • Tomita, M.1    Hayashi, M.2    Horie, T.3    Ishizawa, T.4    Awazu, S.5
  • 69
    • 0023743080 scopus 로고
    • Enhancement of colonic drug absorption by the paracellular permeation route
    • Tomita M., Shiga M., Hayashi M., and Awazu S. Enhancement of colonic drug absorption by the paracellular permeation route. Pharm. Res. 5 (1988) 341-346
    • (1988) Pharm. Res. , vol.5 , pp. 341-346
    • Tomita, M.1    Shiga, M.2    Hayashi, M.3    Awazu, S.4
  • 73
    • 0025778611 scopus 로고
    • Pharmacokinetics of rectal drug administration. Part I. General considerations and clinical applications of centrally acting drugs
    • van Hoogdalem E., de Boer A.G., and Breimer D.D. Pharmacokinetics of rectal drug administration. Part I. General considerations and clinical applications of centrally acting drugs. Clin. Pharmacokinet. 21 (1991) 11-26
    • (1991) Clin. Pharmacokinet. , vol.21 , pp. 11-26
    • van Hoogdalem, E.1    de Boer, A.G.2    Breimer, D.D.3
  • 74
    • 0023784448 scopus 로고
    • Absorption enhancement of rectally infused cefoxitin sodium by medium-chain fatty acids in conscious rats: concentration-effect relationship
    • van Hoogdalem E.J., Hardens M.A., de Boer A.G., and Breimer D.D. Absorption enhancement of rectally infused cefoxitin sodium by medium-chain fatty acids in conscious rats: concentration-effect relationship. Pharm. Res. 5 (1988) 453-456
    • (1988) Pharm. Res. , vol.5 , pp. 453-456
    • van Hoogdalem, E.J.1    Hardens, M.A.2    de Boer, A.G.3    Breimer, D.D.4
  • 77
    • 0034306505 scopus 로고    scopus 로고
    • Epithelial enhancing paracellular permeability by modulating epithelial tight junctions
    • Ward P.D., Tippin T.K., and Thakker D.R. Epithelial enhancing paracellular permeability by modulating epithelial tight junctions. Pharm. Sci. Technol. Today 3 (2000) 346-358
    • (2000) Pharm. Sci. Technol. Today , vol.3 , pp. 346-358
    • Ward, P.D.1    Tippin, T.K.2    Thakker, D.R.3
  • 78
    • 85056974343 scopus 로고    scopus 로고
    • Permeation pathways in rectal absorption
    • Touitou E., and Barry B.W. (Eds), CRC Press
    • Watanabe Y. Permeation pathways in rectal absorption. In: Touitou E., and Barry B.W. (Eds). Enhancement in Drug Delivery (2006), CRC Press 135-146
    • (2006) Enhancement in Drug Delivery , pp. 135-146
    • Watanabe, Y.1
  • 79
    • 46749122375 scopus 로고    scopus 로고
    • Safe and effective permeation enhancers for oral drug delivery
    • Whitehead K., Karr N., and Mitragotri S. Safe and effective permeation enhancers for oral drug delivery. Pharm. Res. 25 (2008) 1782-1788
    • (2008) Pharm. Res. , vol.25 , pp. 1782-1788
    • Whitehead, K.1    Karr, N.2    Mitragotri, S.3
  • 80
    • 0028657017 scopus 로고
    • Enzymatic barriers for GI peptide and protein delivery
    • Woodley J.F. Enzymatic barriers for GI peptide and protein delivery. Crit. Rev. Ther. Drug Carrier Syst. 11 (1994) 61-95
    • (1994) Crit. Rev. Ther. Drug Carrier Syst. , vol.11 , pp. 61-95
    • Woodley, J.F.1
  • 81
    • 0030446148 scopus 로고    scopus 로고
    • Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane
    • Yamamoto A., Uchiyama T., Nishikawa R., Fujita T., and Muranishi S. Effectiveness and toxicity screening of various absorption enhancers in the rat small intestine: effects of absorption enhancers on the intestinal absorption of phenol red and the release of protein and phospholipids from the intestinal membrane. J. Pharm. Pharmacol. 48 (1996) 1285-1289
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 1285-1289
    • Yamamoto, A.1    Uchiyama, T.2    Nishikawa, R.3    Fujita, T.4    Muranishi, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.