Identification of key functional residues in the active site of human β1,4-galactosyltransferase 7: A major enzyme in the glycosaminoglycan synthesis pathway

Journal of Biological Chemistry

Volumn 285, Issue 48, 2010, Pages 37342-37358

  Talhaoui, Ibtissam ^a   Bui, Catherine ^a,d   Oriol, Rafael ^b   Mulliert, Guillermo ^a   Gulberti, Sandrine ^a   Netter, Patrick ^a   Coughtrie, Michael W H ^c   Ouzzine, Mohamed ^a   Fournel Gigleux, Sylvie ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b INSTITUT ANDRÉ LWOFF   (France)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARBOXYLATION; MEDICAL APPLICATIONS; SUBSTRATES;

BIOMEDICAL APPLICATIONS; ENZYME ACTIVE SITES; FUNCTIONAL DOMAINS; FUNCTIONAL PEPTIDES; FUNCTIONAL RESIDUES; GLYCOSAMINOGLYCANS; PHYLOGENETIC ANALYSIS; SYSTEMATIC ENGINEERING;

ENZYMES;

ASPARTIC ACID; BETA 1,4 GALACTOSYLTRANSFERASE 7; CARBOXYLIC ACID; GALACTOSYLTRANSFERASE; GLYCOSAMINOGLYCAN; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MODIFICATION; ENZYME PURIFICATION; ENZYME SUBSTRATE COMPLEX; EX VIVO STUDY; GENE MUTATION; GENE SEQUENCE; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN MOTIF; SITE DIRECTED MUTAGENESIS;

EID: 78549282816     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.151951     Document Type: Article

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