Interdependence of backbone flexibility, residue conservation, and enzyme function: A case study on β1,4-Galactosyltransferase-I

Biochemistry

Volumn 42, Issue 13, 2003, Pages 3674-3687

  Gunasekaran, K ^a   Ma, Buyong ^a   Ramakrishnan, B ^a,b   Qasba, Pradman K ^a   Nussinov, Ruth ^a,b,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; SOLVENTS; SUBSTRATES;

ENZYME FUNCTIONS;

ENZYMES;

BETA1,4 GALACTOSYLTRANSFERASE I; GALACTOSYLTRANSFERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENETIC CONSERVATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN FAMILY; SIMULATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CATTLE; COMPUTER SIMULATION; CONSERVED SEQUENCE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; GALACTOSYLTRANSFERASES; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; TRYPTOPHAN; URIDINE DIPHOSPHATE GALACTOSE;

EID: 0037426326     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034046r     Document Type: Article

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