Crystal structure of β1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site

Journal of Molecular Biology

Volumn 318, Issue 2, 2002, Pages 491-502

  Ramakrishnan, B ^a,b   Balaji, P V ^a,b   Qasba, Pradman K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

Conformational changes; Crystal structure; Oligosaccharide binding site; UDP Gal binding; 1,4 galactosyltransferase

Indexed keywords

BETA1,4 GALACTOSYLTRANSFERASE; GALACTOSE; GALACTOSYLTRANSFERASE; GLYCAN DERIVATIVE; MANGANESE CHLORIDE; MONOSACCHARIDE; N ACETYLGLUCOSAMINE; OLIGOSACCHARIDE; PENTASACCHARIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOSE; BETA 1,4 GALACTOSYLTRANSFERASE I; BETA-1,4-GALACTOSYLTRANSFERASE I; MANGANESE;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; HUMAN; MOLECULAR INTERACTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DIMERIZATION; ELECTRICITY; ENZYME SPECIFICITY; GENETICS; IN VITRO STUDY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

BOVINAE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CATTLE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ELECTROSTATICS; GALACTOSYLTRANSFERASES; HUMANS; MANGANESE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOSACCHARIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; URIDINE DIPHOSPHATE GALACTOSE;

EID: 0036019552     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00020-7     Document Type: Article

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